Article
Neurosciences
Elijah Agoalikum, Benjamin Klugah-Brown, Hang Yang, Pan Wang, Shruti Varshney, Bochao Niu, Bharat Biswal
Summary: In this study, dynamic functional network connectivity differences in adult, adolescent, and child ADHD were investigated using resting-state functional magnetic resonance imaging data. The findings suggest that there are connectivity differences among the three age groups, providing new insights for future case-control studies and treatment strategies.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Immunology
Johnna R. Swartz, Angelica F. Carranza, Laura M. Tully, Annchen R. Knodt, Janina Jiang, Michael R. Irwin, Camelia E. Hostinar
Summary: The study found associations between peripheral inflammation and adolescent brain connectivity, with higher TNF-α levels linked to changes in neural network connections. Associations with IL-6 and CRP were not significant, suggesting that inflammation may have unique effects on brain connectivity during adolescence.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Serafeim Loukas, Lara Lordier, Djalel-Eddine Meskaldji, Manuela Filippa, Joana Sa de Almeida, Dimitri Van de Ville, Petra S. Hueppi
Summary: Research indicates that even during the newborn period, familiar music and unfamiliar music are processed differently by the brain. After music listening, functional connectivity between brain regions in all newborns is modulated. Premature infants exposed to music experience enhanced functional connectivity between brain regions after listening to music.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Anees Abrol, Zening Fu, Yuhui Du, Tony W. W. Wilson, Yu-Ping Wang, Julia M. M. Stephen, Vince D. D. Calhoun
Summary: The brain's functional architecture and organization undergo continuous development and modification throughout adolescence. This study systematically evaluated over 47,000 youth and adult brains to examine time-resolved functional connectivity patterns and found distinct differences between the two life stages, indicating an overall inverted U-shaped trajectory in the strengthening and modularization of functional coupling. These findings suggest greater synchrony and integration of the brain's functional connections beyond adolescence, with a gradual decline during healthy aging.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Limin Peng, Zhiguo Luo, Ling-Li Zeng, Chenping Hou, Hui Shen, Zongtan Zhou, Dewen Hu
Summary: This study developed a brain parcellation method based on dynamic functional connectivity and created a new functional brain atlas. The atlas can reveal finer functional boundaries that static methods may overlook, and shows good agreement with cytoarchitectonic areas and task activation maps.
Article
Clinical Neurology
Yan Tong, Xin Huang, Chen-Xing Qi, Yin Shen
Summary: The study utilized ReHo technique to investigate altered spontaneous brain activity in patients with iridocyclitis. Patients exhibited disturbed synchronous neural activities in specific brain areas, suggesting potential neuropathological or compensatory mechanisms in iridocyclitis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychology, Clinical
Lizhu Luo, Christelle Langley, Laura Moreno-Lopez, Keith Kendrick, David K. Menon, Emmanuel A. Stamatakis, Barbara J. Sahakian
Summary: This study examined the association between depressive symptoms in traumatic brain injury (TBI) patients and altered resting-state functional connectivity (rs-fc) or voxel-based morphology in brain regions involved in emotional regulation and associated with depression. The results showed a positive association between depression scores and rs-fc between limbic regions and cognitive control regions, while there was a negative association between depression scores and rs-fc between limbic and frontal regions involved in emotion regulation. These findings contribute to a better understanding of the mechanisms underlying depression following TBI and can inform treatment decisions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neuroimaging
Xuan Li, Yuchao Jiang, Wei Li, Yingjie Qin, Zhiliang Li, Yan Chen, Xin Tong, Fenglai Xiao, Xiaojun Zuo, Qiyong Gong, Dong Zhou, Dezhong Yao, Dongmei An, Cheng Luo
Summary: The study revealed decreased functional connectivity in white matter networks among unilateral temporal lobe epilepsy patients, especially dysfunction between cerebellar white matter and cerebral cortex, as well as reduced connectivity with ipsilateral hippocampus, suggesting insufficient functional integration in unilateral TLE. Moreover, right TLE showed more severe abnormalities in white matter functional connectivity compared to left TLE.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Clinical Neurology
Michael Eyre, Sean P. Fitzgibbon, Judit Ciarrusta, Lucilio Cordero-Grande, Anthony N. Price, Tanya Poppe, Andreas Schuh, Emer Hughes, Camilla O'Keeffe, Jakki Brandon, Daniel Cromb, Katy Vecchiato, Jesper Andersson, Eugene P. Duff, Serena J. Counsell, Stephen M. Smith, Daniel Rueckert, Joseph Hajnal, Tomoki Arichi, Jonathan O'Muircheartaigh, Dafnis Batalle, A. David Edwards
Summary: The Developing Human Connectome Project provides a framework to study brain development in humans at term-equivalent age, showing maturation of resting state networks and alterations in functional connectivity in preterm infants. Female infants exhibit increased connectivity in certain brain regions, while preterm birth leads to extensive disruptions in functional connectivity.
Article
Psychology, Multidisciplinary
Emil Holmer, Krister Schonstrom, Josefine Andin
Summary: This study investigates the associations between linguistic skills in sign language and resting-state functional connectivity (rsFC). The results show that worse sentence processing skill is associated with stronger positive rsFC between the left inferior frontal gyrus (IFG) and left sensorimotor regions. Additionally, sign language phonological processing skill is associated with positive rsFC from right IFG to middle frontal gyrus/frontal pole, although this association could possibly be explained by domain-general cognitive functions.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Neuroimaging
Hua Lin, Muwei Li, Yang Zhan, Li Lin, Kun Yang, Shimin Hu, Ying Han
Summary: The study investigated the impact of APOE ε4 on specific white matter functional connectivity in aMCI patients, revealing decreased functional connectivity in specific regions in APOE ε4 carriers, which differed from regions of aMCI-related changes. The findings suggest that APOE ε4 genotype exerts a negative impact on neural activity in both gray and white matter, potentially contributing to functional disconnection and memory decline in aMCI.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Medicine, General & Internal
Xue Jiao, Ming Yuan, Qiuju Li, Yufei Huang, Miaomiao Ji, Jing Li, Shumin Yan, Hao Sun, Xinyu Wang, Zangyu Pan, Qianhui Ren, Dawei Wang, Guoyun Wang
Summary: This study used resting-state functional magnetic resonance imaging to investigate brain morphological alterations and regional dysfunctions in patients with adenomyosis-related pain. The results showed changes in multiple brain regions associated with pain as well as anxiety and depression symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Chiara Pizzanelli, Ilaria Pesaresi, Chiara Milano, Paolo Cecchi, Lorenzo Fontanelli, Sara Giannoni, Filippo Sean Giorgi, Mirco Cosottini, Enrica Bonanni
Summary: This study found asymmetric disruption of FC in patients with benign MTLE, which was related to the side of the focus. Left patients, who performed worse in verbal memory tests, showed wide bilateral hypoconnectivity of the hippocampus and amygdala with language and memory network areas. The strength of FC between left limbic areas and the language and memory network correlated with better performances in verbal memory tests.
FRONTIERS IN NEUROLOGY
(2022)
Article
Psychiatry
Xiaoyi Sun, Jin Liu, Qing Ma, Jia Duan, Xindi Wang, Yuehua Xu, Zhilei Xu, Ke Xu, Fei Wang, Yanqing Tang, Yong He, Mingrui Xia
Summary: The study examined the intersubject variability of the functional connectome in schizophrenia patients and healthy controls based on resting-state fMRI data. The schizophrenia group showed higher IVFC in sensorimotor, visual, auditory, and subcortical regions compared to healthy controls, and these alterations were associated with clinical variables. Alterations in the sensorimotor, auditory, and subcortical cortices were specific to schizophrenia, suggesting potential implications for individualized clinical diagnosis and treatment.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Neurosciences
Gianvincenzo Sparacia, Giuseppe Parla, Giuseppe Mamone, Mariangela Caruso, Fabio Torregrossa, Giovanni Grasso
Summary: Resting-state functional magnetic resonance imaging (rest-fMRI) is a neuroimaging technique that shows promise in providing valuable information for pre-surgical planning in brain tumor patients, ensuring a balance between tumor resection extent and preservation of functional connectivity.
Article
Psychology, Clinical
Debo Dong, Dezhong Yao, Yulin Wang, Seok-Jun Hong, Sarah Genon, Fei Xin, Kyesam Jung, Hui He, Xuebin Chang, Mingjun Duan, Boris C. Bernhardt, Daniel S. Margulies, Jorge Sepulcre, Simon B. Eickhoff, Cheng Luo
Summary: This study investigated the pathological interaction of sensory and cognitive function in schizophrenia and its relationship to system-level imbalance. The results revealed a compression of the cortical hierarchy organization, leading to a diminished separation between sensory and cognitive systems. Furthermore, the analysis showed reduced connectivity within unimodal regions and increased connectivity between unimodal regions and other areas. These findings suggest that disruptions in the somatosensory-motor system and inefficient integration of sensory information contribute to high-level cognitive deficits in schizophrenia.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Tao Yin, Zhaoxuan He, Yuan Chen, Ruirui Sun, Shuai Yin, Jin Lu, Yue Yang, Xiaoyan Liu, Peihong Ma, Yuzhu Qu, Tingting Zhang, Xueling Suo, Du Lei, Qiyong Gong, Yong Tang, Fanrong Liang, Fang Zeng
Summary: This study successfully predicted the responsiveness of functional dyspepsia (FD) patients to acupuncture treatment by using functional brain network features and constructing support vector machine models. The results showed a certain level of accuracy in predicting patient responsiveness and symptom relief. Thirty-eight functional brain network features associated with the orbitofrontal cortex, caudate, hippocampus, and anterior insula were identified as critical predictive features. Changes in these features were more pronounced in responders than in non-responders. This research provides a promising approach for predicting individual acupuncture efficacy.
Article
Psychology, Developmental
Xun Zhang, Bochao Cheng, Xun Yang, Xueling Suo, Nanfang Pan, Taolin Chen, Song Wang, Qiyong Gong
Summary: Trait emotional intelligence (TEI) is an important personality trait that influences mental health outcomes. This study used neuroimaging and behavioral measures to reveal a negative correlation between TEI and spontaneous activity in the bilateral medial orbitofrontal cortex (OFC), a region associated with emotion processing. The findings suggest that TEI may mitigate depressive and anxious symptoms by modulating activity in the OFC.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Neurosciences
Du Lei, Wenbin Li, Kun Qin, Yuan Ai, Maxwell J. Tallman, L. Rodrigo Patino, Jeffrey A. Welge, Thomas J. Blom, Christina C. Klein, David E. Fleck, Qiyong Gong, Caleb M. Adler, Jeffrey R. Strawn, John A. Sweeney, Melissa P. DelBello
Summary: This study aimed to investigate the disruptions in the limbic system and emotion regulation function during acute manic episodes in youth with bipolar disorder and the effects of pharmacological treatment on these deficits. The results showed that quetiapine treatment had a more rapid improvement in manic symptoms and functional brain changes compared to lithium treatment, and the baseline activation status in these regions could predict treatment outcome.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Xueling Suo, Chao Zuo, Huan Lan, Wenbin Li, Lingjiang Li, Graham J. Kemp, Song Wang, Qiyong Gong
Summary: This study found that patients with posttraumatic stress disorder (PTSD) have abnormal brain functional networks, characterized by decreased network switching rates in the frontoparietal, default mode, and limbic networks, as well as frontal and temporal regions. These disruptions in dynamic functional network stability are related to the severity of PTSD symptoms.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Neurosciences
Ying Chen, Xun Yang, Xun Zhang, Hengyi Cao, Qiyong Gong
Summary: This study investigated the structural brain networks in social anxiety disorder (SAD) using structural MRI. The results showed that the SAD patients had less optimized topological configuration in the brain's gray matter networks, with decreased clustering coefficient and characteristic path length. Altered topological properties were found in the fronto-limbic and sensory processing systems, and these changes were associated with illness duration and symptom severity in SAD.
Article
Radiology, Nuclear Medicine & Medical Imaging
Simin Zhang, Huaiqiang Sun, Xibiao Yang, Xinyue Wan, QiaoYue Tan, Shuang Li, Hanbin Shao, Xiaorui Su, Qiang Yue, Qiyong Gong
Summary: This study investigated the alterations in cortical thickness and local gyration index (LGI) in patients with unilateral frontal lobe diffuse low-grade glioma (DLGG). The results showed cortical thickness compensation in contralateral homotopic location and some distant contralateral regions, as well as decreased cortical thickness in the contralateral precentral gyrus and hypogyrification in the contralateral lingual gyrus. In the left frontal lobe group, a negative association was found between four textural features of DLGG and LGI in the right medial orbitofrontal gyrus.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Neurosciences
Xu Qi, Jiayu Sun, Jiayu Zhu, Dechen Kong, Neil Roberts, Yijing Dong, Xiaoqi Huang, Qiang He, Haoyang Xing, Qiyong Gong
Summary: Neuromodulation technology offers novel therapeutic approaches for neural circuit dysfunction-related diseases. Transcranial focused ultrasound (FU) is an emerging approach with noninvasiveness and sharp focus, even in deep brain regions. It has advantages in precision and safety for neuromodulation of the peripheral and central nervous systems. Rating: 8/10
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Zhilin Li, Hao Cai, Zhiqian Li, Long Ren, Xuelei Ma, Hongyan Zhu, Qiyong Gong, Hu Zhang, Zhongwei Gu, Kui Luo
Summary: To improve the response rate of immune checkpoint inhibitors in immunosuppressive cancers, a self-amplified biomimetic nanosystem was constructed to induce immunogenic cell death at tumor sites. The nanosystem effectively reverses the immunosuppressive tumor microenvironment, leading to distinctive inhibition of tumor growth and metastasis when combined with immune checkpoint inhibitors.
BIOACTIVE MATERIALS
(2023)
Article
Neurosciences
Xun Zhang, Han Lai, Qingyuan Li, Xun Yang, Nanfang Pan, Min He, Graham J. Kemp, Song Wang, Qiyong Gong
Summary: Phenotyping approaches grounded in structural network science can provide insights into the underlying neurobiology of psychiatric diseases, particularly at the individual level in social anxiety disorder (SAD). This study used a novel approach to construct single-subject structural covariance networks (SCNs) based on multivariate morphometry and analyzed their global/nodal network properties. The findings revealed altered network organization in SAD patients, with higher global efficiency, shorter characteristic path length, and stronger small-worldness compared to healthy controls. Abnormal nodal centrality was observed in specific brain regions, and these topological metrics were associated with symptom severity and duration. Additionally, graph-based metrics allowed accurate classification of SAD versus healthy controls. These results contribute to our understanding of network-level neuropathology in SAD.
Article
Chemistry, Multidisciplinary
Yuting Jiang, Zhongyuan Cai, Shengxiang Fu, Haojie Gu, Xiaomin Fu, Jiang Zhu, Yubin Ke, Hanqiu Jiang, Weidong Cao, Changqiang Wu, Chunchao Xia, Su Lui, Bin Song, Qiyong Gong, Hua Ai
Summary: This study investigates the effect of water coordination numbers on the relaxivity of manganese-based hybrid micellar contrast agents and proposes a strategy to enhance relaxivity by increasing the water coordination numbers. The results demonstrate the feasibility of the strategy and show the potential of the hybrid micelles for in vivo imaging.
Article
Clinical Neurology
Hanbing Shao, Ni Chen, Xiaorui Su, Linmao Zheng, Xibiao Yang, Xinyue Wan, Simin Zhang, Qiaoyue Tan, Shuang Li, Qiyong Gong, Qiang Yue
Summary: This study explored the predictive value of quantitative features extracted from conventional magnetic resonance imaging in wild-type ependymomas. The results showed that enhancement quality, thickness of the enhancing margin, and edema crossing the midline have high predictive performance in identifying ZFTA-RELA fusion-positive and ZFTA-RELA fusion-negative ependymomas.
WORLD NEUROSURGERY
(2023)
Article
Psychiatry
Bo Tao, Yuan Xiao, Bin Li, Wei Yu, Fei Zhu, Ziyang Gao, Hengyi Cao, Qiyong Gong, Shi Gu, Changjian Qiu, Su Lui
Summary: This study found significant structural abnormalities of the corpus callosum (CC) and dysregulated interhemispheric functional connectivity (FC) in schizophrenia. The patients showed reduced fractional anisotropy (FA) values of the CC subregions and dysregulated connectivity between two cerebral hemispheres. There were strong correlations between FA values of the CC subregions and interhemispheric FC in patients.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Qing Wang, Lingyu Qi, Cancan He, Haixia Feng, Chunming Xie, Depression Imaging Res Consortium
Summary: This study examined the effects of age and gender on large-scale resting-state networks (RSNs) in the healthy brain. It found that age and gender have independent and interactive influences on RSNs and their topological properties. The study also discovered that these differential network features can predict brain age and cognitive impairment.
Letter
Medicine, General & Internal
Xun Zhang, Qingyuan Li, Xun Yang, Nanfang Pan, Xueling Suo, Min He, Song Wang, Graham J. Kemp, Qiyong Gong
CHINESE MEDICAL JOURNAL
(2023)
