Article
Oncology
Hyun J. Jang, Christine Caron, Calvin K. Lee, Lu Wang, Burhan Jama, Jack D. Bui, Gerald P. Morris
Summary: The discovery that 16% of T cells naturally co-express two T-cell receptor (TCR) clonotypes prompts the examination of the role of dual TCR cells in immune functions. Using TCR alpha-reporter transgenic mice, the study tested the role of dual TCR cells in antitumor immune responses and found that they had a selective advantage in tumor responses. Dual TCR cells demonstrated an advantage in recognition of B16F10-derived neoantigens, suggesting their potential in antitumor immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Shota Aoyama, Ryosuke Nakagawa, Satoshi Nemoto, Patricio Perez-Villarroel, James J. Mule, Adam William Mailloux
Summary: The study revealed a significant shift in TIL populations and effector function between early and late stages of MC38 tumor growth. Antibody therapy accelerated a transition from an NKT-driven immune response to a CD4(+)/CD8(+)T cell-driven immune response in MC38 tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata S. Patil, Patricia de Almeida, Edward E. Kadel, Shravan Madireddi, Amelia Au-Yeung, Chikara Takahashi, Ying-Jiun Chen, Zora Modrusan, Jacqueline McBride, Rhea Nersesian, Ehab A. El-Gabry, Mark D. Robida, Jeffrey C. Hung, Marcin Kowanetz, Wei Zou, Mark McCleland, Patrick Caplazi, Shadi Toghi Eshgi, Hartmut Koeppen, Priti S. Hegde, Ira Mellman, W. Rodney Mathews, Thomas Powles, Sanjeev Mariathasan, Jane Grogan, William E. O'Gorman
Summary: CD8+ tissue-resident memory T (T-RM) cells expressing CD103 (ITGAE) are believed to actively suppress cancer progression, and their presence in tumors may predict response to immunotherapy. This study found that in inflamed tumors, CD103+ CD8+ T-RM cells exhibit a complex phenotype characterized by increased clonal expansion, expression of checkpoint regulators, and cytotoxic proteins, suggesting their involvement in antitumor response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, General & Internal
Leah Zuroff, Ayman Rezk, Koji Shinoda, Diego A. Espinoza, Yehezqel Elyahu, Bo Zhang, Andrew A. Chen, Russell T. Shinohara, Dina Jacobs, Roy N. Alcalay, Thomas F. Tropea, Alice Chen-Plotkin, Alon Monsonego, Rui Li, Amit Bar-Or
Summary: In the study comparing untreated MS patients with normal controls, it was found that MS patients exhibited early and persistent redistribution of naive and memory CD4 T-cell compartments. While most CD4 and CD8 T-cell aging trajectories were similar between groups, MS patients demonstrated abnormal age-associated increases, particularly in patients over 60.
Article
Cell Biology
Dornatien Chuo Anang, Tamara H. Ramwadhdoebe, Janine S. Hahnlein, Bo van Kuijk, Noortje Smits, Krijn P. van Lienden, Mario Maas, Danielle M. Gerlag, Paul P. Tak, Niek de Vries, Lisa G. M. van Baarsen
Summary: In early RA patients and individuals at risk for RA, there is an increase in Tfh cells in lymphoid tissues with decreased IL-21 production.
Article
Multidisciplinary Sciences
Dominik Funken, Yi Yu, Xiaoyan Feng, Tawan Imvised, Faikah Gueler, Immo Prinz, Omid Madadi-Sanjani, Benno M. Ure, Jochen F. Kuebler, Christian Klemann
Summary: Research has shown that gamma delta-T cells play a significant role in intestinal ischemia-reperfusion injury, and their deficiency can alleviate pro-inflammatory cytokine production, neutrophil infiltration, and distant organ injury.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Laura Fernandez-Prades, Mariano Brasal-Prieto, Gonzalo Alba, Victoria Martin, Sergio Montserrat-de la Paz, Marta Cejudo-Guillen, Consuelo Santa-Maria, Hala Dakhaoui, Beatriz Granados, Francisco Sobrino, Francisca Palomares, Soledad Lopez-Enriquez
Summary: This study found that sulforaphane (SFN) has immunomodulatory effects on monocyte-derived dendritic cells (moDCs), reducing autophagy and enhancing apoptosis. SFN also decreased the expression of markers and cytokine levels, leading to a regulatory profile shift in moDCs/T cells. These findings suggest that SFN may have potential as a treatment for inflammatory pathologies.
Article
Oncology
Yi-Na Wang, Yuan-Yuan Wang, Jin Wang, Wen-Juan Bai, Nai-Jun Miao, Jing Wang
Summary: This study investigates the effect of cellular morphology on macrophage polarization and antitumor response. It is found that the microtubule destabilizer VBL can drive macrophage polarization into the M1 phenotype. Mechanistically, VBL activates NF-κB and Cyba-dependent reactive oxygen species generation, inducing TAM polarization to the M1 phenotype. Additionally, VBL promotes transcription factor EB nuclear translocation, inducing lysosome biogenesis and enhancing phagocytic activity in macrophages.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Oncology
Stefanie Herda, Andreas Heimann, Benedikt Obermayer, Elisa Ciraolo, Stefanie Althoff, Josefine Russ, Corinna Grunert, Antonia Busse, Lars Bullinger, Antonio Pezzutto, Thomas Blankenstein, Dieter Beule, Il-Kang Na
Summary: Extended in vitro expansion of T cells can enhance T cell yield and functionality, providing a practicable alternative for patients with insufficient T cells after standard manufacturing process. This approach has shown positive results in both murine and human T cells, increasing accessibility to adoptive T cell therapy for patients in need.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Aubrey S. Smith, Hannah M. Knochelmann, Megan M. Wyatt, Guillermo O. Rangel Rivera, Amalia M. Rivera-Reyes, Connor J. Dwyer, Michael B. Ware, Anna C. Cole, David M. Neskey, Mark P. Rubinstein, Bei Liu, Jessica E. Thaxton, Eric Bartee, Chrystal M. Paulos
Summary: TLR agonists can be repurposed ex vivo to condition T cells, improving immunotherapy and revealing the vital role of B cells in the generation of potent CD8(+) T cell-based therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Naama Margolis, Hanna Moalem, Tomer Meirson, Gilli Galore-Haskel, Ettai Markovits, Erez N. Baruch, Bella Vizel, Avner Yeffet, Julia Kanterman-Rifman, Assaf Debby, Michal J. Besser, Jacob Schachter, Gal Markel
Summary: The interaction between melanoma cells and T cells can enhance the chemotaxis of new T cells. ADAR1-p150 expression is correlated with immune infiltration and can be induced by immunotherapy. ADAR1 regulates T cell migration through the secretion of chemokines.
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Immunology
Marzia Caproni, Manuela Capone, Maria Caterina Rossi, Veronica Santarlasci, Laura Maggi, Alessio Mazzoni, Beatrice Rossettini, Daniela Renzi, Lavinia Quintarelli, Beatrice Bianchi, Alessandra Ninci, Gabriele Lami, Antonio Calabro, Lorenzo Cosmi, Francesco Annunziato, Francesco Liotta
Summary: The study suggests a role of TNF alpha and IL-17A producing cells in the development of dermatitis herpetiformis, with circulating T cells producing TNF alpha and IL-17A decreasing after a gluten-free diet. Furthermore, TG2 and TG3-specific T cells in dermatitis herpetiformis patients showed heightened reactivity to antigen stimulation. The data also showed a crossed T cell response towards the two transglutaminases isoforms in both groups of patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Khalid W. Kalim, Jun-Qi Yang, Mark Wunderlich, Vishnu Modur, Phuong Nguyen, Yuan Li, Ting Wen, Ashley Kuenzi Davis, Ravinder Verma, Qing Richard Lu, Anil G. Jegga, Yi Zheng, Fukun Guo
Summary: Targeting Cdc42 in Treg cells has shown promising therapeutic potential in cancer immunotherapy, by enhancing antitumor T-cell immunity without triggering autoimmune reactions. This approach involves inducing Treg cell instability through Cdc42 targeting, leading to improved immune responses against tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Faizah Alotaibi, Mark Vincent, Wei-Ping Min, James Koropatnick
Summary: CD5, a marker for T cells and a subset of B cells, is negatively correlated with anti-tumor activity in lung cancer patients, potentially impairing activation of anti-tumor T cells. T cells with high CD5 levels in tumors and lymphoid organs exhibit higher levels of activation and effector function, indicating that CD5 may be a therapeutic target for immunotherapeutic activation in cancer therapy.
FRONTIERS IN IMMUNOLOGY
(2021)