Article
Cell Biology
Eloise de Tredern, Yasmine Rabah, Laure Pasquer, Julia Minatchy, Pierre-Yves Placais, Thomas Preat
Summary: The research finds a mechanism of glucose transport from cortex glia to neurons in Drosophila, which plays a role in the formation of olfactory long-term memory. Real-time imaging experiments show that insulin signaling increases glucose concentration in glia, promoting the transport of glucose to neuronal somata in the olfactory memory center.
Article
Plant Sciences
Yushuai Wang, Aimei Dai, Yiping Chen, Tian Tang
Summary: The contribution of induced epigenetic changes to long-term adaptation is debated, but recent studies suggest that environmentally cued changes in gene body methylation can aid acclimatization. Mangroves have gained more gene body methylation through convergent evolution compared to their terrestrial relatives. These changes help maintain gene expression stability under salt stress, contributing to long-term adaptation.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Neurosciences
Julia M. Gouws, Aidan Sherrington, Shaojie Zheng, Joon S. Kim, Karl J. Iremonger
Summary: This study investigated the mechanism by which noradrenaline regulates activity within the corticotropin-releasing hormone neuronal network. Using in vitro imaging and electrophysiology, the researchers found that noradrenaline induces excitability increase in a proportion of neurons, leading to bursting activity. This activation requires specific receptors and channels, and can be suppressed by elevated corticosterone levels.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Multidisciplinary Sciences
Avik Mukherjee, Jade Ealy, Yanqing Huang, Nina Catherine Benites, Mark Polk, Markus Basan
Summary: Utilizing a combination of experiments and computer simulations, researchers have found that the emergence and persistence of coexistence of multiple ecotypes in Escherichia coli long-term evolution experiment can be explained by two interacting trade-offs rooted in biochemical constraints. Faster growth enabled by higher fermentation and obligate acetate excretion results in longer lag times when utilizing acetate after glucose is depleted, creating an ecological niche for a slower-growing ecotype specialized in switching to acetate. These findings highlight the importance of trade-offs in the evolution of complex microbial communities.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Maria Markaki, Dikaia Tsagkari, Nektarios Tavernarakis
Summary: Neurons are highly polarized cells with unique morphology and complexity. They rely heavily on a healthy mitochondrial network for proper function and maintenance. Mitophagy, a selective form of autophagy that targets dysfunctional or unnecessary mitochondria for degradation, plays a crucial role in maintaining neuronal energy homeostasis. Dysregulated mitophagy has been implicated in the development of neurodegenerative diseases.
JOURNAL OF CELL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Sotaro Takano, Hiromi Takahashi, Yoshie Yama, Ryo Miyazaki, Chikara Furusawa, Saburo Tsuru
Summary: Non-growing is a dominant life form of microorganisms in nature, where available nutrients and resources are limited. In laboratory culture systems, Escherichia coli can survive for years under starvation, denoted as long-term stationary phase, where a small fraction of cells manages to survive by recycling resources released from nonviable cells. This study analyzed the transcriptional profiles of cells in the long-term stationary phase and found that they exhibit higher expressions of stress-response genes and lower expressions of growth-related genes compared to cells in the short-term stationary phase.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Matthias Fritsche, Samuel G. Solomon, Floris P. de Lange
Summary: Visual processing is influenced by recent stimulus history, and the visual system optimizes encoding by exploiting the temporal statistics of the world. Neurons in the early visual cortex maintain long-term memory traces of individual stimuli, leading to long-term and stimulus-specific adaptation.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Martin J. Dahl, Agnieszka Kulesza, Markus Werkle-Bergner, Mara Mather
Summary: Memory is crucial for defining our identity and guiding behavior based on past experiences. However, as we age, memory declines and disrupts the lives of older adults. Recent research suggests that degeneration of the locus coeruleus, a brain region responsible for dopamine and noradrenaline production, results in deficient modulation of hippocampal plasticity, leading to memory decline.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Zoology
Kangkang Zhang, Tong Liu, Shengjing Song, Xin Zhao, Shijun Sun, Walter Metzner, Jiang Feng, Ying Liu
Summary: This study introduces a bi-directional long short-term memory network to separate overlapping echolocation-communication calls of different bat species and reconstruct waveforms. The results show the reliability and effectiveness of separating and reconstructing calls through parameter comparisons and clustering analysis.
INTEGRATIVE ZOOLOGY
(2022)
Article
Multidisciplinary Sciences
Mara C. P. Rue, Leandro M. Alonso, Eve Marder
Summary: The study investigated the effects of altered extracellular potassium concentration on the output of the pyloric circuit in the crab, revealing changes in neuronal activity and circuit robustness in response to high potassium saline and subsequent challenges.
Article
Economics
Matthew E. Kahn, Kamiar Mohaddes, Ryan N. C. Ng, M. Hashem Pesaran, Mehdi Raissi, Jui-Chung Yang
Summary: The study shows that persistent changes in temperature can negatively impact economic activity, while changes in precipitation do not have a statistically significant effect. Losses from climate change vary significantly across countries.
Article
Biodiversity Conservation
Jason Riggio, Andrew Engilis Jr, Hanika Cook, Evelien De Greef, Daniel S. Karp, Melanie L. Truan
Summary: This study examined the impacts of habitat use and weather on the reproduction of cavity-nesting songbirds in California's Central Valley. The results showed that the selection of nest sites was influenced by habitat variables, and reproductive success and nestling weight were highest in selected habitats. Higher maximum nesting season temperatures had negative effects on clutch size, reproductive success, and nestling weight for all species. The effects of precipitation varied by species and timing. Overall, this study highlights the importance of long-term monitoring to understand the impacts of global change on fitness.
BIOLOGICAL CONSERVATION
(2023)
Article
Environmental Sciences
Shira Bukchin-Peles, Ram Fishman
Summary: Smallholder agriculture, which employs the majority of the global poor and produces substantial shares of food in developing countries, is highly vulnerable to environmental change. Despite potential reversal in Asia and slowdown in Africa of past trends of decreasing farm size, smallholders are projected to continue occupying substantial shares of rural populations and cultivated land, bearing a sizable portion of climate change impacts. However, increased economic possibilities in rural areas can rapidly attenuate these assessments.
ENVIRONMENTAL RESEARCH LETTERS
(2021)
Article
Environmental Sciences
Jung Hee Hyun, Ji Yeon Kim, Chae Yeon Park, Dong Kun Lee
Summary: Decision-makers need to translate future climate change impacts into policy goals effectively. A decision-support model simulating adaptation pathways was used to find optimal strategies for reducing heat-related mortality in Seoul. Results suggest that efficient pairing of budget levels with adaptation goals is crucial, and delays in investment may lead to irreversible reduction in adaptation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Ming Wang, Gwangho Yoon, Juhyun Song, Jihoon Jo
Summary: Studies have shown that GLP-1 and its receptor agonists have neuroprotective effects in improving cognitive function and brain insulin resistance in metabolic-imbalanced mice, particularly demonstrating positive results in synaptic plasticity and long-term potentiation.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Peter V. Lovell, Nicole A. Huizinga, Samantha R. Friedrich, Morgan Wirthlin, Claudio V. Mello
Letter
Biochemistry & Molecular Biology
Christopher R. Olson, Marcela Fernandez-Peters, Christine V. Portfors, Claudio V. Mello
Review
Endocrinology & Metabolism
C. V. Mello, P. V. Lovell
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2018)
Article
Neurosciences
Claudio V. Mello, Taylor Kaser, Alexa A. Buckner, Morgan Wirthlin, Peter V. Lovell
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Multidisciplinary Sciences
Zachary W. Bell, Peter Lovell, Claudio V. Mello, Ping K. Yip, Julia M. George, David F. Clayton
SCIENTIFIC REPORTS
(2019)
Article
Evolutionary Biology
Jamily Lorena, Christopher R. Olson, Carla S. Fontana, Claudio V. Mello, Maria Paula C. Schneider, Patricia N. Schneider
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
(2019)
Article
Behavioral Sciences
Constantine Pavlides, Tomohiro Donishi, Sidarta Ribeiro, Claudio V. Mello, Wilfredo Blanco, Sonoko Ogawa
NEUROBIOLOGY OF LEARNING AND MEMORY
(2019)
Article
Biotechnology & Applied Microbiology
Samantha R. Friedrich, Peter V. Lovell, Taylor M. Kaser, Claudio V. Mello
Article
Neurosciences
Peter Lovell, Morgan Wirthlin, Taylor Kaser, Alexa A. Buckner, Julia B. Carleton, Brian R. Snider, Anne K. McHugh, Alexander Tolpygo, Partha P. Mitra, Claudio Mello
JOURNAL OF COMPARATIVE NEUROLOGY
(2020)
Correction
Multidisciplinary Sciences
Shaohong Feng, Josefin Stiller, Yuan Deng, Joel Armstrong, Qi Fang, Andrew Hart Reeve, Duo Xie, Guangji Chen, Chunxue Guo, Brant C. Faircloth, Bent Petersen, Zongji Wang, Qi Zhou, Mark Diekhans, Wanjun Chen, Sergio Andreu-Sanchez, Ashot Margaryan, Jason Travis Howard, Carole Parent, George Pacheco, Mikkel-Holger S. Sinding, Lara Puetz, Emily Cavill, Angela M. Ribeiro, Leopold Eckhart, Jon Fjeldsa, Peter A. Hosner, Robb T. Brumfield, Les Christidis, Mads F. Bertelsen, Thomas Sicheritz-Ponten, Dieter Thomas Tietze, Bruce C. Robertson, Gang Song, Gerald Borgia, Santiago Claramunt, Irby J. Lovette, Saul J. Cowen, Peter Njoroge, John Philip Dumbacher, Oliver A. Ryder, Jerome Fuchs, Michael Bunce, David W. Burt, Joel Cracraft, Guanliang Meng, Shannon J. Hackett, Peter G. Ryan, Knud Andreas Jonsson, Ian G. Jamieson, Rute R. da Fonseca, Edward L. Braun, Peter Houde, Siavash Mirarab, Alexander Suh, Bengt Hansson, Suvi Ponnikas, Hanna Sigeman, Martin Stervander, Paul B. Frandsen, Henriette van der Zwan, Rencia van der Sluis, Carina Visser, Christopher N. Balakrishnan, Andrew G. Clark, John W. Fitzpatrick, Reed Bowman, Nancy Chen, Alison Cloutier, Timothy B. Sackton, Scott V. Edwards, Dustin J. Foote, Subir B. Shakya, Frederick H. Sheldon, Alain Vignal, Andre E. R. Soares, Beth Shapiro, Jacob Gonzalez-Solis, Joan Ferrer-Obiol, Julio Rozas, Marta Riutort, Anna Tigano, Vicki Friesen, Love Dalen, Araxi O. Urrutia, Tamas Szekely, Yang Liu, Michael G. Campana, Andre Corvelo, Robert C. Fleischer, Kim M. Rutherford, Neil J. Gemmell, Nicolas Dussex, Henrik Mouritsen, Nadine Thiele, Kira Delmore, Miriam Liedvogel, Andre Franke, Marc P. Hoeppner, Oliver Krone, Adam M. Fudickar, Borja Mila, Ellen D. Ketterson, Andrew Eric Fidler, Guillermo Friis, Angela M. Parody-Merino, Phil F. Battley, Murray P. Cox, Nicholas Costa Barroso Lima, Francisco Prosdocimi, Thomas Lee Parchman, Barney A. Schlinger, Bette A. Loiselle, John G. Blake, Haw Chuan Lim, Lainy B. Day, Matthew J. Fuxjager, Maude W. Baldwin, Michael J. Braun, Morgan Wirthlin, Rebecca B. Dikow, T. Brandt Ryder, Glauco Camenisch, Lukas F. Keller, Jeffrey M. DaCosta, Mark E. Hauber, Matthew I. M. Louder, Christopher C. Witt, Jimmy A. McGuire, Joann Mudge, Libby C. Megna, Matthew D. Carling, Biao Wang, Scott A. Taylor, Glaucia Del-Rio, Alexandre Aleixo, Ana Tereza Ribeiro Vasconcelos, Claudio V. Mello, Jason T. Weir, David Haussler, Qiye Li, Huanming Yang, Jian Wang, Fumin Lei, Carsten Rahbek, M. Thomas P. Gilbert, Gary R. Graves, Erich D. Jarvis, Benedict Paten, Guojie Zhang
Article
Multidisciplinary Sciences
Arang Rhie, Shane A. McCarthy, Olivier Fedrigo, Joana Damas, Giulio Formenti, Sergey Koren, Marcela Uliano-Silva, William Chow, Arkarachai Fungtammasan, Juwan Kim, Chul Lee, Byung June Ko, Mark Chaisson, Gregory L. Gedman, Lindsey J. Cantin, Francoise Thibaud-Nissen, Leanne Haggerty, Iliana Bista, Michelle Smith, Bettina Haase, Jacquelyn Mountcastle, Sylke Winkler, Sadye Paez, Jason Howard, Sonja C. Vernes, Tanya M. Lama, Frank Grutzner, Wesley C. Warren, Christopher N. Balakrishnan, Dave Burt, Julia M. George, Matthew T. Biegler, David Iorns, Andrew Digby, Daryl Eason, Bruce Robertson, Taylor Edwards, Mark Wilkinson, George Turner, Axel Meyer, Andreas F. Kautt, Paolo Franchini, H. William Detrich, Hannes Svardal, Maximilian Wagner, Gavin J. P. Naylor, Martin Pippel, Milan Malinsky, Mark Mooney, Maria Simbirsky, Brett T. Hannigan, Trevor Pesout, Marlys Houck, Ann Misuraca, Sarah B. Kingan, Richard Hall, Zev Kronenberg, Ivan Sovi, Christopher Dunn, Zemin Ning, Alex Hastie, Joyce Lee, Siddarth Selvaraj, Richard E. Green, Nicholas H. Putnam, Ivo Gut, Jay Ghurye, Erik Garrison, Ying Sims, Joanna Collins, Sarah Pelan, James Torrance, Alan Tracey, Jonathan Wood, Robel E. Dagnew, Dengfeng Guan, Sarah E. London, David F. Clayton, Claudio Mello, Samantha R. Friedrich, Peter Lovell, Ekaterina Osipova, Farooq O. Al-Ajli, Simona Secomandi, Heebal Kim, Constantina Theofanopoulou, Michael Hiller, Yang Zhou, Robert S. Harris, Kateryna D. Makova, Paul Medvedev, Jinna Hoffman, Patrick Masterson, Karen Clark, Fergal Martin, Kevin Howe, Paul Flicek, Brian P. Walenz, Woori Kwak, Hiram Clawson, Mark Diekhans, Luis Nassar, Benedict Paten, Robert H. S. Kraus, Andrew J. Crawford, M. Thomas P. Gilbert, Guojie Zhang, Byrappa Venkatesh, Robert W. Murphy, Klaus-Peter Koepfli, Beth Shapiro, Warren E. Johnson, Federica Di Palma, Tomas Marques-Bonet, Emma C. Teeling, Tandy Warnow, Jennifer Marshall Graves, Oliver A. Ryder, David Haussler, Stephen J. O'Brien, Jonas Korlach, Harris A. Lewin, Kerstin Howe, Eugene W. Myers, Richard Durbin, Adam M. Phillippy, Erich D. Jarvis
Summary: The Vertebrate Genome Project and the international Genome 10K consortium have collaborated to generate high-quality genome assemblies for 16 species representing six major vertebrate lineages, leading to new biological discoveries. Long-read sequencing technologies are essential for maximizing genome quality, and addressing complex repeats and haplotype heterozygosity are crucial for reducing assembly errors and improving completeness of reference genomes. The lessons learned from this project have paved the way for the Vertebrate Genomes Project (VGP), an international effort to generate high-quality, complete reference genomes for all known vertebrate species.
Article
Multidisciplinary Sciences
Tarciso A. F. Velho, Peter Lovell, Samantha R. Friedrich, Christopher R. Olson, Joshua Miles, Paul A. Mueller, Hagai Tavori, Sergio Fazio, Carlos Lois, Claudio Mello
Summary: The study reveals significant divergence in the LDLR of songbirds, with key domains missing, resulting in lower infectivity by lentiviruses pseudotyped with VSV G in zebra finches, which can be rescued by human LDLR expression. Additionally, finches exhibit an atypical plasma lipid distribution depending largely on HDL, providing insights into genetic and evolutionary aspects of viral infectivity and cholesterol transport mechanisms in vertebrates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Baruch Haimson, Oren Meir, Reut Sudakevitz-Merzbach, Gerard Elberg, Samantha Friedrich, Peter Lovell, Sonia Paixao, Ruediger Klein, Claudio Mello, Avihu Klar
Summary: Flight in birds evolved through wing patterning from forelimbs and transition from alternating gait to synchronous flapping. In mammals, the ephrin-B3 protein guides wiring for limb alternation, with its deletion leading to synchronous hopping gait. The avian ephrin-B3 protein lacks certain motifs found in vertebrates, reducing its affinity for the EphA4 receptor and influencing the development of the brachial spinal cord circuitry.
Article
Multidisciplinary Sciences
Benjamin M. Zemel, Alexander A. Nevue, Andre Dagostin, Peter Lovell, Claudio Mello, Henrique von Gersdorff
Summary: The study found that resurgent Na+ currents emerge in RA neurons in male zebra finches during early stages of song development, promoting high-frequency firing. Nav beta 4 and its associated I-NaR were shown to enhance neuronal excitability, which is crucial for the execution of fine motor skills.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Shaohong Feng, Josefin Stiller, Yuan Deng, Joel Armstrong, Qi Fang, Andrew Hart Reeve, Duo Xie, Guangji Chen, Chunxue Guo, Brant C. Faircloth, Bent Petersen, Zongji Wang, Qi Zhou, Mark Diekhans, Wanjun Chen, Sergio Andreu-Sanchez, Ashot Margaryan, Jason Travis Howard, Carole Parent, George Pacheco, Mikkel-Holger S. Sinding, Lara Puetz, Emily Cavill, Angela M. Ribeiro, Leopold Eckhart, Jon Fjeldsa, Peter A. Hosner, Robb T. Brumfield, Les Christidis, Mads F. Bertelsen, Thomas Sicheritz-Ponten, Dieter Thomas Tietze, Bruce C. Robertson, Gang Song, Gerald Borgia, Santiago Claramunt, Irby J. Lovette, Saul J. Cowen, Peter Njoroge, John Philip Dumbacher, Oliver A. Ryder, Jerome Fuchs, Michael Bunce, David W. Burt, Joel Cracraft, Guanliang Meng, Shannon J. Hackett, Peter G. Ryan, Knud Andreas Jonsson, Ian G. Jamieson, Rute R. da Fonseca, Edward L. Braun, Peter Houde, Siavash Mirarab, Alexander Suh, Bengt Hansson, Suvi Ponnikas, Hanna Sigeman, Martin Stervander, Paul B. Frandsen, Henriette van der Zwan, Rencia van der Sluis, Carina Visser, Christopher N. Balakrishnan, Andrew G. Clark, John W. Fitzpatrick, Reed Bowman, Nancy Chen, Alison Cloutier, Timothy B. Sackton, Scott V. Edwards, Dustin J. Foote, Subir B. Shakya, Frederick H. Sheldon, Alain Vignal, Andre E. R. Soares, Beth Shapiro, Jacob Gonzalez-Solis, Joan Ferrer-Obiol, Julio Rozas, Marta Riutort, Anna Tigano, Vicki Friesen, Love Dalen, Araxi O. Urrutia, Tamas Szekely, Yang Liu, Michael G. Campana, Andre Corvelo, Robert C. Fleischer, Kim M. Rutherford, Neil J. Gemmell, Nicolas Dussex, Henrik Mouritsen, Nadine Thiele, Kira Delmore, Miriam Liedvogel, Andre Franke, Marc P. Hoeppner, Oliver Krone, Adam M. Fudickar, Borja Mila, Ellen D. Ketterson, Andrew Eric Fidler, Guillermo Friis, Angela M. Parody-Merino, Phil F. Battley, Murray P. Cox, Nicholas Costa Barroso Lima, Francisco Prosdocimi, Thomas Lee Parchman, Barney A. Schlinger, Bette A. Loiselle, John G. Blake, Haw Chuan Lim, Lainy B. Day, Matthew J. Fuxjager, Maude W. Baldwin, Michael J. Braun, Morgan Wirthlin, Rebecca B. Dikow, T. Brandt Ryder, Glauco Camenisch, Lukas F. Keller, Jeffrey M. DaCosta, Mark E. Hauber, Matthew I. M. Louder, Christopher C. Witt, Jimmy A. McGuire, Joann Mudge, Libby C. Megna, Matthew D. Carling, Biao Wang, Scott A. Taylor, Glaucia Del-Rio, Alexandre Aleixo, Ana Tereza Ribeiro Vasconcelos, Claudio V. Mello, Jason T. Weir, David Haussler, Qiye Li, Huanming Yang, Jian Wang, Fumin Lei, Carsten Rahbek, M. Thomas P. Gilbert, Gary R. Graves, Erich D. Jarvis, Benedict Paten, Guojie Zhang