Review
Immunology
Erica M. Pasini, Clemens H. M. Kocken
Summary: This article reviews the modeling of relapsing parasites Plasmodium vivax and Plasmodium ovale in non-human primates, highlighting the contribution of these models to our current understanding of the factors that govern parasite-host interactions.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Jie Bai, Fei Liu, Fan Yang, Yan Zhao, Xitong Jia, Sataporn Thongpoon, Wanlapa Roobsoog, Jetsumon Sattabongkot, Li Zheng, Zeshi Cui, Wenqi Zheng, Liwang Cui, Yaming Cao
Summary: The potential of Pv22 as a transmission-blocking vaccine (TBV) candidate was evaluated by expressing it in transgenic Plasmodium berghei parasites. The study showed that Pv22 has weaker TB activity, suggesting it may not be a promising TBV candidate for Plasmodium vivax.
Article
Immunology
Usheer Kanjee, Christof Gruring, Prasad Babar, Anosha Meyers, Rashmi Dash, Ligia Pereira, Anjali Mascarenhas, Mudit Chaand, Gabriel W. Rangel, Martha A. Clark, Laura Chery, Edwin Gomes, Pradipsinh K. Rathod, Manoj T. Duraisingh
Summary: Plasmodium vivax utilizes two invasion pathways, DARC and TfR1, with significant variation in receptor usage among strains, suggesting alternative invasion pathways similar to Plasmodium falciparum, impacting pathogenesis and vaccine development.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Dewu Bi, Xiaodong Huang, Lu Lin, Xike Tang, Yuexi Lu, Zhenxu Lan, Shunda Luo, Jianyan Lin, Xiaocheng Luo
Summary: Objective Microscopy was used to investigate platelet-Plasmodium-infected erythrocyte interactions in malaria patients. The study found that platelets directly attached to parasitized erythrocytes and played a role in parasite killing. Platelet counts were inversely correlated with parasitaemia and parasite clearance duration. Artemisinin combination therapy was more effective in clearing Plasmodium in patients with thrombocytopenia.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Warot Chotpatiwetchkul, Sirin Sittiwanichai, Jitti Niramitranon, Prapasiri Pongprayoon
Summary: This study investigated the substrate binding of ADA in the malaria parasite P. vivax. The orientation of substrates and interactions with specific amino acids were found to play crucial roles in the stability of the binding. These findings have important implications for the development of new anti-malarial drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Infectious Diseases
Kelry Mazurega Oliveira Dinelly, Sheila Vitor-Silva, Jose Diego Brito-Sousa, Vanderson Souza Sampaio, Milena Gabriela Oliveira Silva, Andre Machado Siqueira, Cassio Peterka, Sheila Rodovalho, Aretha Gomes Omena, Wuelton Marcelo Monteiro, Marcus Vinicius Guimaraes Lacerda, Gisely Cardoso Melo
Summary: Supervised treatment with chloroquine and PQ led to lower risk of recurrence compared to unsupervised treatment, highlighting the importance of health worker supervision in improving treatment compliance and reducing relapse risk. Future studies should expand this analysis to different settings in the Brazilian Amazon.
Article
Immunology
Iris Aparici-Herraiz, Melisa Gualdron-Lopez, Carlos J. Castro-Cavadia, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Carmen Fernandez-Becerra, Hernando A. del Portillo
Summary: In this study, we identified new candidate vaccine antigens for Plasmodium vivax by analyzing parasite proteins in circulating extracellular vesicles (EVs) of P. vivax patients. We also confirmed the antigenicity of the PHIST-c protein. This research represents a significant advancement in the development of vaccines against this human malaria parasite.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biology
Tobias Mourier, Denise Anete Madureira de Alvarenga, Abhinav Kaushik, Anielle de Pina-Costa, Olga Douvropoulou, Qingtian Guan, Francisco J. Guzman-Vega, Sarah Forrester, Filipe Vieira Santos de Abreu, Cesare Bianco Junior, Julio Cesar de Souza Junior, Silvia Bahadian Moreira, Zelinda Maria Braga Hirano, Alcides Pissinatti, Maria de Fatima Ferreira-da-Cruz, Ricardo Lourenco de Oliveira, Stefan T. Arold, Daniel C. Jeffares, Patricia Brasil, Cristiana Ferreira Alves de Brito, Richard Culleton, Claudio Tadeu Daniel-Ribeiro, Arnab Pain
Summary: Plasmodium simium, a malaria parasite of non-human primates, likely originated in South America from Plasmodium vivax and has recently acquired the ability to infect humans. Genetic analysis suggests that specific gene deletions in P. simium, especially in the Duffy-binding protein 1 (DBP1), may play a role in its ability to invade human red blood cells, leading to recent zoonotic infections.
Article
Infectious Diseases
Anand Odedra, Kari Mudie, Glen Kennedy, Rebecca E. Watts, Emilie Rossignol, Hayley Mitchell, Jeremy Gower, Maria Rebelo, Zuleima Pava, Rebecca Pawliw, Stephen Woolley, David G. Lalloo, Greg Robinson, Sean Lynch, Katharine A. Collins, Fiona Amante, James McCarthy
Summary: The study assessed the safety and effectiveness of using apheresis for extracting and concentrating P. vivax parasites, finding that apheresis can concentrate asexual parasites and gametocytes, but the concentration level is modest and may not be ideal for harvesting P. vivax.
Article
Biology
James A. Watson, Robert J. Commons, Joel Tarning, Julie A. Simpson, Alejandro Llanos Cuentas, Marcus V. G. Lacerda, Justin A. Green, Gavin C. K. W. Koh, Cindy S. Chu, Francois H. Nosten, Richard N. Price, Nicholas P. J. Day, Nicholas J. White
Summary: Tafenoquine is a new antimalarial drug, and its efficacy is primarily determined by the dosage. Increasing the dosage can significantly reduce the risk of P. vivax recurrence. Additionally, tafenoquine's half-life and methaemoglobin concentration are associated with recurrence. These findings suggest that the production of oxidative metabolites is central to tafenoquine's efficacy.
Article
Biology
Joao L. Silva-Filho, Joao C. K. Dos-Santos, Carla Judice, Dario Beraldi, Kannan Venugopal, Diogenes Lima, Helder Nakaya, Erich De Paula, Stefanie C. P. Lopes, Marcus V. G. Lacerda, Matthias Marti, Fabio T. M. Costa
Summary: In patients with vivax malaria, there is a correlation between peripheral and total parasite biomass and host response, with high heterogeneity in clinical features, parasite burden, and host signatures. Patients can be categorized into Vivax(low) and Vivax(high) clusters based on differences in total parasite biomass, rather than peripheral parasitaemia, showing distinct alterations in various parameters related to host homeostasis.
Review
Infectious Diseases
Loick P. Kojom Foko, Aditi Arya, Amit Sharma, Vineeta Singh
Summary: This study conducted a systematic review and meta-analysis of Indian literature on severe vivax malaria, providing evidence for P. vivax as the etiologic agent of severe malaria leading to deaths in some cases. Further research is needed on SVM in pregnancy, SVM in drug resistance, and correlations with cytoadherence in disease severity due to P. vivax.
JOURNAL OF INFECTION
(2021)
Review
Infectious Diseases
Tsige Ketema, Ketema Bacha, Kefelegn Getahun, Quique Bassat
Summary: The study synthesized evidence on the efficacy of anti-malarial drugs against clinical P. vivax malaria in Ethiopia, showing generally high efficacy but with variations and influencing factors. Chloroquine remained highly efficacious and the addition of primaquine is recommended for sustained protection. Continuous surveillance and clinical trials are necessary to prevent the emergence and spread of drug-resistant P. vivax in Ethiopia.
Review
Medicine, General & Internal
Aung Pyae Phyo, Prabin Dahal, Mayfong Mayxay, Elizabeth A. Ashley
Summary: Plasmodium vivax infects around 7 million people annually and its severe clinical impacts, including severe anemia in children and adverse effects on pregnancy, are increasingly reported. Mortality from vivax malaria is estimated to be low but hospital settings show higher mortality rates. There are knowledge gaps regarding the pathophysiology and geographical distribution of severe complications, and an adapted case definition for severe vivax malaria is recommended for better understanding and surveillance.
Review
Infectious Diseases
Nicholas J. White
Summary: Prevention of relapses in Plasmodium vivax malaria is achieved through the use of 8-aminoquinolines, while treatment of blood stage infections helps suppress early relapses but does not completely eliminate them. The therapeutic responses are influenced by factors such as the number of hypnozoites, drug dosage, and drug resistance levels. The steep dose-response relationship for radical curative efficacy of primaquine and tafenoquine could explain the suboptimal efficacy of tafenoquine at the current recommended dose.
Article
Cell Biology
Jane H. Kinnaird, Meetali Singh, Victoria Gillan, William Weir, Ewen D. D. Calder, Isabel Hostettler, Utpal Tatu, Eileen Devaney, Brian R. Shiels
CELLULAR MICROBIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Nitya Sarjapuram, Niharika Mekala, Meetali Singh, Utpal Tatu
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2017)
Article
Multidisciplinary Sciences
Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schubeler, Charles Vinson, Jussi Taipale
Article
Biochemistry & Molecular Biology
Chandradhish Ghosh, Shweta Chaubey, Utpal Tatub, Jayanta Haldar
Article
Multidisciplinary Sciences
Divya Beri, Balu Balan, Shweta Chaubey, Suraj Subramaniam, Bachu Surendra, Utpal Tatu
SCIENTIFIC REPORTS
(2017)
Article
Cell & Tissue Engineering
Vivekanandan Palaninathan, Sreejith Raveendran, Ankit K. Rochani, Neha Chauhan, Yasushi Sakamoto, Tomofumi Ukai, Toru Maekawa, D. Sakthi Kumar
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2018)
Article
Chemistry, Multidisciplinary
Srishti Agarwal, M. Sheikh Mohamed, Sreejith Raveendran, Ankit K. Rochani, Toru Maekawa, D. Sakthi Kumar
Article
Pharmacology & Pharmacy
Edwin Lam, Ankit Rochani, Gagan Kaushal, Brandi N. Thoma, Julian Tanjuakio, Frances Mae West, Hitoshi Hirose
CLINICAL THERAPEUTICS
(2019)
Article
Ophthalmology
Rohit Shetty, Jagadeesh R. Naidu, Archana Padmanabhan Nair, Tanuja Arun Vaidya, Sharon D'Souza, Himanshu Matalia, Vrushali Deshpande, Swaminathan Sethu, Arkasubhra Ghosh, Koushik Chakrabarty
Article
Chemistry, Analytical
Ankit Rochani, Edwin Lam, Julian Tanjuakio, Hitoshi Hirose, Walter K. Kraft, Gagan Kaushal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Chemistry, Multidisciplinary
Sreejana Ray, Desiree Tillo, Stewart R. Durell, Syed Khund-Sayeed, Charles Vinson
Summary: NFATc2 is a DNA binding protein that shows differential binding to various types of DNA, with stronger binding observed when both cytosines in the CG dinucleotide are methylated.
Article
Biochemistry & Molecular Biology
Samayitree Das, Sharon D'Souza, Bhavya Gorimanipalli, Rohit Shetty, Arkasubhra Ghosh, Vrushali Deshpande
Summary: Infection mediated ocular surface stress responses are important early defense mechanisms in response to host cell damage. Understanding the etiology and pathogenesis of ocular infections is crucial for early diagnosis and effective treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Krishnatej Nishtala, Trailokyanath Panigrahi, Rohit Shetty, Dhanananajay Kumar, Pooja Khamar, Rajiv R. Mohan, Vrushali Deshpande, Arkasubhra Ghosh
Summary: This study used quantitative proteomics to identify key factors involved in the differentiation-dependent protein profile changes in human corneal stromal cells. The differentiated fibroblasts and myofibroblasts expressed proteins related to cellular signaling pathways, SLIT-ROBO pathways, and extracellular matrix, indicating their potential role in corneal wound healing. The identified proteins such as profilin 1 and talin could potentially serve as targets for treating corneal fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Srinivasan Sanjay, Gairik Kundu, Vrushali Deshpande, Swaminathan Sethu, Ruchika Agrawal, Arkasubhra Ghosh, Ankush Kawali, Padmamalini Mahendradas, Rohit Shetty
Summary: This retrospective case report demonstrates the presence of viral proteins and inflammatory cytokines in a patient with unilateral keratouveitis. Tear samples collected from the patient showed higher levels of viral proteins, including SARS-CoV-2, compared to control samples. Inflammatory markers were also elevated in the affected eye. Treatment with antiviral medication and topical steroids resulted in resolution of the keratouveitis.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Desiree Tillo, Sreejana Ray, Khund-Sayeed Syed, Mary Rose Gaylor, Ximiao He, Jun Wang, Nima Assad, Stewart R. Durell, Aleksey Porollo, Matthew T. Weirauch, Charles Vinson