Article
Cell Biology
Maria E. C. Bruno, Sujata Mukherjee, Arnold J. Stromberg, Hiroshi Saito, Marlene E. Starr
Summary: Elevated levels of PAI-1 are associated with disease severity and mortality in sepsis patients. Studies have demonstrated that induction and secretion of PAI-1 from VAT is regulated by a complex interaction among immune and nonimmune cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Neurosciences
Wu Jiang, Fan He, Guoming Ding, Junsong Wu
Summary: TPT reduces neuronal death and improves functional recovery after SCI, possibly through inhibition of caspase-1-dependent pyroptosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yajun Liu, Meifang Wang, Derek Wang, William P. Fay, Ronald J. Korthuis, Grzegorz Sowa
Summary: This study investigates the role of caveolin-2 in ischemia/reperfusion tissue injury and demonstrates that caveolin-2 plays a protective role by reducing PAI-1 protein levels in intestinal tissue and leukocyte-endothelial adhesive interactions in postcapillary venules. The findings suggest that caveolin-2 may alleviate tissue injury in response to I/R by dampening PAI-1 protein levels and reducing leukocyte-endothelial adhesive interactions.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Cell Biology
Pingping Ma, Guang Li, Xiaorui Jiang, Xinkun Shen, Hong Li, Li Yang, Wanqian Liu
Summary: This study revealed that high salt intake can promote atherosclerosis through NFAT5-mediated control of PAI-1. Overexpression of NFAT5 increased PAI-1-mediated antifibrinolytic activity and expression of inflammatory adhesion-related genes, while knockdown of NFAT5 inhibited these effects. The findings suggest that NFAT5 plays a key role in inducing fibrinolytic dysfunction and inflammatory cell adhesion in high salt-induced atherosclerosis.
Article
Cell Biology
Guanyu Chen, Honghui Zeng, Xinyun Li, Jianbo Liu, Zhao Li, Runze Xu, Yuntao Ma, Chuanyong Liu, Bing Xue
Summary: Activation of GPER prevents CIM by inhibiting DNA damage in a ERK1/2-dependent manner, suggesting GPER might be a potential target for preventing CIM.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Lini Jin, Binfeng Yu, Hongju Wang, Lingling Shi, Jingjuan Yang, Longlong Wu, Cui Gao, Hong Pan, Fei Han, Weiqiang Lin, En Yin Lai, Yong-Fei Wang, Yi Yang
Summary: This study demonstrates that STING plays a critical role in ferroptosis during ischemic acute kidney injury. It facilitates NCOA4-mediated ferritinophagy, leading to iron overload and exacerbating renal dysfunction.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Fahim Syed, Wei Li, Ryan F. Relich, Patrick M. Russell, Shanxiang Zhang, Michelle K. Zimmerman, Qigui Yu
Summary: The study found that COVID-19 patients exhibit a unique inflammatory profile, with high levels of MMP-1 and hyperactivation of endothelial cells (ECs) associated with disease severity.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Elvira Ruslanovna Akhmetzyanova, Margarita Nikolaevna Zhuravleva, Anna Viktorovna Timofeeva, Leisan Gazinurovna Tazetdinova, Ekaterina Evgenevna Garanina, Albert Anatolevich Rizvanov, Yana Olegovna Mukhamedshina
Summary: A spinal cord injury (SCI) triggers biochemical reactions and interactions between cells, which determine the potential for regeneration and preservation of nervous tissue functions. Microglia play a key role in these processes. Our study examined the behavior of microglia in vitro after mild, moderate, and severe SCI at different post-traumatic periods. We found that microglia contribute significantly to both pro- and anti-inflammatory patterns after severe SCI for a prolonged period, but reduced severities of SCI do not lead to prolonged activation of microglia. Furthermore, the severity of SCI inversely correlates with the proliferative and phagocytic activity of microglia in all post-traumatic periods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Camille Cohen, Oceane Le Goff, Frederic Soysouvanh, Florence Vasseur, Marine Tanou, Clement Nguyen, Lucile Amrouche, Julien Le Guen, Oriana Saltel-Fulero, Tanguy Meunier, Thao Nguyen-Khoa, Marion Rabant, Dominique Nochy, Christophe Legendre, Gerard Friedlander, Bennett G. Childs, Daren J. Baker, Bertrand Knebelmann, Dany Anglicheau, Fabien Milliat, Fabiola Terzi
Summary: The study uncovered a detrimental cross-talk between senescent glomerular endothelial cells and podocytes through PAI-1, affecting glomerular lesion development and podocyte loss in aged mice. Selective inactivation of PAI-1 or blocking its action prevented podocyte apoptosis, and depletion of senescent cells prevented podocyte loss in old transgenic mice. Furthermore, glomerular PAI-1 expression was predictive of poor outcomes in elderly donor kidney transplants and urinary PAI-1 levels were associated with age-related chronic kidney disease in elderly patients.
EMBO MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jinxuan Zhao, Qi Zhang, Wei Cheng, Qing Dai, Zhonghai Wei, Meng Guo, Fu Chen, Shuaihua Qiao, Jiaxin Hu, Junzhuo Wang, Haiting Chen, Xue Bao, Dan Mu, Xuan Sun, Biao Xu, Jun Xie
Summary: This study aims to investigate the role of gut microbiota in the post-ischemia/reperfusion (I/R) inflammatory microenvironment. The researchers found that gut bacteria translocation products were associated with inflammation biomarkers and severity of I/R injury in myocardial infarction patients. Using a mouse model, they identified Proteobacteria blooming as a hallmark of post-I/R dysbiosis and demonstrated the bidirectional heart-gut-microbiome-immune axis in myocardial I/R injury. The administration of glucagon-like peptide 2 (GLP-2) restored gut microbiota disorder, prevented bacteria translocation, and attenuated myocardial I/R injury through alleviating systemic inflammation.
CARDIOVASCULAR RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rui Wang, Teng Pan, Lin Huang, Chengde Liao, Qinqing Li, Huabei Jiang, Jun Yang
Summary: The study demonstrates that photoacoustic imaging (PAI) can effectively detect acute intestinal ischemia injury and quantitatively evaluate tissue viability.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Cell Biology
Xiaoliang Zhou, Hao Wang, Deguan Li, Naling Song, Fujun Yang, Wenqing Xu
Summary: Research has found that the MST1/2 inhibitor XMU-MP-1 can rescue impaired hematopoietic stem cells and progenitor cells under oxidative stress, alleviate intestinal injury caused by radiation, and prolong the survival of mice exposed to lethal doses of radiation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Balaji Krishnamachary, Christine Cook, Ashok Kumar, Leslie Spikes, Prabhakar Chalise, Navneet K. Dhillon
Summary: The protein cargo in EVs can distinguish the severity of COVID-19, with enrichment of proinflammatory, procoagulation, immunoregulatory, and tissue-remodeling proteins. These proteins induce apoptosis of pulmonary microvascular endothelial cells.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Agriculture, Multidisciplinary
Lei Du, Yi-Ming Hao, Yu-Hong Yang, Yan Zheng, Zi-Jian Wu, Meng-Qing Zhou, Bao-Zhen Wang, Yu-Ming Wang, Hao Wu, Guo-Hai Su
Summary: DHA-PL and EPA-PL maintain intestinal barrier integrity by balancing apoptosis and autophagy in intestinal epithelial cells, and alleviate LPS-induced intestinal barrier injury by inhibiting NF-κB and MAPKs pathways activation and activating Nrf2 antioxidant pathway.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Hematology
Suellen Rodrigues Martins, Silvia Leticia de Oliveira Toledo, Aislander Junio da Silva, Fernanda Santos Mendes, Marina Mendes de Oliveira, Leticia Goncalves Resende Ferreira, Luci Maria Sant'Ana Dusse, Maria das Gracas Carvalho, Danyelle Romana Alves Rios, Patricia Nessralla Alpoim, Melina de Barros Pinheiro
Summary: Elevated levels of ADMA and PAI-1 may be associated with more severe SCD, with high levels of ADMA compromising NO synthesis and leading to endothelial dysfunction, while high levels of PAI-1 in all patients may indicate not only endothelial dysfunction but also a hypofibrinolytic state.
ANNALS OF HEMATOLOGY
(2022)
Article
Biology
Stephane Grison, Dimitri Kereselidze, David Cohen, Celine Gloaguen, Christelle Elie, Philippe Lestaevel, Audrey Legendre, Line Manens, Baninia Habchi, Mohamed Amine Benadjaoud, Georges Tarlet, Fabien Milliat, Jean-Charles Martin, Jean-Marc Lobaccaro, Maamar Souidi
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2019)
Article
Oncology
Frederic Soysouvanh, Mohamed Amine Benadjaoud, Morgane Dos Santos, Michele Mondini, Jeremy Lavigne, Annaig Bertho, Valerie Buard, Georges Tarlet, Serge Adnot, Eric Deutsch, Olivier Guipaud, Vincent Paget, Agnes Francois, Fabien Milliat
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Review
Oncology
Michele Mondini, Antonin Levy, Lydia Meziani, Fabien Milliat, Eric Deutsch
MOLECULAR ONCOLOGY
(2020)
Article
Oncology
Annaig Bertho, Morgane Dos Santos, Valerie Buard, Vincent Paget, Olivier Guipaud, Georges Tarlet, Fabien Milliat, Agnes Francois
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2020)
Article
Multidisciplinary Sciences
M. Ben Kacem, M. A. Benadjaoud, M. Dos Santos, F. Soysouvanh, V. Buard, G. Tarlet, B. Le Guen, A. Francois, O. Guipaud, F. Milliat, V. Paget
SCIENTIFIC REPORTS
(2020)
Article
Gastroenterology & Hepatology
Alexia Lapiere, Mallia Geiger, Veronique Robert, Christelle Demarquay, Sandrine Auger, Sead Chadi, Mohamedamine Benadjaoud, Gabriel Fernandes, Fabien Milliat, Philippe Langella, Marc Benderitter, Jean-Marc Chatel, Alexandra Semont
Article
Biochemistry & Molecular Biology
Benoit Usunier, Clement Brossard, Bruno L'Homme, Christine Linard, Marc Benderitter, Fabien Milliat, Alain Chapel
Summary: Fibrosis is a leading cause of death in occidental states, and mesenchymal stem cells (MSC) have been shown to reduce radiation-induced colorectal fibrosis by controlling extracellular matrix (ECM) turnover.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Morgane Dos Santos, Vincent Paget, Francois Trompier, Gaetan Gruel, Fabien Milliat
Summary: The proposal suggests a dosimetry protocol for cell irradiations using low energy X-ray facility, aiming to estimate doses as close to real conditions as possible. It includes steps such as determining irradiation parameters, beam quality index, dose rate measurement, attenuation and scattering quantification, and dose rate determination at the cellular level. The methodology needs to be performed for each new cell irradiation configuration due to the potential impact of modifying parameters on the actual dose deposition.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Cell & Tissue Engineering
Lydia Bensemmane, Claire Squiban, Christelle Demarquay, Noelle Mathieu, Marc Benderitter, Bernard Le Guen, Fabien Milliat, Christine Linard
Summary: The study demonstrates that stromal vascular fraction (SVF) derived from adipose tissue can effectively treat GIS after abdominal radiation by promoting intestinal regeneration and reducing mortality in mice through anti-inflammatory effects.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Environmental Sciences
A. Bertho, M. Dos Santos, A. Francois, F. Milliat
Summary: Stereotactic body radiation therapy, made possible by advances in dose delivery technology, improves treatment accuracy and reduces healthy tissue exposure, leading to excellent tumor control, particularly in inoperable early stage non-small cell lung cancer.
Article
Cell & Tissue Engineering
Lara Moussa, Alexia Lapiere, Claire Squiban, Christelle Demarquay, Fabien Milliat, Noelle Mathieu
CELL TRANSPLANTATION
(2020)
Article
Environmental Sciences
A. Bertho, M. Dos Santos, A. Francois, F. Milliat