Article
Multidisciplinary Sciences
Alysha K. Lee, Jeremy H. Wei, Paula V. Welander
Summary: The marine myxobacterium Enhygromyxa Salina can produce cholesterol and undergo further modifications, similar to eukaryotes. However, complete demethylation at the C-4 position is achieved through unique bacterial proteins.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
William R. Blevins, Jorge Ruiz-Orera, Xavier Messeguer, Bernat Blasco-Moreno, Jose Luis Villanueva-Canas, Lorena Espinar, Juana Diez, Lucas B. Carey, M. Mar Alba
Summary: Recent research has identified 213 de novo originated transcripts in Saccharomyces cerevisiae, with half of them expressed from regions that already contain other genes. These transcripts show similar expression changes in response to stress and some are capable of translating small proteins.
NATURE COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Elena Espinos, Sandra Daniel, Sara B. Hernandez, Anthony Goudin, Felipe Cava, Francois-Xavier Barre, Elisa Galli
Summary: Research shows that L-arabinose induces the formation of nondividing spherical cells in Vibrio cholerae, which can resume growth and normal morphology after removal of L-arabinose. The histidine kinase/response regulator pair WigKR plays a role in preventing the lysis of spheroplasts during growth restart. Physiological perturbations caused by L-arabinose import and catabolic processing in V. cholerae can be avoided, providing insights into the genetic program governing physiological states in response to stressful conditions.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sandra Lorena Ament-Velasquez, Ciaran Gilchrist, Alexandre Rego, Devin P. Bendixsen, Claire Brice, Julie Michelle Grosse-Sommer, Nima Rafati, Rike Stelkens
Summary: This study investigates the dynamics of fitness and genomic changes in yeast populations adapting to different environments. The results show that populations rapidly increase in fitness in stressful environments, while allele frequencies exhibit diverse trajectories. The study also identifies parallel genomic changes within and between environments.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Review
Plant Sciences
Antoine Nicolas, Patrick Laufs
Summary: Plant aerial development relies on meristem activity, with shoot apical meristem (SAM) formed in the embryo contributing to the main stem and axillary meristems (AMs) formed post-embryonically contributing to the branched structure. This review discusses recent findings on the de novo establishment of AMs and emphasizes the progressive process of stem cell formation, different from functional meristems.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Scott R. Burlingham, Nicole F. Wong, Lindsay Peterkin, Lily Lubow, Carolina Dos Santos Passos, Orion Benner, Michael Ghebrial, Thomas P. Cast, Matthew A. Xu-Friedman, Thomas C. Sudhof, Soham Chanda
Summary: The presynaptic release of neurotransmitters can signal the organization of relevant postsynaptic structures and modify the synaptic identity of neurons.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Guixian Liang, Chunyu Zhou, Xiangxiang Jiang, Yifan Zhang, Baofeng Huang, Suwei Gao, Zhixin Kang, Dongyuan Ma, Fengchao Wang, Berthold Gottgens, Hongmei Wang, Jing-Dong J. Han, Feng Liu
Summary: This study revealed the transcriptional landscape of mouse fetal placental hematopoiesis and identified a CD44(+) subpopulation of placental endothelial cells with hemogenic potential. Lineage tracing showed that these cells could produce placental macrophages, named Hofbauer cell (HBC)-like cells. Further analysis identified two subtypes of HBC-like cells and their potential roles in angiogenesis and antigen presentation.
DEVELOPMENTAL CELL
(2021)
Review
Biochemistry & Molecular Biology
Patricia Garcia, Ruben Celador, Jorge Perez-Parrilla, Yolanda Sanchez
Summary: This article focuses on the role of fission yeast Rho1p GEFs in maintaining the shape and homeostasis of yeast cells. These proteins activate Rho1p in different ways and at different times, and also have noncanonical roles in genomic instability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Christophe E. Pierreux
Summary: Thyroid organogenesis is a complex process involving thickening, differentiation, migration, and organization of progenitor cells to form functional thyroid follicles. Intrinsic and extrinsic factors play roles in this process, which shares similarities and common mechanisms with developmental steps in other endoderm-derived organs.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Cell Biology
Kasuga Takumi, Daiju Kitagawa
Summary: Centrioles can be assembled in the vicinity of pre-existing centrioles or in the absence of pre-existing centrioles, a process known as de novo centriole formation. This process can be triggered by the removal of all pre-existing centrioles in the cell or through the overexpression of certain regulatory proteins. De novo centriole formation can occur naturally in some species. This review summarizes previous findings on de novo centriole formation, particularly under experimental conditions, and discusses its regulatory mechanisms.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kezia Jack, Graham S. Jackson, Jan Bieschke
Summary: This article reviews a range of experimental approaches for generating PrP amyloid assemblies and discusses the definition of prions, non-protein requirements, and the current state of prion amplification and generation in vitro.
Article
Neurosciences
Nina Colitti, Franck Desmoulin, Alice Le Friec, Wafae Labriji, Lorenne Robert, Amandine Michaux, Fabrice Conchou, Carla Cirillo, Isabelle Loubinoux
Summary: This study demonstrates the importance of long-term treatment with nerve growth factor (NGF) delivered intranasally in promoting neurogenesis and tissue reconstruction after stroke. However, it also indicates that NGF treatment may limit motor recovery. Additionally, the study establishes the use of MRI as a biomarker for evaluating neurogenesis and tissue reconstruction.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Kyounghee Lee, Ok-Sun Park, Ji Yun Go, Jihyeon Yu, Jun Hee Han, Jungmook Kim, Sangsu Bae, Yu Jin Jung, Pil Joon Seo
Summary: ATXR2 regulates de novo shoot organogenesis by interacting with auxin and cytokinin in plants, which plays a crucial role in determining cell fate transition.
Article
Biology
Jia Chen, Daniel St Johnston
Summary: In the adult Drosophila midgut, the process of enteroblast integration resembles lumen formation in mammalian epithelial cysts, with enteroblasts forming a pre-assembled apical compartment and an apical membrane initiation site (AMIS) before integrating into the epithelium.
Article
Biology
Shuangying Jiang, Yuanwei Tang, Liang Xiang, Xinlu Zhu, Zelin Cai, Ling Li, Yingxi Chen, Peishuang Chen, Yuge Feng, Xin Lin, Guoqiang Li, Jafar Sharif, Junbiao Dai
Summary: Synthetic genomics has opened new avenues for the functional study of viral and microbial genomes, as well as providing a method for constructing larger genomes of higher organisms. The study introduces an efficient pipeline for constructing large DNA fragments and describes a scar-free engineering method for assembling sequences. This method offers a standard framework for producing long DNA molecules crucial for synthetic genomics and metabolic engineering.
SCIENCE CHINA-LIFE SCIENCES
(2022)