Review
Medicine, Research & Experimental
Yi Qin, Zhong-hua Chen, Jun-Jie Wu, Zhen-Yu Zhang, Zheng-Dong Yuan, Dan-Yang Guo, Meng-Nan Chen, Xia Li, Feng-Lai Yuan
Summary: The circadian clock plays a crucial role in regulating bone metabolism, including bone loss. Clock-related genes control signaling pathways and transcription factors in osteoblasts and osteoclasts, while also regulating osteocytes and endothelial cells. Furthermore, the regulation of circadian clock genes by novel modulators presents a potential strategy for preventing and treating bone diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Qin Zhou, Kankan Wang, Jiameng Qiu, Di Zhu, Tian Tian, Yunfei Zhang, Ximing Qin
Summary: Bipolar disorder is a psychiatric disorder characterized by alternate episodes of mania and depression. Studies have found that lithium salt can upregulate the expression of the clock gene Per2 by reducing the expression of the transcription factor E4BP4. This provides a new therapeutic target and approach for treating BPD.
Article
Clinical Neurology
Himanshu K. Mishra, Heather Wei, Kayla E. Rohr, Insu Ko, Caroline M. Nievergelt, Adam X. Maihofer, Paul D. Shilling, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark Frye, Fred Gage, Elliot Gershon, Melvin G. McInnis, John Nurnberger, Ketil J. Oedegaard, Peter P. Zandi, John R. Kelsoe, Michael J. McCarthy
Summary: Bipolar disorder (BD) is characterized by mood episodes, disrupted circadian rhythms, and gray matter reduction in the brain. Lithium, an effective pharmacotherapy for BD, has neuroprotective properties and beneficial effects on circadian rhythms that may distinguish lithium responders (Li-R) from non-responders (Li-NR). Patterns of co-expression among circadian clock and cell survival genes were found in BD patients and controls, as well as in Li-R vs. Li-NR cells. The coordination between circadian clock and cell survival genes in BD may help predict lithium response.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Karolina Liska, Tereza Dockal, Pavel Houdek, Martin Sladek, Vendula Luzna, Kateryna Semenovykh, Milica Drapsin, Alena Sumova
Summary: Lithium affects the circadian clock in the ventricle barrier complex, and its therapeutic effects may be related to improving brain function in psychiatric patients. The study suggests that personalized timing of lithium treatment is important for bipolar disorder patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
He Ma, Songtao Liu, Pingping Wei, Fan Fei, Jilong Ren, Mingyun Dai, Zhen Ma, Ying Liu
Summary: The study found that light spectrum can affect the biological clock system of fish, influencing the expression of clock genes in the fish brain and disrupting the rhythm of gene expression of the biological clock. The findings highlight the importance of light spectrum information in the fish brain circadian system.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Matteo Astone, Roxana E. Oberkersch, Giovanni Tosi, Alberto Biscontin, Massimo M. Santoro
Summary: This study demonstrates that endothelial cells possess an endogenous circadian clock, and core clock genes exhibit robust circadian oscillations. Impairing the function of the circadian clock transcriptional activator BMAL1 leads to angiogenesis defects in both developmental and pathological contexts. BMAL1 regulates endothelial cell cycle progression by binding to the promoters of CCNA1 and CDK1 genes.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Himanshu K. Mishra, Noelle M. Ying, Angelica Luis, Heather Wei, Metta Nguyen, Timothy Nakhla, Sara Vandenburgh, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark A. Frye, Fred H. Gage, Elliot S. Gershon, Melvin G. McInnis, Caroline M. Nievergelt, John I. Nurnberger, Paul D. Shilling, Ketil J. Oedegaard, Peter P. Zandi, R. Kelsoe John, David K. Welsh, Michael J. McCarthy
Summary: Neuronal circadian rhythm abnormalities are present in patients with bipolar disorder, with the most pronounced deficits observed in individuals who do not respond to lithium treatment. Stimulation of entrainment pathways may partly reverse these rhythm deficits.
MOLECULAR PSYCHIATRY
(2021)
Article
Biochemistry & Molecular Biology
Weiyun Zhang, Chi-Tang Ho, Muwen Lu
Summary: This study found that piperine improves lipid metabolism disorders in HepG2 cells by regulating the Bmal1 and Clock genes, reducing circadian desynchrony, ROS overproduction, and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou
Summary: This paper reviews the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2022)
Article
Multidisciplinary Sciences
Nisha Misra, Manohar Damara, Pierre Chambon
Summary: This article investigates the role of transcriptional regulators RevErbα, E4BP4, and CRY1/PER1 in generating circadian rhythms. Molecular and genetic analyses reveal that the chromatin protein HP1α plays a crucial role in transcriptional repressions of circadian clock genes and their output genes. The presence of HP1α is critical for chromatin compaction, formation of repressed biomolecular hydrophobic condensates, and recruitment and methylation of DNA methylating enzymes on the intronic deoxyCpG islands within the circadian output genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Maria Savino, Claudio Carmine Guida, Maria Nardella, Emanuele Murgo, Bartolomeo Augello, Giuseppe Merla, Salvatore De Cosmo, Antonio Fernando Savino, Roberto Tarquini, Francesco Cei, Filippo Aucella, Gianluigi Mazzoccoli
Summary: This article investigates the relationship between heme biosynthesis disorders and altered expression of circadian genes, finding that changes in circadian gene expression may be associated with the symptoms and signs of porphyria patients.
Article
Biochemical Research Methods
Prabina Kumar Meher, Ansuman Mohapatra, Subhrajit Satpathy, Anuj Sharma, Isha Saini, Sukanta Kumar Pradhan, Anil Rai
Summary: A computational method based on Support Vector Machine (SVM) was developed to identify circadian genes, achieving an accuracy of 62.48%. The method was also applied for proteome-wide identification of circadian proteins in two cereal crops and functional annotation with Gene Ontology terms.
Review
Biochemistry & Molecular Biology
Sara M. Ortega-Campos, Eva M. Verdugo-Sivianes, Ana Amiama-Roig, Jose R. Blanco, Amancio Carnero
Summary: The molecular machinery of the circadian clock regulates gene expression and cellular activities to adapt to daily light-dark cycles. Disruption of the circadian rhythm is an independent risk factor for cancer and circadian genes may play dual roles as tumor suppressors and oncogenes. Understanding the molecular basis of the circadian clock can help identify new markers and targets for cancer prognosis and therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Psychiatry
Kounseok Lee, Hye-Kyung Lee, Sunhae Kim, Seok Hyeon Kim
Summary: The study found that evening-type university students were more likely to experience hypomanic symptoms, while there was no significant difference between intermediate-type and morning-type groups among male students. The evening-type group had a higher positive response rate for most items in the MDQ.
PSYCHIATRY RESEARCH
(2021)
Article
Microbiology
Zala Zuzek, Lucija Raspor Dall'Olio, Katka Pohar, Alojz Ihan, Miha Moskon, Damjana Rozman, Ursa Kovac, Marjanca Starcic Erjavec
Summary: Research has shown that dysbiosis of gut microbiota can affect the circadian clock of mammalian hosts, highlighting the importance of genetic background of E. coli in influencing the host's circadian clock genes.
Article
Biochemistry & Molecular Biology
Azmeraw T. Amare, Klaus Oliver Schubert, Liping Hou, Scott R. Clark, Sergi Papiol, Micah Cearns, Urs Heilbronner, Franziska Degenhardt, Fasil Tekola-Ayele, Yi-Hsiang Hsu, Tatyana Shekhtman, Mazda AdIi, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Stephane Jamain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Stefan Herms, Per Hoffmann, Andrea Hofmann, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John R. Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Koenig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Alfonso Tortorella, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Noethen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Urban Osby, Andrea Pfennig, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Mario Maj, Gustavo Turecki, Eduard Vieta, Julia Veeh, Stephanie H. Witt, Adam Wright, Peter P. Zandi, Philip B. Mitchell, Michael Bauer, Martin Alda, Marcella Rietschel, Francis J. McMahon, Thomas G. Schulze, Bernhard T. Baune
Summary: The study found a significant association between polygenic susceptibility to major depression and response to lithium treatment in patients with bipolar disorder. Patients with a lower polygenic load for depression were more likely to respond well to lithium. This highlights the genetic contribution to lithium response in bipolar disorder and supports the concept of a lithium-responsive biotype.
MOLECULAR PSYCHIATRY
(2021)
Editorial Material
Clinical Neurology
Monica Federoff, Michael J. McCarthy
Article
Biochemistry & Molecular Biology
Himanshu K. Mishra, Noelle M. Ying, Angelica Luis, Heather Wei, Metta Nguyen, Timothy Nakhla, Sara Vandenburgh, Martin Alda, Wade H. Berrettini, Kristen J. Brennand, Joseph R. Calabrese, William H. Coryell, Mark A. Frye, Fred H. Gage, Elliot S. Gershon, Melvin G. McInnis, Caroline M. Nievergelt, John I. Nurnberger, Paul D. Shilling, Ketil J. Oedegaard, Peter P. Zandi, R. Kelsoe John, David K. Welsh, Michael J. McCarthy
Summary: Neuronal circadian rhythm abnormalities are present in patients with bipolar disorder, with the most pronounced deficits observed in individuals who do not respond to lithium treatment. Stimulation of entrainment pathways may partly reverse these rhythm deficits.
MOLECULAR PSYCHIATRY
(2021)
Review
Clinical Neurology
Michael J. McCarthy, John F. Gottlieb, Robert Gonzalez, Colleen A. McClung, Lauren B. Alloy, Sean Cain, Davide Dulcis, Bruno Etain, Benicio N. Frey, Corrado Garbazza, Kyle D. Ketchesin, Dominic Landgraf, Heon-Jeong Lee, Cynthia Marie-Claire, Robin Nusslock, Alessandra Porcu, Richard Porter, Philipp Ritter, Jan Scott, Daniel Smith, Holly A. Swartz, Greg Murray
Summary: Symptoms of bipolar disorder include changes in mood, activity, energy, sleep, and appetite, with circadian rhythm disturbance considered a biological feature underlying BD. Research has found associations between the circadian system and mood regulation, but circadian disruption is not specific to BD and is present across various psychiatric disorders. Future studies on circadian rhythms and its role in BD should carefully define associations and integrate across levels of analysis for more comprehensive insights.
Article
Clinical Neurology
Monica Federoff, Michael J. McCarthy, Amit Anand, Wade H. Berrettini, Holli Bertram, Abesh Bhattacharjee, Cynthia Calkin, Carla Conroy, William H. Coryell, Nicole D'Arcangelo, Anna DeModena, Carrie Fisher, Scott Feeder, Nicole Frazier, Mark A. Frye, Keming Gao, Julie Garnham, Elliot S. Gershon, Ney Alliey-Rodriguez, Kara Glazer, Fernando Goes, Toyomi Karberg, Gloria Harrington, Petter Jakobsen, Masoud Kamali, Marisa Kelly, Susan G. Leckband, Falk Lohoff, Adam X. Maihofer, Melvin G. McInnis, Francis Mondimore, Gunnar Morken, John Nurnberger, Ketil J. Oedegaard, Megan Ritchey, Kelly Ryan, Martha Schinagle, Helle Schoeyen, Candice Schwebel, Martha Shaw, Paul D. Shilling, Claire Slaney, Andrea Stautland, Bruce Tarwater, Joseph R. Calabrese, Martin Alda, Caroline M. Nievergelt, Peter P. Zandi, John R. Kelsoe
Summary: Exposure to lithium is associated with reduced circadian disruption, and lithium response at 12 weeks was selectively associated with the reduction of circadian depressive symptoms.
Article
Psychiatry
Micah Cearns, Azmeraw T. Amare, Klaus Oliver Schubert, Anbupalam Thalamuthu, Joseph Frank, Fabian Streit, Mazda Adli, Nirmala Akula, Kazufumi Akiyama, Raffaella Ardau, Barbara Arias, Jean-Michel Aubry, Lena Backlund, Abesh Kumar Bhattacharjee, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Joanna M. Biernacka, Armin Birner, Clara Brichant-Petitjean, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Alexandre Dayer, Franziska Degenhardt, Maria Del Zompo, J. Raymond De Paulo, Bruno Etain, Peter Falkai, Andreas J. Forstner, Louise Frisen, Mark A. Frye, Janice M. Fullerton, Sebastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Andrea Hofmann, Liping Hou, Yi Hsiang Hsu, Stephane Jamain, Esther Jimenez, Jean-Pierre Kahn, Layla Kassem, Po-Hsiu Kuo, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Barbara Konig, Ichiro Kusumi, Gonzalo Laje, Mikael Landen, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Lina Martinsson, Michael J. McCarthy, Susan McElroy, Francesc Colom, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Markus M. Nothen, Tomas Novak, Claire O'Donovan, Norio Ozaki, Vincent Millischer, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fasil Tekola-Ayele, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Stephanie H. Witt, Gloria Roberts, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Thomas G. Schulze, Marcella Rietschel, Scott R. Clark, Bernhard T. Baune
Summary: This study utilized a combination of genetic and clinical factors to predict lithium response in patients with bipolar disorder. By stratifying patients genetically and training machine-learning models with clinical predictors, significant improvements in lithium response prediction were achieved.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Review
Neurosciences
Kayla E. Rohr, Michael J. McCarthy
Summary: Studies have shown that lithium affects cellular circadian rhythms and increases morningness behaviors in bipolar disorder (BD) patients, which may contribute to its therapeutic effects. However, current evidence is limited and further research is needed to understand the exact mechanisms behind lithium's effects on circadian rhythms and the longitudinal changes in circadian rhythms in BD patients.
NEUROSCIENCE LETTERS
(2022)
Biographical-Item
Neurosciences
Michael J. J. McCarthy, Maria Hadjiconstantinou
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Himanshu K. Mishra, Atulya D. Mandyam, Wulfran Trenet, Heather Wei, Caroline M. Nievergelt, Adam X. Maihofer, Paul D. Shilling, Martin Alda, Elliot Gershon, John R. Kelsoe, Michael J. McCarthy, Melvin G. McInnis
Summary: Bipolar disorder (BD) is a psychiatric illness characterized by manic and depressive episodes. Lithium is commonly used as a treatment, but only a subset of patients respond to it. This study examined the effects of METH on neuronal cells derived from lithium responder (Li-R) and nonresponder (Li-NR) BD patients, as well as healthy controls. The results showed that Li-R cells were less vulnerable to METH-induced cell death compared to Li-NR cells and controls. Additionally, pre-treatment with a dopamine receptor antagonist reversed the neurotoxic effects of METH. These findings suggest that dopamine signaling and lithium response may play a role in the pathophysiology of BD.
Article
Psychiatry
Michael J. Mccarthy, Ty Brumback, Michael L. Thomas, Alejandro D. Meruelo
Summary: This study analyzed a sample of high-risk adolescents and found associations between chronotype, stressful life events, and impulsivity. Increased eveningness was associated with a higher number of stressful life events and increased impulsivity.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Meeting Abstract
Neurosciences
Michael McCarthy, Connor McCabe, Alejandro Meruelo
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Kayla Rohr, Michael McCarthy
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Psychiatry
Rizaldy C. Zapata, Allison Silver, Dongmin Yoon, Besma Chaudry, Avraham Libster, Michael J. McCarthy, Olivia Osborn
Summary: This study investigates the interaction between antipsychotic drugs (AP), circadian rhythms, and metabolic side-effects. Through experiments on mice and observations on humans, it is found that the timing of AP dosing has a significant impact on the development of metabolic side-effects. Additionally, time restricted feeding (TRF) is identified as a potential intervention to mitigate AP-induced metabolic side-effects. These findings provide insight into methods for reducing metabolic side-effects associated with AP.
Meeting Abstract
Neurosciences
Neal Swerdlow, Yash Joshi, Juan Molina, Michael McCarthy
BIOLOGICAL PSYCHIATRY
(2022)
Article
Immunology
Michael J. Mccarthy
Summary: This article reviews ME/CFS from the perspective of circadian rhythms, focusing on the disrupted TGFB signaling that may play a role in disrupting physiological rhythms in sleep, activity, and cognition associated with ME/CFS. Advances in chronobiology and biomarker research justify renewed interest in circadian rhythm research in ME/CFS, especially in the context of the COVID-19 pandemic.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2022)