Article
Immunology
Yan Ding, Zining Zhou, Xingyu Li, Chen Zhao, Xiaoxiao Jin, Xiaotao Liu, Yandan Wu, Xueyin Mei, Jian Li, Jie Qiu, Chuanlai Shen
Summary: This study functionally validated 62 T cell epitopes from HBV main proteins and elucidated their HLA-A restrictions. It provides important insights for the development of T cell epitope-based vaccines and therapies, as well as the evaluation of HBV-specific T cell function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Jennifer Habel, Andrea Nguyen, Louise Rowntree, Christopher Szeto, Nicole Mifsud, E. Bridie Clemens, Liyen Loh, Weisan Chen, Steve Rockman, Jane W. Nelson, Jane Davies, Adrian Miller, Steven Y. C. T. Tong, Jamie Rossjohn, Stephanie M. Gras, Anthony Purcell, Luca M. Hensen, Katherine Kedzierska, Patricia M. Illing
Summary: HLA-A*11:01 is highly prevalent in East Asian and Oceanian populations and is associated with high risk of severe influenza disease. Using immunopeptidomics, researchers identified novel CD8(+) T cell targets for influenza A and influenza B viruses in HLA-A*11:01-expressing individuals. These findings have implications for the design of broadly cross-reactive influenza vaccines.
Article
Immunology
Alexander Hellesen, Sigrid Aslaksen, Lars Breivik, Ellen Christine Royrvik, Oyvind Bruserud, Kine Edvardsen, Karl Albert Brokstad, Anette Susanne, Boe Wolff, Eystein Sverre Husebye, Eirik Bratland
Summary: In patients with AAD, a significantly higher frequency of HLA-A2 restricted LLNATIAEV-specific cells was found compared to controls. However, negligible frequencies of EPLARLEL-specific T cells were detected, with significant IFNγ production observed in response to a longer peptide encompassing EPLARLEL. The slightly offset ARLELFVVL peptide was identified as a novel dominant epitope restricted by HLA-C7.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Zhaojin Yu, Wensi Liu, Ying He, Mingli Sun, Jiankun Yu, Xue Jiao, Qiang Han, Haichao Tang, Bing Zhang, Yunkai Xian, Jing Qi, Jing Gong, Wang Xin, Gang Shi, Fengping Shan, Rui Zhang, Jianping Li, Minjie Wei
Summary: This study developed therapeutic tumour vaccines based on double-activation of CD8(+) T and NK cells, showing that LA-induced immune antitumour activity through DC cross-activation with CD8(+) T and NK cells can suppress tumours in vivo, providing evidence for the capability and safety of a novel therapeutic tumour vaccine.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jianmei Xiao, Xing Wan, Haoliang Wang, Guohong Deng
Summary: CD4 T cells play important roles in chronic hepatitis B and can be classified into different functional subsets based on the cytokines they secrete. Analysis of HBV-specific CD4 T cells based on cytokine secretion provides information on their response magnitude and functional subsets.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Letter
Immunology
Christian B. Lindstad, Shuo-Wang Qiao, Marie K. Johannesen, Lars Fugger, Ludvig M. Sollid, M. Fleur du Pre
Summary: The study established a TCR transgenic mouse model with CD4(+) T cells recognizing a specific gluten epitope, which may provide new insights into the pathogenesis of celiac disease.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Agata Lopes-Ribeiro, Patricia de Melo Oliveira, Henrique Morais Retes, Edel Figueiredo Barbosa-Stancioli, Flavio Guimaraes da Fonseca, Moriya Tsuji, Jordana Grazziela Alves Coelho-dos-Reis
Summary: This study investigated the presence of MHC-I immunodominant viral peptides in coronavirus subfamilies and SARS-CoV-2 Variants of Concern (VOCs) using in silico and in vitro tools. The results showed that HLA-A*02 haplotype had the highest number of immunodominant epitopes but with the lowest combined prediction score. Furthermore, it was observed that the mutations on the VOCs are promoting escape from HLA-A2-mediated antigen presentation, indicating an immune evasion process.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Yawei Wang, Min Wang, Renlong Bao, Ligui Wang, Xinying Du, Shaofu Qiu, Chaojie Yang, Hongbin Song
Summary: In this study, a tri-receptor transgenic mouse model expressing the three best-characterized human cellular receptors for HAdV was generated. The model accurately represents human HAdV infection and pathogenesis, making it useful for studying the mechanisms of HAdV and evaluating potential vaccines and therapeutic modalities.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Letter
Oncology
Kenji Fujiwara, Yingkuan Shao, Nan Niu, Tengyi Zhang, Brian Herbst, Mackenzie Henderson, Stephen Muth, Pingbo Zhang, Lei Zheng
Summary: This study identified T cell epitopes in PDAC using mass spectrometry and found that these epitopes can be shared by patients with different HLA types. Furthermore, these epitopes induced immune responses in peripheral T cells, suggesting their potential application in both HLA-type matched and non-matched patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Immunology
Xiaoxiao Jin, Yan Ding, Shihui Sun, Xinyi Wang, Zining Zhou, Xiaotao Liu, Miaomiao Li, Xian Chen, Anran Shen, Yandan Wu, Bicheng Liu, Jianqiong Zhang, Jian Li, Yi Yang, Haibo Qiu, Chuanlai Shen, Yuxian He, Guangyu Zhao
Summary: This study validated multiple T cell epitopes related to SARS-CoV-2 and developed vaccines that induce specific T cell responses. Utilizing different combination strategies and immunogens, the vaccines successfully elicited robust and specific CD8(+) T cell responses.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Bei Zhang, Zhiyao Ren, Jianfu Zhao, Yue Zhu, Boya Huang, Chanchan Xiao, Yan Zhang, Jieping Deng, Lipeng Mao, Lei Tang, Dan Lan, Lijuan Gao, Hongyi Zhang, Guobing Chen, Oscar Junhong Luo
Summary: This study identified candidate T-cell receptors (TCRs) that can target HLA-A2 restricted MAGE-A3 tumor antigen. The researchers screened tumor epitopes and characterized corresponding TCRs using various techniques. They found that these TCRs could induce the activation and cytotoxicity of CD8+ T cells and exhibited strong recognition and killing effect on MAGE-A3+ tumor cells.
Article
Cell Biology
Jieping Deng, Junping Pan, Minghui Qiu, Lipeng Mao, Zhigang Wang, Guodong Zhu, Lijuan Gao, Jun Su, Yutian Hu, Oscar Junhong Luo, Guobing Chen, Pengcheng Wang
Summary: This study identified specific CD8(+) T cell epitopes in the structural proteins of SARS-CoV-2, which effectively activated and induced the production of specific immune competent CD8(+) T cells by predicting specific epitopes and exploring their immunogenic properties.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroshi Tsuzuki, Yasuko Nagatsuka, Mitsuhiro Iwata, Noboru Kitamura, Yosuke Nagasawa, Taro Matsumoto, Ryoji Ito, Takeshi Takahashi, Mamoru Ito, Hideki Nakamura, Masami Takei
Summary: An improved humanized mouse model of chronic GVHD was established using HLA-DR transgenic NOD/Shi-scid, IL-2R gamma KO mice. Histological findings showed human T-cell infiltration indicating the presence of GVHD, along with B-cell clusters and IgG ANA in the spleen. This study demonstrates the potential application of this new model for studying chronic GVHD in humanized mice.
Article
Biochemistry & Molecular Biology
Laura Ciacchi, Carine Farenc, Shiva Dahal-Koirala, Jan Petersen, Ludvig M. Sollid, Hugh H. Reid, Jamie Rossjohn
Summary: This study investigates the T-cell receptor specificity and cross-reactivity of two immunodominant wheat gluten epitopes in celiac disease. The researchers find that the differences in binding between the epitopes and T-cell receptors at position 7 explain the cross-reactivity between the two epitopes.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Valentina Tedeschi, Giorgia Paldino, Josephine Alba, Emanuele Molteni, Fabiana Paladini, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Manuela Di Franco, Loretta Tuosto, Rosa Sorrentino, Marco D'Abramo, Maria Teresa Fiorillo
Summary: The HLA-B*27 family of alleles is strongly associated with ankylosing spondylitis (AS), but some non-associated HLA-B*27 variants have been found. The quantity of presented epitopes, rather than the quality, may explain the difference. The ERAP1/2 haplotype and the B*27:05 allele play crucial roles in shaping the CD8+ T cell response to viral and self-B*27 peptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Jiang-Fan Li, Lei He, Yong-Qiang Deng, Shu-Hui Qi, Yue-Hong Chen, Xiao-Lu Zhang, Shi-Xiong Hu, Rui-Wen Fan, Guang-Yu Zhao, Cheng-Feng Qin
Summary: A nanobody phage-displayed library was constructed from alpacas immunized with the recombinant RBD of SARS-CoV, leading to the identification of S14 nanobody with high affinity and potent neutralization activity against SARS-CoV. This novel nanobody showed competitive inhibition of SARS-CoV RBD binding to ACE2, suggesting its potential therapeutic utility.
Article
Infectious Diseases
Jia Li, Yali Zheng, Lili Zhao, Zhihong Yue, Feng Pan, Yuehong Chen, Bing Yu, Yanwen Chen, Guangyu Zhao, Yusen Zhou, Zhancheng Gao
Summary: The study found that 15 years after SARS-CoV infection, some patients still experienced lung damage, with slightly enhanced immune function. For SARS survivors, there is a long-lasting immune memory response to coronaviruses that requires further research.
BMC INFECTIOUS DISEASES
(2021)
Article
Chemistry, Physical
Huihuang Huang, Guangyu Zhao, Xianbo Yu, Xiaojie Shen, Ming Wang, Xiaoming Bai, Naiqing Zhang
Summary: The study successfully synthesized V-doped T-Nb2O5 sub-microspheres, which exhibited excellent reversible capacity, rate performance, and long-term stability, demonstrating outstanding electrochemical performance.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Immunology
Yingying Fang, Yan Guo, Tongtong Gao, Xuelian Han, Yuting Jiang, Min Li, Wei Xue, Binhui Yang, Yujun Cui, Shihui Sun, Guangyu Zhao
Summary: By investigating the role of complement activation in MHV-3 infection, this study provides further understanding of the pathogenic mechanism of betacoronavirus. Fine-tuning complement activation may be an intervention for the treatment of diseases induced by betacoronavirus infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Jean M. Kanellopoulos, David M. Ojcius
Summary: This special edition provides a summary of significant progress in understanding signaling by T lymphocytes. It explores the changes in T cell adhesion and actin cytoskeleton during interactions with antigen-presenting cells (APCs) and other immune cells. The articles discuss the mediators of these changes within T cells and on the T cell surface. They specifically focus on inside-out integrin signaling, components of the immunological synapse, T cell receptor signaling from endosomes, membrane transfer between APCs and T cells via trogocytosis, immune deficiencies in T cell signaling pathways, and the role of THEMIS in thymocyte development and peripheral T cell function.
BIOMEDICAL JOURNAL
(2022)
Article
Virology
Xiao-Kun Li, Bo Tu, Xiao-Ai Zhang, Wen Xu, Jia-Hao Chen, Guang-Yu Zhao, Biao Xu, Jun-Jie Zheng, Yan-Feng Yan, Peng-Fei Hao, Reginald Cole, Mohamed Boie Jalloh, Qing-Bin Lu, Chang Li, Stephen Sevalie, Wei Liu, Wei-Wei Chen
Summary: Metabolic analysis of COVID-19 patients from Sierra Leone revealed the association between glutamine and glutamate metabolism and disease severity. Further analysis confirmed these findings and suggested that targeting these metabolic pathways could be a potential therapeutic approach for severe COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Chemistry, Physical
Yixin Zhu, Shuang He, Jiayi Ding, Guangyu Zhao, Fang Lian
Summary: In this study, a new local high-concentration sulfolane-based electrolyte (DLi) is proposed, which can be stably applied to high nickel ternary cathode in a wide operating temperature range, improving the high-temperature storage performance and capacity retention of the battery.
Review
Biochemistry & Molecular Biology
Jan Martel, Shih-Hsin Chang, Gaetan Chevalier, David M. Ojcius, John D. Young
Summary: Living organisms have evolved in the natural electromagnetic fields of the earth, which include atmospheric electrical circuit, Schumann resonances, and geomagnetic field. The circadian rhythm, which regulates physiological functions, can be affected by both light and the earth's electromagnetic fields. Solar disturbances and weakening of the geomagnetic field can disrupt the circadian rhythm, increase inflammation, and lead to infectious and chronic diseases. Possible mechanisms for sensing the earth's electromagnetic fields involve electron and electromagnetic wave entrainment, light-dependent radical pair formation, and magnetite nanoparticles. Factors such as electromagnetic pollution, shielding materials, and geomagnetic anomalies may also contribute to circadian rhythm disruption and disease development.
BIOMEDICAL JOURNAL
(2023)
Review
Immunology
Jakob Einhaus, Xiaoyuan Han, Dorien Feyaerts, John Sunwoo, Brice Gaudilliere, Somayeh H. Ahmad, Nima Aghaeepour, Karl Bruckman, David Ojcius, Christian M. Schuerch, Dyani K. Gaudilliere
Summary: Oral mucosal pathologies are prevalent diseases worldwide and have medical significance. They can cause disfigurement and greatly reduce quality of life in a confined space with important physiological and social functions. However, treatment for these diseases is often ineffective and there is limited research on them. The host's immune system plays a major role in the development, maintenance, and resolution of oral mucosal pathologies, making a precise understanding of immunological mechanisms crucial for accurate diagnosis, targeted immunotherapy, and personalized treatment. This review highlights recent advancements in multiomic and single-cell approaches that provide comprehensive insights and clinically relevant biological signatures for these pathophysiological processes.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Review
Multidisciplinary Sciences
Cassio Luiz Coutinho Almeida-da-Silva, Leticia Ferreira Cabido, Wei-Chun Chin, Ge Wang, David M. Ojcius, Changqing Li
Summary: Engineered nanoparticles smaller than 100 nm, such as silica and titanium, are present in various consumer products and can interact with epithelial tissues, leading to inflammation and potential precancerous lesions. Detecting these particles and lesions in biopsies is challenging, especially in clinical settings that screen large numbers of patients. Therefore, there is a need for improved imaging techniques to detect foreign particles and markers of inflammation in epithelial tissues for early disease diagnosis.
Article
Chemistry, Multidisciplinary
Xiaoming Bai, Guangyu Zhao, Guiye Yang, Ming Wang, Zhaoyu Chen, Naiqing Zhang
Summary: By using a high-activity titanium-oxygen cluster as a brazing filler, the LLZTO and Li anode are brazed into a whole unit, resulting in significantly lower interfacial impedance and inhibition of Li dendrite growth. The cell exhibits an ultrahigh critical current density and stable cycling performance at 25 degrees Celsius.
Article
Chemistry, Multidisciplinary
Xiaoming Bai, Guangyu Zhao, Guiye Yang, Ming Wang, Zhaoyu Chen, Naiqing Zhang
Summary: In this study, a high-activity titanium-oxygen cluster was used as a brazing filler to successfully braze LLZTO with a lithium anode into a whole unit, leading to a significant reduction in interfacial impedance and inhibition of lithium dendrite growth.
Review
Medicine, General & Internal
Jiali Zhao, Guangyu Zhao, Lin Lu, Chunxia Li, Ruirui Yang
Summary: This case report describes a patient with NF1 and vertebral arteriovenous fistulae (AVFs). After endovascular intervention, the AVF disappeared but a new aneurysm appeared during follow-up. Further angiography should be considered in patients with NF1 presenting with neurological symptoms. Awareness of the coexistence between NF1 and AVF or aneurysm is crucial to avoid diagnostic delays.
Article
Endocrinology & Metabolism
Liangqin Tong, Xiaoping Xiao, Min Li, Shisong Fang, Enhao Ma, Xi Yu, Yibin Zhu, Chunli Wu, Deyu Tian, Fan Yang, Jing Sun, Jing Qu, Nianzhen Zheng, Shumin Liao, Wanbo Tai, Shengyong Feng, Liming Zhang, Yuhan Li, Lin Wang, Xuelian Han, Shihui Sun, Long Yang, Hui Zhong, Jincun Zhao, Wenjun Liu, Xiaohui Liu, Penghua Wang, Liang Li, Guangyu Zhao, Renli Zhang, Gong Cheng
Summary: The severity and mortality of COVID-19 in patients with diabetes mellitus are often higher, but the reasons for increased susceptibility in these individuals are not fully understood. In this study, the researchers identified a metabolite called 1,5-anhydro-d-glucitol (1,5-AG), which is associated with diabetes and has effective antiviral activity against SARS-CoV-2. They found that the level of 1,5-AG is significantly lower in patients with diabetes, and supplementation of 1,5-AG can reduce viral replication in their serum. In animal experiments, diabetic mice had higher viral loads and more severe respiratory tissue damage when infected with SARS-CoV-2, but sustained supplementation of 1,5-AG reduced the viral loads and disease severity to similar levels as non-diabetic mice. The researchers also discovered that 1,5-AG directly binds to the spike protein of SARS-CoV-2, interrupting the virus-host membrane fusion. These findings suggest that 1,5-AG supplementation may be beneficial for diabetic patients in preventing severe COVID-19.
Article
Chemistry, Physical
Xianbo Yu, Guangyu Zhao, Chao Liu, Huihuang Huang, Xiaojie Shen, Naiqing Zhang
Summary: The new O-MoS2/HN-CNFs material achieves simultaneous intercalation of Mg2+ and Li+, demonstrating excellent performance at high rates, including superior rate capabilities, good cycling performance, and long-term stability.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
