Lrp5 Is Not Required for the Proliferative Response of Osteoblasts to Strain but Regulates Proliferation and Apoptosis in a Cell Autonomous Manner

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it

(2011) Leanne K. Saxon et al.   BONE

Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone

(2010) Mohamed A. Kamel et al.   BONE

WNT11 Expression Is Induced by Estrogen-Related Receptor   and  -Catenin and Acts in an Autocrine Manner to Increase Cancer Cell Migration

(2010) M. A. Dwyer et al.   CANCER RESEARCH

Cell proliferation of human fibroblasts and osteoblasts in osteogenesis imperfecta: Influence of age

(2010) N.S. Fedarko et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: A role for prostacyclin in adaptive bone remodeling?

(2010) Simon C.F. Rawlinson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Age-related changes in osteogenic stem cells in mice

(2010) R.J. Bergman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Endosteal human bone cells (EBC) show age-related activity in vitro

(2009) A. Battmann et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling

(2009) Andrew Sunters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of age and gender on WNT gene expression in human bone marrow stromal cells

(2009) Longxiang Shen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Adult Rat Bones Maintain Distinct Regionalized Expression of Markers Associated with Their Development

(2009) Simon C. F. Rawlinson et al.   PLoS One

Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum

(2008) Vijay K. Yadav et al.   CELL

β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts

(2008) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Collagen1α1 promoter drives the expression of Cre recombinase in osteoblasts of transgenic mice

(2008) Lagabaiyila Zha et al.   Journal of Genetics and Genomics