Article
Biochemistry & Molecular Biology
Teng Guan, Ting Zhou, Xiaosha Zhang, Ying Guo, Chaoxian Yang, Justin Lin, Jiasi Vicky Zhang, Yongquan Cheng, Hassan Marzban, Yu Tian Wang, Jiming Kong
Summary: Selective removal of misfolded SOD1 delays the onset of ALS, indicating that it is a promising treatment for the disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Francesco Pantano, Martine Croset, Keltouma Driouch, Natalia Bednarz-Knoll, Michele Iuliani, Giulia Ribelli, Edith Bonnelye, Harriet Wikman, Sandra Geraci, Florian Bonin, Sonia Simonetti, Bruno Vincenzi, Saw See Hong, Sofia Sousa, Klaus Pantel, Giuseppe Tonini, Daniele Santini, Philippe Clezardin
Summary: This study identified ITGA5 as a mediator of breast-to-bone metastasis, with high expression correlating with poor bone metastasis-free survival. Silencing ITGA5 impaired tumor cell functions and bone metastasis, while inhibition with M200 showed similar effects.
Letter
Oncology
Jing Yuan, Jie Li, Zhouhuan Dong, Wei Xu, Zhanbo Wang
Summary: This is a rare case of coexistence of primary hepatic myopericytoma and multiple cystic hepatic lesions, which was successfully treated with left hemihepatectomy. The patient recovered well after surgery and showed no recurrence of the primary pathological entity.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Engineering, Biomedical
Thomas M. Grace, Lucian B. Solomon, Gerald J. Atkins, Dominic Thewlis, Mark Taylor
Summary: Estimating strain distribution in the acetabulum before and after the development of pen-prosthetic osteolytic lesions secondary to total hip arthroplasty can help understand the pathogenesis of this condition. Patient-specific finite element analysis can be used to compare the strain values from different models and determine the relationship between strain distribution and factors such as bone loss.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Oncology
Sofie Snipstad, Frida Bremnes, Mats Dehli Haugum, Einar Sulheim
Summary: This study characterized six different immunocompetent murine models based on four different cell lines, including metastatic lung cancer, triple-negative breast cancer, pancreatic cancer, and colon cancer. The responsiveness toward anti-PD1 checkpoint inhibitor varied among these models, providing insights into the heterogeneity of immune responses to immunotherapies.
Article
Chemistry, Multidisciplinary
Lan-song Xu, Su-xin Zheng, Liang-he Mei, Ke-xin Yang, Ya-fang Wang, Qiang Zhou, Xiang-tai Kong, Ming-yue Zheng, Hua-liang Jiang, Cheng-ying Xie
Summary: A novel and highly potent KRAS(G12C) inhibitor, 143D, was identified through a structure-based and focused chemical library analysis. It showed comparable antitumor efficacy to AMG510 and MRTX849 and selectively inhibited cell proliferation by downregulating KRAS(G12C)-dependent signal transduction, inducing cell cycle arrest and apoptosis.
ACTA PHARMACOLOGICA SINICA
(2023)
Review
Biochemistry & Molecular Biology
Farhana Akter, Brennan Simon, Nadine Leonie de Boer, Navid Redjal, Hiroaki Wakimoto, Khalid Shah
Summary: Researchers have developed various models for preclinical studies to recapitulate human brain tumors, but the existing animal models have limitations that need to be addressed, calling for the development of new models to bridge the gap between preclinical and clinical translation.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Medicine, Research & Experimental
Huan Ge, Caolin Wang, Chaoquan Tian, Yanyan Diao, Wanqi Wang, Xiangyu Ma, Jian Zhang, Honglin Li, Zhenjiang Zhao, Lili Zhu
Summary: WWQ-131, a highly selective JAK2 inhibitor, effectively inhibits cell proliferation, blocks aberrant activation of JAK2 signaling pathway, and shows therapeutic potential in mouse models for MPNs treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Chemistry, Medicinal
Abdellah Yamani, Daria Zdzalik-Bielecka, Joanna Lipner, Aleksandra Stanczak, Natalia Piorkowska, Paulina Seweryna Stanczak, Patrycja Olejkowska, Joanna Hucz-Kalitowska, Marta Magdycz, Karolina Dzwonek, Krzysztof Dubiel, Monika Lamparska-Przybysz, Delfina Popiel, Jerzy Pieczykolan, Maciej Wieczorek
Summary: The FGFR family comprises four receptors (FGFR 1-4) that bind to 18 ligands known as fibroblast growth factors (FGFs). A novel pyrazole-benzimidazole derivative compound 56q has been synthesized and identified as a potent pan-FGFR inhibitor showing low IC50 values for FGFR1, -2, -3. Due to its favorable pharmacokinetic profile, low toxicity, and potent anti-tumor activity, compound 56q is currently undergoing phase I clinical trials for the treatment of bladder, gastric, and squamous cell lung cancers.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Won-Min Song, Praveen Agrawal, Richard Von Itter, Barbara Fontanals-Cirera, Minghui Wang, Xianxiao Zhou, Lara K. Mahal, Eva Hernando, Bin Zhang
Summary: This study establishes predictive gene network models of molecular alterations in primary melanoma by integrating various types of data, revealing key factors influencing melanoma development. Tumors with high immune infiltrates are associated with good prognosis, potentially due to induced CD8+ T-cell cytotoxicity. Experimental validation shows that 17 key regulators associated with poor prognosis have pro-tumorigenic effects in melanoma.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Lingling Ou, Shujing Liu, Huaishan Wang, Yeye Guo, Lei Guan, Longbin Shen, Ruhui Luo, David E. Elder, Alexander C. Huang, Giorgos Karakousis, John Miura, Tara Mitchell, Lynn Schuchter, Ravi Amaravadi, Ahron Flowers, Haiwei Mou, Fan Yi, Wei Guo, Jina Ko, Qing Chen, Bin Tian, Meenhard Herlyn, Xiaowei Xu
Summary: The study presents two methods for generating melanoma patient-derived organoids (MPDOs) and demonstrates their utility in evaluating treatment effectiveness and immune cell function. The MPDOs show similar morphology and immune cell composition to their parental melanoma tissues. Anti-PD-1 antibodies reinvigorate CD8+ T cells and induce melanoma cell death in the MPDOs.
Review
Immunology
Ximing Yang, Miaozhi Gao, Runshi Xu, Yangyang Tao, Wang Luo, Binya Wang, Wenliang Zhong, Lan He, Yingchun He
Summary: Thermotherapy can be divided into thermal ablation and mild hyperthermia based on temperature difference. Both therapies have advantages in targeting tumors and inhibiting metastasis, but neither induces sustained systemic immunity. This paper summarizes the research on hyperthermia combined with immune checkpoint inhibitor (ICI) therapies and compares the efficacy of the two combinations to provide a better treatment for the recurrence and metastasis of malignant tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Deobrat Dixit, Briana C. Prager, Ryan C. Gimple, Tyler E. Miller, Qiulian Wu, Shira Yomtoubian, Reilly L. Kidwell, Deguan Lv, Linjie Zhao, Zhixin Qiu, Guoxin Zhang, Derrick Lee, Donglim Esther Park, Robert J. Wechsler-Reya, Xiuxing Wang, Shideng Bao, Jeremy N. Rich
Summary: In this study, DPY30 was identified as an in vivo-specific glioblastoma dependency using in vivo genetic screening. By examining the chromatin characteristics of glioblastoma stem cells, DPY30 was found to regulate angiogenesis and hypoxia pathways critical for tumor growth. However, DPY30 was dispensable in vitro. Additionally, DPY30 was shown to regulate the downstream effector PDE4B, with the inhibitor rolipram preferentially targeting DPY30-expressing cells and impairing the growth of patient-derived xenograft tumors in mice.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Kristin Stirm, Peter Leary, Daria Wust, Dominique Stark, Nicole Joller, Ufuk Karakus, Onur Boyman, Alexandar Tzankov, Anne Mueller
Summary: Half of DLBCLs are infiltrated by Tregs, and the presence of effector Tregs is associated with poor prognosis in DLBCL patients. However, the role of Tregs in lymphoma initiation and progression is poorly understood.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Myrto K. Moutafi, Weiwei Tao, Richard Huang, James Haberberger, Brian Alexander, Shakti Ramkissoon, Jeffrey S. Ross, Konstantinos Syrigos, Wei Wei, Lajos Pusztai, David L. Rimm, Ioannis A. Vathiotis
Summary: Metastatic lesions tend to have higher PD-L1 expression levels compared to primary lesions, with variation based on histologic subtype, sampling site, and gender. This observation may impact future patient management and trial design.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Editorial Material
Anatomy & Morphology
Erik W. W. Thompson, Guojun Sheng
CELLS TISSUES ORGANS
(2022)
Letter
Anatomy & Morphology
Guojun Sheng, Erik Thompson, Donald Newgreen, Hans-Werner Denker
CELLS TISSUES ORGANS
(2022)
Review
Hematology
Martin Vu, Koen Degeling, Ella R. Thompson, Piers Blombery, David Westerman, Maarten J. IJzerman
Summary: This study systematically reviewed the economic evidence for molecular biomarker tests in hematological malignancies and found that while there are promising health economic results, the research in this area is currently limited, with many applications of technological advances yet to be evaluated.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, Research & Experimental
Ankit P. Jain, Janani Sambath, Gajanan Sathe, Irene A. George, Akhilesh Pandey, Erik W. Thompson, Prashant Kumar
Summary: This study developed a targeted proteomics method to accurately measure the abundance of EMT-associated proteins in cancer cell lines, and revealed discrepancies between proteomic and transcriptomic data. The study also found that changes in the EMT proteome may play a role in tumor transformation across different types of cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Food Science & Technology
Renwu Zhou, Adel Rezaeimotlagh, Rusen Zhou, Tianqi Zhang, Peiyu Wang, Jungmi Hong, Behdad Soltani, Anne Mai-Prochnow, Xinyu Liao, Tian Ding, Tao Shao, Erik W. Thompson, Kostya (Ken) Ostrikov, Patrick J. Cullen
Summary: This review provides insights into the in-package plasma technology for food preservation. It has been shown that in-package plasma is effective in sterilization, maintaining food quality, and preventing cross-contamination. Recommendations are made to overcome its limitations, such as using oxygen-reduced atmospheres and advanced biopolymer materials.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Editorial Material
Genetics & Heredity
Xiaofeng Dai, Xinyu Lv, Erik W. Thompson, Kostya (Ken) Ostrikov
Summary: Y histone lactylation and acetylation compete for epigenetic modification and mark the levels of lactates and acetyl-CoA. The choice between lactate and acetyl-CoA generation from glycolysis determines cell fate towards malignancy. Controlling the glycolytic switch marked by lactylation may offer novel therapeutic opportunities against cancer.
TRENDS IN GENETICS
(2022)
Review
Oncology
Meilan Hu, Fule He, Erik W. Thompson, Kostya (Ken) Ostrikov, Xiaofeng Dai
Summary: The article aims to explore the intrinsic connections between lysine acetylation and cancer properties, and propose novel modalities such as combining histone deacetylase inhibitors with cold atmospheric plasma as precision onco-therapies.
Article
Biochemistry & Molecular Biology
Paras Jain, Sugandha Bhatia, Erik W. Thompson, Mohit Kumar Jolly
Summary: Phenotypic heterogeneity is a hallmark of aggressive cancer behavior and a clinical challenge. This study suggests that fluctuations or noise in content duplication and partitioning of the SNAIL gene during cell division can explain spontaneous phenotypic switching and dynamic heterogeneity in PMC42-LA cells.
Article
Engineering, Biomedical
Maria K. Koch, Akhilandeshwari Ravichandran, Berline Murekatete, Julien Clegg, Mary Teresa Joseph, Madison Hampson, Mitchell Jenkinson, Hannah S. Bauer, Cameron Snell, Cheng Liu, Madeline Gough, Erik W. Thompson, Carsten Werner, Dietmar W. Hutmacher, Larisa M. Haupt, Laura J. Bray
Summary: Breast cancer is a complex and dynamic disease, and the leading cause of cancer-related death in women worldwide. Evaluation of breast cancer heterogeneity is crucial for identifying new treatment strategies. A new ex vivo culture model using poly(ethylene glycol) and maleimide-functionalized heparin hydrogels is presented, which allows for the culture of human mammary tissue for up to 3 weeks and maintains the tissue structure and phenotype. The model is relevant for testing therapeutic interventions and highlights the importance of donor-to-donor variability and tissue heterogeneity.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Nathalie Bock, Farzaneh Forouz, Luke Hipwood, Julien Clegg, Penny Jeffery, Madeline Gough, Tirsa van Wyngaard, Christopher Pyke, Mark N. Adams, Laura J. Bray, Laura Croft, Erik W. Thompson, Thomas Kryza, Christoph Meinert
Summary: 3D organoid model technologies and tunable hydrogel matrices provide innovative tools for cancer precision medicine, specifically for drug testing in breast cancer by mimicking key characteristics of the disease's extracellular matrix.
Article
Chemistry, Multidisciplinary
Charlene Waryah, Joseph Cursons, Momeneh Foroutan, Christian Pflueger, Edina Wang, Ramyar Molania, Anabel Sorolla, Christopher Wallis, Colette Moses, Irina Glas, Leandro Magalhaes, Erik W. Thompson, Liam G. Fearnley, Christine L. Chaffer, Melissa Davis, Anthony T. Papenfuss, Andrew Redfern, Ryan Lister, Manel Esteller, Pilar Blancafort
Summary: This work successfully silenced ZEB1 in triple negative breast cancer (TNBC) models through CRISPR/dCas9-mediated epigenetic editing, leading to significant tumor inhibition and the discovery of ZEB1-dependent-signature genes. Epigenetic changes, including reactivation and enhanced chromatin accessibility, were observed in cell adhesion loci, indicating a shift towards a more epithelial state. Silencing of ZEB1 also induced heterochromatin expansion, DNA methylation changes, and chromatin modifications in the ZEB1 promoter. This study demonstrated the potential of epigenome-engineering approaches and customizable precision molecular oncology for targeting poor outcome breast cancers.
Review
Oncology
Charlene Waryah, Eric Alves, Roberta Mazzieri, Riccardo Dolcetti, Erik W. Thompson, Andrew Redfern, Pilar Blancafort
Summary: The article reviews the importance of epithelial plasticity in cancer development, discussing the role of epithelial-to-mesenchymal transition (EMT) in cancer metastasis, drug resistance, etc., and introduces the related regulatory factors and treatment strategies.
Article
Biotechnology & Applied Microbiology
Shengfang Wang, Peiyu Wang, Rik Thompson, Kostya Ostrikov (Ken), Yin Xiao, Yinghong Zhou
Summary: PAM can reduce the inflammatory response of macrophages by activating autophagy and promote the regeneration of periodontal tissues, making it an ideal choice for periodontitis treatment.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Sugandha Bhatia, Jennifer H. Gunter, Joshua Burgess, Mark N. Adams, Kenneth O'Byrne, Erik W. Thompson, Pascal H. G. Duijf
Summary: Epithelial-mesenchymal plasticity (EMP) is a characteristic of cancer that promotes invasion, metastasis, and therapy resistance. This study shows that non-cancerous human epithelial lung cells can spontaneously shift towards a mesenchymal-like state without genetic changes. This suggests that acquisition of metastasis-associated features may occur prior to genetic alterations and cancerous transformation.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Jinyong Lin, Dong Li, Changhong Li, Ziqi Zhuang, Chengchao Chu, Kostya (Ken) Ostrikov, Erik W. W. Thompson, Gang Liu, Peiyu Wang
Summary: Cancer cells are more susceptible to oxidative stress and nanomaterials-based therapies that generate reactive oxygen species (ROS) have been effective in eliminating cancer cells. These therapies, including chemodynamic therapy, photodynamic therapy, sonodynamic therapy, as well as multi-modal therapies such as combination therapy, have shown significant inhibition of tumor growth. However, the limitations of multi-modal therapy in material preparation and operation protocols hinder its clinical application. Cold atmospheric plasma (CAP), as a reliable source of ROS, light, and electromagnetic fields, provides a simple alternative for implementing multi-modal treatments. Therefore, the emerging field of tumor precision medicine is expected to benefit from these promising multi-modal therapies based on ROS-generating nanomaterials and reactive media like CAPs.