Article
Gastroenterology & Hepatology
Nan Ru, Xiao-Nan Xu, Yu Cao, Jia-Hui Zhu, Liang-Hao Hu, Sheng-Yong Wu, Yang-Yang Qian, Jun Pan, Wen-Bin Zou, Zhao-Shen Li, Zhuan Liao
Summary: This study conducted a research on a large cohort of chronic pancreatitis patients and found that alcohol consumption and smoking are closely related to the development of pancreatic insufficiency. However, rare pathogenic gene mutations did not show significant correlation with pancreatic insufficiency.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Hongyang Shi, Yonghong Zhang, Yu Wang, Ping Fang, Yun Liu
Summary: This study found that there is a potential association between CYP4F2 gene polymorphisms and lung cancer risk, and this association may be affected by gender and smoking status.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biophysics
Xu Ding, Fengxia Wang, Hui Hu, Sarah Imhanria, Wei Wang, Ji Zhang
Summary: This study reports a facile and green strategy of fabricating catkin-like CuAg nanocomposites using tea-polyphenols as the reduction agent. The nanocomposites exhibit a catkin-like special morphology as characterized by physical characterizations. The electrochemical detection hydrogen peroxide (H2O2) results demonstrate the good sensitivity, stability, and anti-interference of the catkin-like CuAg nanocomposites, which can detect H2O2 without any additional mediator or enzyme.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Oncology
Chia-Chen Huang, Chung-Yu Lai, Chin-Hung Tsai, Jiun-Yao Wang, Ruey-Hong Wong
Summary: Our study suggests that the DNMT3B -149 TT genotype, which has higher promoter activity, can increase the lung cancer risk elicited by smoking, and DNA damage may further promote smoking related lung cancer development.
Article
Biology
Md Jakir Hossain, Utpala Nanda Chowdhury, M. Babul Islam, Shahadat Uddin, Mohammad Boshir Ahmed, Julian M. W. Quinn, Mohammad Ali Moni
Summary: Identifying differentially expressed genes associated with colorectal cancer and other risk factors, and predicting their functions through molecular pathway and protein-protein interaction analysis. Comparing the identified genes with known CRC biomarkers and conducting prognostic analysis by integrating transcriptome data to identify potential therapeutic targets and significant biomarkers.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Oncology
Jingjing Zhu, Stephanie A. Smith-Warner, Danxia Yu, Xuehong Zhang, William J. Blot, Yong-Bing Xiang, Rashmi Sinha, Yikyung Park, Shoichiro Tsugane, Emily White, Woon-Puay Koh, Sue K. Park, Norie Sawada, Seiki Kanemura, Yumi Sugawara, Ichiro Tsuji, Kim Robien, Yasutake Tomata, Keun-Young Yoo, Jeongseon Kim, Jian-Min Yuan, Yu-Tang Gao, Nathaniel Rothman, DeAnn Lazovich, Sarah K. Abe, Md Shafiur Rahman, Erikka Loftfield, Yumie Takata, Xin Li, Jung Eun Lee, Eiko Saito, Neal D. Freedman, Manami Inoue, Qing Lan, Walter C. Willett, Wei Zheng, Xiao-Ou Shu
Summary: This study found that higher consumption of coffee or tea was associated with increased lung cancer risk, but this relationship may be influenced by confounding factors such as smoking.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Chia-Chen Huang, Chung-Yu Lai, I-Hsin Lin, Chin-Hung Tsai, Shi-Mei Tsai, Kit-Lai Lam, Jiun-Yao Wang, Chun-Chieh Chen, Ruey-Hong Wong
Summary: This study aimed to evaluate the joint effects of smoking and green tea consumption on miR-29b and DNMT3B mRNA expression in lung cancer development. The results showed that lung cancer patients had lower miR-29b expression and higher DNMT3B mRNA expression, and smokers with low miR-29b and high DNMT3B mRNA expression had an elevated risk of lung cancer. The interaction of green tea consumption with miR-29b expression and DNMT3B mRNA expression in lung cancer was also significant.
Review
Oncology
Makan Cheraghpour, Masomeh Askari, Sascha Tierling, Sajad Shojaee, Amir Sadeghi, Pardis Ketabi Moghadam, Maryam Khazdouz, Hamid Asadzadeh Aghdaei, Moein Piroozkhah, Ehsan Nazemalhosseini-Mojarad, Nayeralsadat Fatemi
Summary: This study found that genetic variants in IGF1 rs6214C>T, IRS1 rs1801278G>A, and IRS2 rs1805097G>A were associated with an increased risk of colorectal cancer (CRC) through a systematic review and meta-analysis. These findings contribute to a better understanding of the complex genetic mechanisms involved in CRC development and can inform future research on prevention and treatment strategies for this disease.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Wenwen Wei, Xin Wang, Yuanzhong Zhou, Xuejun Shang, Hongsong Yu
Summary: Pregnancy-induced hypertension (PIH) is a severe pregnancy complication that can lead to maternal mortality. Various genetic factors have been shown to play an important role in the occurrence and development of PIH. This review summarizes the genetic risk factors involved in the renin-angiotensin system, endothelin system, inflammatory factors, oxidative stress, and other functional networks that may contribute to the pathogenesis of PIH.
Article
Chemistry, Multidisciplinary
Qiulan Tong, Zeng Yi, Yaqin Ran, Xiangyu Chen, Guangcan Chen, Xudong Li
Summary: This study prepared a novel antioxidative HIPPE stabilized by tea polyphenol nanoparticles, demonstrating good stability and antioxidation capacity, suitable for use in food, cosmetics, and pharmaceutical systems.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Clinical Neurology
Seo Yeon Yoon, You Hyun Park, Hyo Jeong Lee, Dae Ryong Kang, Yong Wook Kim
Summary: This study found associations between lifestyle factors and the development of Parkinson's disease (PD) in a Korean population. Smoking had an inverse association with PD in men, while alcohol consumption and physical activity were related to reduced PD development in both sexes. Regular health screening showed a consistent relationship between lifestyle factors and PD development, while lifestyle factors in those without regular health screening had a decreased relationship with PD.
Article
Food Science & Technology
Yu-Hong Chen, Yan-Hong Zhang, Gen-Sheng Chen, Jun-Feng Yin, Jian-Xin Chen, Fang Wang, Yong-Quan Xu
Summary: Phenolic acids are important components in green tea and are positively correlated with the bitterness and astringency of the tea infusion. They can increase the bitterness of epigallocatechin gallate (EGCG) while behaving differently for astringency. Gallic acid enhances astringency at all concentrations, while caffeic acid, chlorogenic acid, and Que-rut have dual effects on astringency, inhibiting at lower concentrations but enhancing at higher ones. Phenolic acids and Que-rut synergistically interact with tea infusion, and as their concentration increases, the synergistic enhancement of bitterness and astringency also increases.
NPJ SCIENCE OF FOOD
(2022)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Kyoko Kondo, Kanzo Suzuki, Masakazu Washio, Satoko Ohfuji, Satoru Adachi, Sakae Kan, Seiichiro Imai, Kunihiko Yoshimura, Naoyuki Miyashita, Nobumitsu Fujisawa, Akiko Maeda, Wakaba Fukushima, Yoshio Hirota
Summary: A large prospective cohort study in the United States found an inverse association between pneumonia and influenza deaths and coffee intake. In Japan, where the mortality rate of pneumonia in elderly people is high, a hospital-based case control study investigated the association between coffee and green tea intake and pneumonia among the elderly. The study suggested a preventive association between coffee intake over 2 cups per day and pneumonia in the elderly.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Yuan Liu, Rui Wang, Peizhen Wen, Wenbin An, Jinxin Zheng, Tao Zhang, Pengshan Zhang, Haoyu Wang, Fan Zou, Hui Pan, Junwei Fan, Zhihai Peng
Summary: This study investigated the genetic risk of patients with tacrolimus intolerance after liver transplantation. The results suggested that switching to cyclosporine (SFTC) may increase the risk of dyslipidemia and insulin resistance, while specific SNPs of CYP3A5 gene could be potential genetic risks for tacrolimus intolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Chih-Yen Tu, Fang-Ju Cheng, Chuan-Mu Chen, Shu-Ling Wang, Yu-Chun Hsiao, Chia-Hung Chen, Te-Chun Hsia, Yu-Hao He, Bo-Wei Wang, I-Shan Hsieh, Yi-Lun Yeh, Chih-Hsin Tang, Yun-Ju Chen, Wei-Chien Huang
MOLECULAR ONCOLOGY
(2018)
Article
Medicine, Research & Experimental
Yu-Hao He, Ming-Hsin Yeh, Hsiao-Fan Chen, Tsu-Shing Wang, Ruey-Hong Wong, Ya-Ling Wei, Thanh Kieu Huynh, Dai-Wei Hu, Fang-Ju Cheng, Jhen-Yu Chen, Shu-Wei Hu, Chia-Chen Huang, Yeh Chen, Jiaxin Yu, Wei-Chung Cheng, Pei-Chun Shen, Liang-Chih Liu, Chih-Hao Huang, Ya-Jen Chang, Wei-Chien Huang
Summary: This study found that mutp53 mediates lincRNA-p21 expression by targeting the G-quadruplex structure, promoting chemosensitivity, but ERα suppresses this process and upregulates DDB2 for DNA repair and chemoresistance. The results suggest that targeting lincRNA-p21 and DDB2 may increase chemosensitivity in mutp53 breast cancer patients.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)