Article
Biochemistry & Molecular Biology
Karolina A. P. Wijnands, Dennis M. Meesters, Benjamin Vandendriessche, Jacob J. Briede, Hans M. H. van Eijk, Peter Brouckaert, Anje Cauwels, Wouter H. Lamers, Martijn Poeze
Summary: Competition between NOS3 and NOS2 for arginine during endotoxemia appears crucial in the derangement of microcirculatory flow. This study found that L-citrulline supplementation enhances de novo arginine synthesis and NO production in mice during endotoxemia, especially in mice with functional NOS3-enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Shinya Ishiko, Ghada Ben Rahoma, Sharath Kandhi, An Huang, Dong Sun
Summary: In this study, liposomal nanocarriers were created to restore the degraded endothelial glycocalyx (EG) in sepsis. The nanocarriers successfully fused with endothelial cells and restored EG, leading to improved survival and endothelial function in a mouse model of sepsis.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Kei Yamamoto, Yosuke Masakari, Yasuko Araki, Atsushi Ichiyanagi, Kotaro Ito
Summary: This study aimed to develop an enzyme that could specifically detect citrulline and successfully improved the specific dehydrogenase activity by introducing a mutation. The enzymatic detection system using this enzyme can effectively detect citrulline in human blood.
Article
Environmental Sciences
Congcong Yang, Linchao Xia, Yi Zeng, Yao Chen, Sheng Zhang
Summary: This study found that hexaploid willows have better abilities in lead (Pb) uptake, translocation, and detoxification compared to diploid willows, and males have better abilities in these aspects than females. This study provides valuable insights for selecting better willow materials to mitigate Pb contamination.
Review
Health Care Sciences & Services
Eva Benedicte Dieudonnee Molendijk, Nicole Marie Anna Blijlevens
Summary: There is still a need for effective preventive and treatment strategies for mucositis induced by chemotherapy and radiotherapy in cancer patients, with a focus on restoring nitric oxide (NO) production through amino acids such as citrulline. Recent studies suggest that mucositis severity is more influenced by host response rather than direct DNA damage, and that citrulline depletion may be responsible for NO depletion, making it a promising candidate for NO donor treatment in mucositis. Clinical trials are needed to further investigate the potential benefits of citrulline, as current studies are lacking in mucositis patients.
CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE
(2021)
Article
Chemistry, Medicinal
Honoka Obata, Atsushi B. Tsuji, Katsushi Kumata, Hitomi Sudo, Katsuyuki Minegishi, Kotaro Nagatsu, Hideo Takakura, Mikako Ogawa, Akihiro Kurimasa, Ming-Rong Zhang
Summary: This study aims to establish new labeling methods for no-carrier-added radio-Pt (191Pt) and evaluate the in vitro properties of 191Pt-labeled agents compared with those of agents labeled with the common emitter 111In. The results showed that 191Pt labeled via DTPA or Cys had a comparable intranuclear fraction to 111In labeled via DTPA, but demonstrated a significantly higher DNA-binding/cellular uptake ratio. This suggests that 191Pt has better DNA targeting capabilities than 111In.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Physiology
Clarissa Germano Barp, Daniella Bonaventura, Jamil Assreuy
Summary: PVAT, as a potential target for intervention in cardiovascular diseases, still requires further research to fully understand its role in physiology and pathology. The traditional idea of the beneficial anti-contractile effect and harmful pro-contractile effect of PVAT is being challenged, as factors like NO, ROS, and RAS may have varying roles depending on the context and disease.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Tomokazu Fukuda, Kai Furuya, Kouhei Takahashi, Ai Orimoto, Eriko Sugano, Hiroshi Tomita, Sayo Kashiwagi, Tohru Kiyono, Tsuyoshi Ishii
Summary: This study compared the biological characteristics and genome-wide expression profiles of immortalized human dermal papilla cells generated by different methods to determine the optimal immortalization method. The data would be valuable to scientists aiming to establish new immortalized cell lines.
Article
Plant Sciences
Gustavo Ferreira da Silva, Juliano Carlos Calonego, Bruno Cesar Ottoboni Luperini, Vinicius Brasil Silveira, Larissa Chamma, Rogerio Peres Soratto, Fernando Ferrari Putti
Summary: Soil management systems can directly impact crop yield by altering the physical and hydraulic properties of the soil. Long-term experiments have shown that the no-tillage system improves soil density and compaction resistance, enhances root development, and increases soybean yield by 6.5%, without affecting water infiltration.
Article
Computer Science, Information Systems
Fengli Xu, Zhen Tu, Hongjia Huang, Shuhao Chang, Funing Sun, Diansheng Guo, Yong Li
Summary: The study suggests that check-in records can be vulnerable to privacy attacks and proposes a new privacy criterion to protect user privacy.
IEEE TRANSACTIONS ON MOBILE COMPUTING
(2021)
Article
Agriculture, Dairy & Animal Science
Pawel Konieczka, Dariusz Mikulski, Katarzyna Ognik, Jerzy Juskiewicz, Zenon Zdunczyk, Jan Jankowski
Summary: Differences in dietary recommendations for essential amino acids in turkey diets may impact feed cost and bird physiology. Further understanding of bird's amino acid needs is crucial for achieving high growth rates and sustainable production in the rapidly growing turkey sector.
Article
Ecology
Hannah Wirtz, Jan P. Ruppelt, Jos H. M. Schippers, Andrea E. Neinhuis, Laura Luetjens, Joost T. van Dongen, Johannes Pinnekamp, Katharina Tondera
Summary: Highway runoffs introduce various pollutants into surface waters, endangering environmental health. In Germany, sedimentation basins with oil retention baffles are mandatory for treating highway runoff in water protection areas. This study evaluated the effectiveness of retrofitting stormwater retention basins to floating treatment wetlands (FTWs) instead of post-treatment vertical-flow treatment wetlands (VFWs), and the adaptation of native plant species to the oxygen-deprived and salt-enriched environment. Results showed that plants can thrive in the basins despite hostile conditions. The removal efficiency of stormwater retention basins was sufficient for some pollutants, but VFWs were more efficient for metals and ammonium nitrogen, while FTWs were more efficient for nitrate nitrogen. None of the treatment systems effectively reduced chloride concentrations from deicing salts.
ECOLOGICAL ENGINEERING
(2023)
Article
Astronomy & Astrophysics
Till Sawala, Meri Teeriaho, Peter H. Johansson
Summary: This study analyzes the UCHUU simulation to constrain the mass of the Local Group and its two most massive members. The total mass of the Local Group is estimated to be around 3.2×10^12 solar masses, lower than the previous estimation from the timing argument. The mass of the Milky Way and M31 are found to be approximately 0.9×10^12 solar masses and 2.3×10^12 solar masses, respectively, indicating that the Milky Way is likely less massive than M31.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2023)
Article
Agriculture, Multidisciplinary
Surajit Mondal, Debashis Chakraborty, Ranjit Kumar Paul, Arun Mondal, J. K. Ladha
Summary: No-till is considered more as a climate change mitigation option than a practice for managing soil organic C content. A global meta-analysis was conducted, showing that no-till significantly increased SOC concentration by 38% in the 0-5 cm soil layer compared to conventional tillage.
AGRICULTURE ECOSYSTEMS & ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Sascha Kempf, Nicolas Altobelli, Juergen Schmidt, Jeffrey N. Cuzzi, Paul R. Estrada, Ralf Srama
Summary: There is ongoing debate about whether Saturn's main rings are young or ancient. The rings are mostly composed of water-ice but are polluted by non-icy material. Continuous bombardment from micrometeoroids from outside the Saturnian system is the source of this pollution. By measuring the micrometeoroid flux into the Saturnian system, it is possible to estimate the rings' exposure time and infer their age. The final measurements by Cassini's Cosmic Dust Analyzer indicate a ring exposure time of less than or similar to 100 to 400 million years, supporting recent ring formation scenarios.
Article
Genetics & Heredity
Heloise Proquin, Carolina Rodriguez-Ibarra, Carolyn G. J. Moonen, Ismael M. Urrutia Ortega, Jacob J. Briede, Theo M. de Kok, Henk van Loveren, Yolanda I. Chirino
Article
Food Science & Technology
HeloIse Proquin, Marlon J. Jetten, Marloes C. M. Jonkhout, Luis G. Garduno-Balderas, Jacob J. Briede, Theo M. de Kok, Yolanda I. Chirino, Henk van Loveren
FOOD AND CHEMICAL TOXICOLOGY
(2018)
Article
Toxicology
Jacob J. Briede, Lize Deferme, Jarno E. J. Wolters, Sandra M. H. Claessen, Twan van den Beucken, Richard J. Wagner, Simone G. van Breda, Jos C. S. Kleinjans
TOXICOLOGY IN VITRO
(2018)
Article
Food Science & Technology
Darius Henatsch, Gertjan J. M. den Hartog, Adriaan M. Duijvestijn, Petra F. Wolffs, Esther Phielix, Robert J. Stokroos, Jacob J. Briede
JOURNAL OF FUNCTIONAL FOODS
(2018)
Article
Multidisciplinary Sciences
Heloise Proquin, Marlon J. Jetten, Marloes C. M. Jonkhout, Luis Guillermo Garduno-Balderas, Jacob J. Briede, Theo M. de Kok, Henk van Loveren, Yolanda I. Chirino
SCIENTIFIC REPORTS
(2018)
Correction
Genetics & Heredity
Heloise Proquin, Carolina Rodriguez-Ibarra, Carolyn Moonen, Ismael M. Urrutia Ortega, Jacob J. Briede, Theo M. de Kok, Henk van Loveren, Yolanda Irasema Chirino
Article
Multidisciplinary Sciences
Dominique Mannaerts, Ellen Faes, Paul Cos, Jacob J. Briede, Wilfried Gyselaers, Jerome Cornette, Yury Gorbanev, Annemie Bogaerts, Marc Spaanderman, Emeline Van Craenenbroeck, Yves Jacquemyn
Article
Nutrition & Dietetics
Simone G. J. van Breda, Jacob J. Briede, Theo M. C. M. de Kok
Article
Pharmacology & Pharmacy
Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Gaiment, Jiri Aubrecht, Gerry A. F. Nicolaes, Jos C. S. Kleinjans, Jacco J. Briede
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2019)
Article
Multidisciplinary Sciences
Heloise Proquin, Marloes C. M. Jonkhout, Marlon J. Jetten, Henk van Loveren, Theo M. de Kok, Jacob J. Briede
SCIENTIFIC REPORTS
(2019)
Review
Biochemistry & Molecular Biology
Nicolaj S. Bischoff, Theo M. de Kok, Dick T. H. M. Sijm, Simone G. van Breda, Jacco J. Briede, Jacqueline J. M. Castenmiller, Antoon Opperhuizen, Yolanda I. Chirino, Hubert Dirven, David Gott, Eric Houdeau, Agnes G. Oomen, Morten Poulsen, Gerhard Rogler, Henk van Loveren
Summary: Titanium dioxide is commonly used as a food additive and can be found in various products, but the nano-sized particle fraction may pose potential health risks that require further investigation. Research is needed to evaluate the adverse health effects of ingested TiO2 and address knowledge gaps in its gastrointestinal absorption and distribution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Karolina A. P. Wijnands, Dennis M. Meesters, Benjamin Vandendriessche, Jacob J. Briede, Hans M. H. van Eijk, Peter Brouckaert, Anje Cauwels, Wouter H. Lamers, Martijn Poeze
Summary: Competition between NOS3 and NOS2 for arginine during endotoxemia appears crucial in the derangement of microcirculatory flow. This study found that L-citrulline supplementation enhances de novo arginine synthesis and NO production in mice during endotoxemia, especially in mice with functional NOS3-enzyme.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Nicolaj S. Bischoff, Heloise Proquin, Marlon J. Jetten, Yannick Schrooders, Marloes C. M. Jonkhout, Jacco J. Briede, Simone G. van Breda, Danyel G. J. Jennen, Estefany Medina-Reyes, Norma L. Delgado-Buenrostro, Yolanda Chirino, Henk van Loveren, Theo M. de Kok
Summary: A study using transgenic mouse models suggests that the food additive E171 (titanium dioxide) may contribute to the formation and progression of colorectal cancer by modulating inflammation, immune response activation, cell cycle, and cancer signaling pathways.
Article
Biochemistry & Molecular Biology
Inne Vanreusel, Dorien Vermeulen, Inge Goovaerts, Tibor Stoop, Bert Ectors, Jacky Cornelis, Wendy Hens, Erwin de Bliek, Hilde Heuten, Emeline M. Van Craenenbroeck, An Van Berendoncks, Vincent F. M. Segers, Jacob J. Briede
Summary: This study investigated the levels of oxidative stress in adults with congenital heart disease (CHD) and its association with inflammation, exercise capacity, and endothelial function. The results showed that levels of superoxide anion radical were not significantly different between CHD patients and healthy controls. However, a significant negative correlation was found between oxidative stress and iron saturation. This study suggests that iron levels may play a more important role in oxidative stress mechanisms in CHD than in healthy individuals.
Article
Multidisciplinary Sciences
Heloise Proquin, Marlon J. Jetten, Marloes C. M. Jonkhout, Luis G. Garduno-Balderas, Jacob J. Briede, Theo M. de Kok, Yolanda I. Chirino, Henk van Loveren