Article
Hematology
Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
Summary: MLL/AF4 fusion gene defines a high-risk subtype of B-precursor acute lymphoblastic leukemia. Relapse can result in lineage switch to acute myeloid leukemia, which is associated with changes in chromatin accessibility and transcriptional programs. The altered expression and mutation of chromatin modifiers are recurrently associated with the relapsed myeloid phenotype, indicating disrupted epigenetic regulation drives and maintains lineage switching in MLL/AF4 leukemia.
Article
Biology
Natalia S. Shulgina, Maria Churova, Svetlana A. Murzina, Marina Yu Krupnova, Nina N. Nemova
Summary: The study found that continuous lighting had a positive effect on weight gain and influenced the expression levels of key genes in hatchery-reared Atlantic salmon. Additionally, there was a positive correlation between the expression levels of MRFs and MSTN paralogs under hatchery conditions.
Article
Cell Biology
Fatemeh Safi, Parashar Dhapola, Sarah Warsi, Mikael Sommarin, Eva Erlandsson, Jonas Ungerback, Rebecca Warfvinge, Ewa Sitnicka, David Bryder, Charlotta Boiers, Ram Krishna Thakur, Goran Karlsson
Summary: By investigating the chromatin accessibility of single cells, it has been found that there is a population of cells that display both stem-like and lineage-affiliated chromatin signatures. These cells are positioned between stem cells and committed progenitors, showing multi-lineage potential but lacking self-renewal activity.
Article
Fisheries
Enrique Pino Martinez, Pablo Balseiro, Sigurd O. Stefansson, Nobuto Kaneko, Birgitta Norberg, Mitchell S. Fleming, Albert K. D. Imsland, Sigurd O. Handeland
Summary: Early maturation of Atlantic salmon male postsmolts has negative effects on growth and adaptation in aquaculture. This study found that temperature and feeding ration significantly influenced sexual maturation in salmon, with higher temperatures and feeding rations leading to more early maturation.
Article
Oncology
Ling-Yu Zhu, Jun-Bo Yuan, Li Zhang, Chun-Xiao He, Xiao Lin, Bin Xu, Guang-Hui Jin
Summary: This study investigated the role of MLL in menin-regulated lung tumorigenesis. The results showed that MLL deficiency suppressed Kras-induced lung tumorigenesis by decreasing H3K4me3 levels and suppressing the expression of Rasgrf1 gene. Rasgrf1 was essential for the activation of Kras and its downstream pathways, which are involved in cancer-promoting activities.
Article
Environmental Sciences
Andre S. Bogevik, Elisabeth Ytteborg, Alexander Klevedal Madsen, Ann-Elise Olderbakk Jordal, Odd Andre Karlsen, Ivar Ronnestad
Summary: In this study, polyethylene (PE) microplastics were added to Atlantic cod feeds at 1%, either in their original form or spiked with PCB-126. After a 4-week period, cod fed spiked PE showed a higher concentration of PCB-126 in liver and muscle samples compared to control and fish ingesting virgin PE. The expression of hepatic cyp1a was higher in cod fed spiked PE, indicating an accumulation of PCB-126 in the liver. Moreover, both spiked PE and virgin PE had an effect on the skin, suggesting a reduced skin barrier in fish fed a diet containing PE.
MARINE POLLUTION BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
A. Doyle, M. E. Cowan, H. Migaud, P. J. Wright, A. Davie
Summary: The research revealed that Atlantic cod is a short day breeder and reduction in day-length stimulates gametogenesis. Pituitary eya3 may act as a regulator of sexual maturation in cod, and restricted feeding significantly suppresses maturation.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Hematology
Camille Malouf, Eric T. B. Antunes, Michael O'Dwyer, Helene Jakobczyk, Franziska Sahm, Sophie-Luise Landua, Richard A. Anderson, Abdenour Soufi, Christina Halsey, Katrin Ottersbach
Summary: t(4;11) MLL-AF4 acute leukemia is one of the most aggressive malignancies in infants and children, with limited understanding of the molecular mechanisms driving disease progression. This study identifies miR-130b and miR-128a as downstream targets of MLL-AF4, contributing to the transition from pre-leukemia to acute leukemia in murine models. The overexpression of these miRNAs recapitulates human disease phenotypes, providing potential targets for novel therapeutic approaches.
Article
Cell Biology
Yao Xiong, Yan Wang, Ling Ma, Ying Zhang, Xinlan Qu, Lei Huang, Xue Wen, Huimin Liu, Ming Zhang, Yuanzhen Zhang
Summary: Studies have shown that MLL1 plays a key role in endometrial receptivity by regulating hormone stimulation during decidualization. Inhibiting MLL1 function reduces the transformation of HESCs and decreases expression of PGR and its target genes. MLL1 acts as a co-activator of ER alpha, promoting PGR transcription and progesterone signaling transmission.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Fisheries
Ina Stoltenberg, Karl Michael Werner, Stefanie M. H. Ismar-Rebitz, Heino O. Fock
Summary: The study examined the relationship between trophic niches and body condition in Atlantic cod in different habitats in Greenland waters, indicating that habitat heterogeneity and trophic niche are important factors influencing reproductive success in cod.
FISHERIES RESEARCH
(2021)
Article
Multidisciplinary Sciences
Bridie Jean Marie Allan, Jessica Louise Ray, Maik Tiedemann, Valeriya Komyakova, Frode Vikebo, Katrine Sandnes Skaar, Martina H. Stiasny, Arild Folkvord, Richard D. M. Nash, Erling Kare Stenevik, Olav Sigurd Kjesbu
Summary: Mortality rates in early life-history stages of fishes are high, with Atlantic herring recruitment decreasing in the Norwegian Sea due to increased predation pressure by Atlantic mackerel. Research using particle drift simulations and ddPCR analysis confirms mackerel predation on herring larvae, highlighting the importance of accurately quantifying predation pressure for effective conservation and management strategies.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
M. Fernandez-Miguez, V. Puvanendran, E. Burgerhout, P. Presa, H. Tveiten, K. Vorkamp, O. J. Hansen, G. S. Johansson, A. S. Bogevik
Summary: This study evaluated the effects of feed containing naturally weathered microplastics from the Oslofjord on the reproductive physiology of Atlantic cod. The results showed that microplastics had some effects on the sex hormone levels and enzyme production and function of the fish, but there were no major differences in overall biometrics or gonad histology. These findings suggest that the long-term consequences of microplastics on the ecosystem should be considered.
ENVIRONMENTAL POLLUTION
(2023)
Article
Fisheries
Marit Bjornevik, Albert K. D. Imsland, Henriette Hanssen, Bjorn Roth, Erik Vikingstad, Atle Foss
Summary: This study found that alternate day feeding of Atlantic cod can significantly increase weight gain and improve feed conversion ratio, while reducing feed consumption. Feeding on alternate days can greatly reduce feeding costs without compromising biomass growth.
AQUACULTURE NUTRITION
(2021)
Article
Multidisciplinary Sciences
Guobjoerg Asta Olafsdottir, Shaun Turnbull, Ingibjoerg G. Jonsdottir, Anja Nickel, Hjalti Karlsson, Theresa Henke, Einar Eg Nielsen, Snaebjoern Palsson
Summary: Atlantic cod, an economically important fish in the North Atlantic, shows population variation and life-history changes. A study in NW-Iceland found distinct segregation of juvenile cod by depth. Understanding the physiological mechanism behind this segregation is important for marine spatial planning and conservation tools.
Article
Oncology
Jia Liu, Wei-Yi Zhou, Xiao-Jing Luo, Yan-Xing Chen, Chau-Wei Wong, Ze-Xian Liu, Jia- Bo Zheng, Hai- Yu Mo, Jun-Quan Chen, Jia-Jun Li, Ming Zhong, Yu-Hong Xu, Qi-Hua Zhang, Heng-Ying Pu, Qi-Nian Wu, Ying Jin, Zi-Xian Wang, Rui-Hua Xu, Hui-Yan Luo
Summary: This study reveals the critical role of the RIME-MLL1-H3K4me3 axis in tumor immunosuppression. RIME may serve as a potential prognostic biomarker for immunotherapy, and developing drugs targeting RIME may be a new therapeutic strategy to overcome immunotherapy resistance.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Mare Geraerts, Carl Vangestel, Tom Artois, Jorge Manuel de Oliveira Fernandes, Michiel W. P. Jorissen, Auguste Chocha Manda, Celestin Danadu Mizani, Karen Smeets, Jos Snoeks, Gontran Sonet, Yang Tingbao, Maarten Van Steenberge, Emmanuel Vreven, Soleil Lunkayilakio Wamuini, Maarten P. M. Vanhove, Tine Huyse
Summary: This study examines the genetic consequences of introducing Nile tilapia into the Congo Basin, finding evidence of genetic admixture with other tilapia species and the potential threat to the genetic integrity of native tilapias. The study also identifies genetic differentiation between Nile tilapia populations from different regions, suggesting independent introductions. The authors recommend avoiding further introductions of Nile tilapia in non-native regions and using native tilapias in future aquaculture efforts.
Article
Microbiology
Yousri Abdelhafiz, Jorge M. O. Fernandes, Claudio Donati, Massimo Pindo, Viswanath Kiron
Summary: In this study, the vertical transmission of microbes across generations in fishes was investigated using Nile tilapia. The analysis revealed that the core microbiome in the parents' buccal cavity and posterior intestine shapes the gut microbiome of the progeny. The identified core microbiome bacteria, Nocardioides, Propionibacterium, and Sphingomonas, play an essential role in the health and development of offspring in a similar way as in mammals.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Environmental Sciences
Ioannis Konstantinidis, Joana P. Firmino, Alberto Ruiz, Bruno Inarra, David San Martin, Alicia Estevez, Jorge M. O. Fernandes, Enric Gisbert
Summary: This study evaluated the replacement of dietary protein sources with Brewer's spent dry yeast (SDY) in gilthead sea bream and found that SDY had a modulatory effect on the host's immunity, oxygen carrier capacity, steroidogenesis, metabolism, and digestion. The results indicate that SDY can be considered as both a sustainable raw material and a functional ingredient.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Ecology
Omid Jafari, Mehrshad Zeinalabedini, Diego Robledo, Jorge M. O. Fernandes, Ali-Akbar Hedayati, Babak Arefnezhad
Summary: Understanding the population structure and genetic diversity of wild populations is crucial for stock management and conservation. This study investigated the population structure and genetic diversity of common carp in the Southern Caspian basin using genotyping-by-sequencing. The results showed low differentiation between populations and high within population variation. Frequent migration events were observed, but each population still had distinct genetic profiles. However, high inbreeding and low heterozygosity were detected, indicating the need for additional conservation efforts.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Biology
Omid Jafari, Mansour Ebrahimi, Seyed Ali-Akbar Hedayati, Mehrshad Zeinalabedini, Hadi Poorbagher, Maryam Nasrolahpourmoghadam, Jorge M. O. Fernandes
Summary: This study used data mining algorithms to investigate the population classification of common carp in the southern Caspian basin and identified the most important characteristic for distinguishing between Iranian and farmed common carp. The results showed that machine learning methods had higher prediction rates, with head height on eye area being the best marker. The study contributes to the understanding of domestication syndrome in common carp and provides a novel approach for automated detection of farmed fish.
Article
Genetics & Heredity
Eugenia Boulygina, Fedor Sharko, Maksim Cheprasov, Maria Gladysheva-Azgari, Natalia Slobodova, Svetlana Tsygankova, Sergey Rastorguev, Lena Grigorieva, Martina Kopp, Jorge M. O. Fernandes, Gavril Novgorodov, Gennady Boeskorov, Albert Protopopov, Woo-Suk Hwang, Alexei Tikhonov, Artem Nedoluzhko
Summary: This study demonstrates the maternal philopatry of the Northeastern Eurasian U. arctos population during the several thousand years of the Holocene through ancient DNA analysis and comparative phylogenetic analysis.
Article
Biochemical Research Methods
Fedor Sharko, Golam Rbbani, Prabhugouda Siriyappagouder, Joost A. M. Raeymaekers, Jorge Galindo-Villegas, Artem Nedoluzhko, Jorge M. O. Fernandes
Summary: In this study, the CircPrime web platform was developed, which provides a user-friendly solution for circRNA identification by designing specific circular RNA primers. It works in collaboration with popular bioinformatic predictors of circRNAs.
BMC BIOINFORMATICS
(2023)
Article
Fisheries
Kazue Nagasawa, Makoto Kanamori, Jeongwoong Yoon, Mutsuko Kobayashi, Mariia Mokrina, Takahiro Kato, Makoto Osada
Summary: This study established methodologies for studying the hemocytes of Yesso scallop and assessed their cell morphology, seasonal fluctuation, transcriptomes, and cellular behavior during the immune response. The Yesso scallop possesses a single type of leukocyte-type hemocytes similar to other bivalve granulocytes, and five molecular marker genes specific to the scallop hemocytes were identified. Using these markers, tissue transplantation was confirmed to induce an immune response and mobilize circulating hemocytes for encapsulation.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Golam Rbbani, Artem Nedoluzhko, Prabhugouda Siriyappagouder, Fedor Sharko, Jorge Galindo-Villegas, Joost A. M. Raeymaekers, Rajesh Joshi, Jorge M. O. Fernandes
Summary: This study used an integrative omics approach to identify myogenic circular RNAs (circRNAs) in Nile tilapia, and found 1947 mRNAs, 9 miRNAs, and 4 circRNAs that were differentially expressed between fast- and slow-growing individuals. These miRNAs can regulate myogenic genes and have binding sites for the novel circRNA circMef2c. The study suggests that circ-Mef2c may interact with three miRNAs and 65 differentially expressed mRNAs to form multiple competing endogenous RNA networks that regulate growth, providing new insights into the role of circRNAs in muscle growth regulation in teleosts.
Article
Multidisciplinary Sciences
Ioannis Konstantinidis, Pal Saetrom, Jorge M. O. Fernandes
Summary: This study presents a genome-wide epigenetic dataset that quantifies DNA hydroxymethylation in Nile tilapia with distinct growth performance. They found several growth-related genes that are differentially hydroxymethylated, especially within gene bodies and promoters. This dataset can be analyzed in various contexts and compared to other epigenomic datasets in the future.
Article
Agriculture, Dairy & Animal Science
Giovanni De Benedetto, Fabiano Capparucci, Sabrina Natale, Serena Savoca, Kristian Riolo, Claudio Gervasi, Marco Albano, Alessia Giannetto, Gabriella Gaglio, Carmelo Iaria
Summary: This study investigated the helminth fauna of mullets in Ganzirri Lagoon, Italy. It identified the presence of the Acanthocephalan parasite Neoechinorhynchus agilis and the digenean trematode Haploporus benedeni, with the latter requiring molecular analysis for identification. It concluded that none of the parasitic species pose a risk to human health.
Article
Zoology
Thrissawan Traijitt, Sukanya Jaroenporn, Kazue Nagasawa, Makoto Osada, Noppadon Kitana, Jirarach Kitana
Summary: This study investigated the steroidogenic potential of the gonads in the rice field frog. The expression levels of CYP17 and CYP19 mRNA were analyzed in males and females at different stages of development. The results showed a sexual dimorphic pattern in steroidogenic potential, with CYP17 mRNA being higher in males and localized in the Leydig cells of the testis, while CYP19 mRNA was higher in females and correlated with gonadal development in the ovary.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Likith R. Pinninti, Marius F. Maurstad, Siv N. K. Hoff, Torstein Kristensen, Leslie R. Noble, Sissel Jentoft, Jorge M. O. Fernandes
Summary: The complete mitochondrial genome of the Atlantic spiny lumpsucker (Eumicrotremus spinosus) was sequenced using PacBio Sequel II HiFi platform. It has a length of 19,281 bp and includes 13 protein-coding sequences, 22 tRNA genes, 2 rRNA genes, a control region with D-loop (2383 bp), and a duplicate control region (1133 bp). Phylogenetic analysis indicated that E. spinosus is closely related to Siberian lumpsucker (E. asperrimus). The mitogenome of spiny lumpsucker is valuable for population genomics and systematic studies of Cyclopteridae, Liparidae, and Cottidae.
MITOCHONDRIAL DNA PART B-RESOURCES
(2023)
Article
Biochemistry & Molecular Biology
Kristian Riolo, Archimede Rotondo, Giovanna Loredana La Torre, Ylenia Marino, Gianluca Antonio Franco, Rosalia Crupi, Roberta Fusco, Rosanna Di Paola, Sabrina Oliva, Giuseppe De Marco, Domenico Savastano, Salvatore Cuzzocrea, Enrico Gugliandolo, Alessia Giannetto
Summary: In this study, protein hydrolysates (BPHs) produced from black soldier fly larvae were characterized and evaluated for their potential biological activity. The BPHs showed antioxidant activity and could protect cells from oxidative stress. These findings suggest that BPHs could be used as ingredients to promote animal health in feed formulations.
Article
Fisheries
Giacomo Zaccone, Alessio Alesci, Doaa M. M. Mokhtar, Marialuisa Aragona, Maria Cristina Guerrera, Gioele Capillo, Marco Albano, Jorge de Oliveira Fernandes, Viswanath Kiron, Ramy K. A. Sayed, Marwa M. M. Hussein, Patrizia Lo Cascio, Michal Kuciel, Krystyna Zuwala, Antonino Germana, Jose Manuel Icardo, Eugenia Rita Lauriano
Summary: The recognition and elimination of invading pathogens are essential for host survival. Macrophages, which function similarly to vertebrate macrophages, play a crucial role in host protection in all multicellular organisms. CD14 is a pattern responsible for bacterial recognition found on the surface of macrophages. These cells store antimicrobial molecules and display polarization states similar to mammalian macrophages. The present study reports the presence of various cell markers, including CD14, in the intestinal macrophages of catfish and bonytongue, providing insights into the in vivo function of macrophages in fish.
