Review
Dermatology
Pushpa Pandiyan, Thomas S. McCormick
Summary: This review focuses on the IL-17A family of cytokines produced by T lymphocytes and other immune cells and their involvement in cutaneous pathogenic responses. It also discusses cutaneous dysbiosis and the role of FOXP3(+) regulatory T cells in inflammatory conditions linked to IL-17 responses in the skin. Specifically, it reviews key literature on chronic mucocutaneous candidiasis and psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Immunology
Alexander O. O. Mann, Bola S. S. Hanna, Andres R. Munoz-Rojas, Inga Sandrock, Immo Prinz, Christophe Benoist, Diane Mathis
Summary: The accumulation and function of γδT cells during skeletal muscle regeneration after acute injury are microbiota-dependent, providing a new perspective for the treatment of muscle pathologies.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Allergy
Min-Seok Rha, Young Hoon Yoon, June-Young Koh, Jae Hyung Jung, Ha Seok Lee, Soo Kyoung Park, Su-Hyung Park, Yong Min Kim, Ki-Sang Rha, Eui-Cheol Shin
Summary: Sinonasal MAIT cells exhibit an activated phenotype and produce higher levels of IL-17A in patients with CRSwNP. These alterations are associated with the extent of disease in patients with E-NP.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Felix Simon Ruben Picard, Veronika Lutz, Anna Brichkina, Felix Neuhaus, Teresa Ruckenbrod, Anna Hupfer, Hartmann Raifer, Matthias Klein, Tobias Bopp, Petra Ina Pfefferle, Rajkumar Savai, Immo Prinz, Ari Waisman, Sonja Moos, Hyun-Dong Chang, Stefan Heinrich, Detlef K. Bartsch, Malte Buchholz, Shiv Singh, Mengyu Tu, Lukas Klein, Christian Bauer, Robert Liefke, Andreas Burchert, Ho-Ryun Chung, Philipp Mayer, Thomas M. Gress, Matthias Lauth, Matthias Gaida, Magdalena Huber
Summary: Pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic stroma composed of cancer-associated fibroblasts (CAF) and immune cells. In this study, the role of a non-canonical CD8(+) T-cell subpopulation producing IL-17A (Tc17) in PDAC was evaluated.
Article
Immunology
Sarah C. Edwards, Ann Hedley, Wilma H. M. Hoevenaar, Robert Wiesheu, Teresa Glauner, Anna Kilbey, Robin Shaw, Katerina Boufea, Nizar Batada, Shinya Hatano, Yasunobu Yoshikai, Karen Blyth, Crispin Miller, Kristina Kirschner, Seth B. Coffelt
Summary: This study reveals that different subsets of IL-17A-producing gamma delta T cells in the lung of mice are controlled by PD-1 and TIM-3 in steady-state and cancer. Vγ6(+) cells express high levels of PD-1, while Vγ4(+) cells upregulate TIM-3 in response to tumor-related stimulation. Inhibition of PD-1 or TIM-3 increases the numbers of Vγ6(+) and Vγ4(+) cells respectively. Moreover, genetic deletion of gamma delta T cells enhances responsiveness to anti-PD-1 and anti-TIM-3 immunotherapy in a mammary tumor model, indicating that IL-17A-producing gamma delta T cells contribute to immunotherapy resistance.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Microbiology
Tej Pratap Singh, Augusto M. Carvalho, Lais Amorim Sacramento, Elizabeth A. Grice, Phillip Scott
Summary: This study demonstrates the involvement of IL-17A-producing ILCs in microbiota-driven immunopathology in cutaneous leishmaniasis. Skin microbiota promotes the generation of ROR gamma t(+) IL-17A-producing ILCs, which exacerbate skin inflammation in the disease.
Article
Allergy
Sung Hee Kim, Jongwook Oh, Won Seok Roh, Jeyun Park, Kyung Bae Chung, Gwang Hee Lee, Youn Sook Lee, Jong Hoon Kim, Heung Kyu Lee, Ho Lee, Chang-Ook Park, Do -Young Kim, Min-Geol Lee, Tae-Gyun Kim
Summary: Peli1 plays a crucial role in psoriatic inflammation by regulating the activity of skin-resident T17 cells and the NF-kB pathway. Inhibition of Peli1 can alleviate psoriatic lesions by reducing T17 cell activation and NF-kB activation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Cell Biology
Rong Xu, Laura C. Jacques, Shadia Khandaker, Miguel Leon-Rios, Daan Beentjes, Xiaoqing Wei, Neil French, Daniel R. Neill, Aras Kadioglu
Summary: Streptococcus pneumoniae is a highly morbid and mortal pathogen. Activation of pulmonary Treg cells with upregulated TNFR2 expression occurs upon pneumococcal infection. Deficiency in TNFR2 compromises Treg cell responses, leading to highly activated IL-17A-producing y8 T cell responses and increased susceptibility to disease. Blocking IL-17A at early stage of infection improves survival in TNFR2-deficient mice.
Article
Multidisciplinary Sciences
Yanyun Du, Qianwen Peng, Du Cheng, Ting Pan, Wanwei Sun, Heping Wang, Xiaojian Ma, Ruirui He, Huazhi Zhang, Zhihui Cui, Xiong Feng, Zhiqiang Liu, Tianxin Zhao, Wenjun Hu, Lei Shen, Wenyang Jiang, Na Gao, Bradley N. Martin, Cun-Jin Zhang, Zhanguo Zhang, Chenhui Wang
Summary: This study reveals that BTNL2 is a potent suppressor of anti-tumor immune response. Blockade of BTNL2 attenuates tumor progression and prolongs survival in tumor-bearing mice. BTNL2 interacts with γ δ T cell populations to promote IL-17A production, leading to a dysfunctional tumor immune microenvironment. High BTNL2 expression is associated with tumor types and negatively correlates with patient survival.
NATURE COMMUNICATIONS
(2022)
Review
Neurosciences
Jingjing Wang, Yuxiao Gao, Yujia Yuan, Huan Wang, Zhao Wang, Xiangjian Zhang
Summary: This paper reviews the mechanism of action of Th17 cells and IL-17A in ischemic stroke and the progress of research on targeted therapy.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Immunology
Song Zhang, Jia Zhang, Juanjuan Yu, Xiaolu Chen, Fangyuan Zhang, Wei Wei, Lingyun Zhang, Wenmao Chen, Nengxing Lin, Yan Wu
Summary: In this study, it was found that hyperforin alleviates inflammation in psoriasis by suppressing IL-17A-producing gamma delta T cells and related cytokines through modulating MAPK/STAT3 pathways. The study also showed that hyperforin reduced epidermal thickness, suppressed infiltration of T cells, and decreased expression of inflammatory cytokines in mice with IMQ-induced psoriasis. Additionally, hyperforin inhibited splenomegaly, reduced TNF-alpha and IL-6 levels, and suppressed the activation of specific pathways in human keratinocytes and gamma delta T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaokun Shen, Huiyun Zhang, Hua Xie, Liping Chen, Shinan Li, Junjuan Zheng, Ruonan Chai, Zhao Wang, Yanyan Zang, Shaoheng He
Summary: Human regulatory T (Treg) cells play a central role in controlling allergic inflammation in the airways. Different subsets of Treg cells were investigated in healthy individuals and allergic asthma patients, revealing lower levels of certain Treg cell subsets in the latter group. Studies using mouse models suggested that CCR6(+) Treg cells may play a crucial role in the pathology of allergic asthma by promoting Th17 responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jiajia Fu, Yan Huang, Ting Bao, Chengcheng Liu, Xi Liu, Xueping Chen
Summary: Neurodegenerative diseases are characterized by progressive loss of neurons, and immune pathway dysregulation is a common feature. Th 17 cells and IL-17A play important roles in the pathogenesis of these diseases. Targeting IL-17A may represent a potential therapeutic approach for neurodegenerative diseases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Immunology
Qifeng He, Yijun Lu, Wenfang Tian, Runqiu Jiang, Weiwei Yu, Yong Liu, Meiling Sun, Fei Wang, Haitian Zhang, Ning Wu, Zhongjun Dong, Beicheng Sun
Summary: Loss of TOX in thymocytes impairs mTEC maturation and promotes Tγδ17 cell generation, leading to the development of fatal autoimmune hepatitis (AIH). TOX interacts with TCF1 to maintain the balance of γδT cell development, and its expression is negatively correlated with AIH diagnostic score.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Tracy X. Cui, Alexander E. Brady, Ying-Jian Zhang, Chase Anderson, Antonia P. Popova
Summary: Activated IL-17a+ γδ T cells and NKG2D signaling play a central role in neonatal LPS-induced lung injury.
FRONTIERS IN IMMUNOLOGY
(2023)