Article
Immunology
Ying Qian, Yue Pei, Wei Jiang, Caihong Zheng
Summary: This study found that astilbin has a therapeutic effect on rats with RSA by regulating the balance of Th1/Th2 in maternal circulation and likely in decidual tissue.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Food Science & Technology
Li Ren, Shu Niu, Yantong Sun, Yuan Liang, Jingqi Zhao, Tiehua Zhang, Jie Zhang
Summary: Betulin binds to glucocorticoid receptor and exerts anti-inflammatory action by modulating the receptor, potentially offering a reduced side effect profile while maintaining its efficacy in inflammation control.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Medicine, General & Internal
G. U. A. N. G. Y. I. XIONG, J. I. N. XU, H. A. I. B. O. YIN, L. I. N. A. XU, R. U. I. L. I. N. WANG
Summary: This study analyzed the role of the transcriptional regulatory factor T-bet and GATA connexin 3 in the inflammatory response and related mechanisms of rheumatoid arthritis. The results showed that interference with T-bet expression can reduce inflammatory damage to rheumatoid arthritis cells and may be related to the regulation of the Th1/Th2 ratio by T-bet.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Biochemistry & Molecular Biology
Liping Qin, Yu Song, Fan Zhang, Ru Wang, Li Zhou, Shiqi Jin, Chaojia Chen, Chunyang Li, Molin Wang, Baichun Jiang, Gongping Sun, Chunhong Ma, Yaoqin Gong, Peishan Li
Summary: CUL4B plays a critical role in Th cell differentiation through regulating histone modifications.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Wenyue Zhang, Xinyue Sun, Xu Shi, Xue Qi, Shaoqian Shang, Hongjin Lin
Summary: This study reveals that subacute Cd exposure is closely associated with necroptosis in swine lung. The mechanisms may involve Th1/Th2 imbalance, down-regulation of miR-181-5p, increased TNF-alpha expression, and activation of the NF-kappa B/NLRP3 and JAK/STAT pathways and RIPK1/RIPK3/MLKL axis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Lu Peng, Jing Liu, Erqun Song, Yang Song
Summary: This study evaluated the immunotoxic effects of PCB29-pQ, an active quinone-type metabolite of PCBs. The results showed that exposure to PCB29-pQ led to reduced body weight and increased organ index of the spleen and lungs in mice, along with changes in their morphology and structure. Additionally, there was a significant decrease in certain types of lymphocyte subsets in the spleen, indicating immune dysfunction. Furthermore, PCB29-pQ induced apoptosis and an imbalance of Th1/Th2 cytokines. These findings provide new insights into the immunotoxicity mechanism of PCBs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Mingcui Ding, Chengpeng Zhang, Wei Wang, Pengpeng Wang, Yangqing Pei, Na Wang, Shan Huang, Changfu Hao, Wu Yao
Summary: Exosomal miR-125a-5p promotes the development of silicosis by targeting TRAF6 to regulate T cell differentiation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Xiaoxu Duan, Guowei Xu, Jinlong Li, Nan Yan, Xin Li, Xuping Liu, Bing Li
Summary: This study found that arsenic induces continuous immune-inflammatory responses in the liver and kidney, leading to structural damage and inflammatory infiltration. It also enhances the expression of inflammatory factors and affects the differentiation of T cells and immune balance.
MEDIATORS OF INFLAMMATION
(2022)
Article
Food Science & Technology
Zhihua Ren, Pei Gao, Samuel Kumi Okyere, Yujing Cui, Juan Wen, Bo Jing, Junliang Deng, Yanchun Hu
Summary: This study investigated the impact of Ageratina adenophora on splenic immune function in rats. It found that A. adenophora led to a decrease in CD3(+) T cells, chemokine expression, and an imbalance in Th1/Th2 cell ratios in the spleen, indicating potential immunotoxicity. These findings suggest that A. adenophora alters the FRC network and affects immune function in the spleen.
Article
Endocrinology & Metabolism
Rosario Pivonello, Irina Bancos, Richard A. A. Feelders, Atil Y. Y. Kargi, Janice M. M. Kerr, Murray B. B. Gordon, Cary N. N. Mariash, Massimo Terzolo, Noel Ellison, Andreas G. G. Moraitis
Summary: The study evaluated the efficacy and safety of the SGRM relacorilant in patients with endogenous Cushing syndrome, showing clinical benefit for hypertension and/or hyperglycemia. In the low-dose group, about 41.7% of hypertensive patients and 15.4% of hyperglycemic patients achieved clinical response, while in the high-dose group, approximately 63.6% of hypertensive patients and 50% of hyperglycemic patients achieved response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yiyun Lou, Zhujing Fu, Ye Tian, Minhao Hu, Qijing Wang, Yuanyuan Zhou, Ning Wang, Qin Zhang, Fan Jin
Summary: The study found that the decrease in progesterone and estradiol (E-2) levels during threatened miscarriages was associated with reduced expression of SGK1 in decidual macrophages. The activation of E-2-sensitive SGK1 was found to promote macrophage polarization and immune regulation at the maternal-fetal interface. These findings provide new insights into potential preventative strategies for recurrent pregnancy loss.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Cell Biology
Yu-Chuen Huang, Chun-Ping Huang, Chin-Ping Lin, Kai-Chien Yang, Yu-Jie Lei, Hao-Pei Wang, Yueh-Hsiung Kuo, Yu-Jen Chen
Summary: Daphnoretin extracted from the stem and roots of Wikstroemia indica has been found to inhibit cell growth and induce megakaryocytic differentiation in chronic myeloid leukemia cells. It shows potential as a differentiation therapy agent for CML, but further investigations are needed to validate its efficacy in vivo and in patients.
Article
Biochemistry & Molecular Biology
Jian Wei Xu, Ye Yan, Lei Wang, Dong Wu, Nai Kuan Ye, Shi Hong Chen, Feng Li
Summary: Dieckol, a polyphenolic bioactive compound extracted from brown algae, has been proven to induce apoptosis and inhibit cell progression of human pancreatic cancer cells in vitro, showing its potential as a marine-based phytochemical for pancreatic cancer treatment.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Oncology
Lingling Pang, Pengfei Yu, Xueping Liu, Yingqi Fan, Ying Shi, Shenchun Zou
Summary: The study demonstrated that co-exposure to PM2.5 and OVA significantly exacerbated airway inflammation and Th1/Th2 cell imbalance, mainly through upregulating G1TA3 and downregulating Runx3.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Asif Raza, Amandeep Singh, Shantu Amin, Julian E. Spallholz, Arun K. Sharma
Summary: A series of seleno-biotin analogs were synthesized and compound 2 showed better anticancer activity and induced apoptosis in ovarian cancer cells. Its cytotoxicity was mediated by reactive oxygen species and biotin receptor.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Immunology
Carla Noemi Castro, Michelle Rosenzwajg, Raphael Carapito, Mohammad Shahrooei, Martina Konantz, Amjad Khan, Zhichao Miao, Miriam Gross, Thibaud Tranchant, Mirjana Radosavljevic, Nicodeme Paul, Tristan Stemmelen, Fabien Pitoiset, Aurelie Hirschler, Benoit Nespola, Anne Molitor, Veronique Rolli, Angelique Pichot, Laura Eva Faletti, Bruno Rinaldi, Sylvie Friant, Mark Mednikov, Hatice Karauzum, M. Javad Aman, Christine Carapito, Claudia Lengerke, Vahid Ziaee, Wafaa Eyaid, Stephan Ehl, Fayhan Alroqi, Nima Parvaneh, Seiamak Bahram
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Immunology
Luis Almeida, Ayesha Dhillon-LaBrooy, Carla N. Castro, Nigatu Adossa, Guilhermina M. Carriche, Melanie Guderian, Saskia Lippens, Sven Dennerlein, Christina Hesse, Bart N. Lambrecht, Luciana Berod, Leif Schauser, Bruce R. Blazar, Markus Kalesse, Rolf Mueller, Luis F. Moita, Tim Sparwasser
Summary: Linezolid and other ribosomal-targeting antibiotics effectively inhibit T cell activity, disrupt mitochondrial function, reduce oxidative phosphorylation levels, and prevent the occurrence of autoimmune diseases.
Article
Multidisciplinary Sciences
B. Maertens, A. Gagnaire, O. Paerewijck, K. De Bosscher, P. Geldhof
Summary: This study investigated how the intestinal microbiome affects the protective Th17 response against Giardia, finding that antibiotic treatment significantly impacted infection dynamics, reduced protective immune markers, and decreased intestinal motility, resulting in decreased parasite clearance.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Jolien Vandewalle, Steven Timmermans, Ville Paakinaho, Lies Vancraeynest, Liza Dewyse, Tineke Vanderhaeghen, Charlotte Wallaeys, Lise Van Wyngene, Kelly Van Looveren, Louise Nuyttens, Melanie Eggermont, Sylviane Dewaele, Tiago R. Velho, Luis F. Moita, Sebastian Weis, Christoph Sponholz, Leo A. van Grunsven, Mieke Dewerchin, Peter Carmeliet, Karolien De Bosscher, Johan Van de Voorde, Jorma J. Palvimo, Claude Libert
Summary: Defects in the glucocorticoid receptor signaling pathway exacerbate sepsis pathophysiology by reducing lactate clearance and sensitizing mice to lactate-induced toxicity, ultimately leading to lethal vascular collapse.
Editorial Material
Multidisciplinary Sciences
Dorien Clarisse, Karolien De Bosscher
Summary: Research suggests that synthetic glucocorticoids used in combination with chemotherapy for solid malignant tumors may lead to cancer resistance, and proposes a potential escape strategy.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Lise Van Wyngene, Tineke Vanderhaeghen, Ioanna Petta, Steven Timmermans, Katrien Corbeels, Bart Van der Schueren, Jolien Vandewalle, Kelly Van Looveren, Charlotte Wallaeys, Melanie Eggermont, Sylviane Dewaele, Leen Catrysse, Geert van Loo, Rudi Beyaert, Roman Vangoitsenhoven, Toshinori Nakayama, Jan Tavernier, Karolien De Bosscher, Claude Libert
Summary: The study demonstrates the essential role of ZBTB32 in glucocorticoid production during starvation response, as ZBTB32(-/-) mice fail to increase GC production. This deficiency in GC synthesis is linked to defective cholesterol import and metabolic adaptation abnormalities, leading to progressive weight gain in ZBTB32(-/-) mice. In conclusion, ZBTB32 interacts with GR to regulate adrenal GC production during metabolic adaptation to starvation.
Review
Pharmacology & Pharmacy
Dorien Clarisse, Lisa Deng, Karolien de Bosscher, Achim Lother
Summary: Mineralocorticoid receptor antagonists are effective therapies for cardiovascular and renal diseases, but their widespread clinical use is limited by the risk of hyperkalaemia. New strategies are needed to selectively target the harmful effects of the mineralocorticoid receptor while preserving its physiological function.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tineke Vanderhaeghen, Steven Timmermans, Deepika Watts, Ville Paakinaho, Melanie Eggermont, Jolien Vandewalle, Charlotte Wallaeys, Lise Van Wyngene, Kelly Van Looveren, Louise Nuyttens, Sylviane Dewaele, Joke Vanden Berghe, Kelly Lemeire, Joey De Backer, Laura Dirkx, Wim Vanden Berghe, Guy Caljon, Bart Ghesquiere, Karolien De Bosscher, Ben Wielockx, Jorma J. Palvimo, Rudi Beyaert, Claude Libert
Summary: The study found that hypoxia impacts the hepatic response of glucocorticoid receptors to dexamethasone in mice, leading to three types of reprogramming of GR: weaker induction of classical GR-responsive genes, induction of specific genes in hypoxia, and activation of a group of genes by the HPA axis under hypoxia. Additionally, hypoxia-induced activation of the HPA axis is associated with GR-dependent lipolysis and ketogenesis.
Article
Biochemistry & Molecular Biology
Steven Timmermans, Nicolette J. D. Verhoog, Kelly Van Looveren, Sylviane Dewaele, Tino Hochepied, Melanie Eggermont, Barbara Gilbert, Anne Boerema-de Munck, Tineke Vanderhaeghen, Joke Vanden Berghe, Natalia Garcia Gonzalez, Jolien Vandewalle, Yehudi Bloch, Mathias Provost, Savvas N. Savvides, Karolien De Bosscher, Wim Declercq, Robbert J. Rottier, Ann Louw, Claude Libert
Summary: The GR(dim/dim) mice with reduced dimerization propensity have helped define the functions of GR monomers and dimers, while the newly generated GR(D+L/D+L) mice exhibit insufficient ligand binding, leading to perinatal lethality.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Kato Bredael, Silke Geurs, Dorien Clarisse, Karolien De Bosscher, Matthias D'hooghe
Summary: Lead optimization involves the fine-tuning of lead compounds to improve their drug-like properties. This literature overview focuses on the use of bioisosteres to replace the carboxylic acid functionality, which is commonly associated with poor pharmacokinetic properties and toxicity. By replacing this functionality, the activity and pharmacokinetic properties of the lead compounds can be maintained or even enhanced.
JOURNAL OF CHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Laura Van Moortel, Jonathan Thommis, Brecht Maertens, An Staes, Dorien Clarisse, Delphine De Sutter, Claude Libert, Onno C. Meijer, Sven Eyckerman, Kris Gevaert, Karolien De Bosscher
Summary: In this study, the researchers characterized a set of diverse glucocorticoid receptor ligands and found that monitoring GR Ser211 phosphorylation levels can reliably predict compound effects on endogenous GR target genes.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Luz Andreone, Florencia Fuertes, Carolina Setula, Andres E. Barcala Tabarrozzi, Miranda S. Orellano, Ricardo A. Dewey, Rita Bottino, Karolien De Bosscher, Marcelo J. Perone
Summary: This study suggests that CpdA has therapeutic potential for T1D cellular and animal models. CpdA can improve ER stress, promote the survival and function of beta-cells in a proinflammatory cytokine environment, delay disease onset, and reduce diabetes incidence.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Silke Geurs, Dorien Clarisse, Freya Baele, Jorick Franceus, Tom Desmet, Karolien De Bosscher, Matthias D'hooghe
Summary: In this study, a set of HDAC6-selective inhibitors with low side effects and significant inhibitory activity in the nanomolar range were successfully synthesized using a lean inhibitor strategy.
CHEMICAL COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jacobus C. Buurstede, Susana N. Paul, Karolien De Bosscher, Onno C. Meijer, Jan Kroon
Summary: Glucocorticoids exert their effects by activating the glucocorticoid receptor (GR) throughout the body. This study investigated the interaction between glucocorticoids and androgen signaling in the liver transcriptome. The results showed that a substantial proportion of the hepatic transcriptome is androgen-dependent after chronic exposure, while the effects of glucocorticoids are largely androgen-independent after acute exposure. The study suggests that prolonged glucocorticoid exposure may upregulate androgen receptor expression, leading to androgen dependence not driven by direct interactions between the androgen receptor and glucocorticoid receptor.
Article
Immunology
Maria Elena Maccari, Sebastian Fuchs, Patrick Kury, Geoffroy Andrieux, Simon Volkl, Bertram Bengsch, Myriam Ricarda Lorenz, Maximilian Heeg, Jan Rohr, Sabine Jagle, Carla N. Castro, Miriam Gross, Ursula Warthorst, Christoph Koenig, Ilka Fuchs, Carsten Speckmann, Julian Thalhammer, Friedrich G. Kapp, Markus G. Seidel, Gregor Duckers, Stefan Schoenberger, Catharina Schuetz, Marita Fuhrer, Robin Kobbe, Dirk Holzinger, Christian Klemann, Petr Smisek, Stephen Owens, Gerd Horneff, Reinhard Kolb, Nora Naumann-Bartsch, Maurizio Miano, Julian Staniek, Marta Rizzi, Tomas Kalina, Pascal Schneider, Anika Erxleben, Rolf Backofen, Arif Ekici, Charlotte M. Niemeyer, Klaus Warnatz, Bodo Grimbacher, Hermann Eibel, Andreas Mackensen, Andreas Philipp Frei, Klaus Schwarz, Melanie Boerries, Stephan Ehl, Anne Rensing-Ehl
Summary: The identification and characterization of a population of FAS-controlled TCR alpha beta(+) T cells in autoimmune lymphoproliferative syndrome show numerous unique features, including a distinct molecular signature, high proliferation rates, noncytotoxicity, and IL-10 cytokine bias. Mechanistically, the regulation of this population involves FAS and CTLA4 signaling, as well as mTOR and STAT3 signals, and genetic alterations in these pathways can lead to significant lymphoproliferative disease.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)