Article
Oncology
Jie Zhang, Yang Hong, Liang Wang, Weiheng Hu, Guangming Tian, Di Wu, Yang Wang, Ling Dai, Ziran Zhang, Yue Yang, Jian Fang
Summary: This study aimed to detect and describe the distribution characteristics of circulating tumor cells (CTCs) and circulating tumor-derived endothelial cells (CTECs) in patients with advanced lung cancer, and explore the correlation between CTC/CTEC subtypes and novel prognostic biomarkers. CTCs and CTECs derived from 52 patients with advanced lung cancer were identified using the subtraction enrichment-immunofluorescence in situ hybridization (SE-iFISH) system.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Lazaros Vasilikos, Kay Hanggi, Lisanne M. Spilgies, Samanta Kisele, Stefanie Rufli, W. Wei-Lynn Wong
Summary: The loss of cIAP1 hampers tumor cell extravasation by affecting endothelial cell response to tumor cell signals, rather than causing endothelial cell death. Lymphotoxin alpha secreted by tumor cells plays a critical role in the extravasation process.Targeting cIAP1/2 with Smac mimetics reduces lung metastasis by inhibiting tumor cell extravasation.
Article
Multidisciplinary Sciences
Zehua Zuo, Jie Liu, Zhihao Sun, Yu-Wei Cheng, Michael Ewing, Thomas H. Bugge, Toren Finkel, Stephen H. Leppla, Shihui Liu
Summary: The current antitumor microenvironment strategies have limited efficacy due to poor understanding of the roles and contributions of tumor stromal cells in tumor development. Researchers have developed a versatile in vivo delivery system for an anthrax toxin protein, which allows for clear genetic evaluation of individual tumor stromal elements. The findings reveal the specific contribution of tumor endothelial cells (ECs) to the antitumor activity of the toxin, highlighting the importance of the MEK-ERK-c-Myc central metabolic axis in tumor ECs for tumor progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Oncology
Jacopo Lidonnici, Massimo M. Santoro, Roxana E. Oberkersch
Summary: Angiogenesis plays an important role in tumor growth and metastasis, and understanding the metabolic characteristics and interactions of tumor endothelial cells (TECs) with tumor cells is crucial. The metabolic differences between normal and tumor vasculature provide a basis for developing targeted therapies with higher specificity and fewer side effects, improving patient outcomes.
Review
Biochemistry & Molecular Biology
Melissa Garcia-Caballero, Liliana Sokol, Anne Cuypers, Peter Carmeliet
Summary: The dynamic crosstalk between different components of the tumor microenvironment plays a critical role in cancer progression and metastasis. Angiogenesis is crucial for tumor growth, but abnormal blood vessels can lead to hypoxia and acidosis in the tumor microenvironment. Cancer and stromal cells can alter their metabolism to meet high energy demands and promote tumor proliferation. Recent studies have shown that the metabolism of tumor endothelial cells is reprogrammed and targeting these metabolic pathways can affect blood vessel formation. Therefore, metabolic antiangiogenic therapies combined with immunotherapies offer a clinical opportunity for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jiaojiao Huang, Yue Zhao, Kexin Zhao, Kai Yin, Shengjun Wang
Summary: This review focuses on how MDSCs survive and function in high levels of ROS, and summarizes immunotherapy targeting ROS in MDSCs. The distinctive role of ROS in MDSCs will inspire us to widely apply the blocked oxidative stress strategy in targeting MDSC therapy to future clinical therapeutics.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Carlos Jimenez-Cortegana, Claudia Galassi, Vanessa Klapp, Dmitry Gabrilovich, Lorenzo Galluzzi
Summary: MDSCs, a group of cells with immunosuppressive functions, have been found to be associated with tumor progression and treatment resistance. They also affect the efficacy of radiotherapy, making them potential targets for immunotherapeutic tumor control.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Oncology
Zong-Tao Chai, Xiu-Ping Zhang, Jian-Yang Ao, Xiao-Dong Zhu, Meng-Chao Wu, Wan Yee Lau, Hui-Chuan Sun, Shu-Qun Cheng
Summary: The study found that high AXL expression in TECs is associated with poor prognosis in HCC patients and promotes cell migration and tube formation through activation of the PI3K/AKT/SOX2/DKK-1 axis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ying Sun, Lei Xing, Jun Luo, Ming-Tao Yu, Xiao-Jie Wang, Yi Wang, Tian-Jiao Zhou, Hu-Lin Jiang
Summary: The newly developed Pro-Metastatic Derivatives Eliminator (PMDE) can simultaneously remove CTCs and TDEs from peripheral blood and efficiently inhibit their distribution in distant organs.
Review
Immunology
Lifei Liang, Xiaoqing Xu, Jiawei Li, Cheng Yang
Summary: This review summarizes and discusses the bidirectional regulation between miRNAs and MDSCs in the tumor microenvironment, revealing the impact of miRNAs and MDSCs on tumor immune escape and metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mingming Zhang, Shan Gao, Dongjuan Yang, Yan Fang, Xiaojie Lin, Xuechao Jin, Yuli Liu, Xiu Liu, Kexin Su, Kai Shi
Summary: This review discusses the challenges and mechanisms of nanoparticle infiltration in tumor microenvironment, as well as the strategies for enhancing therapeutic efficacy through adjusting the characteristics and structure of nanoparticles. The comprehensive summary provided in this review aims to guide future research in improving cancer treatment outcomes.
ACTA PHARMACEUTICA SINICA B
(2021)
Review
Cell Biology
Tianmiao Ma, Bernhard W. Renz, Matthias Ilmer, Dominik Koch, Yuhui Yang, Jens Werner, Alexandr V. Bazhin
Summary: Myeloid-derived suppressor cells (MDSCs) play a crucial role in the tumor microenvironment (TME) and have been linked to poor prognosis and drug resistance in cancer. Further research is needed to fully understand the definition and phenotypes of MDSCs in humans.
Review
Immunology
Xidan Gao, Hongshu Sui, Shang Zhao, Xingmei Gao, Yanping Su, Peng Qu
Summary: MDSCs, a heterogeneous population of immature myeloid cells accumulating in tumor-bearing hosts, play a critical role in promoting tumor immune escape. Therapeutic strategies targeting MDSCs have shown potential in enhancing the efficacy of tumor immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Physical
Chong Yu, Qiong Liu, Jin Wang
Summary: Heterogeneity is common in stem cells, cancer cells, and cancer stem cells, and it poses a significant obstacle to successful anticancer therapy. Understanding the origins and effects of heterogeneity is important for the treatment response, therapeutic resistance, and cancer metastasis.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Xiao Yu Ng, Gary S. L. Peh, Gary Hin-Fai Yam, Hwee Goon Tay, Jodhbir S. Mehta
Summary: Corneal endothelial dysfunction is a major cause of corneal blindness, and the current treatment option is corneal transplantation. However, there is a shortage of suitable donor graft material, leading to the exploration of stem cell-based regenerative medicine using induced pluripotent stem cells (iPSCs). This review discusses the progress and challenges in inducing iPSCs into corneal endothelial cells (CECs), as well as the potential risks and solutions for clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)