Review
Endocrinology & Metabolism
Robert S. Viger, Karine de Mattos, Jacques J. Tremblay
Summary: Understanding how genes are turned on and off is crucial for the development and function of different cell types. Transcription factors, such as the GATA family, play essential roles in controlling gene expression in the male gonads, impacting testis development, fetal testis gene expression, testicular disease, and XY sex differentiation in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Li Li, Rui Ni, Ziwei Li, Yue Ming, Li Liu, Dan Peng, Yongqing Cai, Yuanlin Wu, Tingting Jiang, Yanping Li, Yao Liu
Summary: This review summarizes the regulatory factors involved in the process of platelet formation, including cytokines, growth factors, transcription factors, and gene expression, as well as the roles of the TPO/Mpl signaling pathway, RasGTPases family, estrogen, and microRNAs. Understanding these molecular mechanisms contributes to a better understanding of megakaryocyte differentiation and platelet formation.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Immunology
Rong Geng, Xiaobin Huang, Linxi Li, Xin Guo, Qingru Wang, Yuhua Zheng, Xiaoling Guo
Summary: By analyzing gene expression profiles, enriching immune and metabolic pathways, and screening transcription factors, AEBP1, HOXB6, KLF2, and RORB were identified as potential biomarkers for endometriosis. Among them, KLF2 and HOXB6 were found to play crucial roles in the gene interaction network of endometriosis. Additionally, molecular docking revealed that goserelin and dienogest may target AEBP1, HOXB6, KLF2, and RORB.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Plant Sciences
Carlos Sanchez-Gomez, David Pose, Carmen Martin-Pizarro
Summary: Fruit ripening is a complex process involving various physiological and biochemical changes, aiming to maximize fruit quality and consumer acceptance. It involves changes in color, content of sugars, organic acids, and secondary metabolites, as well as remodeling of cell walls. Transcription factors and phytohormones play important roles in regulating fruit ripening.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Rheumatology
Anne B. Satterthwaite
Summary: New research has shown that TLR7 signaling plays a crucial role in driving autoimmune responses in B cells, influenced by the disease-associated cytokine environment. TLR7, IFN gamma, and IL-21 work together to promote the formation of autoreactive germinal centers and the ABC/DN2 B cell subset in systemic lupus erythematosus (SLE).
CURRENT RHEUMATOLOGY REPORTS
(2021)
Article
Genetics & Heredity
Annie Robic, Thomas Faraut, Katia Feve, Sarah Djebali, Armelle Prunier, Catherine Larzul, Laurence Liaubet
Summary: The study revealed that the transcriptional activities of key enzyme genes involved in steroid metabolism in the porcine testis are correlated, but the gene HSD17B3, which is related to testosterone production, was absent from the study group.
Article
Multidisciplinary Sciences
Phillip A. Frankino, Talha F. Siddiqi, Theodore Bolas, Raz Bar-Ziv, Holly K. Gildea, Hanlin Zhang, Ryo Higuchi-Sanabria, Andrew Dillin
Summary: The transcription factor SKN-1/NRF2 can sense and respond to changes in metabolic state. Knockdown of the amidohydrolase T12A2.1/amdh-1 activates a unique subset of SKN-1 regulated genes, independent of P38-MAPK signaling components. Histidine catabolism genes are required for this activation, possibly through accumulation of a specific catabolite. Activating SKN-1 results in increased oxidative stress resistance but decreased survival to heat stress.
Article
Biochemistry & Molecular Biology
Pengfei Cai, Wenyi Zhang, Sufei Jiang, Yiwei Xiong, Huwei Yuan, Zijian Gao, Xuanbing Gao, Cheng Ma, Yongkang Zhou, Yongsheng Gong, Hui Qiao, Shubo Jin, Hongtuo Fu
Summary: This study investigated the potential of using dsIAG to induce sex reversal in Macrobrachium nipponense and identified the molecular mechanisms underlying crustacean reproduction and sex differentiation. The results showed that dsIAG could induce partial sex reversal in M. nipponense during a critical period. Key genes related to reproduction and sex differentiation were identified through transcriptome analysis, and it was confirmed that IAG played an important role in the reproduction, growth, and metabolism of M. nipponense.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Xin Yan, Wenjie Ding, Xiuyi Wu, Lianggui Wang, Xiulian Yang, Yuanzheng Yue
Summary: This study conducted a genome-wide analysis of MYB-related proteins in sweet osmanthus and identified three genes that play a significant role in regulating the synthesis of floral volatile organic compounds (VOCs). The results provide important candidate genes for the floral aroma breeding of sweet osmanthus.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Madelaine C. Brearley-Sholto, David M. Loczenski-Brown, Sarah Jones, Zoe C. T. R. Daniel, Francis J. P. Ebling, Tim Parr, John M. Brameld
Summary: Overexpression of ISR-related genes, such as Arginase-2 and Activating transcription factor-5, in mouse skeletal muscle can lead to decreased muscle hypertrophy effects and upregulation of ISR-related gene expression. ATF5 may act as a transcriptional regulator of Idh2. Persistent overexpression of ATF5 may maintain ISR activation, leading to reduced protein synthesis and/or increased protein degradation, ultimately inhibiting muscle growth.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Yuji Nozaki
Summary: Biologics targeting inflammation-related molecules have revolutionized the treatment of rheumatoid arthritis and ANCA-associated vasculitis. However, challenges remain in treating vasculitis effectively. New drugs in clinical trials offer promising options for vasculitis treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Shanlin Shen, Jiafeng Wei, Weiting Kang, Tengteng Wang
Summary: This study identified common biomarkers and pathways shared between kidney stones and diabetes, and explored the protective effects of resveratrol. Molecular docking simulation and first-principles calculations provided evidence for resveratrol-based drug development. The study unveiled common molecular mechanisms, identified potential diagnostic biomarkers, and highlighted the role of resveratrol.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Dmitri Sviridov, Michael Bukrinsky
Summary: HIV-associated neurocognitive disorders (HAND) refer to a range of cognitive impairments that accompany HIV infection. While successful antiretroviral therapy (ART) can reduce severe forms of HAND, milder forms are still prevalent in over 50% of people living with HIV. The pathogenesis of HAND in the ART era remains unclear, but this article proposes impairment of cholesterol homeostasis and lipid rafts by the HIV-1 protein Nef as a possible contributing factor. The study explores the impact of Nef on cellular cholesterol balance and potential therapeutic targets for HAND.
Article
Oncology
Ina Dewenter, Joerg Kumbrink, Philipp Poxleitner, Wenko Smolka, Paris Liokatis, Riham Fliefel, Sven Otto, Katharina Theresa Obermeier
Summary: Oral squamous cell carcinoma (OSCC) is the most common cancer in the oral cavity, with 350,000 new cases per year globally. Curative resection and adjuvant radiation therapy or a combination of radiotherapy with chemotherapy are the standard treatment options, but local and lymph nodal recurrence, as well as radiation complications, remain major causes of mortality. Reactive oxygen species play a role in the etiology of OSCC and are also of interest in therapy.
Review
Cell Biology
Karen Yu, Paul Proost
Summary: This article provides a comprehensive overview of PAD enzyme expression at the RNA and protein levels, as well as a list of annotated substrates for each PAD isozyme. The authors discuss novel roles of citrullination in cellular growth, epigenetic regulation, tissue remodeling, inflammation, and cancer in mouse models and humans. Additionally, they cluster similar effects of protein deimination to provide a different perspective and improve understanding of citrullination in health and disease.
TRENDS IN CELL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Rok Kosir, Ursula Prosenc Zmrzljak, Anja Korencic, Peter Juvan, Jure Acimovic, Damjana Rozman
SCIENTIFIC REPORTS
(2016)
Article
Microbiology
D. Paveljsek, P. Juvan, R. Kosir, D. Rozman, B. Hacin, K. Ivicak-Kocjan, I. Rogelj
BENEFICIAL MICROBES
(2018)
Editorial Material
Gastroenterology & Hepatology
Damjana Rozman
DIGESTIVE DISEASES AND SCIENCES
(2014)
Article
Biochemistry & Molecular Biology
Wei Wang, Aino-Liisa Mutka, Ursula Prosenc Zmrzljak, Damjana Rozman, Heikki Tanila, Helena Gylling, Anne M. Remes, Henri J. Huttunen, Elina Ikonen
Article
Genetics & Heredity
Tanja Burnik Papler, Eda Vrtacnik Bokal, Klementina Fon Tacer, Peter Juvan, Irma Virant Klun, Rok Devjak
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2014)
Article
Pharmacology & Pharmacy
Jana Nekvindova, Juan Antonio Contreras, Peter Juvan, Klementina Fon Tacer, Pavel Anzenbacher, Zdenek Zidek, Michaela Kopecna Zapletalova, Damjana Rozman, Eva Anzenbacherova
Article
Multidisciplinary Sciences
Anja Korencic, Rok Kosir, Grigory Bordyugov, Robert Lehmann, Damjana Rozman, Hanspeter Herzel
SCIENTIFIC REPORTS
(2014)
Article
Multidisciplinary Sciences
Jure Acimovic, Sandeep Goyal, Rok Kosir, Marko Golicnik, Martina Perse, Ales Belic, Ziga Urlep, F. Peter Guengerich, Damjana Rozman
SCIENTIFIC REPORTS
(2016)
Article
Biotechnology & Applied Microbiology
Matteo Cereda, Uberto Pozzoli, Gregor Rot, Peter Juvan, Anthony Schweitzer, Tyson Clark, Jernej Ule
Article
Biochemistry & Molecular Biology
Kaja Blagotinsek Cokan, Ziga Urlep, Miha Moskon, Miha Mraz, Xiang Yi Kong, Winnie Eskild, Damjana Rozman, Peter Juvan, Tadeja Rezen
Summary: Through mouse models, it was found that various genetic models of liver fibrosis exhibit a common transcriptional program and downregulated lipid pathways, while different metabolic subtypes of liver fibrosis were proposed, aiding in improved stratification of other fibrosis-related pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Ursula Prosenc Zmrzljak, Rok Kosir, Zoran Krivokapic, Dragica Radojkovic, Aleksandra Nikolic
Summary: Liquid biopsy and cell-free DNA have great potential in cancer diagnostics, with a custom ddPCR assay designed for quantification of cfDNA in serum. The study validated the assay on CRC patients, hemorrhoid patients, and healthy controls, comparing mutation status in primary tumors and cfDNA isolated from serum. The findings suggest caution in interpreting decisions based solely on cfDNA levels in patient serum, and explore the potential of ddPCR somatic mutations detection from liquid biopsy as a supplement to tissue biopsy in personalized CRC patient management.
Article
Toxicology
Luise Hochmuth, Christiane Korner, Fritzi Ott, Daniela Volke, Kaja Blagotinsek Cokan, Peter Juvan, Mario Brosch, Ute Hofmann, Ralf Hoffmann, Damjana Rozman, Thomas Berg, Madlen Matz-Soja
Summary: The liver is one of the most sexually dimorphic organs, with significant differences in metabolic pathways and disease prevalence between males and females. Research shows that sex affects gene expression, proteome, and metabolome parameters of liver cells, which may have important implications for drug metabolism, treatment, and efficacy.
ARCHIVES OF TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jelena Munjas, Miron Sopic, Aleksandra Stefanovic, Rok Kosir, Ana Ninic, Ivana Joksic, Tamara Antonic, Vesna Spasojevic-Kalimanovska, Ursula Prosenc Zmrzljak
Summary: Preeclampsia is a significant cause of maternal and neonatal morbidity and mortality worldwide, with abnormalities in lncRNAs and miRNAs in the placenta being associated with its pathophysiology. Currently, there is a lack of clinically available predictive biomarkers for Preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Vilim Molnar, Vid Matisic, Ivan Kodvanj, Roko Bjelica, Zeljko Jelec, Damir Hudetz, Eduard Rod, Fabijan Cukelj, Trpimir Vrdoljak, Dinko Vidovic, Mario Staresinic, Srecko Sabalic, Borut Dobricic, Tadija Petrovic, Darko Anticevic, Igor Boric, Rok Kosir, Ursula Prosenc Zmrzljak, Dragan Primorac
Summary: Osteoarthritis is a common cause of disability worldwide, affecting all joint tissues equally. The pathogenesis involves low-grade inflammation leading to an imbalance between anabolic and catabolic processes. The complex network of cytokines regulating these processes plays a central role in the development and progression of osteoarthritis, with concentrations of proinflammatory and anti-inflammatory cytokines varying based on disease stage and activity levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)