Article
Anesthesiology
Ian Yuan, Justin Skowno, Bingqing Zhang, Andrew Davidson, Britta S. von Ungern-Sternberg, David Sommerfield, Jianmin Zhang, Xingrong Song, Mazhong Zhang, Ping Zhao, Huacheng Liu, Yifei Jiang, Yunxia Zuo, Jurgen C. de Graaff, Laszlo Vutskits, Vanessa A. Olbrecht, Peter Szmuk, Charles D. Kurth
Summary: This international observational study found that isoelectric events during anesthesia were common in young children and associated with age, specific anesthetic practices, and intraoperative hypotension.
Article
Hematology
Stuart Scott, Ashley Cartwright, Sebastian Francis, Liam Whitby, A. Pia Sanzone, Andre Mulder, Sara Galimberti, Stephanie Dulucq, Carole Maute, Calogero Lauricella, Matthew Salmon, Susan Rose, Josh Willoughby, Nancy Boeckx, Niels Pallisgaard, Jacqueline Maier, Elisabeth O. Leibundgut, Hana Zizkova, Liuh Ling Goh, Chinh Duong, Wing F. Tang, Edmond Ma, Yogesh Shivakumar, Lan Beppu, Prasanthi Bhagavatula, Andrew Chantry
Summary: Measurement of BCR-ABL1 mRNA levels is critical in treatment protocols for chronic myeloid leukaemia, but interlaboratory variation remains an issue. This study demonstrated that RTddPCR can effectively detect BCR-ABL1 at different levels with improved linearity and reduced interlaboratory variation compared to RTqPCR.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Steven G. Deeks, Nancie Archin, Paula Cannon, Simon Collins, R. Brad Jones, Marein A. W. P. de Jong, Olivier Lambotte, Rosanne Lamplough, Thumbi Ndung'u, Jeremy Sugarman, Caroline T. Tiemessen, Linos Vandekerckhove, Sharon R. Lewin
Summary: Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong treatment is required and there is no cure. Various methods including immune activators, neutralizing antibodies, therapeutic vaccines, and gene editing tools have shown promise in curing HIV in nonhuman primate models, with optimism for human clinical trials. Future HIV cure strategies may focus on in vivo delivery of gene-editing tools to target the virus, boost immunity, or protect cells from infection.
Article
Health Care Sciences & Services
Maryam Y. Garza, Tremaine Williams, Sahiti Myneni, Susan H. Fenton, Songthip Ounpraseuth, Zhuopei Hu, Jeannette Lee, Jessica Snowden, Meredith N. Zozus, Anita C. Walden, Alan E. Simon, Barbara McClaskey, Sarah G. Sanders, Sandra S. Beauman, Sara R. Ford, Lacy Malloch, Amy Wilson, Lori A. Devlin, Leslie W. Young
Summary: Background studies have shown that medical record abstraction is a significant source of error in clinical research relying on secondary data. However, the quality of data collected through this method is often not assessed. This study demonstrates the importance of formalized training and continuous quality control in improving data quality over time.
BMC MEDICAL RESEARCH METHODOLOGY
(2022)
Article
Critical Care Medicine
Holly R. Keir, Amelia Shoemark, Alison J. Dicker, Lidia Perea, Jennifer Pollock, Yan Hui Giam, Guillermo Suarez-Cuartin, Megan L. Crichton, Mike Lonergan, Martina Oriano, Erin Cant, Gisli G. Einarsson, Elizabeth Furrie, J. Stuart Elborn, Christopher J. Fong, Simon Finch, Geraint B. Rogers, Francesco Blasi, Oriol Sibila, Stefano Aliberti, Jodie L. Simpson, Jeffrey T. J. Huang, James D. Chalmers
Summary: Bronchiectasis is a neutrophilic inflammatory disease, and research has shown that neutrophilic inflammation is associated with disease severity and treatment response. Studying the role of NETs in bronchiectasis can help develop new treatment strategies.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Health Care Sciences & Services
Arvind Rajamani, Stephen Huang, Ashwin Subramaniam, Michele Thomson, Jinghang Luo, Andrew Simpson, Anthony McLean, Anders Aneman, Thodur Vinodh Madapusi, Ramanathan Lakshmanan, Gordon Flynn, Latesh Poojara, Jonathan Gatward, Raju Pusapati, Adam Howard, Debbie Odlum
Summary: The study found that staff without formal data collection training significantly overestimated the severity-of-illness scores and risks of death for ICU patients, with both trained and untrained groups showing wide variability.
BMJ QUALITY & SAFETY
(2021)
Article
Medicine, General & Internal
Silja Kosola, Evelyn Culnane, Hayley Loftus, Anna Tornivuori, Mira Kallio, Michelle Telfer, Paivi J. Miettinen, Kaija-Leena Kolho, Kristiina Aalto, Taneli Raivio, Susan Sawyer
Summary: The Bridge study aims to investigate the associations of transition readiness and care experiences with transition success for adolescents with chronic conditions, focusing on health status, quality of life, medical appointment adherence, and costs of care, as well as tracking their growing independence and educational and employment pathways during the transition process. Results will be published in international peer-reviewed journals and disseminated to funders, patients, and their parents/guardians.
Review
Clinical Neurology
Swati Sathe, Jen Ware, Jamie Levey, Eileen Neacy, Robi Blumenstein, Simon Noble, Alzbeta Muhlback, Anne Rosser, G. Bernhard Landwehrmeyer, Cristina Sampaio
Summary: Established in 2012, Enroll-HD is a global clinical research platform that provides clinical data and biosamples to facilitate research on Huntington's disease, aiding in recruitment for interventional trials and other studies. The platform operates worldwide with a focus on standardization, data quality, and participant privacy.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Hana J. Abukhadijah, Karam Turk-Adawi, Nora Dewart, Sherry L. Grace
Summary: This study tested the perceived usability of the International Cardiac Rehabilitation Registry (ICRR) and optimized it. The results showed that ICRR was easy to use, relevant, efficient, with easy learnability, operability, perceived usefulness, positive perceptions of output quality, and high end-user satisfaction.
Article
Multidisciplinary Sciences
Noam Angrist, Simeon Djankov, Pinelopi K. Goldberg, Harry A. Patrinos
Summary: Human capital is a critical component of economic development, and comparable global learning metrics are essential for understanding and tracking its formation. The use of international achievement tests, primarily in developed countries, limits analysis of learning patterns in developing countries. Research shows limited global progress in learning, with human capital playing a significant role in explaining income differences across countries. Additionally, considerable heterogeneity exists among income groupings across countries and regions, underscoring the importance of including countries at various stages of economic development in analysis. Our database provides a measure of human capital more closely associated with economic growth than current measures included in existing tables and indexes.
Article
Emergency Medicine
Gerie J. Glas, Janneke Horn, Markus W. Hollmann, Benedikt Preckel, Kirsten Colpaert, Manu Malbrain, Ary Serpa Neto, Karim Asehnoune, Marcello Gamma de Abreu, Ignacio Martin-Loeches, Paolo Pelosi, Folke Sjoberg, Jan M. Binnekade, Berry Cleffken, Nicole P. Juffermans, Paul Knape, Bert G. Loef, David P. Mackie, Perenlei Enkhbaatar, Nadia Depetris, Anders Perner, Eva Herrero, Lucia Cachafeiro, Marc Jeschke, Jeffrey Lipman, Matthieu Legrand, Johannes Horter, Athina Lavrentieva, Alex Kazemi, Anne Berit Guttormsen, Frederik Huss, Mark Kol, Helen Wong, Therese Starr, Luc De Crop, Wilson de Oliveira Filho, Joao Manoel Silva Junior, Cintia M. C. Grion, Marjorie Burnett, Frederik Mondrup, Francois Ravat, Mathieu Fontaine, Renan Le Floch, Mathieu Jeanne, Morgane Bacus, Maite Chaussard, Marcus Lehnhardt, Bassem Daniel Mikhail, Jochen Gille, Aidan Sharkey, Nicole Trommel, Auke C. Reidinga, Nadine Vieleers, Anna Tilsley, Henning Onarheim, Maria Teresa Bouza, Alexander Agrifoglio, Filip Freden, Tina Palmieri, Lynda E. Painting, Marcus J. Schultz
Summary: The study found that lung-protective ventilation was used in the majority of burn patients in the ICU, regardless of the presence of inhalation trauma. The use of low V-T ventilation was not associated with a reduction in VFD-28.
Article
Health Care Sciences & Services
Carsten Oliver Schmidt, Stephan Struckmann, Cornelia Enzenbach, Achim Reineke, Jurgen Stausberg, Stefan Damerow, Marianne Huebner, Boerge Schmidt, Willi Sauerbrei, Adrian Richter
Summary: This study introduces a data quality framework for health research data collections, with supporting software implementations to facilitate quality assessments. The framework comprises 34 data quality indicators targeting completeness, consistency, and accuracy of data.
BMC MEDICAL RESEARCH METHODOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mercedes Martinez, Emily R. Perito, Pamela Valentino, Cara L. Mack, Madeleine Aumar, Annemarie Broderick, Laura G. Draijer, Eleonora D. T. Fagundes, Katryn N. Furuya, Nitika Gupta, Simon Horslen, Maureen M. Jonas, Binita M. Kamath, Nanda Kerkar, Kyung Mo Kim, Kaija-Leena Kolho, Bart G. P. Koot, Trevor J. Laborda, Christine K. Lee, Kathleen M. Loomes, Tamir Miloh, Douglas Mogul, Saeed Mohammed, Nadia Ovchinsky, Girish Rao, Amanda Ricciuto, Alexandre Rodrigues Ferreira, Kathleen B. Schwarz, Vratislav Smolka, Atsushi Tanaka, Mary E. M. Tessier, Venna L. Venkat, Bernadette E. Vitola, Marek Woynarowski, Melissa Zerofsky, Mark R. Deneau
Summary: This retrospective study evaluated risk factors for rPSC in 140 children and found that patients with rPSC were younger at LT, had faster progression from PSC diagnosis to LT, and had a higher prevalence of inflammatory bowel disease. rPSC subjects experienced more episodes of acute rejection, complications of portal hypertension, and higher mortality rates post-LT.
Article
Medicine, General & Internal
Van Thu Nguyen, Mishelle Engleton, Mauricia Davison, Philippe Ravaud, Raphael Porcher, Isabelle Boutron
Summary: Reporting of essential information of study design in observational studies remained suboptimal. Selection bias and immortal time bias were common methodological issues that researchers and physicians should be aware of when interpreting the results of observational studies using routinely collected data.
Article
Clinical Neurology
Christine Verboon, Thomas Harbo, David R. Cornblath, Richard A. C. Hughes, Pieter A. van Doorn, Michael P. Lunn, Kenneth C. Gorson, Fabio Barroso, Satoshi Kuwabara, Giuliana Galassi, Helmar C. Lehmann, Susumu Kusunoki, Ricardo C. Reisin, Davide Binda, Guido Cavaletti, Bart C. Jacobs
Summary: In patients with mild GBS, treatment with one course of IVIg did not improve the disease course overall. Despite some benefits such as shorter time to regain muscle strength, residual symptoms were often present after one year, indicating the need for better treatments for mild GBS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2021)