Review
Plant Sciences
Thomas Efferth, Onat Kadioglu, Mohamed E. M. Saeed, Ean-Jeong Seo, Armelle T. Mbaveng, Victor Kuete
Summary: Research has shown that certain herbs and phytochemicals have better killing effects on multidrug-resistant cells, while another portion of compounds have similar effects on sensitive and multidrug-resistant cells, leading to cross-resistance. The phenomenon of collateral sensitivity, where some compounds exhibit higher efficacy against multidrug-resistant cells, provides potential for further drug development and rational phytotherapy.
PHYTOCHEMISTRY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Anna Tosi, Lavinia Nardinocchi, Maria Luigia Carbone, Lorena Capriotti, Elena Pagani, Simona Mastroeni, Cristina Fortes, Fernanda Scopelliti, Caterina Cattani, Francesca Passarelli, Antonio Rosato, Stefania D'Atri, Cristina Maria Failla, Andrea Cavani
Summary: The study found that in cutaneous melanoma, there is a lower percentage of Th17 lymphocytes compared to basal cell carcinomas, and TIL clones could not differentiate into the Th17 phenotype in vitro. The presence of Th17 cells did not correlate with patient characteristics, but a lower amount was observed in samples from female donors. The expression of placenta growth factor by melanoma cells may be associated with the presence of Th17 lymphocytes.
Article
Biochemistry & Molecular Biology
Gustavo Untiveros, Aleksandr Raskind, Laura Linares, Alessandro Dotti, Luigi Strizzi
Summary: The research indicates that Neogenin-expressing aggressive melanoma cells show higher migratory attraction towards Netrin-1, potentially through ERK1/2 signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physics, Fluids & Plasmas
Ian Braga, Lucas Wardil
Summary: The evolution of cooperation has been widely studied in evolutionary biology, with a focus on the importance of spatial structure. This study examines the impact of stochasticity on cooperation in group-structured populations and finds that cooperation can be favored if certain conditions are met. The research demonstrates that even in the absence of population viscosity and with an infinite number of finite-size groups, cooperation can still thrive. The study highlights the significance of stochastic fluctuations in facilitating cooperation, suggesting that it may be a general principle.
Article
Biochemistry & Molecular Biology
Jessica Ruehle, Marco Ginzel, Stefanie Dietz, Julian Schwarz, Trim Lajqi, Sandra Beer-Hammer, Christian F. Poets, Christian Gille, Natascha Koestlin-Gille
Summary: Newborns, especially preterm infants, are more susceptible to infections due to their immature immune system. In particular, neonatal neutrophils have an immunomodulatory effect on T-cells. This study investigated the role of neonatal neutrophils in T-cell development in the thymus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Christopher W. Bakerlee, Alex N. Nguyen Ba, Yekaterina Shulgina, Jose I. Rojas Echenique, Michael M. Desai
Summary: Epistasis plays a significant role in evolutionary trajectories, with idiosyncratic interactions observed among specific mutations. Protein-level fitness landscapes have shown such interactions, while genome-wide mutations demonstrate ubiquitous patterns of diminishing-returns and increasing-costs epistasis.
Article
Dermatology
Hirofumi Kamada, Shinji Yasuhira, Masahiko Shibazaki, Hiroo Amano, Chihaya Maesawa
Summary: This study identified the role of DUSP4 in melanoma genesis. The findings suggest that DUSP4 maintains high ERK1/2 activity by negatively regulating DUSP6, contributing to the survival and growth of melanoma cells.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Endocrinology & Metabolism
Lucile Butruille, Martine Batailler, Marie-Line Cateau, Ariane Sharif, Valerie Leysen, Vincent Prevot, Pascal Vaudin, Delphine Pillon, Martine Migaud
Summary: In adult mammals, neural stem cells are localized in three neurogenic regions, including the subventricular zone and subgranular zone, as well as the hypothalamus. The depletion of GFAP-expressing tanycytes in the hypothalamus leads to a decrease in testosterone levels and testicular weight, as well as impaired sexual behavior.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marta Venturella, Alessandro Falsini, Federica Coppola, Gaia Giuntini, Fabio Carraro, Davide Zocco, Antonio Chiesi, Antonella Naldini
Summary: This study investigated the effects of hypoxia on the release of small extracellular vesicles (sEVs) in two melanoma in vitro models. It was found that melanoma cells release sEVs under both normoxic and hypoxic conditions, but only hypoxia-induced sEVs express CA-IX mRNA and protein. An optimized ELISA assay provided evidence for CA-IX protein expression on the membranes of the sEVs. These CA-IX-positive sEVs may serve as potential biomarkers for liquid biopsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Barbara Gyuricza, Agnes Szucs, Judit P. Szabo, Viktoria Arato, Zita Kepes, Daniel Szucs, Dezso Szikra, Gyorgy Trencsenyi, Aniko Fekete
Summary: This study developed a novel carbohydrate-based radiotracer for the highly selective determination of Gal-3-expressing melanoma cells. The synthesized radiotracer showed high tumor accumulation and excellent contrast, indicating its potential for melanoma detection.
Article
Biochemistry & Molecular Biology
Jae-Han Lee, Eun-Seon Yoo, So-Hee Han, Gi-Hwan Jung, Eun-Ji Han, Eun-Young Choi, Su-Ji Jeon, Soo-Hyun Jung, BumSeok Kim, Sung-Dae Cho, Jeong-Seok Nam, Changsun Choi, Jeong-Hwan Che, Ji-Youn Jung
Summary: This study investigated the anticancer effects of Chrysin in human melanoma cells and found that it can inhibit cell viability by inducing apoptosis and autophagy. The response to autophagy varies in different cell types, and Chrysin also affects the mTOR/S6K pathway.
Article
Biochemistry & Molecular Biology
Li Zhang, Linyu Zhu, Xiaohan Yao, Xiaohan Lou, Jiajia Wan, Xixi Duan, Longze Pan, Anqi Li, Zhuoyu Gu, Ming Wang, Fazhan Wang, Zhihai Qin
Summary: Chemotherapeutic drug paclitaxel (PTX) inhibits tumor growth at the injection site but enhances lymphatic metastasis of melanoma cells by upregulating C-C chemokine receptor type 7 (CCR7) expression and activating fNK and p38 signaling pathways.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Farhana Yesmin, Keiko Furukawa, Mariko Kambe, Yuhsuke Ohmi, Robiul Hasan Bhuiyan, Mohammad Abul Hasnat, Momoka Mizutani, Orie Tajima, Noboru Hashimoto, Akiko Tsuchida, Kei Kaneko, Koichi Furukawa
Summary: Exosomes, small extracellular vesicles, play significant roles in cell-to-cell communication and have been extensively studied for their contents, generation mechanisms, and functions. However, the presence and roles of glycans, especially glycosphingolipids, in exosomes have been rarely reported. This study investigated the expression and function of the cancer-associated ganglioside GD2 in malignant melanomas. The results showed that GD2-expressing melanoma-derived exosomes enhanced the malignant phenotypes of GD2-negative melanomas and induced increased phosphorylation of signaling molecules.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Niloofar Heshmati Aghda, Susana Torres Hurtado, Shahad M. Abdulsahib, Emilio J. Lara, James W. Tunnell, Tania Betancourt
Summary: This study focuses on using nanomedicine-mediated combination therapy to induce immunogenic cell death in melanoma cells by delivering ICD inducers Dox and ICG loaded into BSA nanoparticles, which inhibits tumor growth by enhancing the immunogenicity of the tumor microenvironment.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Oncology
Orit Adir, Orit Sagi-Assif, Tsipi Meshel, Shlomit Ben-Menachem, Metsada Pasmanik-Chor, Dave S. B. Hoon, Isaac P. Witz, Sivan Izraely
Summary: Brain metastatic melanoma cells reprogram microglia and upregulate JunB expression. High-JunB microglia promote tumor progression, while low-JunB microglia inhibit tumor progression.
Article
Biochemistry & Molecular Biology
Cecile Desjobert, Mounir El Mai, Tom Gerard-Hirne, Dominique Guianvarc'h, Arnaud Carrier, Cyrielle Pottier, Paola B. Arimondo, Joelle Riond
Article
Oncology
Stephane Vispe, Arthur Deroide, Emeline Davoine, Cecile Desjobert, Fabrice Lestienne, Lucie Fournier, Natacha Novosad, Sophie Breand, Jerome Besse, Florence Busato, Joerg Tost, Luc De Vries, Didier Cussac, Joelle Riond, Paola B. Arimondo
Meeting Abstract
Oncology
Chantal Etievant, Cecile Desjobert, Arnaud Carrier, Audrey Delmas, Jorg Tost, Gilles Favre, Joelle Riond, Paola Arimondo
Article
Oncology
Cecile Desjobert, Arnaud Carrier, Audrey Delmas, Diego M. Marzese, Antoine Daunay, Florence Busato, Arnaud Pillon, Jorg Tost, Joelle Riond, Gilles Favre, Chantal Etievant, Paola B. Arimondo
CLINICAL EPIGENETICS
(2019)
Article
Pharmacology & Pharmacy
Fatima Bilal, Anne Montfort, Julia Gilhodes, Virginie Garcia, Joelle Riond, Stephane Carpentier, Thomas Filleron, Celine Colacios, Thierry Levade, Ahmad Daher, Nicolas Meyer, Nathalie Andrieu-Abadie, Bruno Segui
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Oncology
Anne Montfort, Florie Bertrand, Julia Rochotte, Julia Gilhodes, Thomas Filleron, Jean Milhes, Carine Dufau, Caroline Imbert, Joelle Riond, Marie Tosolini, Christopher J. Clarke, Florent Dufour, Andrei A. Constantinescu, Nilton De Franca Junior, Virginie Garcia, Michel Record, Pierre Cordelier, Pierre Brousset, Philippe Rochaix, Sandrine Silvente-Poirot, Nicole Therville, Nathalie Andrieu-Abadie, Thierry Levade, Yusuf A. Hannun, Herve Benoist, Nicolas Meyer, Olivier Micheau, Celine Colacios, Bruno Segui
Summary: Dysregulation of lipid metabolism affects cancer cell behavior, and increasing SMPD3 expression can reduce melanoma growth and enhance Th1 polarization and CD8(+) T-cell-dependent immune responses.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Biology
Arnaud Carrier, Cecile Desjobert, Loic Ponger, Laurence Lamant, Matias Bustos, Jorge Torres-Ferreira, Rui Henrique, Carmen Jeronimo, Luisa Lanfrancone, Audrey Delmas, Gilles Favre, Antoine Daunay, Florence Busato, Dave S. B. Hoon, Jorg Tost, Chantal Etievant, Joelle Riond, Paola B. Arimondo
Summary: This study identified 229 differentially hypermethylated genes in aggressive melanoma cell lines, and eight hypermethylated gene promoters were validated in tissues from melanoma patients. Additionally, five identified CpGs from primary melanoma tissues were transformed into a DNA methylation score that can predict patient survival. This strategy has the potential to be applied to other diseases with DNA methylation alterations.
Article
Oncology
Arnaud Carrier, Cecile Desjobert, Valerie Lobjois, Lise Rigal, Florence Busato, Jorg Tost, Miquel Ensenyat-Mendez, Diego M. Marzese, Anne Pradines, Gilles Favre, Laurence Lamant, Luisa Lanfrancone, Chantal Etievant, Paola B. Arimondo, Joelle Riond
Summary: Protocadherin proteins play an important role in cell adhesion and signaling pathways. The study found that the PCDHB15 gene's specific exon is hypermethylated in melanoma, leading to its silencing. This silencing contributes to the aggressiveness of melanoma.
CLINICAL EPIGENETICS
(2022)
Review
Oncology
Laurence Pellerin, Lorry Carrie, Carine Dufau, Laurence Nieto, Bruno Segui, Thierry Levade, Joelle Riond, Nathalie Andrieu-Abadie
Article
Immunology
J. Riond, J. Elhmouzi, D. Hudrisier, J. E. Gairin
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2007)
Article
Immunology
B. Rubin, J. Riond, J. Leghait, J. E. Gairin
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2006)
Article
Immunology
D Hudrisier, J Riond, L Garidou, C Duthoit, E Joly
EUROPEAN JOURNAL OF IMMUNOLOGY
(2005)
Article
Biochemistry & Molecular Biology
D Hudrisier, J Riond, H Mazarguil, JE Gairin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2001)
Article
Virology
D Hudrisier, J Riond, JE Gairin
JOURNAL OF VIROLOGY
(2001)