Article
Genetics & Heredity
Borel Djiappi-Tchamen, Mariette Stella Nana-Ndjangwo, Konstantinos Mavridis, Abdou Talipouo, Elysee Nchoutpouen, Idene Makoudjou, Roland Bamou, Audrey Marie Paul Mayi, Parfait Awono-Ambene, Timoleon Tchuinkam, John Vontas, Christophe Antonio-Nkondjio
Summary: The study investigated insecticide susceptibility and resistance mechanisms in Aedes mosquitoes from urban Cameroon, revealing resistance in Aedes aegypti in Douala and detection of kdr mutations. Overexpression of detoxification genes was observed in Aedes aegypti populations from Douala and Yaounde. The emergence of insecticide resistance in Aedes mosquitoes in Cameroon highlights the need for alternative strategies in arboviral vector-borne disease control.
Article
Agronomy
Hasan Mohammad Al-Amin, Narayan Gyawali, Melissa Graham, Mohammad Shafiul Alam, Audrey Lenhart, Leon E. Hugo, Gordana Rasic, Nigel W. Beebe, Gregor J. Devine
Summary: Dengue control in Bangladesh relies on targeting the primary vector Aedes aegypti with insecticides and larval source management. However, intense insecticide resistance in vector populations is compromising the effectiveness of control strategies. A more sustainable and effective approach is needed.
PEST MANAGEMENT SCIENCE
(2023)
Article
Infectious Diseases
Matthew Montgomery, James F. Harwood, Aurelie P. Yougang, Theodel A. Wilson-Bahun, Armel N. Tedjou, Christophe Rostand Keumeni, Auston Marm Kilpatrick, Charles S. Wondji, Basile Kamgang
Summary: The study revealed resistance of Aedes aegypti and Ae. albopictus to multiple insecticides, with multiple resistance mechanisms identified, which could guide insecticide use for controlling arbovirus vectors in Cameroon.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Microbiology
Wendy S. Salinas, Teresa P. Feria-Arroyo, Christopher J. Vitek
Summary: The study found that Aedes albopictus had higher susceptibility to insecticides compared to Aedes aegypti, and mosquitoes kept at different temperatures exhibited varying levels of susceptibility to insecticides. The results suggest that public health officials should consider the temperature effects when controlling mosquitoes with insecticides.
Article
Biochemistry & Molecular Biology
Yifan Wang, Xin Wang, Dylan J. Brown, Mengru An, Rui-De Xue, Nannan Liu
Summary: This study investigates the resistance of Aedes aegypti mosquitoes to common insecticides and explores the mechanisms behind the resistance. The study finds that both detoxification through cytochrome P450 and mutations in voltage-gated sodium channels contribute to the high levels of resistance.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Entomology
Andrea Arevalo-Cortes, Yurany Granada, David Torres, Omar Triana-Chavez
Summary: This study analyzed the characteristics of Aedes aegypti populations from different cities in Colombia, including lifespan, fecundity, and mortality. The study found that each population had unique features and patterns, which are important for determining the timing of insecticide application and surveillance.
Article
Biochemistry & Molecular Biology
Woottichai Nachaiwieng, Jintana Yanola, Saowanee Chamnanya, Nongkran Lumjuan, Pradya Somboon
Summary: This study demonstrates that Aedes aegypti and Culex quinquefasciatus have high resistance to pyrethroids. The sprays containing both type I and type II pyrethroids were more effective in controlling these mosquitoes than those containing only type I pyrethroids or pyrethrum with the synergist piperonyl butoxide. High frequencies of mutant alleles were found in survivor groups of both mosquito species.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Evolutionary Biology
Jennifer Baltzegar, Michael Vella, Christian Gunning, Gissella Vasquez, Helvio Astete, Fred Stell, Michael Fisher, Thomas W. Scott, Audrey Lenhart, Alun L. Lloyd, Amy Morrison, Fred Gould
Summary: This study investigates the evolution of knockdown resistance (kdr) haplotypes in Aedes aegypti over 18 years in Iquitos, Peru, in response to pyrethroid insecticide use. The research provides evidence of a direct connection between citywide pyrethroid spraying and the increase in frequency of specific kdr haplotypes, and highlights the rapid evolution of Ae. aegypti populations even under infrequent insecticide pressure. In addition to temporal shifts, spatial suppression experiments demonstrate genetic heterogeneity at both citywide and fine scales within the city.
EVOLUTIONARY APPLICATIONS
(2021)
Article
Parasitology
Abadi M. Mashlawi, Ashwaq M. Al-Nazawi, Elsiddig M. Noureldin, Hussain Alqahtani, Jazem A. Mahyoub, Jassada Saingamsook, Mustapha Debboun, Martha Kaddumukasa, Hesham M. Al-Mekhlafi, Catherine Walton
Summary: Research conducted in southwestern Saudi Arabia found that Aedes aegypti populations carry three known kdr mutations, as well as wild type genotypes. Investigation in Saudi Arabia and other countries showed higher genetic diversity in Saudi Arabia, particularly in Jazan and Sahil regions, compared to Jeddah, Makkah, and Madinah regions.
PARASITES & VECTORS
(2022)
Article
Plant Sciences
Adalberto Alves Pereira Filho, Grasielle C. D'Avila Pessoa, Lydia F. Yamaguchi, Mariana Alves Stanton, Artur M. Serravite, Rafael H. M. Pereira, Welber S. Neves, Massuo Jorge Kato
Summary: The study revealed the larvicidal activity of essential oils from Piper species against Aedes aegypti, showing similar efficacy in strains resistant and susceptible to pyrethroids. Phenylpropanoids and monoterpenes were identified as the main active compounds in the oils, demonstrating high toxicity to larvae.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Parasitology
Christopher M. Owusu-Asenso, Julius A. A. Mingle, David Weetman, Yaw A. Afrane
Summary: This study investigated the spatiotemporal distribution and insecticide resistance status of Aedes aegypti across different ecological zones in Ghana. The results showed that Aedes mosquitoes were found at high densities in all areas and exhibited resistance to certain insecticides. These findings are important for the development of effective vector control programs.
PARASITES & VECTORS
(2022)
Article
Biochemistry & Molecular Biology
Rui Chen, Daniel R. Swale
Summary: The primary mechanism by which mature neurons maintain low intracellular chloride (Cl-) concentration is through the K+/Cl- cotransporter (KCC), which is functionally coupled to the GABA-gated chloride channels (GGCC) in Drosophila central neurons. This study investigated the physiological drivers of KCC function and interactions of ion flux mechanisms upstream of GGCC in insects using electrophysiological and fluorescent microscopy techniques. The findings suggest a functional coupling between inward rectifier potassium (Kir) 2 channels and KCC, expanding our understanding of the physiological roles of KCC and Kir channels in the insect nervous system.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Virology
Kauara Brito Campos, Abdullah A. Alomar, Bradley H. Eastmond, Marcos Takashi Obara, Barry W. Alto
Summary: Aedes aegypti mosquitoes with higher insecticide resistance have lower susceptibility to Zika virus infection.
Article
Biology
Jun Isoe, Carter J. Simington, Max E. Oscherwitz, Alyssa J. Peterson, Alberto A. Rascon, Brooke B. Massani, Roger L. Miesfeld, Michael A. Riehle
Summary: This study identified several essential proteins for eggshell formation in Aedes aegypti and characterized their roles through molecular and biochemical approaches. These proteins, along with additional secreted eggshell enzymes, provide potential targets for future mosquito control strategies. Further research is needed to fully understand the mechanisms by which these proteins regulate eggshell formation and melanization.
Article
Parasitology
Miriam Palomino, Jesus Pinto, Pamela Yanez, Anali Cornelio, Luciana Dias, Quesia Amorim, Ademir Jesus Martins, Audrey Lenhart, Jose Bento Pereira Lima
Summary: This study demonstrates the varying intensities of temephos resistance in Ae. aegypti populations in Peru, even three years after the discontinuation of temephos use. Continued monitoring of resistance to this larvicide is necessary as resistance may decrease in the absence of routine selection pressures.
PARASITES & VECTORS
(2022)
Review
Infectious Diseases
Nicole L. Achee, John P. Grieco, Hassan Vatandoost, Goncalo Seixas, Joao Pinto, Lee Ching-Ng, Ademir J. Martins, Waraporn Juntarajumnong, Vincent Corbel, Clement Gouagna, Jean-Philippe David, James G. Logan, James Orsborne, Eric Marois, Gregor J. Devine, John Vontas
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Infectious Diseases
Gabriela de Azambuja Garcia, Gabriel Sylvestre, Raquel Aguiar, Guilherme Borges da Costa, Ademir Jesus Martins, Jose Bento Pereira Lima, Martha T. Petersen, Ricardo Lourenco-de-Oliveira, Marion F. Shadbolt, Gordana Rasic, Ary A. Hoffmann, Daniel A. M. Villela, Fernando B. S. Dias, Yi Dong, Scott L. O'Neill, Luciano A. Moreira, Rafael Maciel-de-Freitas
PLOS NEGLECTED TROPICAL DISEASES
(2019)
Article
Parasitology
Eric Luiz Rodrigues de Sa, Cynara de Melo Rodovalho, Nilciane Pinto Ribeiro de Sousa, Ivy Luizi Rodrigues de Sa, Diogo Fernandes Bellinato, Luciana dos Santos Dias, Luana Carrara da Silva, Ademir Jesus Martins, Jose Bento Pereira Lima
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2019)
Article
Parasitology
Luana Cristina Farnesi, Thiago Affonso Belinato, Joao Silveira Moledo Gesto, Ademir Jesus Martins, Rafaela Vieira Bruno, Luciano Andrade Moreira
PARASITES & VECTORS
(2019)
Review
Parasitology
Ramon Pereira Lopes, Jose Bento Pereira Lima, Ademir Jesus Martins
PARASITES & VECTORS
(2019)
Article
Parasitology
Ramao Luciano Nogueira Hayd, Luana Carrara, Joel de Melo Lima, Nathalia Coelho Vargas de Almeida, Jose Bento Pereira Lima, Ademir Martins
PARASITES & VECTORS
(2020)
Article
Infectious Diseases
Luciano Veiga Cosme, Andrea Gloria-Soria, Adalgisa Caccone, Jeffrey Robert Powell, Ademir Jesus Martins
PLOS NEGLECTED TROPICAL DISEASES
(2020)
Article
Parasitology
Carlucio Rocha dos Santos, Cynara de Melo Rodovalho, Willy Jablonka, Ademir Jesus Martins, Jose Bento Pereira Lima, Luciana dos Santos Dias, Mario Alberto Cardoso da Silva Neto, Georgia Correa Atella
PARASITES & VECTORS
(2020)
Article
Multidisciplinary Sciences
Monique Melo Costa, Kauara Brito Campos, Luiz Paulo Brito, Emmanuel Roux, Cynara Melo Rodovalho, Diogo Fernandes Bellinato, Jose Bento Pereira Lima, Ademir Jesus Martins
SCIENTIFIC REPORTS
(2020)
Article
Multidisciplinary Sciences
Rafi Ur Rahman, Barbara Souza, Iftikhar Uddin, Luana Carrara, Luiz Paulo Brito, Monique Melo Costa, Muhammad Asif Mahmood, Sozaina Khan, Jose Bento Pereira Lima, Ademir Jesus Martins
Summary: Research found that Aedes populations in Lahore show resistance to pyrethroids while being susceptible to organophosphates and insect growth regulators. High frequency kdr haplotypes were observed in Ae. aegypti, and PBO increased sensitivity to permethrin. Multiple mechanisms, such as kdr mutations and P450 overexpression, are likely responsible for the resistance observed.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Rafi Ur Rahman, Luciano Veiga Cosme, Monique Melo Costa, Luana Carrara, Jose Bento Pereira Lima, Ademir Jesus Martins
Summary: Research found that Aedes aegypti populations in RJ are becoming more susceptible to larvicide temephos, with lower resistance ratios in populations where gene flow might be occurring. Additionally, populations were susceptible to pyriproxyfen and malathion, highly resistant to deltamethrin, and partially explained by high frequencies of kdr alleles. Population genetic analysis identified potential genetic clusters within RJ populations and higher gene flow in a touristic region. The study highlights the importance of monitoring insecticide resistance and genetic diversity for effective vector control programs.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Parasitology
Bruno Gomes, Huarlen Ogelio, Fabiane Brant, Camila Jesus Pereira-Pinto, Michael J. Workman, Monique Costa, Jose Bento Pereira Lima, Ademir Jesus Martins, Marcelo Ramalho-Ortigao, Ravi Durvasula, Ivy Hurwitz, Mariana Rocha David, Fernando Ariel Genta
Summary: The study assessed the efficacy of an orange oil-based larvicide against Ae. aegypti strains with different resistance statuses and found it to be highly active in both laboratory and environmental conditions. This suggests the potential for developing orange oil as an alternative intervention for populations with resistance to common insecticides.
PARASITES & VECTORS
(2021)
Article
Multidisciplinary Sciences
Barbara S. Souza, Leticia F. Lima, Allan K. R. Galardo, Vincent Corbel, Jose Bento P. Lima, Ademir J. Martins
Summary: Insecticide resistance in Aedes aegypti populations in Amapa State, Brazil, poses a significant threat to disease control. This study investigated the genetic structure and spread of kdr mutations in these populations and found a widespread distribution of these mutations. The study also revealed the presence of genetic differentiation among mosquito populations and suggested the existence of passive gene flow between clusters.
SCIENTIFIC REPORTS
(2023)
Article
Parasitology
Aline Cordeiro Loureiro, Alejandra Saori Araki, Rafaela Vieira Bruno, Jose Bento Pereira Lima, Simone Ladeia-Andrade, Liliana Santacoloma, Ademir Jesus Martins
Summary: This study aimed to evaluate the molecular diversity in genes related to behaviour and insecticide resistance in An. darlingi populations from the Amazonian region of Brazil and Colombia. The genes tim, per, and ace-1 showed high levels of polymorphism, and significant genetic differentiation was observed between An. darlingi populations from Brazil and Colombia.
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2023)
Article
Parasitology
Patricia Salgueiro, Johana Restrepo-Zabaleta, Monique Costa, Allan Kardec Ribeiro Galardo, Joao Pinto, Pascal Gaborit, Amandine Guidez, Ademir Jesus Martins, Isabelle Dusfour
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2019)