Article
Clinical Neurology
Huaping Du, Tingting Guo, Huan Ye, Yingshi Bao, Zhuoyin Qiu, Yaming Sun, Shoujiang You, Yuan Liu, Yuan Xu, Chunqing Zhang, Chunfang Qiu
Summary: An elevated concentration of serum phosphorus is associated with carotid atherosclerosis in ischemic stroke patients, as measured by cIMT.
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Vaishali Narendra Naik, R. S. Gamad, P. P. Bansod
Summary: This study investigates the effects of three despeckle filters on the segmentation of carotid IMT in ultrasound images. The results show that the median filter performs better than the hybrid median and IACDF filters.
BIOMEDICAL JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Mengyuan Miao, Guo Zhou, Anran Bao, Yaming Sun, Huaping Du, Liyan Song, Yongjun Cao, Shoujiang You, Chongke Zhong
Summary: This study found an association between TyG index and carotid atherosclerosis in patients with ischemic stroke, suggesting that TyG could be a promising marker for atherosclerosis.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lena Tschiderer, Lisa Seekircher, Raffaele Izzo, Costantino V. Mancusi, Maria Manzi, Damiano Baldassarre, Mauro Amato, Elena Tremoli, Fabrizio Veglia, Tomi-Pekka Tuomainen, Jussi Kauhanen, Ari Voutilainen, Bernhard Iglseder, Lars Lind, Tatjana Rundek, Moise Desvarieux, Akihiko Kato, Eric de Groot, Guelay Asci, Ercan Ok, Stefan Agewall, Joline W. J. D. Beulens, Christopher C. Byrne, Philip C. Calder, Hertzel Gerstein, Paolo Gresele, Gerhard Klingenschmid, Michiaki H. Nagai, Michael Olsen, Grace S. Parraga, Maya Safarova, Naveed Sattar, Michael Skilton, Coen D. A. Stehouwer, Heiko A. Uthoff, Michiel A. van Agtmael, Amber A. van der Heijden, Dorota Zozulinska-Ziolkiewicz, Hyun-Woong Park, Moo-Sik Lee, Jang-Ho Bae, Oscar F. Beloqui, Manuel Landecho, Matthieu Plichart, Pierre Ducimetiere, Jean Philippe Empana, Lena Bokemark, Goeran Bergstroem, Caroline Schmidt, Samuela Castelnuovo, Laura D. Calabresi, Giuseppe Norata, Liliana Grigore, Alberico Catapano, Dong Zhao, Miao Wang, Jing Liu, M. Arfan Ikram, Maryam L. Kavousi, Michiel J. Bots, Michael W. Sweeting, Matthias Lorenz, Peter Willeit
Summary: This study conducted a meta-analysis of individual participant data from 20 prospective studies and found that common carotid artery intima-media thickness (CCA-IMT) is associated with the risk of developing carotid plaque, independent of traditional cardiovascular risk factors.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Clinical Neurology
Naomi Vidal Ferreira, Laiss Bertola, Itamar S. S. Santos, Alessandra C. C. Goulart, Marcio S. S. Bittencourt, Sandhi Maria Barreto, Luana Giatti, Paulo Caramelli, Alexandre Pereira, Paulo Andrade Lotufo, Isabela M. M. Bensenor, Claudia Kimie Suemoto
Summary: Carotid intima-media thickness (cIMT) is associated with cognitive decline, with a stronger association in White than in Black participants. This study highlights the importance of considering race when assessing the relationship between cIMT and cognitive decline.
ALZHEIMERS & DEMENTIA
(2023)
Article
Biology
Kristen M. Meiburger, Francesco Marzola, Guillaume Zahnd, Francesco Faita, Christos P. Loizou, Nolann Laine, Catarina Carvalho, David A. Steinman, Lorenzo Gibello, Rosa Maria Bruno, Ricarda Clarenbach, Martina Francesconi, Andrew N. Nicolaides, Herve Liebgott, Aurelio Campilho, Reza Ghotbi, Efthyvoulos Kyriacou, Nassir Navab, Maura Griffin, Andrie G. Panayiotou, Rachele Gherardini, Gianfranco Varetto, Elisabetta Bianchini, Constantinos S. Pattichis, Lorenzo Ghiadoni, Jose Rouco, Maciej Orkisz, Filippo Molinari
Summary: This study presents technical outlooks on computerized carotid intima-media thickness (CIMT) measurements and provides considerations for the development and comparison of these methods. A multi-center database of 500 images was collected and three manual segmentations and seven computerized methods were employed to measure the CIMT. The computerized methods showed comparable results with previous studies and demonstrated promising segmentation outcomes. The entire database has been made publicly available for further research and comparison.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Environmental Sciences
Yue Leon Guo, Rosario D. Ampon, Ivan C. Hanigan, Luke D. Knibbs, Christy Geromboux, Ta-Chen Su, Kazuaki Negishi, Leanne Poulos, Geoffrey G. Morgan, Guy B. Marks, Bin Jalaludin
Summary: The study found that long-term exposure to low levels of PM2.5 in children may have measurable adverse impacts on cardiovascular risk marker, carotid intima-media thickness (CIMT), by age 11-12 years.
ENVIRONMENTAL POLLUTION
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Jean-Baptiste Moretti, Reinemary Michael, Sylvie Gervais, Emilie Alchourron, Nina Stein, Ziad Farhat, Chantal Lapierre, Josee Dubois, Ramy El-Jalbout
Summary: This study aimed to determine the normal pediatric values of carotid artery intima-media thickness (IMT) by conducting a systematic review of the literature. The results showed that the average IMT in children using B-mode and radiofrequency techniques were 0.43mm and 0.41mm respectively. No significant relationship was found between IMT and age or sex.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Wenzhen Li, Dajie Chen, Yueqing Tao, Zuxun Lu, Dongming Wang
Summary: This study suggests a positive association between the TyG index and carotid atherosclerosis, with a stronger association in males and middle-aged individuals. Additionally, the relationship is stronger among individuals with normal blood pressure and underweight subjects.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Wendy Wang, Faye L. Norby, Kristen M. George, Alvaro Alonso, Thomas H. Mosley, Rebecca F. Gottesman, Michelle L. Meyer, Pamela L. Lutsey
Summary: The study found that higher levels of carotid intima-media thickness and interadventitial diameter in midlife are associated with an increased risk of dementia, while the presence of carotid plaque did not show a significant association. Higher distensibility was associated with a lower risk of dementia.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Evangelos Oikonomou, George Lazaros, Vasiliki Chara Mystakidi, Nikolaos Papaioannou, Panagiotis Theofilis, Georgia Vogiatzi, Christos Chasikidis, Petros Fountoulakis, Maria-Argentina Papakostantinou, Margarita Niki Assimakopoulos, Nikolaos Barmparesos, Panagiotis Tasios, Juan C. Kaski, Dimitris Tousoulis
Summary: The study demonstrates that residents in areas with high concentrations of gaseous air pollutants have increased carotid atherosclerotic burden and inflammation compared to residents in other regions. High levels of CO, NO2, and SO2 were observed in Region 4, where individuals also showed higher levels of C reactive protein and greater carotid plaque burden. Additionally, the propensity score analysis indicated higher differences in mean cIMT among individuals with coronary artery disease in high pollution areas compared to low pollution areas.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Qian Liu, Haozhe Cui, Shuohua Chen, Dongyan Zhang, Wei Huang, Shouling Wu
Summary: This study examined the association between baseline Life's Essential 8 (LE8) score and LE8 score trajectories with continuous carotid intima-media thickness (cIMT) and the risk of high cIMT. The study included 12,980 participants, and the results showed that higher baseline LE8 scores and LE8 score trajectories were associated with lower continuous cIMT and reduced risk of high cIMT.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Koutatsu Maruyama, Salsabila Khairunnisa, Isao Saito, Takeshi Tanigawa, Kiyohide Tomooka, Satomi Minato-Inokawa, Madoka Sano, Misaki Takakado, Ryoichi Kawamura, Yasunori Takata, Haruhiko Osawa
Summary: This study found an association between fish and omega-3 fatty acid intake and carotid intima-media thickness (C-IMT) in the Japanese population, suggesting that omega-3 fatty acid intake may protect against the development of atherosclerosis.
Article
Environmental Sciences
Johan Nilsson Sommar, Margareta Norberg, Christer Gronlund, David Segersson, Ulf Naslund, Bertil Forsberg
Summary: This study estimated the association between long-term exposure to particulate air pollution and sub-clinical atherosclerosis, finding that particle concentrations were related to plaque presence but not associated with plaque progression or carotid intima-media thickness.
ENVIRONMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jun-hao Zhang, Wei Li, Cheng-yue Wang, An-ni Zhang, Ben-zhong Jia, Ya-wei Li, Zhen-duo Shi, Kai-fa Tang, Cong-hui Han
Summary: The study aims to investigate the relationship between serum 25(OH)D and carotid artery intima-media thickness (CIMT) in men with erectile dysfunction (ED). Results showed that serum 25(OH)D levels were significantly decreased in ED patients compared to the healthy control group, while CIMT values were significantly increased in the moderate and severe ED groups compared to the control group. IIEF-5 score was positively correlated with serum 25(OH)D level and negatively correlated with CIMT value. After adjusting for confounding factors, there were significant associations between CIMT values, 25(OH)D levels, and IIEF-5 scores.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Menno P. J. de Winther, Magnus Back, Paul Evans, Delphine Gomez, Isabel Goncalves, Helle F. Jorgensen, Rory R. Koenen, Esther Lutgens, Giuseppe Danilo Norata, Elena Osto, Lea Dib, Michael Simons, Konstantinos Stellos, Seppo Yla-Herttuala, Holger Winkels, Marie-Luce Bochaton-Piallat, Claudia Monaco
Summary: The advent of single-cell biology has opened up new possibilities for understanding human biological processes and diagnosing, monitoring, and treating diseases, including cardiovascular disease (CVD). By analyzing CVD samples at the single-cell level, new cell communities that play a role in disease development can be identified, leading to new therapeutic strategies. This review focuses on the single-cell analysis of atherosclerotic plaques, highlighting the current understanding of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. The clinical impact of single-cell technologies in CVD patient care is emphasized, calling for multidisciplinary and international collaborative efforts.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Fabrizia Bonacina, Giuseppe Danilo Norata
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Lale Tokgozoglu, Carl Orringer, Alberico Catapano
EUROPEAN HEART JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Chiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barilla, Francesco Romeo, Giuseppe Novelli, Francesca Amati
Summary: Coronary heart disease (CHD) is a leading cause of disability and death globally, and its early diagnosis is challenging. A pilot study on peripheral blood cells revealed potential biomarkers, including hsa-miR-200c-3p, for the diagnosis and clinical progression of CHD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Francesca Di Lorenzo, Enrica Marchionni, Valentina Ferradini, Andrea Latini, Laura Pezzoli, Annamaria Martino, Fabiana Romeo, Annamaria Iorio, Stefano Bianchi, Maria Iascone, Leonardo Calo, Giuseppe Novelli, Ruggiero Mango, Federica Sangiuolo
Summary: Variants in desmoplakin gene (DSP) are usually associated with arrhythmogenic cardiomyopathy (ACM) or dilated cardiomyopathy (DCM) inherited in an autosomal dominant manner. This study analyzed a cohort of 18 probands with heterozygous DSP variants and identified 16 pathogenic or likely pathogenic variants. Patients generally presented as asymptomatic or mildly symptomatic, and cardiac magnetic resonance imaging revealed left ventricular myocardial fibrosis. These findings confirm that DSP-related cardiomyopathy is a distinct clinical entity characterized by a high arrhythmic burden, variable degrees of left ventricular enlargement, and myocarditis-like episodes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Giuseppe Novelli, Paola Spitalieri, Michela Murdocca, Eleonora Centanini, Federica Sangiuolo
Summary: In recent years, hiPSC-derived organoids have been extensively studied and used as in vitro models, especially for difficult-to-obtain organs and tissues. Various diseases can be accurately modeled and studied using these organoids. Patient-derived organoids (PDOs) can be used to predict individual drug responses for personalized medicine. Additionally, tissue engineering and 3D printing techniques could be used to replace or regenerate damaged tissue in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Genetics & Heredity
Ludovico Graziani, Giacomo Cinnirella, Valentina Ferradini, Chiara Conte, Federica Lo Bascio, Mario Bengala, Federica Sangiuolo, Giuseppe Novelli
Summary: Baraitser-Winter syndrome (BRWS) is a rare autosomal dominant disease caused by variants in ACTB (BRWS1) or ACTG1 (BRWS2) genes. It is characterized by developmental delay, craniofacial dysmorphisms, and various other abnormalities. We report a case of a 4-year-old girl with psychomotor delay, microcephaly, dysmorphic features, hearing loss, cardiac hypertrophy, and abdominal swelling. Exome sequencing identified a de novo variant in ACTG1 gene, expanding the spectrum of ACTG1-related disorders.
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2023)
Article
Cell Biology
Michela Murdocca, Paola Spitalieri, Maria Rosaria D'Apice, Giuseppe Novelli, Federica Sangiuolo
Summary: Aging is a complex biological process closely linked to cancer and inflammation, which are the subjects of extensive research. The accumulation of DNA damage interferes with cellular function and increases susceptibility to aging conditions.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Angela Pirillo, Alberico L. Catapano
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Elena Olmastroni, Marta Gazzotti, Maurizio Averna, Marcello Arca, Patrizia Tarugi, Sebastiano Calandra, Stefano Bertolini, Alberico L. Catapano, Manuela Casula
Summary: This study aimed to determine the prevalence of LPA risk variants in adult individuals with familial hypercholesterolemia (FH) in Italy. The study found that a portion of FH patients had high lp(a) levels, which could not be explained by monogenic or polygenic causes. It suggests the importance of measuring lp(a) levels in diagnosing FH and excluding other factors that may contribute to the phenotype before performing genetic tests.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Marcello Arca, Simone Celant, Pier Paolo Olimpieri, Antonietta Colatrella, Luca Tomassini, Laura D'Erasmo, Maurizio Averna, Alberto Zambon, Alberico Luigi Catapano, Pierluigi Russo
Summary: This study evaluated the prescription patterns and long-term efficacy of alirocumab and evolocumab in treating familial hypercholesterolemia in clinical practice. The findings showed that these two drugs had comparable LDL-C-lowering efficacy to controlled trials, but a low proportion of patients achieved the recommended LDL-C goals.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Immunology
Rossella Bellini, Annalisa Moregola, Jasmine Nour, Patrizia Uboldi, Fabrizia Bonacina, Giuseppe D. Norata
Summary: DCIR2 deficiency affects the distribution of dendritic cells in the liver and adipose tissue, but not lipid accumulation. It has a redundant role in the progression of obesity and inflammation.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Chris J. Packard, Angela Pirillo, Sotirios Tsimikas, Brian A. Ference, Alberico L. Catapano
Summary: Pharmacological approaches for reducing LDL cholesterol have been effective in reducing cardiovascular disease risk, but residual risk persists. Elevated triglycerides and triglyceride-rich lipoproteins are associated with increased cardiovascular risk, and apoC-III plays a key role in regulating their metabolism. New drugs targeting apoC-III can substantially reduce triglyceride levels.
CARDIOVASCULAR RESEARCH
(2023)
Review
Peripheral Vascular Disease
Angela Pirillo, Alberico L. Catapano
CURRENT ATHEROSCLEROSIS REPORTS
(2023)