Article
Immunology
Silvia Tamburini, Yueru Zhang, Assunta Gagliardi, Gabriele Di Lascio, Elena Caproni, Mattia Benedet, Michele Tomasi, Riccardo Corbellari, Ilaria Zanella, Lorenzo Croia, Guido Grandi, Martin Mueller, Alberto Grandi
Summary: This study demonstrates that L2 epitopes can be efficiently expressed on the surface of E. coli outer membrane vesicles (OMVs), and a polypeptide composed of L2 epitopes from multiple serotypes shows broad cross-protective activity against HPV. This provides a highly effective and inexpensive solution for producing universal anti-HPV vaccines.
Article
Biochemistry & Molecular Biology
Yuying Liu, Yao Zhang, Guifeng Zhang, Zengmin Yang, Yan Wang, Shuming Wu, Dan Chen, Haijiang Zhang, Yongjiang Liu
Summary: A highly specific HPV16 detection kit was developed in this study, which has great potential for wide use in clinical testing and quality control in vaccine production processes.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Engineering, Biomedical
Liming Zhang, Kun Wang, Yuheng Huang, Hui Zhang, Long Zhou, Ang Li, Yunyan Sun
Summary: A novel HPV nanovaccine combining nanotechnology and photodynamic therapy was constructed, which could effectively inhibit the progression of cervical cancer and was experimentally demonstrated in a mouse model.
Article
Biochemical Research Methods
Samira Sanami, Mahmoud Rafieian-Kopaei, Korosh Ashrafi Dehkordi, Hamidreza Pazoki-Toroudi, Fatemeh Azadegan-Dehkordi, Gholam-Reza Mobini, Morteza Alizadeh, Muhammad Sadeqi Nezhad, Maryam Ghasemi-Dehnoo, Nader Bagheri
Summary: This study developed a multi-epitope vaccine with therapeutic potential against cervical cancer using immunoinformatics. The vaccine showed structural stability and non-allergenic and non-toxic properties.
BMC BIOINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Ruixue Wang, Saori Suzuki, Johnathan D. Guest, Brigitte Heller, Maricar Almeda, Alexander K. Andrianov, Alexander Marin, Roy A. Mariuzza, Zhen-Yong Keck, Steven K. H. Foung, Abdul S. Yunus, Brian G. Pierce, Eric A. Toth, Alexander Ploss, Thomas R. Fuerst
Summary: Hepatitis C virus (HCV) is a global disease burden that requires a preventive vaccine. The study found that a vaccine based on sE1E2.LZ can induce broadly neutralizing antibodies, indicating its potential as a promising vaccine candidate for further development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Microbiology
Shiwen Peng, Louise Ferrall, Stephanie Gaillard, Chenguang Wang, Wei-Yu Chi, Chuan-Hsiang Huang, Richard B. S. Roden, T-C Wu, Yung-Nien Chang, Chien-Fu Hung
Summary: Immunotherapy for cervical cancer targeting high-risk human papillomavirus types 16 and 18 shows promising results in preclinical studies, with pBI-11 DNA vaccine inducing strong immune responses and therapeutic effects in mouse models. Combination with TA-HPV boost and PD-1 antibody blockade improves tumor control and survival. Clinical translation of this strategy may provide a new approach for HPV16/18-associated tumors.
Article
Immunology
Luis Ontiveros-Padilla, Cole J. J. Batty, Dylan A. A. Hendy, Erik S. S. Pena, John A. A. Roque III, Rebeca T. T. Stiepel, Michael A. A. Carlock, Sean R. R. Simpson, Ted M. M. Ross, Soman N. N. Abraham, Herman F. F. Staats, Eric M. M. Bachelder, Kristy M. M. Ainslie
Summary: Currently licensed vaccine adjuvants offer limited mucosal immunity, which is needed to combat respiratory infections like influenza more effectively. In this study, researchers developed a nanoparticulate adjuvant composed of a mast cell activator (M7) and a Toll-like receptor ligand (CpG). This novel adjuvant was combined with a computationally optimized broadly reactive antigen (COBRA) for hemagglutinin (HA) of influenza. The combination of M7 and CpG at a specific ratio formed spherical nanoparticles and induced a protective immune response with a broadly reactive influenza antigen via mucosal vaccination, as demonstrated in mouse models.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Ching-Lin Hsieh, Anne P. Werner, Sarah R. Leist, Laura J. Stevens, Ester Falconer, Jory A. Goldsmith, Chia-Wei Chou, Olubukola M. Abiona, Ande West, Kathryn Westendorf, Krithika Muthuraman, Ethan J. Fritch, Kenneth H. Dinnon, Alexandra Schafer, Mark R. Denison, James D. Chappell, Ralph S. Baric, Barney S. Graham, Kizzmekia S. Corbett, Jason S. McLellan
Summary: This study developed stabilized stem (SS) antigens by removing the S1 subunit from the Middle East respiratory syndrome (MERS)-CoV spike (S) glycoprotein using structure-guided protein engineering. Vaccination with MERS SS elicited cross-reactive b-CoV antibody responses and protected mice against lethal MERS-CoV challenge. The discovery of a panel of cross-reactive monoclonal antibodies, among which IgG22 showed high affinity binding to both MERS-CoV and severe acute respiratory syndrome (SARS)-CoV-2 S proteins, indicates the potential for cross-reactive CoV antibodies.
Article
Immunology
Ting Gao, Caixia Gao, Siyu Wu, Yingying Wang, Jiyuan Yin, Yingying Li, Weiwei Zeng, Sven M. Bergmann, Qing Wang
Summary: The study successfully developed GCRV II-based virus-like particles (VLPs) using a bac-to-bac expression system, which demonstrated excellent immunogenicity and showed protective effects in grass carp after immunization.
Article
Pharmacology & Pharmacy
Debaki R. Howlader, Sayan Das, Ti Lu, Gang Hu, David J. Varisco, Zackary K. Dietz, Sierra P. Walton, Siva Sai Kumar Ratnakaram, Francesca M. Gardner, Robert K. Ernst, William D. Picking, Wendy L. Picking
Summary: Researchers investigated a novel Pseudomonas aeruginosa vaccine that demonstrated strong protective efficacy and activated immune responses. By modifying the vaccine formulation, they achieved effective protection against P. aeruginosa.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Li-Wei Shi, Juan Li, Bang-Wei Yu, Li-Rong Huang, Ke Li, Min Ji, Ling-Yun Zhou, Lin Yuan, Shu-Yuan Yang, Jing-Jing Chen, Ling Wang, Zhi-Wei Jiang, Rong-Cheng Li, Yan-Ping Li, Jie-Lai Xia, Zhao-Jun Mo, Chang-Gui Li
Summary: This study evaluated the safety and immunogenicity of a new bivalent HPV16/18 vaccine, and found that it induced high levels of neutralizing antibodies in females of different age groups, which persisted for up to 48 months in the 9-17-year-old age group.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Review
Virology
Kaito A. Nagashima, Jarrod J. Mousa
Summary: Influenza virus is a highly mutable respiratory pathogen causing significant disease annually. Despite efforts to improve vaccine effectiveness against circulating strains, limitations exist, and research into broader neutralizing antibodies has shown progress.
Article
Multidisciplinary Sciences
Monir Ejemel, Todd G. Smith, Lauren Greenberg, William C. Carson, David Lowe, Yong Yang, Felix R. Jackson, Clint N. Morgan, Brock E. Martin, Chantal Kling, Christina L. Hutson, Nadia Gallardo-Romero, James A. Ellison, Susan Moore, Adam Buzby, John Sullivan-Bolyai, Mark Klempner, Yang Wang
Summary: A study has found that a mixture of two or more MAbs can neutralize the diverse rabies viruses in North America. Among them, R173 is the most potent cocktail, with the ability to neutralize North American rabies variants.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Ssu-Hsueh Tseng, Li Liu, Shiwen Peng, Jinhwi Kim, Louise Ferrall, Chien-Fu Hung, T. C. Wu
Summary: The study characterized the immune responses of HLA-A2 restricted HPV16 E7-specific CD8 + T cells using a therapeutic naked DNA vaccine in transgenic mice. Spontaneous oral tumors were generated by transfecting oncogenic DNA plasmids into the submucosal oral cavity of the transgenic mice with electroporation. Treatment with the CRT/E7(N53S) DNA vaccine resulted in significant antitumor effects against the spontaneous HPV16 E6/E7-expressing oral tumors in HLA-A2 (AAD) transgenic mice.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Virology
Yu-Hsuan Yang, Ching-Hui Tai, Dayna Cheng, Ya-Fang Wang, Jen-Ren Wang
Summary: In this study, H5N6 virus-like particles (VLPs) were generated and tested for their potential as a broad-spectrum vaccine candidate against H5Nx avian influenza viruses. The results showed that H5N6 VLPs induced higher neutralizing antibody titers and increased production of immune-related cytokines compared to H5+N6 proteins, suggesting that H5N6 VLPs may be a potential vaccine candidate.
Article
Biochemistry & Molecular Biology
Giuseppe La Venuta, Sabine Wegehingel, Peter Sehr, Hans-Michael Mueller, Eleni Dimou, Julia P. Steringer, Mareike Grotwinkel, Nikolai Hentze, Matthias P. Mayer, David W. Will, Ulrike Uhrig, Joe D. Lewis, Walter Nickel
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
Article
Geriatrics & Gerontology
Thomas Scott Bowen, Volker Adams, Sarah Werner, Tina Fischer, Paulien Vinke, Maria Noel Brogger, Norman Mangner, Axel Linke, Peter Sehr, Joe Lewis, Dittmar Labeit, Alexander Gasch, Siegfried Labeit
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2017)
Article
Immunology
Rengaswamy Sankaranarayanan, Smita Joshi, Richard Muwonge, Pulikottil Okkuru Esmy, Partha Basu, Priya Prabhu, Neerja Bhatla, Bhagwan M. Nene, Janmesh Shaw, Usha Rani Reddy Poli, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Massimo Tommasino, Michael Pawlita, Tarik Gheit, Tim Waterboer, Peter Sehr, Madhavan Radhakrishna Pilla
Article
Biochemistry & Molecular Biology
Mennatallah Ahmed, Cyril Legrand, Ana Yaguee Relimpio, Carlo A. Beretta, Alina Muschko, Sabine Wegehingel, Hans-Michael Mueller, Peter Sehr, David W. Will, Joe D. Lewis, Walter Nickel
Article
Chemistry, Medicinal
Magalie Geraldy, Michael Morgen, Peter Sehr, Raphael R. Steimbach, Davide Moi, Johannes Ridinger, Ina Oehme, Olaf Witt, Mona Malz, Mauro S. Nogueira, Oliver Koch, Nikolas Gunkel, Aubry K. Miller
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Geriatrics & Gerontology
Volker Adams, T. Scott Bowen, Sarah Werner, Peggy Barthel, Christina Amberger, Anne Konzer, Johannes Graumann, Peter Sehr, Joe Lewis, Jan Provaznik, Vladimir Benes, Petra Buettner, Alexander Gasch, Norman Mangner, Christian C. Witt, Dittmar Labeit, Axel Linke, Siegfried Labeit
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2019)
Article
Immunology
Filipe Colaco Mariz, Noemi Bender, Devasena Anantharaman, Partha Basu, Neerja Bhatla, Madhavan Radhakrisna Pillai, Priya R. Prabhu, Rengaswamy Sankaranarayanan, Tiina Eriksson, Michael Pawlita, Kristina Prager, Peter Sehr, Tim Waterboer, Martin Mueller, Matti Lehtinen
Article
Chemistry, Medicinal
Michael Morgen, Raphael R. Steimbach, Magalie Geraldy, Lars Hellweg, Peter Sehr, Johannes Ridinger, Olaf Witt, Ina Oehme, Corey J. Herbst-Gervasoni, Jeremy D. Osko, Nicholas J. Porter, David W. Christianson, Nikolas Gunkel, Aubry K. Miller
Article
Genetics & Heredity
William F. Mueller, Petra Jakob, Han Sun, Sandra Clauder-Muenster, Sonja Ghidelli-Disse, Diana Ordonez, Markus Boesche, Marcus Bantscheff, Paul Collier, Bettina Haase, Vladimir Benes, Malte Paulsen, Peter Sehr, Joe Lewis, Gerard Drewes, Lars M. Steinmetz
G3-GENES GENOMES GENETICS
(2020)
Article
Immunology
Sabrina H. Tsang, Partha Basu, Noemi Bender, Rolando Herrero, Troy J. Kemp, Aimee R. Kreimer, Martin Muller, Gitika Panicker, Michael Pawlita, Ligia A. Pinto, Joshua N. Sampson, Rengaswamy Sankaranarayanan, John Schussler, Peter Sehr, Monica S. Sierra, Elizabeth R. Unger, Tim Waterboer, Allan Hildesheim
Article
Cell Biology
Lyudmila Dimitrova-Paternoga, Pravin Kumar Ankush Jagtap, Anna Cyrklaff, Vaishali, Karine Lapouge, Peter Sehr, Kathryn Perez, Simone Heber, Christian Low, Janosch Hennig, Anne Ephrussi
Summary: Kinesin-1 transports cargos within cells by forming a complex with atypical tropomyosin, aTm1, and a study on the Khch-aTm1 complex reveals the mechanism of this interaction. Additionally, aTm1 plays a stabilizing role in the interaction of Khc with RNA, distinguishing it from classical motor adaptors.
GENES & DEVELOPMENT
(2021)
Article
Infectious Diseases
Filipe Colaro Mariz, Penelope Gray, Noemi Render, Tiina Eriksson, Hanna Kann, Dan Apter, Jorma Paavonen, Emma Pajunen, Kristina M. Prager, Peter Sehr, Helja-Marja Surcel, Tim Waterboer, Martin Mueller, Michael Pawlita, Matti Lehtinen
Summary: This study tracked the data from two international HPV vaccine trials in Finland, and found that HPV vaccine-induced antibodies can last up to 12 years after vaccination. Significant differences were observed in the neutralising antibody efficacy and cross-neutralising antibody efficacy between quadrivalent and bivalent vaccine recipients, which correlated with vaccine efficacy.
LANCET INFECTIOUS DISEASES
(2021)
Article
Virology
Partha Basu, Richard Muwonge, Neerja Bhatla, Bhagwan M. Nene, Smita Joshi, Pulikottil O. Esmy, Usha Rani Reddy Poli, Geeta Joshi, Yogesh Verma, Eric Zomawia, Surendra S. Shastri, Sharmila Pimple, Devasena Anantharaman, Priya R. Prabhu, Sanjay Hingmire, Catherine Sauvaget, Eric Lucas, Michael Pawlita, Tarik Gheit, Kasturi Jayant, Sylla G. Malvi, Maqsood Siddiqi, Angelika Michel, Julia Butt, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Uma Divate, Martina Willhauck-Fleckenstein, Tim Waterboer, Martin Mueller, Peter Sehr, Shachi Vashist, Gauravi Mishra, Radhika Jadhav, Ranjit Thorat, Massimo Tommasino, M. Radhakrishna Pillai, Rengaswamy Sankaranarayanan
PAPILLOMAVIRUS RESEARCH
(2019)
Article
Virology
Neerja Bhatla, Bhagwan M. Nene, Smita Joshi, Pulikottil O. Esmy, Usha Rani Reddy Poli, Geeta Joshi, Yogesh Verma, Eric Zomawia, Sharmila Pimple, Priya R. Prabhu, Partha Basu, Richard Muwonge, Sanjay Hingmire, Catherine Sauvaget, Eric Lucas, Michael Pawlita, Tarik Gheit, Kasturi Jayant, Sylla G. Malvi, Maqsood Siddiqi, Angelika Michel, Julia Butt, Subha Sankaran, Thiraviam Pillai Rameshwari Ammal Kannan, Rintu Varghese, Uma Divate, Martina Willhauck-Fleckenstein, Tim Waterboer, Martin Mueller, Peter Sehr, Alka Kriplani, Gauravi Mishra, Radhika Jadhav, Ranjit Thorat, Massimo Tommasino, M. Radhakrishna Pillai, Rengaswamy Sankaranarayanan
PAPILLOMAVIRUS RESEARCH
(2018)
Article
Surgery
Jan N. Bouwes Bavinck, Mariet C. W. Feltkamp, Adele C. Green, Marta Fiocco, Sylvie Euvrard, Catherine A. Harwood, Shaaira Nasir, Jason Thomson, Charlotte M. Proby, Luigi Naldi, Janouk C. D. Diphoorn, Anna Venturuzzo, Gianpaolo Tessari, Ingo Nindl, Francesca Sampogna, Damiano Abeni, Rachel E. Neale, Jelle J. Goeman, Koen D. Quint, Anne B. Halk, Carmen Sneek, Roel E. Genders, Maurits N. C. de Koning, Wim G. V. Quint, Ulrike Wieland, Soenke Weissenborn, Tim Waterboer, Michael Pawlita, Herbert Pfister
AMERICAN JOURNAL OF TRANSPLANTATION
(2018)