Article
Oncology
Joshua A. Bloom, Yurie Sekigami, Rebekah Young, Lisa Macera, Christy A. Russell, Yu Cao, Rachel J. Buchsbaum, Stephen P. Naber, Abhishek Chatterjee
Summary: This study demonstrates that a clinically significant rate of discordance in Oncotype DX results among patients with bilateral breast cancer may impact discussions regarding chemotherapy treatment.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Biochemical Research Methods
Grant R. Howard, Tyler A. Jost, Thomas E. Yankeelov, Amy Brock
Summary: In this study, a method of optimizing drug schedules in vitro through iterative application of experimentally calibrated models is presented. The study demonstrates the ability to characterize dynamic changes in sensitivity to the chemotherapeutic doxorubicin in breast cancer cell lines. The findings show that the inter-treatment interval is a key variable in determining the performance of sequential dosing schedules, allowing for optimization of drug scheduling.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Review
Medicine, Research & Experimental
Chunping Liu, Huiqi Chen, Sien Guo, Qiaojing Liu, Zhijun Chen, Haiding Huang, Qi Zhao, Longmei Li, Huan Cen, Zebo Jiang, Qiyuan Luo, Xiaoling Chen, Jiaxiong Zhao, Wensheng Chen, Phillip C. Yang, Lei Wang
Summary: With the progress of tumor treatment, the 5-year survival rate of breast cancer is close to 90%. Cardiovascular toxicity caused by chemotherapy has become a vital factor affecting the survival of patients with breast cancer. This article reviews the toxicity and mechanisms of current clinical anti-breast cancer drugs and proposes strategies for preventing cardiovascular toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Lili Yang, Yuya Haga, Akihide Nishimura, Yuki Tsujii, Suzuno Tanahashi, Hirofumi Tsujino, Kazuma Higashisaka, Yasuo Tsutsumi
Summary: Among TNBC subtypes, the BL2 subtype has the lowest survival rate and highest risk of metastasis after chemotherapy treatment. Alpha B-crystallin (CRYAB) is highly expressed in BL2 subtypes and is associated with brain metastasis in TNBC patients. We hypothesized that alpha B-crystallin is associated with increased cell motility in the BL2 subtype after chemotherapy.
SCIENTIFIC REPORTS
(2023)
Review
Immunology
Jinguo Zhang, Shuaikang Pan, Chen Jian, Li Hao, Jie Dong, Qingqing Sun, Hongwei Jin, Xinghua Han
Summary: Breast cancer is the most common malignancy among females, and chemotherapy drugs have been the mainstay of treatment. The advent of immunotherapy has provided new hope for breast cancer treatment. Chemotherapy drugs have shown to stimulate the immune system in multiple ways, including inducing immunogenic cell death and activating immune effector cells while depleting immunosuppressive cells. This review summarizes recent clinical trials on the combination of chemotherapy and immunotherapy in breast cancer and discusses the molecular mechanisms of the immunostimulatory properties of chemotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
G. Gambardella, G. Viscido, B. Tumaini, A. Isacchi, R. Bosotti, D. di Bernardo
Summary: This study characterizes the cell lines of different subtypes of breast cancer using single-cell RNA-seq and trains a deconvolution algorithm to predict drug responses in heterogeneous tumor cell populations. The findings show high heterogeneity in the expression of biomarkers within cancer cells, and transcriptional heterogeneity allows cells with differential drug sensitivity to coexist in the same population. This work provides a framework to determine tumor heterogeneity in terms of cell line composition and drug response.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Andreas Venizelos, Christina Engebrethsen, Wei Deng, Jurgen Geisler, Stephanie Geisler, Gjertrud T. Iversen, Turid Aas, Hildegunn S. Aase, Manouchehr Seyedzadeh, Eli Sihn Steinskog, Ola Myklebost, Sigve Nakken, Daniel Vodak, Eivind Hovig, Leonardo A. Meza-Zepeda, Per E. Lonning, Stian Knappskog, Hans P. Eikesdal
Summary: Subclonal composition of treatment-naive breast cancers undergoes profound changes during neoadjuvant chemotherapy with epirubicin and docetaxel monotherapy, while early truncal mutations and major subclones generally persist through treatment. Tumor mutational burden decreases during neoadjuvant therapy.
Article
Engineering, Multidisciplinary
Shikun Wen, Aihong Ji, Linxian Che, Zhikang Yang
Summary: This work proposes a time-varying external archive differential evolution algorithm for obtaining multiple roots of the system of nonlinear equations for the forward displacement of parallel mechanisms. The algorithm improves the global and local searching capabilities through a time-varying subpopulation strategy and introduces an individual judgment criterion. The experimental results demonstrate the competitive performance of the proposed method compared to other methods in benchmark functions and forward displacement solutions of parallel mechanisms.
APPLIED MATHEMATICAL MODELLING
(2023)
Review
Oncology
Jie Qiu, Qinghui Zheng, Xuli Meng
Summary: This article focuses on the mechanisms of chemotherapy resistance in hyperglycemic breast cancer patients, including abnormal behaviors of cancer cells in the hyperglycemic microenvironment and the impact of abnormal glucose metabolism on key signaling pathways. Understanding the causes of drug resistance in hyperglycemic patients may help to better inform the development of effective treatments.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Heikki Joensuu, Pirkko-Liisa Kellokumpu-Lehtinen, Riikka Huovinen, Arja Jukkola, Minna Tanner, Johan Ahlgren, Paivi Auvinen, Outi Lahdenpera, Kenneth Villman, Paul Nyandoto, Greger Nilsson, Paula Poikonen-Saksela, Vesa Kataja, Petri Bono, Jouni Junnila, Henrik Lindman
Summary: The study suggests that adding capecitabine to a chemotherapy regimen containing docetaxel, epirubicin, and cyclophosphamide can prolong the survival of patients with early breast cancer. Data shows that patients in the TX-CEX group had longer survival compared to those in the T-CEF group, especially for patients with estrogen receptor-negative and triple-negative cancer.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Engineering, Multidisciplinary
Weibin Lan, Shouwen Fan, Shuai Fan
Summary: In this paper, the design defects of the cam transmission mechanism caused by geometric characteristics are analyzed, and self-contained defect identification algorithms are proposed. A complete algorithm based on these algorithms is designed to identify design defects in the cam curve groove. The feasibility of the identification algorithm is validated by numerical examples, showing that the appropriate processing method and component size design directly affect the dynamic behavior of the cam transmission mechanism.
APPLIED MATHEMATICAL MODELLING
(2022)
Article
Multidisciplinary Sciences
Riley Plett, Paul Mellor, Stephanie Kendall, S. Austin Hammond, Aren Boulet, Kristine Plaza, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Deborah H. Anderson
Summary: The lack of targeted therapies for triple-negative breast cancer (TNBC) leads to higher mortality rates and risk of relapse compared to other breast cancer subtypes. In this study, researchers screened an FDA-approved drug library and identified four drugs that were highly cytotoxic towards TNBC cells with CREB3L1 deficiency. Homoharringtonine showed the most significant cytotoxicity and synergistic effect when combined with paclitaxel, suggesting its potential for TNBC treatment.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Diana Duarte, Soraia Falcao, Iouraouine El Mehdi, Miguel Vilas-Boas, Nuno Vale
Summary: The study evaluated the anti-cancer efficacy of honeybee venom in combination with chemotherapeutic or CNS drugs in colon and breast cancer cells. The results showed that the combination of honeybee venom with these drugs can improve their anti-cancer activity, especially at lower concentrations.
Review
Biochemistry & Molecular Biology
Elena A. Filippova, Marina Fridman, Alexey M. Burdennyy, Vitaly Loginov, Irina Pronina, Svetlana S. Lukina, Alexey A. Dmitriev, Eleonora A. Braga
Summary: Long noncoding RNA GAS5 acts as a tumor suppressor in breast cancer through interactions with proteins, DNA, and various microRNAs. By upregulating suppressor proteins and stimulating apoptosis, GAS5 inhibits tumor growth. Additionally, GAS5 plays a crucial role in regulating key signaling pathways in breast cancer and can enhance drug sensitivity and prognosis through epigenetic mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yang Huo, Shuai Shao, Enze Liu, Jin Li, Zhen Tian, Xue Wu, Shijun Zhang, Daniel Stover, Huanmei Wu, Lijun Cheng, Lang Li
Summary: This study conducted pathway and subpathway analyses on transcriptome data of chemotherapy-resistant breast cancer samples. The study revealed the activation of several molecular pathways associated with chemoresistance, including those related to Cushing's syndrome, human papillomavirus infection, proteoglycans in cancer, fluid shear stress, and focal adhesion. Activation of the same chemoresistance pathways was also observed in a subset of triple-negative breast cancer samples.
Article
Oncology
Csilla Olah, Henning Reis, Michele J. Hoffmann, Fabian Mairinger, Saskia Ting, Boris Hadaschik, Ulrich Krafft, Viktor Gruenwald, Peter Nyirady, Melinda Varadi, Balazs Gyorffy, Andras Kiss, Eszter Szekely, Gottfrid Sjodahl, Tibor Szarvas
Summary: The study proposed a method for molecular classification of bladder cancer samples, and evaluated the impact of subtypes on survival after adjuvant chemotherapy. The results showed that luminal subtypes had better survival with chemotherapy, while basal subtypes did not show significant differences. High APOBEC3G expression was associated with better survival in platinum-treated patients. The proposed method is reliable for classifying tissue samples and subtypes have a significant impact on adjuvant chemotherapy.
Review
Multidisciplinary Sciences
Balazs Gyorffy, Boglarka Weltz, Istvan Szabo
Summary: A grant decision support tool was established in Hungary to rank the scientific productivity of researchers. The introduction of this tool increased the correlation between grant selection and scientometric parameters, leading to enhanced transparency in the review process.
Article
Oncology
Melinda Varadi, Nikolett Nagy, Henning Reis, Boris Hadaschik, Christian Niedworok, Orsolya Modos, Attila Szendroi, Jason Ablat, Peter C. Black, David Keresztes, Anita Csizmarik, Csilla Olah, Nadine T. Gaisa, Andras Kiss, Jozsef Timar, Erika Toth, Erzsebet Csernak, Arpad Gerstner, Vinay Mittal, Sofia Karkampouna, Marianna Kruithof de Julio, Balazs Gyorffy, Gabor Bedics, Michael Rink, Margit Fisch, Peter Nyirady, Tibor Szarvas
Summary: In this study, a data-processing pipeline was developed for the detection and interpretation of genetic alterations in two rare cancers. The analysis revealed a high rate of actionable mutations, suggesting potential feasibility for the treatment of urachal adenocarcinoma and primary bladder adenocarcinoma.
Article
Hematology
Anne Sofie Borg Hammer, Kristian Lovvik Juul-Dam, Julie Damgaard Sandahl, Jonas Abrahamsson, Malgorzata Czogala, Emmanuelle Delabesse, Iren Haltrich, Kirsi Jahnukainen, E. Anders Kolb, Gabor Kovacs, Guy Leverger, Franco Locatelli, Riccardo Masetti, Ulrika Noren-Nystrom, Susana C. Raimondi, Mareike Rasche, Dirk Reinhardt, Tomohiko Taki, Daisuke Tomizawa, Bernward Zeller, Henrik Hasle, Eigil Kjeldsen
Summary: Hypodiploidy is a rare and poor prognostic subgroup in pediatric acute myeloid leukemia (AML), even in patients treated with stem cell transplantation.
Article
Obstetrics & Gynecology
J. Cadenas, L. C. Poulsen, D. Nikiforov, M. L. Grondahl, A. Kumar, K. Bahnu, A. L. M. Englund, J. Malm, G. Marko-Varga, I Pla, A. Sanchez, S. E. Pors, C. Yding Andersen
Summary: This study investigates the substances and signal transduction pathways involved in the regulation of human oocyte maturation downstream to the effects of FSH and LH. The results reveal that human oocyte maturation is a multifactorial process involving several different signal transduction pathways. Various pathways, including those involving CNP, EGF-related peptides, TGF-beta family members, activins/inhibins, FF-MAS, and MDK, are potentially active, while the GDF9 and BMP15 pathways show less pronounced influence.
HUMAN REPRODUCTION
(2023)
Article
Biochemistry & Molecular Biology
Aron Bartha, Zsuzsanna Darula, Gyoengyi Munkacsy, Eva Klement, Peter Nyirady, Balazs Gyorffy
Summary: This research used a proteotranscriptomic approach to differentiate normal and tumor tissues in clear cell renal cell carcinoma (ccRCC). Top genes over-expressed in ccRCC were identified using transcriptomic data of patients with malignant and normal tissue samples. Protein level analysis and mass spectrometry further validated the differential protein abundance of these genes. A minimal panel of proteins highly specific for ccRCC tissues was identified using transcriptomic and proteomic data.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Gyongyi Munkacsy, Libero Santarpia, Balazs Gyorffy
Summary: Triple-negative breast cancer is the most aggressive subtype of breast cancer, characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth receptor 2 expression. It has genomic and transcriptional heterogeneity and an immunosuppressive tumor microenvironment with high levels of tumor-infiltrating lymphocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Ines Barone, Luca Gelsomino, Felice Maria Accattatis, Francesca Giordano, Balazs Gyorffy, Salvatore Panza, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Daniela Bonofiglio, Sebastiano Ando, Cinzia Giordano, Stefania Catalano
Summary: Obesity is a known risk factor for various chronic diseases, including breast cancer. This study found that the expression levels of miR-126-3p, miR-4772-3p, and miR-10a-5p in circulating extracellular vesicles were negatively correlated with survival in obese breast cancer patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Lucia Paniagua-Herranz, Bernard Doger, Cristina Diaz-Tejeiro, Adrian Sanvicente, Cristina Nieto-Jimenez, Victor Moreno, Pedro Perez Segura, Balazs Gyorffy, Emiliano Calvo, Alberto Ocana
Summary: This study explored the high expression of EGFR and MET in prostate adenocarcinoma and pancreatic adenocarcinoma, and found that it was related to high expression of PD-L1, suggesting the potential for future combination therapy using bi-specific EGFR/MET antibodies and anti-PD(L)1 inhibitors.
Article
Oncology
Darya Chetverina, Nadezhda E. Vorobyeva, Balazs Gyorffy, Alexander A. Shtil, Maksim Erokhin
Summary: The study identified crucial genes (known as Supertargets) for tumors of specific tissue origin, which can be targeted for personalized treatment strategies. Most of the Supertargets were DNA-binding transcription factors, suggesting the importance of transcriptional mechanisms in cell survival of specific tumors. Targeted inactivation of these factors provides a straightforward approach to optimize therapeutic regimens.
Article
Geriatrics & Gerontology
Balazs Gyorffy
Summary: Progress in the treatment of ovarian cancer is behind other tumor types. A large-scale transcriptomic database was established to identify survival-associated genes. The database includes 1816 samples, with 2468 genes correlated to progression-free survival (PFS) and 704 genes correlated with overall survival (OS).
Article
Pharmacology & Pharmacy
Balazs Gyorffy
Summary: This study established a comprehensive database of transcriptome-level data for lung cancer, which can be used to identify and rank the most promising biomarkers and therapeutic targets for different subtypes of lung cancer.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cinzia Giordano, Felice Maria Accattatis, Luca Gelsomino, Piercarlo Del Console, Balazs Gyorffy, Mario Giuliano, Bianca Maria Veneziani, Grazia Arpino, Carmine De Angelis, Pietro De Placido, Erica Pietroluongo, Francesco Zinno, Daniela Bonofiglio, Sebastiano Ando, Ines Barone, Stefania Catalano
Summary: This study identified novel miRNA signatures, miRNA-27a and miRNA-128, in breast cancer by analyzing the expression profiles of EV-derived miRNAs in the blood circulation. These miRNAs showed diagnostic accuracy in distinguishing breast cancer patients from non-cancer controls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Peter Szluka, Edit Csajbok, Balazs Gyorffy
Summary: An increasing interest in demonstrating the prestige and status of higher education institutions has led to the establishment of several international ranking systems. These rankings often include parameters related to scientific productivity. In this study, we examined the differences between different rankings and their correlation with bibliometric parameters and disciplines for the top universities. The results showed that the most important parameters defining ranking positions include citations, international reputation, and the number of researchers. However, the strength of correlation varied among ranking systems. The absolute number of publications and citations were particularly important in certain rankings, while scientific category normalized citation impact played a central role in others. Additionally, there were variations in performance across different disciplines, with some ranking systems favoring universities with more publications in social sciences and others favoring universities with more publications in science, technology, and medicine fields.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Esther Cabanas Morafraile, Cristina Saiz-Ladera, Cristina Nieto-Jimenez, Balazs Gyorffy, Adam Nagy, Guillermo Velasco, Pedro Perez-Segura, Alberto Ocana
Summary: This study describes a novel therapeutic strategy for treating colorectal cancer (CRC) patients with BRAF mutations. By identifying upregulated proteins on the surface of tumor cells as treatment targets and observing the transcriptional profile associated with antigen presenting cells, it is suggested that a combination of anti PD(L)1 with other co-inhibitor receptors can be explored for treating BRAF-mutated CRC patients.
