Article
Multidisciplinary Sciences
Seon-Hee Kim, Eunjung Cho, Yu Kim, Chungyong Han, Beom K. Choi, Byoung S. Kwon
Summary: The study demonstrates that post-conditioning treatment with anti-CD4 can enhance the anti-tumor efficacy of adoptive T cell therapy (ACT) by promoting the expansion of IL-18R alpha(hi) CD8(+) T cells. This combination treatment accelerates proliferation and differentiation of tumor-reactive CD8(+) T cells and improves tumor suppression and host survival. The enrichment of polyfunctional IL-18R alpha(hi) CD8(+) T cells plays a key role in the induced tumor suppression, mediated by IL-18 signaling and TCR-MHC I interaction.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Xiaoqing Shi, Jiage Ding, Yanyan Zheng, Jiawe Wang, Navid Sobhani, Praveen Neeli, Gang Wang, Junnian Zheng, Dafei Chai
Summary: PLGA/PEI-HMGB1/GPC3 vaccine induced a strong and long-lasting CTL effect, inhibiting the progression and re-attack of hepatocellular carcinoma.
Article
Pharmacology & Pharmacy
Laura E. Swart, Marcel H. A. M. Fens, Anita van Oort, Piotr Waranecki, L. Daniel Mata Casimiro, David Tuk, Martijn Hendriksen, Luca van den Brink, Elizabeth Schweighart, Cor Seinen, Ryan Nelson, Anja Krippner-Heidenreich, Tom O'Toole, Raymond M. Schiffelers, Sander Kooijmans, Olaf Heidenreich
Summary: Lipid nanoparticles (LNPs) are rapidly evolving as promising delivery systems for oligonucleotides, including siRNAs. In this study, LNPs were specifically targeted to hematopoietic progenitor cells in the bone marrow using a modified tripeptide ligand. Functionalized LNPs showed improved uptake and delivery of siRNA in patient-derived leukemia cells, as well as increased accumulation and retention in the bone marrow. These findings suggest the potential of LNPs for targeted therapy in leukemia and other hematological disorders.
Article
Medicine, Research & Experimental
Ying Zhou, Muhammad Asad Farooq, Iqra Ajmal, Cong He, Yaoxin Gao, Dandan Guo, Yixin Duan, Wenzheng Jiang
Summary: The efficacy of CAR-T cell therapy is hindered by factors intrinsic to the tumor microenvironment. Researchers designed a novel inverted cytokine receptor (ICR) to overcome IL-4-mediated immunosuppressive signals. The study found that this strategy improved the efficacy of CAR-T cells in pancreatic tumor microenvironment, leading to increased tumor eradication.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Abiodun Ayo, Pirjo Laakkonen
Summary: The article discusses a new treatment strategy utilizing tumor-targeting peptides to deliver drugs, as well as the structure-function relationship data of different tumor-targeting peptides. The importance of improving peptide activity and conjugation strategies is also highlighted.
Article
Oncology
Marija Mojic, Kiyomi Shitaoka, Chikako Ohshima, Sisca Ucche, Fulian Lyu, Hiroshi Hamana, Hideaki Tahara, Hiroyuki Kishi, Yoshihiro Hayakawa
Summary: By analyzing the immunological status of tumor antigen-specific CD8(+) T cells during tumor progression, it was found that NKG2D can control the fate and TOX expression of tumor-reacting CD8(+) T cells.
Article
Biology
Katherine A. Deets, Randilea Nichols Doyle, Isabella Rauch, Russell E. Vance
Summary: The study demonstrates that activation of inflammasomes in intestinal epithelial cells can initiate adaptive immune responses by activating CD8(+) T cells. However, cross-presentation of IEC-derived antigens to CD8(+) T cells is not solely dependent on IEC pyroptosis.
Article
Multidisciplinary Sciences
Wei Liao, Yong Liu, Chaoyu Ma, Liwen Wang, Guo Li, Shruti Mishra, Saranya Srinivasan, Kenneth Ka-Ho Fan, Haijing Wu, Qianwen Li, Ming Zhao, Xun Liu, Erika L. Demel, Xin Zhang, Yuanzheng Qiu, Qianjin Lu, Nu Zhang
Summary: The stepwise induction of CD69 and CD103 distinguishes different differentiation stages of mucosal Trms, while the majority of non-mucosal Trm do not have CD103 expression. CD69 expression alone is not sufficient to accurately define Trm cells in highly vascularized non-mucosal tissues, such as the kidney. The downregulation of IL-18 receptor (IL-18R) is associated with tissue residency, with IL-18R(lo) exclusively identifying tissue-resident cells and IL-18R(hi) population containing both tissue-resident and migratory cells. Additionally, local cytokines and transcription factors play essential roles in regulating the downregulation of IL-18R during kidney Trm differentiation, allowing for the identification of kidney-resident CD8(+) T cells and the underlying molecular mechanisms.
Article
Chemistry, Multidisciplinary
Kangmin Noh, Saji Uthaman, Chung-Sung Lee, Yugyeong Kim, Shameer Pillarisetti, Hee Sook Hwang, In-Kyu Park, Kang Moo Huh
Summary: In this study, tumor intracellular microenvironment-responsive nanoparticles were developed for tumor-targeted anti-cancer therapy and exhibited a contrast effect in magnetic resonance imaging.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Amanda J. Stolarz, Bijay P. Chhetri, Michael J. Borrelli, Samir Jenkins, Azemat Jamshidi-Parsian, Joshua H. Phillips, Daniel Fologea, Jay Gandy, Robert J. Griffin
Summary: The use of liposomes triggered by ionizing radiation has potential for targeted drug delivery and enhanced therapeutic effect. The mechanism involves the release of protons through the organic halogen chloral hydrate, causing a drop in internal pH and destabilization of the liposomal bilayer. Experimental results demonstrate preferential drug release at the site of tumor irradiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Jingjing Jiang, Renxian Wang, Liang Yang, Yongjie Sha, Songsong Zhao, Jianxun Guo, Dafu Chen, Zhiyuan Zhong, Fenghua Meng
Summary: In this study, researchers modified nanodelivery of chemotherapeutics with IL-11R alpha specific peptide to enhance the specificity and anti-tumor efficacy of chemotherapy for osteosarcoma. The results showed that IL-11R alpha targeted nanodelivery could effectively inhibit the growth and metastasis of osteosarcoma and improve the survival rate of patients.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Chin-Yu Wang, Bai-Ling Lin, Chung-Hsuan Chen
Summary: The DNA aptamer Ap52, developed against the MAGE-A3(111-125) peptide antigen, can target multiple types of cancer cells and achieve targeted delivery when complexed with the anticancer drug doxorubicin (Dox). Image analysis shows selective entry of the ThioAp52-Dox complex into cancer cells, highlighting its potential as a delivery vehicle for therapeutics against multiple cancers.
CANCER BIOLOGY & THERAPY
(2021)
Article
Immunology
Xiyue Zhang, Yusi Zhang, He Liu, Kang Tang, Chunmei Zhang, Meng Wang, Manling Xue, Xiaozhou Jia, Haifeng Hu, Na Li, Ran Zhuang, Boquan Jin, Fanglin Zhang, Yun Zhang, Ying Ma
Summary: This study aimed to investigate the effect of bystander-activated CD8+ T cell responses in HTNV infection. An in vitro infection model was established to mimic endothelium injury in HFRS patients. The results showed that HTNV infection could activate EBV or CMV-specific CD8+ T cells and induce high levels of IL-15 production in HTNV-infected HUVECs, which were correlated with disease severity and NKG2D expression on bystander-activated CD8+ T cells.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Gan Jiang, Chenxuan Wei, Yaoxing Chen, Yingqi Lyu, Jialin Huang, Hongzhuan Chen, Xiaoling Gao
Summary: This passage discusses the process of macropinocytosis, which allows for the internalization of greater quantities of drugs and is a promising avenue for drug delivery. It also introduces various drug delivery systems that utilize macropinocytosis as the primary internalization mechanism. The potential importance of this field lies in its ability to greatly increase the efficiency and specificity of drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Oncology
Jie Wan, Yinqiu Wu, Lan Huang, Yu Tian, Xiaoyun Ji, Mohamed Hamed Abdelaziz, Wei Cai, Kesavan Dineshkumar, Yuqing Lei, Shun Yao, Caixia Sun, Zhaoliang Su, Shengjun Wang, Huaxi Xu
Summary: ILC2s, characterized by secretion of type 2 cytokines, are abundant in colorectal cancer tissue and mainly secrete IL-9, which activates CD8(+) T cells to inhibit tumor growth. The study showed that ILC2-derived IL-9 can promote anti-tumor effects in CRC.
Review
Oncology
Sung-Jong Lee, Andrew Yang, T. -C. Wu, Chien-Fu Hung
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2016)
Article
Virology
Rosie T. Jiang, Joshua W. Wang, Shiwen Peng, Tsui-Chin Huang, Chenguang Wang, Fabiana Cannella, Yung-Nien Chang, Raphael P. Viscidi, Simon R. A. Best, Chien-Fu Hung, Richard B. S. Roden
JOURNAL OF VIROLOGY
(2017)
Article
Endocrinology & Metabolism
Santosh K. Bharti, Flonne Wildes, Chien-Fu Hung, T. C. Wu, Zaver M. Bhujwalla, Marie-France Penet
Article
Pathology
Deyin Xing, Yuehua Liu, Hyeon Jin Park, Inji Baek, Hung Tran, Gloria Cheang, Jorge Novo, Jessica Dillon, Andres Matoso, Emily Farmer, Max A. Cheng, Ya-Chea Tsai, Kara Lombardo, Michael G. Conner, Russell Vang, Chien-Fu Hung, Tzyy-Choou Wu, Wei Song
Article
Obstetrics & Gynecology
Yuehua Liu, Essel Marie B. DeLeon, Salman Okour, Russell Vang, Chien-Fu Hung, Tzyy-Choou Wu, Brigitte M. Ronnett, Deyin Xing
Summary: A 44-year-old woman with menorrhagia and uterine fibroids underwent total laparoscopic hysterectomy, revealing tumors with three distinct morphologies in the uterus. The examination confirmed the presence of FH-deficient atypical leiomyoma and perivascular epithelioid cell tumor, highlighting the importance of thorough examination of uterine mesenchymal tumors with atypical and epithelioid features.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
(2021)
Article
Immunology
Yu-Min Chuang, Noton K. Dutta, James T. Gordy, Victoria L. Campodonico, Michael L. Pinn, Richard B. Markham, Chien-Fu Hung, Petros C. Karakousis
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Ravi K. Anchoori, Logan George, Ssu-Hsueh Tseng, Brandon Lam, Srinidhi Polkampally, Anjali D. Amiano, Palmer Foran, Hannah Tsingine, Harideep Samanapally, Fernanda Carrizo Velasquez, Samarjit Das, Deyin Xing, Ahmad Bin Salam, Balasubramanyam Karanam, Chien-Fu Hung, Richard B. S. Roden
Summary: Research shows that rendering RPN13 inhibitors chiral and asymmetric can enhance their activity against cancer cells, with the S-isomer being more effective. These compounds induce cytotoxicity through various mechanisms, including binding to RPN13, ATP depletion, mitochondrial dysfunction, apoptosis, and DNA damage repair disruption. Additionally, a synergistic cytotoxic response is observed when combining these inhibitors with cisplatin or doxorubicin in ovarian cancer cell lines, suggesting a potential for combination therapy in the treatment of ovarian cancer.
Article
Multidisciplinary Sciences
Chih-Ping Mao, Shih-Chin Wang, Yu-Pin Su, Ssu-Hsueh Tseng, Liangmei He, Annie A. Wu, Richard B. S. Roden, Jie Xiao, Chien-Fu Hung
Summary: Characterizing individual biomarker protein molecules in patient blood samples using single-molecule imaging techniques holds promise for early disease diagnosis and effective treatment. However, current methods have detection limits that are orders of magnitude higher than needed, making them unsuitable for clinical use. The development of SMAC, with its ability to quantify and characterize protein molecules down to the subfemtomolar range, presents a new avenue for noninvasive disease profiling with single-molecule imaging.
Article
Immunology
Alana MacDonald, Brandon Lam, John Lin, Louise Ferrall, Yu Jui Kung, Ya Chea Tsai, T. -C. Wu, Chien-Fu Hung
Summary: The fusion protein AnnV-IL2 effectively enhances T cell activation and promotes expansion of antigen-specific cells capable of interferon gamma production. Administration of AnnV-IL2 results in a stronger secondary expansion upon antigen rechallenge, indicating durability of AnnV-IL2 mediated responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Ssu-Hsueh Tseng, Max A. Cheng, Emily Farmer, Louise Ferrall, Yu Jui Kung, Brandon Lam, Ling Lim, T-C Wu, Chien-Fu Hung
Summary: The fusion of albumin to IFN beta (Alb-IFN beta) enhances immune function, prolongs the half-life of IFN beta, and has a significant antitumor effect. Alb-IFN beta can serve as an innovative adjuvant for vaccine development.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, General & Internal
Ying Liu, Maryam Shahi, Karin Miller, Christian F. Meyer, Chien-Fu Hung, T-C Wu, Russell Vang, Deyin Xing
Summary: The diagnosis of pelvic gastrointestinal stromal tumors (GISTs) is difficult due to their atypical presentation and similarity to gynecological neoplasms. This study describes the clinical and pathological features of 20 GIST cases, highlighting the importance of precise diagnosis through immunohistochemical and molecular analysis.
Article
Biochemistry & Molecular Biology
Song-Fong Huang, Sio-Wai Chong, Chun-Wei Huang, Heng-Yuan Hsu, Kuang-Tse Pan, Chien-Fu Hung, Tsung-Han Wu, Chao-Wei Lee, Chia-Hsun Hsieh, Ching-Ting Wang, Pei-Mei Chai, Ming-Chin Yu
Summary: Sorafenib treatment showed varying responses on different target lesions of advanced hepatocellular carcinoma (aHCC). A study found that 19.3% of patients had complete/partial response, 35.4% had stable disease, and 45.2% had progressive disease after six months of sorafenib administration. Poor outcomes were associated with macroscopic venous thrombus and bone metastases, higher AFP levels, and multiple target lesions. ALBI grade A was associated with better outcomes.
Article
Cell Biology
Yu-Jui Kung, Brandon Lam, Ssu-Hsueh Tseng, Alana MacDonald, Hsin-Fang Tu, Suyang Wang, John Lin, Ya Chea Tsai, T. C. Wu, Chien-Fu Hung
Summary: This study aimed to assess the efficacy of combining microbial-based therapy using Salmonella SL7207 with interleukin-2 (IL-2) in the treatment of murine colon carcinoma. The researchers found that Salmonella SL7207 preferentially accumulates in the tumor microenvironment and stimulates localized innate immunity. Administering IL-2 as a fusion protein further enhanced tumor control and overall survival. The study also demonstrated that the combination therapy led to enhanced T cell population and effector function, which were crucial for tumor control. These findings suggest that Salmonella SL7207 and IL-2 may serve as a promising therapeutic approach for inducing T cell-mediated antitumor immunity and long-term tumor control.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Oncology
Chien-Wei Peng, Wei Teng, Kar-Wai Lui, Chien-Fu Hung, Wen-Juei Jeng, Chien-Hao Huang, Wei-Ting Chen, Chen-Chun Lin, Chun-Yen Lin, Shi-Ming Lin, I-Shyan Sheen
Summary: More than one-fifth of HCC patients achieved complete response after the first session of TACE, with better overall survival. Factors such as Child-Turcotte-Pugh class B, tumor burden, tumor extent, AFP levels, and platelet counts may predict the success of complete response after TACE treatment. A tailored follow-up strategy post-TACE should consider different risk factors for early or late recurrence in patients with complete response.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Ssu-Hsueh Tseng, Li Liu, Shiwen Peng, Jinhwi Kim, Louise Ferrall, Chien-Fu Hung, T. C. Wu
Summary: The study characterized the immune responses of HLA-A2 restricted HPV16 E7-specific CD8 + T cells using a therapeutic naked DNA vaccine in transgenic mice. Spontaneous oral tumors were generated by transfecting oncogenic DNA plasmids into the submucosal oral cavity of the transgenic mice with electroporation. Treatment with the CRT/E7(N53S) DNA vaccine resulted in significant antitumor effects against the spontaneous HPV16 E6/E7-expressing oral tumors in HLA-A2 (AAD) transgenic mice.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)