Article
Chemistry, Analytical
Julius Welzel, David Wendtland, Elke Warmerdam, Robbin Romijnders, Morad Elshehabi, Johanna Geritz, Daniela Berg, Clint Hansen, Walter Maetzler
Summary: Current research on Parkinson's disease is focusing on identifying objective markers for assessing therapy effects and disease progression. This study found that step length has a significant impact on PD progression, while step time shows minimal change, emphasizing the importance of evaluating quantitative gait parameters for making assumptions about disease progression in chronic progressive diseases like PD.
Article
Neurosciences
Chang-hyun Park, Na-Young Shin, Sang-Won Yoo, Haeseok Seo, Uicheul Yoon, Ji-Yeon Yoo, Kookjin Ahn, Joong-Seok Kim
Summary: This study inferred the progression of Parkinson's disease through MRI observations and found that white matter disintegrity tends to occur earlier than cortical thinning. The staging of structural alterations indicates that these alterations mostly happen before major disease complications, and subsequent alterations are related to more severe clinical symptoms.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Hirotaka Iwaki, Cornelis Blauwendraat, Hampton L. Leonard, Mary B. Makarious, Jonggeol J. Kim, Ganqiang Liu, Jodi Maple-Grodem, Jean-Christophe Corvol, Lasse Pihlstrom, Marlies van Nimwegen, Luba Smolensky, Ninad Amondikar, Samantha J. Hutten, Mark Frasier, Khanh-Dung H. Nguyen, Jacqueline Rick, Shirley Eberly, Faraz Faghri, Peggy Auinger, Kirsten M. Scott, Ruwani Wijeyekoon, Vivianna M. Van Deerlin, Dena G. Hernandez, Raphael J. Gibbs, Aaron G. Day-Williams, Alexis Brice, Guido Alves, Alastair J. Noyce, Ole-Bjorn Tysnes, Jonathan R. Evans, David P. Breen, Karol Estrada, Claire E. Wegel, Fabrice Danjou, David K. Simon, Ole A. Andreassen, Bernard Ravina, Mathias Toft, Peter Heutink, Bastiaan R. Bloem, Daniel Weintraub, Roger A. Barker, Caroline H. Williams-Gray, Bart P. van de Warrenburg, Jacobus J. Van Hilten, Clemens R. Scherzer, Andrew B. Singleton, Mike A. Nalls
Summary: This study examined sex associations to PD phenotypes cross-sectionally and longitudinally in large-scale data. Female PD patients were found to have a higher risk of developing dyskinesia early during the follow-up period, with slower progression in daily living difficulties, and a lower risk of developing cognitive impairments compared with male patients. The findings were consistent in both longitudinal, clinic-based cohorts and an online-only cohort.
MOVEMENT DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Hannah S. Sarvasy, Weicong Li, Jaydene Elvin, Paola Escudero
Summary: In many communities, speech to infants and small children has distinct features compared to speech to adults, which can also be observed in speech directed to foreigners. This study examines the vowel acoustics in the Nungon language of Papua New Guinea, specifically in child-directed speech, conversational speech, and monologues directed towards a non-native speaker. The findings show that Nungon child-directed speech lacks vowel hyper-articulation but displays other prosodic traits common to child-directed speech. Furthermore, the vowel patterns in Nungon foreigner-directed speech are significantly different from those in child-directed speech and conversational speech. This study contributes to the understanding of speech variation and its cultural implications in different linguistic communities.
FRONTIERS IN PSYCHOLOGY
(2022)
Letter
Clinical Neurology
Fabian Maass, Bernhard Michalke, Desiree Willkommen, Sezgi Canaslan, Matthias Schmitz, Mathias Baehr, Inga Zerr, Paul Lingor
Summary: Longitudinal PD CSF samples were analyzed using ICP-MS to quantify the total amount of iron and other bioelements. In addition, ferritin and protein biomarkers of neurodegeneration were measured. Over time, mean iron levels significantly increased while ferritin levels decreased.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Jingru Ren, Xiaoyan Zhan, Hao Zhou, Zhiying Guo, Yi Xing, Hangxing Yin, Chen Xue, Jun Wu, Weiguo Liu
Summary: Objective: GBA variants and onset age significantly affect clinical phenotype and progression in Parkinson's disease (PD). This study compared clinical characteristics and cognitive and motor progression among GBA-PD, early-iPD, and late-iPD patients. Results showed that GBA-PD patients had more severe symptoms and faster progression compared to early-iPD and late-iPD patients. However, onset age did not have a significant impact on clinical features and progression in GBA-PD patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Eleonora Fiorenzato, Angelo Antonini, Patrizia Bisiacchi, Luca Weis, Roberta Biundo
Summary: Asymmetric hemispheric loss of dopaminergic neurons in Parkinson's disease affects cognitive and motor performance differently, with greater motor severity associated with predominant right hemisphere nigrostriatal dopaminergic loss and more pronounced left hemisphere denervation affecting cognitive manifestations at onset and progression.
MOVEMENT DISORDERS
(2021)
Article
Computer Science, Interdisciplinary Applications
Quoc Cuong Ngo, Mohammod Abdul Motin, Nemuel Daniel Pah, Peter Drotar, Peter Kempster, Dinesh Kumar
Summary: This study summarizes the literature on speech and voice in detecting and assessing the severity of Parkinson's disease (PD). Speech and voice may be valuable markers for PD, but there are differences between datasets and limitations in analysis methods.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Neurosciences
Sha Zhu, Zhuang Wu, Yaxi Wang, Yinyin Jiang, Ruxin Gu, Min Zhong, Xu Jiang, Bo Shen, Jun Zhu, Jun Yan, Yang Pan, Li Zhang
Summary: This study investigated gait impairment in the early and progressive stages of Parkinson's disease using a wearable sensor-based gait analysis system. The results showed significant differences in gait parameters such as stride length, gait velocity, and joint range of motion between Parkinson's disease patients and healthy controls at different stages. These gait parameters were also found to be correlated with Parkinson's disease rating scales and questionnaires.
Review
Nutrition & Dietetics
Agata Winiarska, Iwona Filipska, Monika Knysak, Tomasz Stompor
Summary: Phosphorus is a crucial nutrient for cell and tissue function, but excess intake can lead to adverse medical consequences, particularly in chronic kidney disease and diabetic kidney disease patients. High levels of phosphorus may impact cardiovascular health and exacerbate mineral and bone disorders.
Article
Biochemistry & Molecular Biology
Maja Grundner, Haris Munjakovic, Tilen Tori, Kristina Sepcic, Rok Gaspersic, Cedomir Oblak, Katja Seme, Graziano Guella, Francesco Trenti, Matej Skocaj
Summary: Periodontal disease is a chronic oral inflammatory disorder caused by pathobiontic bacteria in dental plaques, which, if untreated, can lead to periodontitis and tooth loss. Current diagnosis relies on obvious tissue damage, highlighting the need for improvements in diagnostic methods. Recent research indicates that specific lipids derived from periodontal pathogens could serve as biomarkers for periodontal disease and other chronic inflammatory conditions.
Review
Psychology, Clinical
Elizabeth R. Wallace, Suzanne C. Segerstrom, Craig G. van Horne, Frederick A. Schmitt, Lisa M. Koehl
Summary: This study conducted a meta-analysis on PD-MCI patients and found significant differences in cognitive test performance, with cognitive screeners showing the most pronounced effect. In the progression from PD-MCI to PDD, executive dysfunction exhibits a significant impact.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Infectious Diseases
Kah Wai Looi, Yukari Matsui, Mari Kono, Chandramathi Samudi, Nozomi Kojima, Jin Xu Ong, Chin Aun Tan, Chong Siang Ang, Peter Hao Yuan Tan, Hemalatha Shamnugam, Shamala Devi Sekaran, Sharifah Faridah Syed Omar, Lucy Chai See Lum
Summary: This study evaluated the trend of Immature Platelet Fraction (IPF) as an early recovery indicator of platelets in dengue patients with thrombocytopenia, and its relationship with severe dengue in conjunction with reticulocyte count. The results showed that IPF% increased significantly in severe dengue patients on days 3-5 after the onset of fever, and reticulocyte count also increased significantly on day 5. IPF can be utilized as an early recovery indicator of platelets in patients with dengue and thrombocytopenia.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Clinical Neurology
Harneek Chohan, Konstantin Senkevich, Radhika K. Patel, Jonathan P. Bestwick, Benjamin M. Jacobs, Sara Bandres Ciga, Ziv Gan-Or, Alastair J. Noyce
Summary: The meta-analysis of observational and genetic data showed a significant association between type 2 diabetes and Parkinson's disease risk and progression, providing new evidence for their relationship.
MOVEMENT DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Virginie Roland, Kathy Huet, Bernard Harmegnies, Myriam Piccaluga, Clemence Verhaegen, Veronique Delvaux
Summary: This study aims to detect early, subclinical speech biomarkers of dysarthria in Parkinson's disease (PD), which are systematic atypicalities in speech that are not easily detectible by clinicians. The study found that vowel articulation, assessed by three acoustic metrics, can be used as an early indicator of speech difficulties associated with PD.
FRONTIERS IN PSYCHOLOGY
(2023)
