Article
Nutrition & Dietetics
M. Alcazar, J. Escribano, N. Ferre, R. Closa-Monasterolo, M. Selma-Royo, A. Feliu, G. Castillejo, V Luque
Summary: This study aimed to describe and characterize the gut microbiota composition and diversity in children with obesity according to their metabolic health status. The results showed that children with metabolic unhealthy status had lower microbial diversity and richness, as well as distinct relative abundances of specific microbial taxa.
CLINICAL NUTRITION
(2022)
Article
Nutrition & Dietetics
Sooad Alsulami, Dhanasekaran Bodhini, Vasudevan Sudha, Coimbatore Subramanian Shanthi Rani, Rajendra Pradeepa, Ranjit Mohan Anjana, Venkatesan Radha, Julie A. Lovegrove, Rajagopal Gayathri, Viswanathan Mohan, Karani Santhanakrishnan Vimaleswaran
Summary: The study examined how dietary and genetic factors impact metabolic traits and the risk of type 2 diabetes among Asian Indians. It found that genetic risk scores were associated with a higher risk of developing type 2 diabetes and certain metabolic traits. Additionally, there were significant interactions between genetic risk scores and protein intake, suggesting that lower plant protein intake may contribute to increased susceptibility to diabetes in this population.
Article
Medicine, General & Internal
Lin-Lin Zhang, Xiao-Xiao Wu, Xu-Fan Wang, Dong-Sheng Di, Qian Huang, Rui-Shan Liu, Zong-Wen Shuai, Dong-Qing Ye, Rui-Xue Leng
Summary: The study investigated the association between SNPs in the miR-146a gene and susceptibility of RA, finding that the SNP rs2431697 in miR-146a gene is associated with RA risk. The effect size of this SNP was larger in Asian population compared to European population. Plasma TNF-alpha levels in healthy controls were inversely associated with the risk allele T of the SNP rs2431697.
ANNALS OF MEDICINE
(2021)
Article
Clinical Neurology
Christiane Gasperi, Tun Wiltgen, Julian Mcginnis, Stefano Cerri, Thomas Moridi, Russell Ouellette, Albert Pukaj, Cuici Voon, Cemsel Bafligil, Markus Lauerer, Till F. M. Andlauer, Friederike Held, Lilian Aly, Klementy Shchetynsky, Pernilla Stridh, Adil Harroud, Benedikt Wiestler, Jan S. Kirschke, Claus Zimmer, Aris Baras, Fredrik Piehl, Achim Berthele, Tobias Granberg, Ingrid Kockum, Bernhard Hemmer, Mark Muehlau
Summary: The minor allele of the genetic variant rs10191329 in the DYSF-ZNF638 locus is associated with unfavorable long-term clinical outcomes in multiple sclerosis patients. Each rs10191329*A allele is associated with 28% more brain atrophy in multiple sclerosis patients. Stratification for rs10191329 in clinical trials is encouraged.
ANNALS OF NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Maha M. Hammad, Mohamed Abu-Farha, Prashantha Hebbar, Emil Anoop, Betty Chandy, Motasem Melhem, Arshad Channanath, Fahd Al-Mulla, Thangavel Alphonse Thanaraj, Jehad Abubaker
Summary: The WFS1 gene is associated with genetic diabetes and metabolic traits, particularly obesity in the Southeast Asian population. This study highlights the significant role of ethnic background in the impact of genetic variants on susceptibility to metabolic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Jahad Alghamdi, Manal Alaamery, Tlili Barhoumi, Mamoon Rashid, Hala Alajmi, Nasser Aljasser, Yaseen Alhendi, Hind Alkhalaf, Hanadi Alqahtani, Omer Algablan, Abdulraham Alshaya, Nabiha Tashkandi, Salam Massadeh, Bader Almuzzaini, Salleh N. Ehaideb, Mohammad Bosaeed, Kamal Ayoub, Saber Yezli, Anas Khan, Ahmed Alaskar, Abderrezak Bouchama
Summary: Research shows that the IFITM3-SNP rs12252-G allele is associated with increased risk of hospital admission and mortality in COVID-19 patients, especially in those under 60 years old. There is a significant difference in plasma IFN γ levels between patients with this allele and those without it.
Article
Pharmacology & Pharmacy
Carolina Dagli-Hernandez, Jessica Bassani Borges, Elisangela da Silva Rodrigues Marcal, Renata Caroline Costa de Freitas, Augusto Akira Mori, Rodrigo Marques Goncalves, Andre Arpad Faludi, Victor Fernandes de Oliveira, Glaucio Monteiro Ferreira, Gisele Medeiros Bastos, Yitian Zhou, Volker M. Lauschke, Alvaro Cerda, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata
Summary: In this study, the deleterious variant ABCC1 rs45511401 was found to significantly enhance the LDL-c response to statin treatment in Brazilian FH patients. However, deleterious variants in PK genes were not associated with an increased risk of statin-related adverse events. This suggests that ABCC1 rs45511401 may be a promising candidate for personalized statin therapy.
Article
Pediatrics
Qiying Song, Jieyun Song, Chenxiong Li, Yang Wang, Lu Qi, Haijun Wang
Summary: The study found that genetic variants of the FAM3C gene were associated with dyslipidemia and lipid traits in Chinese children, particularly more significantly in girls. Additionally, significant gene-by-sex interactions were observed in the study.
PEDIATRIC RESEARCH
(2021)
Article
Immunology
Xin Xu, James Jiqi Wang, Hu Zhao, Kun Miao, Guanglin Cui, Yuxuan Zhang, Xiaoyun Yang, Luyun Wang, Junfang Wu, Dao Wen Wang
Summary: Our study found that patients with VSA have elevated plasma cytokine levels and increased myocardial and pericoronary inflammation, suggesting an association between VSA and myocarditis.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Emma H. Dahlstroem, Jani Saksi, Carol Forsblom, Nicoline Uglebjerg, Nina Mars, Lena M. Thorn, Valma Harjutsalo, Peter Rossing, Tarunveer S. Ahluwalia, Perttu J. Lindsberg, Niina Sandholm, Per-Henrik Groop
Summary: The low-expression G allele of rs77878271 in the promoter of the FABP4 gene is associated with increased risk of cardiovascular disease in individuals with type 1 diabetes, suggesting that genetically low FABP4 levels may be detrimental in this population.
Article
Clinical Neurology
Punit N. Matta, Tithi D. Baul, Krystel Loubeau, Jennifer Sikov, Natalie Plasencia, Ying Sun, Andrea E. Spencer
Summary: The study found that in urban, predominantly Latinx, school-age children, those who participated in fewer sports were more likely to exhibit withdrawn/depressed symptoms. This suggests that sports participation may help protect children from the effects of depression.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Oncology
Michael A. Vinokurov, Konstantin O. Mironov, Elvira A. Domonova, Tatiana N. Romanyuk, Anna A. Popova, Vasiliy G. Akimkin
Summary: This study aimed to identify genetic risks and their distribution among groups of women with different epidemiological features of HR-HPV infection. Through comparison of four groups of women, it was found that the rs55986091 allele had a protective effect, especially in the CC and CIN 2/3 groups. The results emphasize the importance of developing PCR-based diagnostic kits for the identification of SNP alleles, particularly among HR-HPV-positive women in the Russian population.
FRONTIERS IN ONCOLOGY
(2023)
Article
Pediatrics
Melania Manco, Annalisa Crudele, Antonella Mosca, Romina Caccamo, Maria Rita Braghini, Rita De Vito, Arianna Alterio, Fabrizio Pizzolante, Francesco De Peppo, Anna Alisi
Summary: The LncOb rs10487505 variant is associated with pediatric NAFLD and high leptin levels, as well as weight and leptin reduction after LSG in youths.
PEDIATRIC RESEARCH
(2022)
Article
Psychiatry
Li-ya Pan, Yuan-yue Zhou, Xue Zhang, Hai-yin Jiang
Summary: This study investigated the longitudinal changes in the microbiome during treatment with atypical antipsychotics and found that the baseline composition of the gut microbiome was associated with the risk of weight gain associated with antipsychotic medication.
PSYCHIATRY RESEARCH
(2022)
Article
Obstetrics & Gynecology
Yael R. Stovezky, Phillip A. Romanski, Pietro Bortoletto, Steven D. Spandorfer
Summary: This study found no association between body mass index and the number or proportion of aneuploid, mosaic, or euploid embryos in patients undergoing IVF with PGT-A, suggesting that excess weight may not impact reproductive outcomes through embryo ploidy status.
FERTILITY AND STERILITY
(2021)
Review
Pediatrics
Raman Kumar Marwaha, Aashima Dabas
INDIAN JOURNAL OF PEDIATRICS
(2019)
Article
Biochemistry & Molecular Biology
Shraddha Chakraborty, Shamsudheen Karuthedath Vellarikkal, Sridhar Sivasubbu, Soumya Sinha Roy, Nikhil Tandon, Dwaipayan Bharadwaj
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Khushdeep Bandesh, Dwaipayan Bharadwaj
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2020)
Article
Biochemistry & Molecular Biology
Anil K. Giri, Gauri Prasad, Khushdeep Bandesh, Vaisak Parekatt, Anubha Mahajan, Priyanka Banerjee, Yasmeen Kauser, Shraddha Chakraborty, Donaka Rajashekar, Abhay Sharma, Sandeep Kumar Mathur, Analabha Basu, Mark I. McCarthy, Nikhil Tandon, Dwaipayan Bharadwaj
MOLECULAR GENETICS AND GENOMICS
(2020)
Article
Genetics & Heredity
Jake Lin, Rubina Tabassum, Samuli Ripatti, Matti Pirinen
FRONTIERS IN GENETICS
(2020)
Review
Biochemistry & Molecular Biology
Rubina Tabassum, Samuli Ripatti
Summary: Cardiovascular diseases are the leading cause of global mortality, with plasma lipids playing a crucial role in prediction and prevention. Advancements in lipidomics have enhanced our understanding of CVDs, increasing knowledge of pathophysiological processes and potential biomarkers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Khushdeep Bandesh, Daisy Masih, Nirjhar Bhattacharyya, Dwaipayan Bharadwaj
Summary: Long non-coding RNAs (lncRNAs) play crucial roles in human diseases, serving as both biomarkers for disease status and effective therapeutic targets. Research has shown their mechanistic role in gene expression regulation and their potential applications in human metabolic diseases.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Article
Cardiac & Cardiovascular Systems
Rubina Tabassum, Sanni Ruotsalainen, Linda Ottensmann, Mathias J. Gerl, Christian Klose, Taru Tukiainen, Matti Pirinen, Kai Simons, Elisabeth Widen, Samuli Ripatti
Summary: This study examines sex differences in plasma lipidome and genetic influences on lipidome in men and women. It finds significant sex differences in the levels of 141 lipid species and age-sex interactions in 121 lipid species. The study suggests that common genetic variants do not have a major role in sex differences in lipidome.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Biochemistry & Molecular Biology
Anil K. Giri, Gauri Prasad, Vaisak Parekatt, Donaka Rajashekar, Nikhil Tandon, Dwaipayan Bharadwaj
Summary: The study investigated DNA methylation markers for predicting the risk of Type 2 diabetes mellitus (T2DM) in the Indian population. They identified and validated two novel CpG sites associated with T2DM risk. Additionally, they found a co-methylation network that was related to T2DM risk factors and could be used for patient stratification. The findings contribute to better understanding and management of T2DM in clinical practice.
HUMAN MOLECULAR GENETICS
(2023)
Review
Cardiac & Cardiovascular Systems
Rubina Tabassum, Elisabeth Widen, Samuli Ripatti
Summary: Cardiovascular diseases (CVD) are the leading cause of death worldwide for both men and women, but their prevalence and burden show marked sex differences. This review focuses on the sex differences in plasma lipids and the potential contributions of genetic factors and sex-specific physiological factors to the disparities in lipidomic profiles. The advancement of technology has made it possible to explore individual lipid species, collectively called the lipidome, which may provide further insights into the understanding of sex differences in CVD.
Article
Biochemistry & Molecular Biology
Khushdeep Bandesh, Muneesh Pal, Abitha Balakrishnan, Pradeep Gautam, Punam Jha, Nikhil Tandon, Beena Pillai, Dwaipayan Bharadwaj
Summary: Human disease-associated genetic variations often map to long non-coding RNA (lncRNA) genes. In this study, the researchers identified a genetic variant that strongly associates with plasma levels of C-peptide, a hormone that regulates insulin bioavailability. They found that this genetic variant modulates the transcript levels of the lncRNA gene, which then controls the expression of a protein-coding gene associated with synapse strengthening in the cerebellum. This study demonstrates the biological role of a novel lncRNA in determining the ratio of mRNA isoforms of a protein-coding gene and the ability of an embedded variant in modulating lncRNA stability leading to inter-individual differences in protein expression.
HUMAN MOLECULAR GENETICS
(2023)
Article
Immunology
Shraddha Chakraborty, Gauri Prasad, Raman Kumar Marwaha, Analabha Basu, Nikhil Tandon, Dwaipayan Bharadwaj
INDIAN JOURNAL OF MEDICAL RESEARCH
(2020)