Article
Multidisciplinary Sciences
Liang Shi, Boqiang Liu, Dan-Dan Shen, Peijian Yan, Yanan Zhang, Yuanshi Tian, Lidan Hou, Guangyi Jiang, Yinxin Zhu, Yuelong Liang, Xiao Liang, Bo Shen, Hong Yu, Yan Zhang, Yifan Wang, Xing Guo, Xiujun Cai
Summary: The study identified dysregulated circPABPC1 in human hepatocellular carcinoma, which is preferentially lost in tumor cells and inhibits metastasis. It suppresses cell adhesion and migration by down-regulating a key integrin family member, ITGB1, through a unique degradation pathway. These findings provide a new understanding of circRNAs' role in cancer treatment.
Review
Biochemistry & Molecular Biology
Rikako Sanuki, Tomonori Yamamura
Summary: MiR-124 is strongly expressed in neurons and its reduced expression in cancer cells, especially high malignancy ones, is attributed to DNA methylation and absorption by non-coding RNAs in the promoter region. Studies have shown its tumor-suppressive effects in glial cell lineage cancers and top five deadliest cancers. MiR-124 inhibits proliferation, accelerates apoptosis, and suppresses tumor malignant transformation by regulating target genes like STAT3 and EZH2. Interestingly, there are similarities between genes involved in neuronal maturation and cancer cell metastasis, suggesting potential cross-disciplinary discoveries through the study of MiR-124.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Hua-chuan Zheng, Hang Xue, Xin Wu, Hai-lan Xu, En-hong Zhao, Zheng-guo Cui
Summary: ING5 targets histone acetyltransferase or histone deacetylase complexes for local chromatin remodeling and has suppressive effects on gastric cancer. SRF and YY1 interact with the promoter of ING5, up-regulating its expression in gastric cancer. Overexpression of ING5, SRF, and YY1 is associated with worse prognosis in gastric cancer patients. SAHA treatment enhances migration and invasion of ING5 transfectants. ING5 deletion contributes to gastric carcinogenesis and histogenesis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yun Liang, Wenshan Wang, Xiaojun Zhu, Minghua Yu, Caiyun Zhou
Summary: PD-1/PD-L1 inhibitor treatments are not very effective in advanced cervical cancer patients. However, a study has shown that all-trans retinoic acid (ATRA) can differentiate myeloid-derived suppressor cells (MDSCs) into mature myeloid cells. This research aimed to investigate whether ATRA could enhance PD-L1 blockade-mediated tumor immunotherapy by suppressing the function of MDSCs. The results showed that ATRA effectively abrogated the suppressive activity of MDSCs and enhanced the efficacy of anti-PD-L1 cancer immunotherapy in cervical cancer.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Deeptashree Nandi, Pradeep Singh Cheema, Aakriti Singal, Hina Bharti, Alo Nag
Summary: FoxM1 overexpression is associated with tumor aggressiveness, while Artemisinin has been identified to curb its activity and potentially improve therapeutic response, especially in resistant liver cancer cells. The combination of Artemisinin with Thiostrepton showed enhanced efficacy in reducing growth and inducing cell death in liver cancer cells, providing a novel therapeutic option for resistant cancer patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Bai-Hui Liu, Gong-Bao Liu, Bin-Bin Zhang, Jian Shen, Lu-Lu Xie, Xiang-Qi Liu, Wei Yao, Rui Dong, Yun-Li Bi, Kui-Ran Dong
Summary: This study identified seven novel gene mutations in wilms tumor, with MUC6 being the most prevalent mutation. MUC6 acts as a tumor suppressive gene through autophagy dependent beta-catenin pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Guangyuan Song, Xingxin Zhu, Zefeng Xuan, Long Zhao, Haijiang Dong, Jian Chen, Zequn Li, Wenfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Shusen Zheng, Penghong Song
Summary: In this study, we identified that GNA14 is downregulated in HCC and negatively correlated with HBV infection, vascular invasion, and prognosis. HBx regulates GNA14 through DNA methylation, affecting the Notch1 and JMJD6 pathways to inhibit tumor proliferation and metastasis. GNA14 shows potential as a biomarker and therapeutic target in HCC.
Article
Cell Biology
Xiaojuan Li, Fan Wang, Lu Huang, Mengtian Yang, Ersheng Kuang
Summary: This study found that RNF5 interacts with EphA2 and regulates its tumor-suppressive function in HER2-negative breast cancer. RNF5 inhibition increases cell adhesion and decreases cell migration in HER2-negative breast cancer cells.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Tingting Shi, Asahiro Morishita, Hideki Kobara, Tsutomu Masaki
Summary: Long non-coding RNA and microRNA networks play multifaceted functions in the pathogenesis of HCC, serving as potential targets for diagnosis and treatment of HCC, while also exerting regulatory effects in the tumor microenvironment of HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Manlio Tolomeo, Antonio Cascio
Summary: STAT3 is a complex regulator of transcription, with constitutive activation reported in many tumors but less frequent somatic mutations in cancer. Oncogenic targets of STAT3 have been identified, and inhibitors have been developed for cancer prevention and treatment. However, data suggest that STAT3 functions are multifaceted and its cellular role is determined by various signals and factors, making targeted therapies tailored to specific tumor types important.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Usaal Tahir, Mariam Zameer, Qurban Ali, Ayesha Rafique, Syeda Maham Ali, Muhammad Umer Arif, Imtiaz Nawaz, Saif ul Malook, Daoud Ali
Summary: The study aimed to examine the toxic effects of lead on animals and identified lead-resistant bacterial strains with high biodegradation potential. The results showed severe health issues caused by lead exposure in mice, but the lead-resistant bacterial strains could survive in a lead-contaminated environment and effectively degrade lead. This biological strategy provides an ideal alternative for remediating heavy metal contamination and cleaning up the environment.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2023)
Article
Chemistry, Medicinal
Dipti Kanabar, Mimansa Goyal, Emma Kane, Tejashri Chavan, Abbas Kabir, Xuechun Wang, Snehal Shukla, Joseph Almasri, Sona Goswami, Gizem Osman, Marino Kokolis, Donald E. Spratt, Vivek Gupta, Aaron Muth
Summary: This study reports the structure-based design of small molecules that can bind to Gankyrin and inhibit its overexpression in breast and lung cancers, showing potential therapeutic value.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Oncology
Xiaocong Chen, Yang An, Mengsi Tan, Dongrui Xie, Ling Liu, Benjin Xu
Summary: The eukaryotic translation initiation factor eIF4E specifically binds to the cap structure of mRNA 5' end, regulating translation initiation and enhancing translation of carcinogenesis related mRNAs. Abnormally increased eIF4E activity in tumor cells stimulates cell growth, metastasis, and translation of related proteins. Factors affecting eIF4E activity include intranuclear regulation, phosphorylation of 4EBPs, and phosphorylation and sumoylation of eIF4E. This review summarizes the biological functions, research progress, and recent advances in drugs targeting eIF4E, aiming to provide new insights for the treatment of multiple malignancies and development of targeted drugs.
FRONTIERS IN ONCOLOGY
(2023)
Article
Immunology
Ranran Feng, Yong Chen, Ying Liu, Qing Zhou, Wenling Zhang
Summary: B7-H3, a member of the B7 family of molecules, acts as an immune checkpoint promoting tumor progression through immunosuppression and non-immunological functions in the tumor microenvironment. It can serve as a potential biomarker for tumor diagnosis and prognosis, with immunotherapy targeting B7-H3 showing promise in clinical applications.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryota Ono, Nozomu Saeki, Keiichi Kojima, Hisao Moriya, Yuki Sudo
Summary: The growth of budding yeast Saccharomyces cerevisiae is severely impaired under white light illumination in the presence of iodide ions, but not fluoride, chloride and bromide ions. Action spectroscopy reveals that the maximum wavelength of the light is around 373 nm in the UVA region. Several genes, including OPY1, HEM1, and PAU11, have been identified as suppressors of this iodide-dependent UVA-triggered growth inhibition. This method and its suppressive molecules provide insights into cell growth processes in eukaryotes and can be used for medium sterilization using UVA light.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)