Article
Oncology
Paul Chih-Hsueh Chen, Hsuan-Ying Huang, Ming-Yi Chung, Chin-Chen Pan
Summary: Low-grade endometrial stromal sarcoma and ossifying fibromyxoid tumors differ in terms of site, sex, and morphological characteristics, but share a common PHF1 gene-related rearrangement. A case of endometrial stromal sarcoma with distinct ossification was reported, with the identification of a new PHF1-BRD8 fusion transcript using molecular techniques.
Article
Oncology
Josephine K. K. Dermawan, Nooshin Dashti, Sarah Chiang, Gulisa Turashvili, Brendan C. C. Dickson, Lora H. H. Ellenson, Martina Kirchner, Albrecht Stenzinger, Gunhild Mechtersheimer, Abbas Agaimy, Cristina R. R. Antonescu
Summary: In this study, we report a series of endometrial stromal sarcoma (ESS) cases with novel gene fusions. These cases demonstrate morphological and molecular heterogeneity. The identified fusion genes play important roles in the regulation of the PRC2 and/or NuA4/TIP60 complexes.
GENES CHROMOSOMES & CANCER
(2023)
Review
Immunology
Youngah Kim, Dohyang Kim, Woo Jung Sung, Jaewoo Hong
Summary: Endometrial stromal tumor (EST) is a rare and unusual mesenchymal tumor of the uterus, divided by WHO into four categories, with high-grade endometrial stromal sarcoma (HG-ESS) being the most malignant. Immunotherapy could potentially be a successful treatment for HG-ESS patients in the future.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pathology
Ashlyn Fong, Saul Offman
Summary: This study describes a case of ZC3H7B-BCOR fusion gene related tumor, which adds to the understanding of the diagnostic challenges and clinical features of BCOR HG-ESS. It supports the inclusion of BCOR HG-ESS as a sub-entity of uterine mesenchymal tumors and highlights its aggressive behavior.
DIAGNOSTIC PATHOLOGY
(2023)
Article
Oncology
Josephine K. Dermawan, Lei Zhang, Samuel Singer, Ping Chi, Cristina R. Antonescu
Summary: Low-grade endometrial stromal sarcoma (ESS) is a hormone-responsive sarcoma primarily found in the uterine corpus in women, but exceptionally rare in males. Genetic hallmarks of ESS involve recurring gene fusions, with two new cases in male patients reported in this study. Both cases demonstrated similar immunohistochemical and molecular features to ESS, with one case experiencing recurrence with peritoneal sarcomatosis after 2 years.
GENES CHROMOSOMES & CANCER
(2022)
Review
Medicine, General & Internal
Iolia Akaev, Chit Cheng Yeoh, Siavash Rahimi
Summary: Endometrial stromal tumours (ESTs) are rare uterine neoplasms with variegated characteristics, classified into four categories based on the latest WHO classification. The clinical behavior and malignant potential vary among different categories. Integrating morphological and molecular findings can aid in therapeutic decision-making for ESTs.
Article
Pathology
Amir Momeni-Boroujeni, Nissreen Mohammad, Robert Wolber, Stephen Yip, Martin Kobel, Brendan C. Dickson, Martee L. Hensley, Mario M. Leitao, Cristina R. Antonescu, Ryma Benayed, Marc Ladanyi, Cheng-Han Lee, Sarah Chiang
Summary: High-grade endometrial stromal sarcoma (HGESS) can harbor various gene fusions and internal tandem duplications, as well as exhibit upregulation of NTRK3 and pan-Trk expression. Most HGESS show distinct molecular characteristics, including activation of kinases and downregulation of ESR1. Some HGESS express ER and PR despite downregulation of ESR1, which may impact the effectiveness of endocrine therapy.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Bulin Du, Yan Cui, Yu Ma, Yaming Li, Xuena Li
Summary: This article describes a rare case of EESS involving the sigmoid colon and rectum. The F-18-FDG PET/CT scan revealed multiple hypermetabolic lesions in the abdomen and pelvis, initially suspected to be metastatic colorectal cancer. However, pathological confirmation confirmed low-grade EESS. Therefore, it is important to carefully differentiate between widespread EESS with intestine involvement and colorectal cancer with metastases.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Pathology
Alexis Trecourt, Rihab Azmani, Isabelle Hostein, Larry Blanchard, Francois Le Loarerd, Aurelien Bourdon, Melissa Alame, Beatrice Nadaud, Laetitia Mayer, Flora Rebier, Claire Larmonier, Madalena Souto Moura, Isabelle Soubeyran, Cecile Hartog, Isabelle Ray-Coquard, Isabelle Treilleux, Mojgan Devouassoux-Shisheboran, Sabrina Croce
Summary: By conducting a comprehensive study, including clinical, histopathologic, immunohistochemical, and molecular analyses, it has been confirmed that neoplasms harboring a KAT6B/A::KANSL1 fusion represent a distinct clinicopathologic entity with clinical aggressiveness despite a reassuring morphology. Pathologists should be alerted to the criteria and perform KAT6B/A::KANSL1 fusion testing in routine practice.
Article
Pathology
Kyle M. Devins, Ayoma D. Attygalle, Sabrina Croce, Katherine Vroobel, Esther Oliva, W. Glenn McCluggage
Summary: This study reports 5 cases of rare low-grade endometrial stromal tumors that harbor YWHAE::NUTM2 fusions. These tumors showed no typical features of high-grade endometrial stromal sarcomas. Two patients experienced recurrence and rapid transformation to high-grade tumors.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Editorial Material
Obstetrics & Gynecology
Bei Wang, Liping Liu, Na Li, Jing Zhao, Congwei Dai, Xiaowei Dai, Jianli Li
Summary: This report presents an extremely rare case of high-grade endometrial stromal sarcoma originating in the endocervix.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Medicine, General & Internal
Yu Meng, Quan Quan, Fenfen Zhang, Yao Liu, Siling Ren, Xiaoling Mu
Summary: This study investigated the prognostic value of the Ki-67 index in endometrial stromal sarcoma and identified a cut-off value of 35% for predicting recurrence. High Ki-67 index and ovarian preservation were significantly associated with shorter progress free survival. The Ki-67 index could serve as a useful prognostic marker in endometrial stromal sarcoma.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Angiolo Gadducci, Francesco Multinu, Luigi Antonio De Vitis, Stefania Cosio, Silvestro Carinelli, Giovanni Damiano Aletti
Summary: Endometrial stromal tumors (EST) are rare malignancies primarily affecting peri- or postmenopausal women. LG-ESS typically expresses estrogen and progesterone receptors, while HG-ESS and UUS lack specific genetic abnormalities. Total hysterectomy with bilateral salpingo-oophorectomy is the first-line treatment for early-stage LG-ESS, while for early-stage HG-ESS and UUS, it is standard to perform total hysterectomy with bilateral salpingo-oophorectomy. LG-ESS has a relatively favorable prognosis with a 5-year overall survival rate of 80-100%, while HG-ESS and UUS have poorer outcomes.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Evan S. Smith, Corinne Jansen, Kathryn M. Miller, Sarah Chiang, Kaled M. Alektiar, Martee L. Hensley, Jennifer J. Mueller, Nadeem R. Abu-Rustum, Mario M. Leitao Jr
Summary: The study assessed potential predictive variables for nodal metastasis and survival outcomes in patients with newly diagnosed, low-grade endometrial stromal sarcoma. The results showed that lymph node dissection should be reserved for those with clinically suspicious lymphadenopathy. Disease stage correlated with progression-free survival but not disease-specific survival. Post-operative therapy did not improve progression-free survival or disease-specific survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Oncology
Francesca Micci, Sverre Heim, Ioannis Panagopoulos
Summary: Endometrial stromal sarcomas (ESS) are a rare and heterogeneous group of mesenchymal cancers, now classified as low- or high-grade. They may have overlapping clinical presentation, morphology, and immunohistochemical profile. Understanding the molecular characteristics of ESS can improve diagnosis, prognostication, and treatment.
GENES CHROMOSOMES & CANCER
(2021)
Article
Oncology
Ioannis Panagopoulos, Ludmila Gorunova, Ben Davidson, Sverre Heim
Article
Oncology
Ioannis Panagopoulos, Ludmila Gorunova, Bodil Bjerkehagen, Ingvild Lobmaier, Sverre Heim
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Multidisciplinary Sciences
Ioannis Panagopoulos, Ludmila Gorunova, Bodil Bjerkehagen, Sverre Heim
Article
Pathology
Ioannis Panagopoulos, Ludmila Gorunova, Marius Lund-Iversen, Ingvild Lobmaier, Bodil Bjerkehagen, Sverre Heim
Article
Oncology
Ioannis Panagopoulos, Ludmila Gorunova, Ingvild Lobmaier, Bodil Bjerkehagen, Sverre Heim
Article
Multidisciplinary Sciences
Iannis Panagopoulos, Ludmila Gorunova, Eva-Marie Jacobsen, Kristin Andersen, Francesca Micci, Sverre Heim
Review
Biochemistry & Molecular Biology
Ioannis Panagopoulos, Jim Thorsen, Ludmila Gorunova, Francesca Micci, Sverre Heim
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2014)
Article
Oncology
Ioannis Panagopoulos, Bodil Bjerkehagen, Ludmila Gorunova, Jeanne-Marie Berner, Kjetil Boye, Sverre Heim
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)
Article
Oncology
Ioannis Panagopoulos, Petter Brandal, Ludmila Gorunova, Bodil Bjerkehagen, Sverre Heim
INTERNATIONAL JOURNAL OF ONCOLOGY
(2014)
Article
Oncology
Ioannis Panagopoulos, Ludmila Gorunova, Bodil Bjerkehagen, Kjetil Boye, Sverre Heim
Article
Multidisciplinary Sciences
Ioannis Panagopoulos, Synne Torkildsen, Ludmila Gorunova, Anne Tierens, Geir E. Tjonnfjord, Sverre Heim
Review
Oncology
Francesca Micci, Sverre Heim, Ioannis Panagopoulos
Summary: Endometrial stromal sarcomas (ESS) are a rare and heterogeneous group of mesenchymal cancers, now classified as low- or high-grade. They may have overlapping clinical presentation, morphology, and immunohistochemical profile. Understanding the molecular characteristics of ESS can improve diagnosis, prognostication, and treatment.
GENES CHROMOSOMES & CANCER
(2021)
Article
Oncology
Ioannis Panagopoulos, Marta Brunetti, Margrethe Stoltenberg, Ronnaug A. U. Strandabo, Julie Staurseth, Kristin Andersen, Ilya Kostolomov, Tarjei S. Hveem, Susanne Lorenz, Tove Anita Nystad, Trond Flaegstad, Francesca Micci, Sverre Heim
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2019)
Article
Oncology
Ioannis Panagopoulos, Ludmila Gorunova, Hege Kilen Andersen, Astrid Bergrem, Anders Dahm, Kristin Andersen, Francesca Micci, Sverre Heim
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2018)
Article
Pathology
Ioannis Panagopoulos, Ludmila Gorunova, Bodil Bjerkehagen, Kristin Andersen, Marius Lund-Iversen, Sverre Heim
DIAGNOSTIC PATHOLOGY
(2017)