Article
Multidisciplinary Sciences
Phan Tan Toi, Hyun Jae Jang, Kyeongseon Min, Sung-Phil Kim, Seung-Kyun Lee, Jongho Lee, Jeehyun Kwag, Jang-Yeon Park
Summary: Researchers have developed a two-dimensional fast line-scan approach that allows direct imaging of neuronal activity with millisecond precision, while maintaining high spatial resolution. This method was demonstrated in live mouse brain imaging, showing the sequential and laminar-specific propagation of neuronal activity along the thalamocortical pathway.
Review
Oncology
Yue Zheng, Liting You, Baijie Feng, Min Tang, Feifei Na
Summary: Hippocampus avoidance cranial radiation therapy appears to be safe in lung cancer, but it may not be superior to conventional radiation therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Michiel B. de Ruiter, Paul F. C. Groot, Sabine Deprez, Pim Pullens, Stefan Sunaert, Dirk de Ruysscher, Sanne B. Schagen, Jose Belderbos
Summary: The study found that HA-PCI can reduce hippocampal atrophy, but both types of radiotherapy are associated with considerable brain injury. There was no significant association between hippocampal atrophy and memory decline.
Article
Multidisciplinary Sciences
Monique Engelbrecht, Roya Ndimba, Maryna de Kock, Xanthene Miles, Shankari Nair, Randall Fisher, Peter du Plessis, Julie Bolcaen, Matthys Hendrik Botha, Elbie Zwanepoel, Simon Sioen, Ans Baeyens, Jaime Nieto-Camero, Evan de Kock, Charlot Vandevoorde
Summary: The study showed that HSPCs exhibit higher DNA damage induction after neutron irradiation, leading to increased apoptosis rate and levels of cytogenetic damage, which contribute to a higher risk of leukemogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Helge Herthum, Stefan Hetzer, Michael Scheel, Mehrgan Shahryari, Juergen Braun, Friedemann Paul, Ingolf Sack
Summary: Recent studies using magnetic resonance elastography (MRE) found that the range of stiffness changes in white matter lesions due to multiple sclerosis (MS) is similar to the normal variability of white matter, suggesting that in vivo tissue sclerosis may not be a mechanical signature of MS.
ACTA BIOMATERIALIA
(2022)
Article
Oncology
Federico Maldonado, Ana Gonzalez-Ling, Luis F. Onate-Ocana, Luis Antonio Cabrera-Miranda, Zyanya Lucia Zatarain-Barron, Jenny G. Turcott, Diana Flores-Estrada, Francisco Lozano-Ruiz, Bernardo Cacho-Diaz, Oscar Arrieta
Summary: This study evaluated the impact of prophylactic cranial irradiation on quality of life and neurocognitive function in patients with non-small cell lung cancer. The results showed that in a high-risk population for developing brain metastases, prophylactic cranial irradiation did not significantly decrease quality of life or neurocognitive function.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Materials Science, Multidisciplinary
C. Ruiz-Aguilar, L. Gaytan-Tocaven, R. G. Paredes
Summary: Beta-TCP is a promising bioceramic with similar composition to bones and teeth, which stimulates the formation of bone tissue. It can be used in various ways in the human body, mainly for the regeneration and stimulation of cortical and trabecular bone tissue. In a skull implant experiment on rats, the beta-TCP scaffold showed excellent bioactivity, stimulating new bone formation without affecting the animals' motor and cognitive abilities.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Engineering, Biomedical
Yongchao Wang, Guangru Liang, Fei Liu, Qian Chen, Lei Xi
Summary: In this study, a transparent, acoustically and optically transparent, long-term and biocompatible cranial window was designed, fabricated, and evaluated for high-resolution photoacoustic microscopy in rat cerebral cortex. The cranial window made with PDMS demonstrated better imaging quality compared to conventional cover-glass-based cranial window, with an optimal film thickness of 50 μm. The window maintained good quality and stability for long-term in vivo monitoring of rat cerebral cortex.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Review
Oncology
Ziyi Wang, Liang Chen, Lu Sun, Feng Cai, Qiwei Yang, Xiaohai Hu, Qiang Fu, Weiyang Chen, Peiwei Li, Wenya Li
Summary: This meta-analysis found that prophylactic cranial irradiation (PCI) does not significantly improve overall survival (OS) and progression-free survival (PFS), but it can significantly reduce the incidence of brain metastases and improve 1-year survival in patients with extensive stage small cell lung cancer (SCLC). However, PCI does not significantly affect 2, 3, 4, 5-year survival and may increase the risk of adverse events.
FRONTIERS IN ONCOLOGY
(2023)
Article
Chemistry, Analytical
Li-En Lin, Kun Miao, Chenxi Qian, Lu Wei
Summary: Amyloid aggregation, a pathological hallmark in neurodegenerative diseases, was studied using label-free high-resolution imaging and machine learning for specific segmentation of aggregate cores and peripheral filaments. This non-invasive imaging technology allows precise and multiplex high-resolution imaging of protein aggregates and their micro-environment, opening up new biomedical applications.
Article
Oncology
Theresa Suckert, Elke Beyreuther, Johannes Mueller, Behnam Azadegan, Matthias Meinhardt, Felix Raschke, Elisabeth Bodenstein, Clare von Neubeck, Armin Luehr, Mechthild Krause, Antje Dietrich
Summary: The study established a preclinical model to investigate the biological mechanisms underlying high-dose proton irradiation of brain tissue, revealing a dose-dependent onset of blood-brain barrier damage and progressive MRI contrast agent leakage in irradiated brain areas. These effects were consistent within different dose groups and may help generate hypotheses on brain toxicity after proton therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Sandra Leskinen, Harshal A. Shah, Beril Yaffe, Shonna J. Schneider, Netanel Ben-Shalom, John A. Boockvar, Randy S. D'Amico, A. Gabriella Wernicke
Summary: This study systematically reviewed the current landscape of hippocampal-avoidance radiotherapy, specifically focusing on hippocampal tumor recurrence rates and changes in neurocognitive function. The analysis of 19 articles including 1611 patients showed low hippocampal relapse rates and significant differences in neurocognitive function testing, with limitations due to loss to follow-up.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Acoustics
Christian Aurup, Hermes A. S. Kamimura, Elisa E. Konofagou
Summary: The study utilized high-resolution focused ultrasound to induce motor responses in anesthetized mice, revealing target-specific differences in electromyographic characteristics. Even brain targets separated by as little as 1 mm can modulate the responses in individual limbs to different extents.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Review
Oncology
Shuyu Xue, Hanqiao Zeng, Shu Yan, Qianmeng Wang, Xiaojing Jia
Summary: This review discusses the controversy and progress in the clinical application of prophylactic cranial irradiation (PCI) in extensive-stage small-cell lung cancer (ES-SCLC).
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ali Yasin Sonay, Konstantinos Kalyviotis, Sine Yaganoglu, Aysen Unsal, Martina Konantz, Claire Teulon, Ingo Lieberwirth, Sandro Sieber, Shuai Jiang, Shahed Behzadi, Daniel Crespy, Katharina Landfester, Sylvie Roke, Claudia Lengerke, Periklis Pantazis
Summary: Optical imaging probes are important in disease detection, and biodegradable harmonophores offer a new approach for cancer treatment through targeted high-resolution optical imaging.
Article
Oncology
Richard P. Hill, Robert G. Bristow, Anthony Fyles, Marianne Koritzinsky, Michael Milosevic, Bradly G. Wouters
SEMINARS IN RADIATION ONCOLOGY
(2015)
Article
Oncology
Naz Chaudary, Melania Pintilie, David Hedley, Richard P. Hill, Michael Milosevic, Helen Mackay
BRITISH JOURNAL OF CANCER
(2017)
Article
Oncology
Naz Chaudary, Melania Pintilie, Salomeh Jelveh, Patricia Lindsay, Richard P. Hill, Michael Milosevic
CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
Michael F. Milosevic, Carol A. Townsley, Naz Chaudary, Blaise Clarke, Melania Pintilie, Stacy Fan, Rachel Glicksman, Masoom Haider, Sunmo Kim, Helen MacKay, Ivan Yeung, Richard P. Hill, Anthony Fyles, Amit M. Oza
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2016)
Article
Oncology
Ines Lohse, Joanna Rasowski, Pinjiang Cao, Melania Pintilie, Trevor Do, Ming-Sound Tsao, Richard P. Hill, David W. Hedley
Article
Oncology
Delphine Tamara Marie-Egyptienne, Naz Chaudary, Tuula Kalliomaeki, David William Hedley, Richard Peter Hill
Article
Oncology
Qian Tan, Marina Wang, Man Yu, Junyan Zhang, Robert G. Bristow, Richard P. Hill, Ian F. Tannock
Review
Biology
Mohammad Rezaee, Richard P. Hill, David A. Jaffray
RADIATION RESEARCH
(2017)
Review
Oncology
Magali Lecavalier-Barsoum, Naz Chaudary, Kathy Han, Marianne Koritzinsky, Richard Hill, Michael Milosevic
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Multidisciplinary Sciences
Christine How, Melania Pintilie, Jeff P. Bruce, Angela B. Y. Hui, Blaise A. Clarke, Philip Wong, Shaoming Yin, Rui Yan, Daryl Waggott, Paul C. Boutros, Anthony Fyles, David W. Hedley, Richard P. Hill, Michael Milosevic, Fei-Fei Liu
Article
Oncology
Magali Lecavalier-Barsoum, Naz Chaudary, Kathy Han, Melania Pintilie, Richard P. Hill, Michael Milosevic
BRITISH JOURNAL OF CANCER
(2019)
Correction
Oncology
Magali Lecavalier-Barsoum, Naz Chaudary, Kathy Han, Melania Pintilie, Richard P. Hill, Michael Milosevic
BRITISH JOURNAL OF CANCER
(2019)
Article
Oncology
Rachel Glicksman, Naz Chaudary, Melania Pintilie, Eric Leung, Blaise Clarke, Kieyan Sy, Richard P. Hill, Kathy Han, Anthony Fyles, Michael Milosevic
CLINICAL AND TRANSLATIONAL RADIATION ONCOLOGY
(2017)
Article
Oncology
Eric Leung, Rob A. Cairns, Naz Chaudary, Ravi N. Vellanki, Tuula Kalliomaki, Eduardo H. Moriyama, Hilda Mujcic, Brian C. Wilson, Bradly G. Wouters, Richard Hill, Michael Milosevic
Review
Radiology, Nuclear Medicine & Medical Imaging
Richard P. Hill
BRITISH JOURNAL OF RADIOLOGY
(2017)