Article
Pediatrics
Mao-Shui Wang, Jun-Li Wang, Xin-Jie Liu, Yan-An Zhang
Summary: A retrospective study was conducted to evaluate the sensitivity of the diagnostic criteria for childhood tuberculous meningitis (TBM) published by Marais et al. in 2010. The study found that the criteria effectively identified childhood TBM, but further revisions are needed to improve sensitivity and practicality.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Ying Luo, Ying Xue, Qun Lin, Liyan Mao, Guoxing Tang, Huijuan Song, Wei Liu, Shiji Wu, Weiyong Liu, Yu Zhou, Lingqing Xu, Zhigang Xiong, Ting Wang, Xu Yuan, Yong Gan, Ziyong Sun, Feng Wang
Summary: The study established a diagnostic model based on a combination of CSF chlorine, CSF nucleated cell count, CSF lymphocyte proportion, and the tuberculosis-specific antigen/phytohemagglutinin (TBAg/PHA) ratio, which showed excellent utility in discriminating between TBM and BM, with high sensitivity and specificity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Olga Spekker, David R. Hunt, William Berthon, Laszlo Paja, Erika Molnar, Gyorgy Palfi, Michael Schultz
Summary: Abnormally pronounced digital impressions (APDIs) on the endocranial surface are associated with a prolonged rise in intracranial pressure, often resulting from conditions such as hydrocephalus due to tuberculous meningitis. A study comparing skeletons with tuberculosis-related deaths to those with non-tuberculous deaths found that APDIs were significantly more common in the former group, suggesting their potential as a diagnostic criterion for identifying TBM in paleopathological practice and assessing TB frequency in ancient populations.
Review
Microbiology
Charles M. Manyelo, Regan S. Solomons, Gerhard Walz, Novel N. Cheyou
Summary: Tuberculous meningitis is a devastating form of tuberculosis with limited understanding of its immunology and pathogenesis. Further research is urgently needed to improve disease management and develop new therapeutic approaches.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Clinical Neurology
Mailing Huang, Zeyu Ding, Wensheng Li, Weibi Chen, Yadong Du, Hongyan Jia, Qi Sun, Boping Du, Rongrong Wei, Aiying Xing, Qi Li, Naihui Chu, Liping Pan
Summary: This study discovered that specific biomarkers in cerebrospinal fluid can help diagnose and understand the pathogenesis of tuberculous meningitis (TBM). By analyzing the expression of proteins in CSF, it is possible to distinguish between TBM and non-TBM patients, providing a useful panel for TBM diagnosis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Public, Environmental & Occupational Health
Ya-Li Chen, Meng-Meng Zhu, Cui-Ping Guan, Yan-An Zhang, Mao-Shui Wang
Summary: The performance of cerebrospinal fluid lipoarabinomannan (LAM) assay in diagnosing tuberculous meningitis (TBM) is unsatisfactory, according to current evidence. More prospective studies are needed to validate its accuracy, and optimization of the assay should be considered.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Immunology
An Wen, Er-Ling Leng, Shi-Min Liu, Yong-Liang Zhou, Wen-Feng Cao, Dong-Yuan Yao, Fan Hu
Summary: In this meta-analysis, we found that cerebrospinal fluid (CSF) interferon release assays (IGRAs) exhibited a better diagnostic accuracy than blood IGRAs in diagnosing tuberculous meningitis (TBM).
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
You Lan, Wei Chen, Qun Yan, Wenen Liu
Summary: This study systematically evaluated the performance of IGRAs in diagnosing TBM and found suboptimal diagnostic performance, making them unsuitable as biomarkers for TBM diagnosis due to issues with cost, turn-around time, and accessibility.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Review
Microbiology
Yi Shi, Chengxi Zhang, Shuo Pan, Yi Chen, Xingguo Miao, Guoqiang He, Yanchan Wu, Hui Ye, Chujun Weng, Huanhuan Zhang, Wenya Zhou, Xiaojie Yang, Chenglong Liang, Dong Chen, Liang Hong, Feifei Su
Summary: This article reviews the efficacy of emerging technologies in the diagnosis and management of tuberculous meningitis (TBM). Advanced diagnostic technologies like targeted gene sequencing, real-time polymerase chain reaction (RT-PCR), miRNA assays, and metagenomic next-generation sequencing (mNGS) offer promising avenues for early TBM detection. Machine learning algorithms can enhance diagnostic accuracy and guide treatment strategies. However, these emerging technologies still face challenges in clinical implementation.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Immunology
Zheng-Bing Xiang, Er-Ling Leng, Wen-Feng Cao, Shi-Min Liu, Yong-Liang Zhou, Chao-Qun Luo, Fan Hu, An Wen
Summary: mNGS has good specificity and moderate sensitivity in diagnosing TBM. A more sensitive test should be developed to assist in the diagnosis of TBM.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiaona Xing, Zhonghua Sun, Li Chen, Nan Zhang, Wei Xiong, Yu Li
Summary: TBAA typically presents as pseudoaneurysms with mycotic shapes on CT scans, and is usually accompanied by other sites of tuberculosis infections.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Aiqing Lin, Baotao Cheng, Xiaochun Han, Hong Zhang, Xiaoli Liu, Xueping Liu
Summary: The study aimed to evaluate the application of next-generation sequencing (NGS) technology in the early diagnosis of TBM patients. The results showed that NGS technology combined with MTB culture could increase the detection rate of TBM.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Clinical Neurology
F. Deng, P. Touska, K. L. Reinshagen, H. D. Curtin, A. F. Juliano
Summary: Quantitative bone densitometry on multidetector CT of the temporal bone is a helpful diagnostic tool for otosclerosis, but translating it to conebeam CT is challenging due to technical variability. This study found that internally calibrated conebeam CT pixel value measurements can accurately diagnose active fenestral otosclerosis, with a high accuracy rate of 97.2%.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Review
Medicine, General & Internal
Serena Bergamo
Summary: Adamantiades-Behcet's disease is a chronic-relapsing multisystemic inflammatory disease with unknown etiology. Diagnosis is based on clinical judgment using specific signs and symptoms, and there are diagnostic and classification criteria available for reference.
FRONTIERS IN MEDICINE
(2022)
Article
Infectious Diseases
N. N. Pradhan, M. S. Paradkar, A. Kagal, C. Valvi, A. Kinikar, S. Khwaja, R. Dhage, J. Chandane, M. Ithape, M. Bendre, R. Madewar, V Nadgeri, A. Nijampurkar, D. Jain, N. Gupte, A. Gupta, V Mave, K. E. Dooley, K. T. Thakur
Summary: This study assesses the performance of Ultra in diagnosing pediatric TBM, showing higher sensitivity and negative predictive value compared to Xpert. Ultra is a promising diagnostic test for children with nonspecific clinical features.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)
Article
Multidisciplinary Sciences
Keith A. Josephs, Joseph R. Duffy, Heather M. Clark, Rene L. Utianski, Edythe A. Strand, Mary M. Machulda, Hugo Botha, Peter R. Martin, Nha Trang Thu Pham, Julie Stierwalt, Farwa Ali, Marina Buciuc, Matthew Baker, Cristhoper H. Fernandez De Castro, Anthony J. Spychalla, Christopher G. Schwarz, Robert I. Reid, Matthew L. Senjem, Clifford R. Jack, Val J. Lowe, Eileen H. Bigio, Ross R. Reichard, Eric. J. Polley, Nilufer Ertekin-Taner, Rosa Rademakers, Michael A. DeTure, Owen A. Ross, Dennis W. Dickson, Jennifer L. Whitwell
Summary: Progressive apraxia of speech is a neurodegenerative syndrome affecting spoken communication. The study investigated molecular pathology, biochemistry, genetics, and longitudinal imaging in 32 autopsy-confirmed patients with progressive apraxia of speech. The most common underlying pathologies were corticobasal degeneration and progressive supranuclear palsy.
NATURE COMMUNICATIONS
(2021)
Article
Audiology & Speech-Language Pathology
Rene L. Utianski, Peter R. Martin, Joseph R. Duffy, Hugo Botha, Heather M. Clark, Keith A. Josephs
Summary: This study tracked changes in communication limitations in patients with primary progressive apraxia of speech (PPAOS) over a year, finding significant differences in AOS and aphasia severity between visits, with patients experiencing more severe changes in AOS also experiencing greater changes in participation restrictions.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2021)
Article
Virology
Gert Marais, Michelle Naidoo, Kate McMullen, Alan Stanley, Alan Bryer, Diederick van der Westhuizen, Kathleen Bateman, Diana Ruth Hardie
Summary: This study found evidence of central nervous system reactivation of VZV in a significant proportion of young adults with stroke, particularly in HIV-infected individuals.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Multidisciplinary Sciences
D. Jones, V Lowe, J. Graff-Radford, H. Botha, L. Barnard, D. Wiepert, M. C. Murphy, M. Murray, M. Senjem, J. Gunter, H. Wiste, B. Boeve, D. Knopman, R. Petersen, C. Jack
Summary: This study presents a model of the association between dementia symptoms and degenerative brain anatomy using F18-fluorodeoxyglucose PET and dimensionality reduction techniques. The authors propose a global information processing model for mental functions that links neuroanatomy, cognitive neuroscience and clinical neurology. They also apply the model to normal aging and other degenerative diseases of mental functions.
NATURE COMMUNICATIONS
(2022)
Review
Immunology
Alvin Pumelele Ndondo, Brian Eley, Jo Madeleine Wilmshurst, Angelina Kakooza-Mwesige, Maria Pia Giannoccaro, Hugh J. Willison, Pedro M. Rodriguez Cruz, Jeannine M. Heckmann, Kathleen Bateman, Angela Vincent
Summary: This article discusses the understanding of post-infectious autoimmune manifestations of CNS and PNS diseases in the context of Africa, emphasizing the importance of clinical presentation, diagnosis, treatment, and future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Sonja E. Leonhard, Annemiek A. van der Eijk, Henning Andersen, Giovanni Antonini, Samuel Arends, Shahram Attarian, Fabio A. Barroso, Kathleen J. Bateman, Manou R. Batstra, Luana Benedetti, Bianca van den Berg, Peter Van den Bergh, Jan Burmann, Mark Busby, Carlos Casasnovas, David R. Cornblath, Amy Davidson, Alex Y. Doets, Pieter A. van Doorn, Charlotte Dornonville de la Cour, Thomas E. Feasby, Janev Fehmi, Tania Garcia-Sobrino, Jonathan M. Goldstein, Kenneth C. Gorson, Volkan Granit, Robert D. M. Hadden, Thomas Harbo, Hans-Peter Hartung, Imran Hasan, Jakob Holbech, James K. L. Holt, Israt Jahan, Zhahirul Islam, Summer Karafiath, Hans D. Katzberg, Ruud P. Kleyweg, Noah Kolb, Krista Kuitwaard, Motoi Kuwahara, Susumu Kusunoki, Linda W. G. Luijten, Satoshi Kuwabara, Edward Lee Pan, Helmar C. Lehmann, Marijke Maas, Lorena Martin-Aguilar, James Al Miller, Quazi Deen Mohammad, Soledad Monges, Velina Nedkova-Hristova, Eduardo Nobile-Orazio, Julio Pardo, Yann Pereon, Luis Querol, Ricardo Reisin, Wouter Van Rijs, Simon Rinaldi, Rhys C. Roberts, Joyce Roodbol, Nortina Shahrizaila, Soren Hein Sindrup, Beth Stein, Tan Cheng-Yin, Hatice Tankisi, Anne P. Tio-Gillen, Maria J. Sedano Tous, Christine Verboon, Frederique H. Vermeij, Leo H. Visser, Ruth Huizinga, Hugh J. Willison, Bart C. Jacobs
Summary: This study analyzed the role of infections in Guillain-Barre syndrome (GBS) and their association with clinical features and disease severity. The distribution of infections varied across geographical regions, but the association between infection and clinical phenotype differed. Coinfections were common, highlighting the importance of broad serologic testing. Infections were also found to have prognostic value for GBS outcome.
Article
Neurosciences
Nick Corriveau-Lecavalier, Leland R. Barnard, Jeyeon Lee, Ellen Dicks, Hugo Botha, Jonathan Graff-Radford, Mary M. Machulda, Bradley F. Boeve, David S. Knopman, Val J. Lowe, Ronald C. Petersen, Clifford R. Jack, David T. Jones
Summary: This study reveals the heterogeneity of dysexecutive Alzheimer's disease (dAD) and proposes a conceptual framework of executive components based on clinico-radiological associations. The use of data-driven approaches can provide valuable insights into brain-behavior relationships in dAD.
Article
Clinical Neurology
Costanza Pavone, Stephen W. Weigand, Farwa Ali, Heather M. Clark, Hugo Botha, Mary M. Machulda, Rodolfo Savica, Nha Trang Thu Pham, Rosalie M. Grijalva, Christopher G. Schwarz, Matthew L. Senjem, Federica Agosta, Massimo Filippi, Clifford R. Jack, Val J. Lowe, Keith A. Josephs, Jennifer L. Whitwell
Summary: This study aimed to assess the evolution of core clinical features in different variants of progressive supranuclear palsy (PSP) and identify baseline predictors of progression. The results showed differences in ocular motor scores and rates of change among PSP variants. Baseline flortaucipir imaging could predict the rate of decline in PSP patients.
PARKINSONISM & RELATED DISORDERS
(2023)
Editorial Material
Medicine, General & Internal
Jennifer S. Eller, Jessica D. White, Hugo Botha
MAYO CLINIC PROCEEDINGS
(2023)
Article
Audiology & Speech-Language Pathology
Rene L. Utianski, Peter R. Martin, Joseph R. Duffy, Heather M. Clark, Julie A. G. Stierwalt, Hugo Botha, Farwa Ali, Jennifer L. Whitwell, Keith A. Josephs
Summary: Previous studies have shown that communication-related participation restrictions in degenerative disease patients may not align with clinician judgment or objective indices of symptom severity. This study examines the perception discrepancies between care partners and patients with progressive neurologic conditions, particularly in terms of communication participation restrictions. The results indicate that care partner ratings are somewhat correlated with patient experience and symptom severity, but do not exactly match patient ratings. Aphasia partially explains the discrepancies between care partner and patient ratings. These findings suggest that while caution should be exercised when using care partner report as a proxy for patient experience, including care partner ratings can support conversations about differing perceptions and help guide joint intervention planning.
AMERICAN JOURNAL OF SPEECH-LANGUAGE PATHOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Rene L. Utianski, Joseph R. Duffy, Peter R. Martin, Heather M. Clark, Julie A. G. Stierwalt, Hugo Botha, Farwa Ali, Jennifer L. Whitwell, Keith A. Josephs
Summary: The purpose of this study was to investigate the speech modulation capabilities of patients with different motor speech disorders (MSDs). The findings suggest that the ability to modulate speech rate and its impact on articulatory accuracy may aid in differentiating healthy and abnormal speech as well as different subtypes of MSDs.
JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH
(2023)
Article
Clinical Neurology
Neha Atulkumar Singh, Peter R. Martin, Jonathan Graff-Radford, Irene Sintini, Mary M. Machulda, Joseph R. Duffy, Jeffrey L. Gunter, Hugo Botha, David T. Jones, Val J. Lowe, Clifford R. JackJr, Keith A. Josephs, Jennifer L. Whitwell
Summary: Posterior cortical atrophy and logopenic progressive aphasia are atypical clinical presentations of Alzheimer's disease, both showing disruptions in functional networks. The language network is affected in logopenic progressive aphasia, while the visual network is affected in posterior cortical atrophy. However, there is limited knowledge about the differences in connectivity within and between brain networks in these atypical Alzheimer's disease phenotypes.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Nick Corriveau-Lecavalier, Jeffrey L. Gunter, Michael Kamykowski, Ellen Dicks, Hugo Botha, Walter K. Kremers, Jonathan Graff-Radford, Daniela A. Wiepert, Christopher G. Schwarz, Essa Yacoub, David S. Knopman, Bradley F. Boeve, Kamil Ugurbil, Ronald C. Petersen, Clifford R. Jack, Melissa J. Terpstra, David T. Jones
Summary: From a complex systems perspective, clinical syndromes emerging from neurodegenerative diseases are thought to result from multiscale interactions between aggregates of misfolded proteins and the disequilibrium of large-scale networks coordinating functional operations underpinning cognitive phenomena. Age-related disruption of the default mode network is accelerated by amyloid deposition in all syndromic presentations of Alzheimer's disease, while syndromic variability may reflect selective neurodegeneration of modular networks supporting specific cognitive abilities. This study investigates the use of a biomarker of default mode network dysfunction, the network failure quotient, to assess Alzheimer's disease in a normative cohort and differentiate between different phenotypes of the disease. The study provides important insights into the shared pathophysiological mechanisms and distinct neurodegenerative processes involved in Alzheimer's disease.
BRAIN COMMUNICATIONS
(2023)
Letter
Infectious Diseases
Gert Marais, Ziyaad Valley-Omar, Suzaan Marais, Kate Mcmullen, Kathleen Bateman, Diederick van der Westhuizen, Moepeng Maseko, Diana Hardie, Adrian Brink
JOURNAL OF INFECTION
(2023)
Article
Clinical Neurology
Arenn F. Carlos, Nirubol Tosakulwong, Stephen D. Weigand, Marina Buciuc, Farwa Ali, Heather M. Clark, Hugo Botha, Rene L. Utianski, Mary M. Machulda, Christopher G. Schwarz, Robert Reid, Matthew L. Senjem, Clifford R. Jack, J. Eric Ahlskog, Dennis W. Dickson, Keith A. Josephs, Jennifer L. Whitwell
Summary: The study found that increased total tau burden in four-repeat tauopathies was associated with volume loss in subcortical and brainstem regions, driven by glial lesions. Additionally, glial tau lesions in the red nucleus correlated with changes in diffusion tensor imaging metrics. Total tau and glial pathology were also correlated with increased mean diffusivity in the midbrain. Overall, there were clear relationships between antemortem MRI changes and pathology in four-repeat tauopathies.
BRAIN COMMUNICATIONS
(2022)