Article
Cell Biology
R. Vivian Allahyari, Nicolette M. Heinsinger, Daniel Hwang, David A. Jaffe, Javad Rasouli, Stephanie Shiers, Samantha J. Thomas, Theodore J. Price, Abdolmohamad Rostami, Angelo C. Lepore
Summary: This study investigates the astrocyte heterogeneity in the spinal cord and its potential role in synaptic generation. The results suggest that the distribution of astrocyte subpopulations and the expression of synapse formation-associated genes did not change significantly after spinal cord injury in mice. These findings indicate a possible conservation of spinal cord astrocyte heterogeneity across species.
Article
Cell Biology
Hong-Hua Song, Tian-Cheng Song, Ting Yang, Chun-Shuai Sun, Bing-Qiang He, Hui Li, Ying-Jie Wang, Yu Li, Hao Wu, Yu-Ming Hu, Yong-Jun Wang
Summary: The study demonstrates that HMGB1 mediates the astrocyte inflammatory response through regulating the COX2/PGE2 signaling pathway.
NEURAL REGENERATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
S. Liu, X-M Li, J-B Yuan, L-L Li, C. Wang, X-M Lin, X. Miao, Z-C Shi
Summary: The study revealed that miR-665 is downregulated in the serum of SCI patients and LPS-induced BV2 cells, while TREM2 is upregulated. Silenced miR-665 or overexpressed TREM2 is associated with protecting inflammatory response following SCI. Rescue experiments showed that miR-665 participates in regulating inflammatory response following SCI by targeting TREM2.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Review
Immunology
Robert C. Sterner, Rosalie M. Sterner
Summary: Traumatic spinal cord injury (SCI) is a devastating condition that leads to loss of function and disability. The pathophysiology involves immediate cell dysfunction and death followed by secondary injury mechanisms, with inflammation playing a key role. Targeting the immune response after SCI could effectively reduce secondary injury and improve outcomes. Recent studies have provided molecular insights into the timing of the immune response and potential therapies such as pharmaceutical interventions, stem cell therapy, and extracellular vesicle therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mohammad-Masoud Zavvarian, James Hong, Mohamad Khazaei, Jonathon Chon Teng Chio, Jian Wang, Anna Badner, Michael G. Fehlings
Summary: This study demonstrated that intraperitoneal injection of midostaurin in injured rats led to alterations in local inflammasome and gene expression, resulting in enhanced recovery and improved coordination between forelimbs and hindlimbs after injury. Histological analysis also indicated improved tissue preservation and functionality in treated animals during the chronic phase of injury. Overall, systemic administration of midostaurin proved to be an effective strategy for mitigating cervical secondary SCI damage.
Article
Immunology
Yonghui Hou, Jiyao Luan, Taida Huang, Tiancheng Deng, Xing Li, Zhifeng Xiao, Jiheng Zhan, Dan Luo, Yu Hou, Liangliang Xu, Dingkun Lin
Summary: In this study, TUDCA was shown to attenuate axon degeneration induced by oxidative stress in vitro and protect primary cortical neurons. In vivo, TUDCA treatment reduced tissue injury, oxidative stress, inflammation, and apoptosis, while promoting axon regeneration and remyelination in SCI mice. The functional recovery test also indicated that TUDCA treatment significantly improved limb function recovery after SCI.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Alireza Masoudi, Masoumeh Jorjani, Morteza Alizadeh, Solmaz Mirzamohammadi, Mola Mohammadi
Summary: The study demonstrates that astaxanthin offers significant protective effects on SCI rat models by reducing tissue damage and mechanical pain through its anti-inflammatory and antioxidant properties.
BRAIN RESEARCH BULLETIN
(2021)
Article
Cell Biology
Xiaogang Chen, Lin Zhang, Fu Hua, Yu Zhuang, Huan Liu, Shouguo Wang
Summary: The study revealed that EphA4 regulates astrocyte function in neuronal regeneration after spinal cord injury by binding with ephrin-B on the surface of astrocytes, affecting the secretion of neurotrophic factors, adhesion molecules, inflammatory factors, and glial scar formation, subsequently influencing neurite outgrowth and regeneration.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Curtis A. Benson, Kai-Lan Olson, Siraj Patwa, Marike L. Reimer, Lakshmi Bangalore, Myriam Hill, Stephen G. Waxman, Andrew M. Tan
Summary: Research using viral intervention techniques in mice after spinal cord injury found that knocking out Rac1 protein can restore dendritic spine development and reduce H-reflex excitability, thereby reversing spasticity. This indicates a potential mechanistic relationship between abnormal motor neuron dendritic spines and spasticity induced by SCI.
SCIENTIFIC REPORTS
(2021)
Review
Cell & Tissue Engineering
Francisco Javier Rodriguez-Jimenez, Pavla Jendelova, Slaven Erceg
Summary: Ependymal cells, dormant progenitors in the spinal cord, undergo significant changes following spinal cord injury (SCI). The understanding of molecular events that activate ependymal cells after SCI is crucial for controlling the regenerative response in damaged tissues. This review focuses on cell adhesion molecules, cellular membrane receptors, ion channels, and transcription factors that mediate SCI-induced activation of ependymal cells. The coordinated expression of receptors and ion channels regulates ependymal cell activation and may contribute to cellular replacement and tissue regeneration after SCI.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Immunology
Yue Guo, Peng Zhang, Haosen Zhao, Chang Xu, Sen Lin, Xifan Mei, He Tian
Summary: In this study, melatonin was found to promote the beneficial polarization of microglia from pro-inflammatory to anti-inflammation, decrease ROS activity, and restore mitochondrial metabolism. Melatonin may have therapeutic potential for neuroinflammation-related neurological disorders, such as spinal cord injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Weiyi Zhao, Natalie Gasterich, Tim Clarner, Clara Voelz, Victoria Behrens, Cordian Beyer, Athanassios Fragoulis, Adib Zendedel
Summary: This study suggests that activation of Nrf2 in astrocytes protects against spinal cord injury by reducing oxidative damage and neuroinflammation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Neurosciences
Soshi Samejima, Richard Henderson, Jared Pradarelli, Sarah E. Mondello, Chet T. Moritz
Summary: Spinal cord injuries often result in permanent physical impairments despite being incomplete disruptions. However, remaining connections between the brain and spinal cord can induce neural plasticity to improve sensorimotor function, even years post-injury. This review provides an overview of evidence for motor recovery, plasticity, and interventions in spinal cord stimulation for motor control restoration. It discusses both open-loop and closed-loop stimulation approaches, as well as mechanisms of spinal cord neuromodulation for sensorimotor recovery, aiming to advance rehabilitation for spinal cord injuries.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Bo Xu, Jiaqi Fang, Jianguang Wang, Xuehan Jin, Shengfu Liu, Kaihang Song, Ping Wang, Junjian Liu, Shuhao Liu
Summary: This study investigated the protective effect of edaravone on blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). The results showed that edaravone treatment promoted functional recovery, improved vascular damage, and up-regulated BSCB-associated proteins in rats with SCI. In vitro experiments also demonstrated that edaravone improved cell viability, restored intercellular junctions, and promoted angiogenic activities. The underlying mechanism may involve the improvement of autophagy and the phosphorylation of RIP1/RIP3/MLKL. Overall, edaravone can be a potential treatment option for SCI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Sheng-Ping Fu, Si-Yu Chen, Qi-Ming Pang, Meng Zhang, Xiang-Chong Wu, Xue Wan, Wei-Hong Wan, Jun Ao, Tao Zhang
Summary: Regulating macrophage/microglia polarization, particularly from an M1 to M2 phenotype, is crucial for the regression of inflammation and tissue repair following spinal cord injury (SCI). Understanding the role of the inflammatory response and macrophages/microglia in SCI and repair can provide insights into potential therapeutic strategies for SCI.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Katja Horvay, Thierry Jarde, Franca Casagranda, Victoria M. Perreau, Katharina Haigh, Christian M. Nefzger, Reyhan Akhtar, Thomas Gridley, Geert Berx, Jody J. Haigh, Nick Barker, Jose M. Polo, Gary R. Hime, Helen E. Abud
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Neurosciences
Melissa M. Gresle, Helmut Butzkueven, Victoria M. Perreau, Anna Jonas, Junhua Xiao, Stefan Thiem, Fiona E. Holmes, William Doherty, Pik-Ying Soo, Michele D. Binder, Rainer Akkermann, Vilija G. Jokubaitis, Holly S. Cate, Mark P. Marriott, Andrew L. Gundlach, David Wynick, Trevor J. Kilpatrick
Article
Neurosciences
Alberto Capurro, Liviu-Gabriel Bodea, Patrick Schaefer, Ruth Luthi-Carter, Victoria M. Perreau
FRONTIERS IN NEUROSCIENCE
(2015)
Article
Neurosciences
Nicole Bye, Kimberly J. Christie, Alisa Turbic, Harleen S. Basrai, Ann M. Turnley
EXPERIMENTAL NEUROLOGY
(2016)
Article
Neurosciences
He Xu, Victoria M. Perreau, Krista A. Dent, Ashley I. Bush, David I. Finkelstein, Paul A. Adlard
JOURNAL OF ALZHEIMERS DISEASE
(2016)
Article
Psychiatry
A. K. Short, K. A. Fennell, V. M. Perreau, A. Fox, M. K. O'Bryan, J. H. Kim, T. W. Bredy, T. Y. Pang, A. J. Hannan
TRANSLATIONAL PSYCHIATRY
(2016)
Article
Psychiatry
A. K. Short, S. Yeshurun, R. Powell, V. M. Perreau, A. Fox, J. H. Kim, T. Y. Pang, A. J. Hannan
TRANSLATIONAL PSYCHIATRY
(2017)
Article
Medicine, Research & Experimental
Anna Jonas, Stefan Thiem, Tanja Kuhlmann, Raimund Wagener, Attila Aszodi, Cameron Nowell, Mann Hagemeier, Louise Laverick, Victoria Perreau, Vilija Jokubaitis, Ben Emery, Trevor Kilpatrick, Helmut Butzkueven, Melissa Gresle
JOURNAL OF CLINICAL INVESTIGATION
(2014)
Article
Neurosciences
Melissa M. Gresle, Katrin Schulz, Anna Jonas, Victoria M. Perreau, Tania Cipriani, Alan G. Baxter, Socorro Miranda-Hernandez, Judith Field, Vilija G. Jokubaitis, Robert Cherny, Irene Volitakis, Samuel David, Trevor J. Kilpatrick, Helmut Butzkueven
JOURNAL OF NEUROSCIENCE RESEARCH
(2014)
Article
Multidisciplinary Sciences
Kathryn M. Munro, Kirsty J. Dixon, Melissa M. Gresle, Anna Jonas, Dennis Kemper, William Doherty, Louis J. Fabri, Catherine M. Owczarek, Martin Pearse, Andrew W. Boyd, Trevor J. Kilpatrick, Helmut Butzkueven, Ann M. Turnley
Review
Neurosciences
Kimberly J. Christie, Ann M. Turnley
FRONTIERS IN CELLULAR NEUROSCIENCE
(2013)
Article
Biochemistry & Molecular Biology
David P. Q. Clark, Victoria M. Perreau, Sandy R. Shultz, Rhys D. Brady, Enie Lei, Shilpi Dixit, Juliet M. Taylor, Philip M. Beart, Wah Chin Boon
NEUROCHEMICAL RESEARCH
(2019)
Article
Neurosciences
Michelle S. Zajac, Thibault Renoir, Victoria M. Perreau, Shanshan Li, Wendy Adams, Maarten van den Buuse, Anthony J. Hannan
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Leigh C. Walker, Alice E. Berizzi, Nicola A. Chen, Patricia Rueda, Victoria M. Perreau, Katherine Huckstep, Jirawoot Srisontiyakul, Piyarat Govitrapong, Jia Xiaojian, Craig W. Lindsley, Carrie K. Jones, Darren M. Riddy, Arthur Christopoulos, Christopher J. Langmead, Andrew J. Lawrence
BIOLOGICAL PSYCHIATRY
(2020)
Article
Genetics & Heredity
Gary R. Hime, Katja Horvay, Thierry Jarde, Franca Casagranda, Victoria M. Perreau, Helen E. Abud