Article
Virology
Irene Mueller, Lisa Janson, Martina Sauter, Kathleen Pappritz, Sophie Van Linthout, Carsten Tschoepe, Karin Klingel
Summary: The study investigated the impact of MDSC on acute CVB3 myocarditis using a murine model. Results indicated that MDSC can promote the development of chronic CVB3 myocarditis by inhibiting NK cell activity.
Article
Virology
Chengrui Niu, Wei Xu, Sidong Xiong
Summary: The appendix plays a role in regulating the composition of the intestinal microbiota and has an impact on cardiac infection and inflammation.
Article
Immunology
Liang Chen, Meng-ying Zhu, Gao-xiang Wang, Li-Li Lu, Li Lin, Lei Lei, Ting Wu
Summary: This study found that ruxolitinib can improve acute viral myocarditis caused by Coxsackievirus B3 by inhibiting the activation of the JAK-STAT pathway, reducing inflammatory cell infiltration and necroptosis of the myocardium. This finding provides a new strategy for the treatment of viral myocarditis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Virology
Yimin Xue, Mingguang Chen, Qian Chen, Tingfeng Huang, Qiaolian Fan, Fenghui Lin, Jun Ke, Feng Chen
Summary: The research showed that the expression of IL-38 and IL-36R was significantly elevated in mice with AVMC, with IL-38 levels negatively correlated with disease severity. Neutralizing IL-38 exacerbated CVB3-induced AVMC, leading to worsened outcomes and increased viral replication. These findings suggest that IL-38 could potentially be a therapeutic target for AVMC by modulating the balance of Th1/Th17 cells and inhibiting viral replication.
Article
Cell Biology
Pengcheng Yan, Xiaoning Song, Joanne Tran, Runfa Zhou, Xinran Cao, Gang Zhao, Haitao Yuan
Summary: Dapagliflozin has a protective effect on viral myocarditis, reducing its severity, improving survival rate, and ameliorating cardiac function. It decreases pro-inflammatory cytokines levels, inhibits macrophage differentiation to M1 phenotype, and activates the polarization of M2 phenotype through the Stat3 signal pathway.
Article
Virology
Sandra Pinkert, Meike Kespohl, Nicolas Kelm, Ziya Kaya, Arnd Heuser, Karin Klingel, Antje Beling
Summary: The study demonstrates that the use of tramadol in the CVB3 myocarditis mouse model does not have disruptive effects on viral pathogenicity or immune response in the heart. This supports the consideration of the demonstrated protocol as a general analgesic strategy for CVB3 infection.
Article
Plant Sciences
Bowen Sun, Lin Lin, Tian Yao, Jingchun Yao, Guimin Zhang, Yunlun Li, Chao Li
Summary: This study found that Jingfang Granules (JFG) significantly alleviated pathological damage in the cardiac tissues of coxsackievirus B3-induced viral myocarditis mice and attenuated the expression of inflammatory genes. JFG may exert its therapeutic effects by enhancing autophagy to suppress cell apoptosis, thereby reducing cell damage.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Pathology
Linghe Wu, Mitchell D. Fiet, Daan R. Raaijmakers, Linde Woudstra, Albert C. van Rossum, Hans W. M. Niessen, Paul A. J. Krijnen
Summary: This study investigated inflammation, fibrosis, and viral genome in the atria after mild CVB3-induced viral myocarditis. The results showed that CVB3 infection caused an inflammatory response in the atria, with peaks in lymphocytes, macrophages, neutrophils, and mast cells during the acute phase. However, there were no significant changes in the amount of atrial fibrosis.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2022)
Article
Chemistry, Applied
Li Qin, Hui Liu, Jinghua Wang, Wei Wang, Lei Zhang
Summary: The study demonstrated that crocetin has a cardio-protective effect in an experimental murine model of acute viral myocarditis, increasing survival rates, reducing myocardial necrotic lesions, and inhibiting viral replication and inflammatory response. These findings suggest that crocetin may be a potential therapeutic agent for patients with viral myocarditis.
JOURNAL OF OLEO SCIENCE
(2021)
Article
Cell Biology
Zhihong Cen, Yong Li, Bin Wei, Weifeng Wu, Yanlan Huang, Jing Lu
Summary: The study found that B cells play an important role in viral myocarditis, not only independently of T cells in the pathological process, but also influencing the differentiation of Th1 and Th17 cells while inhibiting Th2 cell differentiation.
Article
Microbiology
Yuxuan Fu, Sidong Xiong
Summary: This study found that exosomes can serve as vehicles for CVB3 virus, delivering the virus into cells and infecting receptor-negative cells. Exosomes carrying CVB3 virus have higher infection efficiency compared to free virus, and can overcome restrictions to viral tropism by accessing different routes.
Article
Multidisciplinary Sciences
Paolo Carai, Giulia Ruozi, Alexandra Paye, Yannick Debing, Francesca Bortolotti, Julie Lecomte, Lorena Zentilin, Elizabeth A. Jones, Mauro Giacca, Stephane Heymans
Summary: Viral myocarditis is a significant cause of heart failure in both children and adults, and the molecular determinants and cardioprotective molecules involved in cardiac inflammation and cardiomyocyte necrosis are not well characterized. In this study, researchers used an in vivo method called functional selection to identify novel immunomodulatory molecules in a mouse model of Coxsackievirus B3-induced myocarditis. They found that IL9 and four other cytokines were cardioprotective factors in this model.
SCIENTIFIC REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Linghe Wu, Linde Woudstra, Tariq A. Dam, Tjeerd Germans, Albert C. van Rossum, Hans W. M. Niessen, Paul A. J. Krijnen
Summary: The study found that viral myocarditis induces transient changes in myocardial electrical conduction that are strongly related to cardiac cellular inflammation, particularly infiltration of lymphocytes, macrophages, and neutrophils. These changes did not significantly correlate with lesion size and fibrosis.
CARDIOVASCULAR PATHOLOGY
(2021)
Article
Virology
Tingjun Liu, Jing Tong, Chen Shao, Junyan Qu, Hua Wang, Yi Shi, Yajing Lin, Yun Liu, Shihe Shao, Hongxing Shen
Summary: The study showed that miR-324-3p targets TRIM27 to inhibit CVB3 replication and reduce viral load, thereby alleviating cardiac injury associated with viral myocarditis.
Article
Immunology
Yuan Luo, Hongkai Zhang, Jie Yu, Lin Wei, Min Li, Wei Xu
Summary: This study reveals the important role of mast cells (MCs) in the progression of Coxsackievirus B3-induced viral myocarditis (VMC) and fibrosis. MCs interact with fibroblasts, aggravating cardiac fibrosis during the early infection stages.
Article
Cardiac & Cardiovascular Systems
Yoichi Imori, Ken Kato, Victoria L. Cammann, Konrad A. Szawan, Manfred Wischnewsky, Sara Dreiding, Michael Wuerdinger, Maximilian Schoenberger, Vanya Petkova, David Niederseer, Rena A. Levinson, Davide Di Vece, Sebastiano Gili, Burkhardt Seifert, Masaki Wakita, Noriko Suzuki, Rodolfo Citro, Eduardo Bossone, Susanne Heiner, Maike Knorr, Thomas Jansen, Thomas Muenzel, Fabrizio D'Ascenzo, Jennifer Franke, Ioana Sorici-Barb, Hugo A. Katus, Annahita Sarcon, Jerold Shinbane, L. Christian Napp, Johann Bauersachs, Milosz Jaguszewski, Reiko Shiomura, Shunichi Nakamura, Hitoshi Takano, Michel Noutsias, Christof Burgdorf, Iwao Ishibashi, Toshiharu Himi, Wolfgang Koenig, Heribert Schunkert, Holger Thiele, Behrouz Kherad, Carsten Tschope, Burkert M. Pieske, Lawrence Rajan, Guido Michels, Roman Pfister, Shingo Mizuno, Alessandro Cuneo, Claudius Jacobshagen, Gerd Hasenfuss, Mahir Karakas, Hiroki Mochizuki, Alexander Pott, Wolfgang Rottbauer, Samir M. Said, Ruediger C. Braun-Dullaeus, Adrian Banning, Toshiaki Isogai, Akihisa Kimura, Florim Cuculi, Richard Kobza, Thomas A. Fischer, Tuija Vasankari, K. E. Juhani Airaksinen, Yasuhiro Tomita, Monika Budnik, Grzegorz Opolski, Rafal Dworakowski, Philip MacCarthy, Christoph Kaiser, Stefan Osswald, Leonarda Galiuto, Filippo Crea, Wolfgang Dichtl, Tsutomu Murakami, Yuji Ikari, Klaus Empen, Daniel Beug, Stephan B. Felix, Clement Delmas, Olivier Lairez, Tetsuo Yamaguchi, Ibrahim El-Battrawy, Ibrahim Akin, Martin Borggrefe, John D. Horowitz, Martin Kozel, Petr Tousek, Petr Widimsky, Ekaterina Gilyarova, Alexandra Shilova, Mikhail Gilyarov, Michael Neuhaus, Philippe Meyer, Jose David Arroja, Christina Chan, Paul Bridgman, Jan Galuszka, Gregor Poglajen, Pedro Carrilho-Ferreira, Fausto J. Pinto, Christian Hauck, Lars S. Maier, Kan Liu, Carlo Di Mario, Carla Paolini, Claudio Bilato, Matteo Bianco, Lucas Joerg, Hans Rickli, David E. Winchester, Christian Ukena, Michael Boehm, Jeroen J. Bax, Abhiram Prasad, Charanjit S. Rihal, Shigeru Saito, Yoshio Kobayashi, Thomas F. Luscher, Frank Ruschitzka, Wataru Shimizu, Jelena R. Ghadri, Christian Templin
Summary: This study compared clinical characteristics and in-hospital outcomes between Japanese and European takotsubo syndrome (TTS) patients, revealing differences in triggers and outcomes between the two ethnic groups. Despite worse in-hospital outcomes for Japanese patients, ethnicity itself does not appear to impact TTS patient outcomes. Machine learning analysis identified physical stressors as the most important prognostic factor for both Japanese and European TTS patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Florian Krackhardt, Magnus Jornten-Karlsson, Matthias Waliszewski, Mikael Knutsson, Anna Niklasson, Karl-Friedrich Appel, Ralf Degenhardt, Alexander Ghanem, Till Koehler, Marc-Alexander Ohlow, Carsten Tschoepe, Heinz Theres, Juergen vom Dahl, Bjorn W. Karlson, Lars S. Maier
Summary: This study evaluated the effectiveness of a patient support tool app in improving medication adherence and lifestyle changes in patients with acute coronary syndrome. Results showed that the app intervention significantly improved medication adherence compared to a control group. General improvements in health status and lifestyle changes were observed in both groups.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Milan Haffke, Helma Freitag, Gordon Rudolf, Martina Seifert, Wolfram Doehner, Nadja Scherbakov, Leif Hanitsch, Kirsten Wittke, Sandra Bauer, Frank Konietschke, Friedemann Paul, Judith Bellmann-Strobl, Claudia Kedor, Carmen Scheibenbogen, Franziska Sotzny
Summary: A subset of PCS patients exhibit evidence of endothelial dysfunction with altered endothelial biomarkers. Different associations of the RHI with clinical parameters and varying biomarker profiles may suggest distinct pathomechanisms among patient subgroups.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Patrick Doeblin, Fridolin Steinbeis, Cian M. Scannell, Collin Goetze, Sarah Al-Tabatabaee, Jennifer Erley, Alessandro Faragli, Felix Proepper, Martin Witzenrath, Thomas Zoller, Christian Stehning, Holger Gerhardt, Javier Sanchez-Gonzalez, Ebraham Alskaf, Titus Kuehne, Burkert Pieske, Carsten Tschoepe, Amedeo Chiribiri, Sebastian Kelle
Summary: This study examined microvascular perfusion in patients with persistent cardiac symptoms post-COVID-19. The study found that post-COVID-19 patients had lower stress myocardial blood flow and higher T2 relaxation time compared to healthy controls. The reduction in microvascular perfusion was not related to symptoms or COVID-19 severity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Mariann Gyongyosi, Pilar Alcaide, Folkert W. Asselbergs, Bianca J. J. M. Brundel, Giovanni G. Camici, Paula da Costa Martins, Peter Ferdinandy, Marianna Fontana, Henrique Girao, Massimiliano Gnecchi, Can Gollmann-Tepekoylu, Petra Kleinbongard, Thomas Krieg, Rosalinda Madonna, Melanie Paillard, Antonis Pantazis, Cinzia Perrino, Maurizio Pesce, Gabriele G. Schiattarella, Joost P. G. Sluijter, Sabine Steffens, Carsten Tschope, Sophie Van Linthout, Sean M. Davidson
Summary: Long COVID is a global non-communicable epidemic characterized by long-lasting multiorgan symptoms after SARS-CoV-2 infection has subsided. This scientific document aims to provide insight into the cardiovascular manifestations of long COVID and the possible causes and therapeutic options available. Imaging has shown evidence of chronic perimyocarditis, arterial wall inflammation, and microthrombosis in certain patient populations. Understanding the underlying cellular and molecular mechanisms is crucial for the development of effective treatment strategies. However, current biomarkers are not highly predictive for the presence or outcome of long COVID.
CARDIOVASCULAR RESEARCH
(2023)
Review
Cardiac & Cardiovascular Systems
A. Hagendorff, A. Helfen, R. Brandt, E. Altiok, O. Breithardt, D. Haghi, J. Knierim, D. Lavall, N. Merke, C. Sinning, S. Stobe, C. Tschope, F. Knebel, S. Ewen
Summary: Currently, the diagnosis of HFpEF is based on echocardiographic parameters and clinical symptoms combined with natriuretic peptide levels. However, this diagnosis includes multiple pathophysiological entities, making it difficult to develop a uniform management plan. Therefore, a standardized echocardiographic workflow is necessary to characterize the underlying cardiac pathologies in patients with preserved ejection fraction and symptoms of heart failure.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Cecilia Linde, Marcin Grabowski, Piotr Ponikowski, Ishu Rao, Angela Stagg, Carsten Tschoepe
Summary: This pilot study aimed to assess the potential benefits of Cardiac Contractility Modulation (CCM) in patients with Heart Failure with Preserved Ejection Fraction (HFpEF). The study found that CCM significantly improved the health status of HFpEF patients without obvious safety concerns.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Carsten Tschoepe, Vivian Nelki, Tobias Daniel Trippel, Karin Klingel, Dawud Abawi, Alessio Alogna
Summary: This study evaluates the feasibility and safety of endomyocardial biopsy (EMB) in patients with a left ventricular (LV) implanted Impella (R) device. The results show that EMB can be safely performed in these patients and can diagnose relevant inflammatory heart diseases in approximately 50% of the cases.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Chemistry, Analytical
Yong Chul Ju, Ivan Kraljevski, Heiko Neunubel, Constanze Tschope, Matthias Wolff
Summary: Based on the importance of cogwheels in manufacturing and the need for non-destructive testing, this study proposes an approach that utilizes acoustic resonance testing and machine learning for quality control of sintered cogwheels. By analyzing time-frequency domain features and applying machine learning algorithms to small datasets, we are able to detect damaged samples effectively. Despite the small data size, our approach achieves robust performance.
Article
Medicine, General & Internal
Carsten Tschoepe, Ahmed Elsanhoury, Sonja Diekmann, Uwe Kuehl
Summary: Cardiomyopathies encompass various types including dilated, restrictive, and hypertrophic cardiomyopathies. Hypertrophic cardiomyopathy (HCM) is diagnosed when the left ventricular wall thickness is equal to or greater than 15 mm. Genetic sarcomeric diseases, storage diseases, or syndromes can mask the diagnosis of HCM. Sarcomere mutations and cardiac amyloidoses are particularly important in clinical practice due to the challenges in distinguishing between them, emphasizing the significance of early disease detection for prognosis.
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2022)
Review
Cardiac & Cardiovascular Systems
Maurizio Pesce, Georg N. Duda, Giancarlo Forte, Henrique Girao, Angel Raya, Pere Roca-Cusachs, Joost P. G. Sluijter, Carsten Tschope, Sophie Van Linthout
Summary: A growing body of evidence suggests that the mechanical functions of cardiac fibroblasts, as a necessary component, play an active role in myocardial growth and homeostasis. This review describes cell mechanosensation as a regulator of cardiac maturation and disease, and provides evidence that changes in the mechanical properties of the myocardium can occur due to disease-induced remodeling of the cardiac extracellular matrix.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Danielle J. Beetler, Katelyn A. Bruno, Damian N. Di Florio, Erika J. Douglass, Swikriti Shrestha, Carsten Tschoepe, Madeleine W. Cunningham, Jan Krejci, Julie Bienertova-Vasku, Sabine Pankuweit, Dennis M. McNamara, Eun-Seok Jeon, Sophie van Linthout, Lori A. Blauwet, Leslie T. Cooper, DeLisa Fairweather
Summary: This study aimed to investigate the sex and age differences in soluble ST2 (sST2) levels for various cardiovascular diseases (CVDs). Using ELISA kit, sST2 levels were measured in patients with myocarditis, cardiomyopathy, coronary artery disease (CAD), myocardial infarct (MI), and congestive heart failure (CHF) and compared to controls without CVDs. The results showed that myocarditis occurred in younger patients around the age of 40, while other CVDs were more common in individuals around the age of 60. There were significant differences in sST2 levels between sexes in myocarditis and cardiomyopathy, but not in other CVDs.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fabian Freiberg, Meghna Thakkar, Wiebke Hamann, Jacobo Lopez Carballo, Rene Juettner, Felizia K. Voss, Peter M. Becher, Dirk Westermann, Carsten Tschoepe, Arnd Heuser, Oliver Rocks, Robert Fischer, Michael Gotthardt
Summary: Heart attack leads to the death of heart muscle cells, causing lesions that turn into fibrotic tissue. Inhibiting the cell contact protein CAR can limit the damage and improve survival in patients with myocardial infarction, suggesting it as a potential therapeutic target.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Hematology
Marc Moghbel, Aline Roth, Daniela Baptista, Kapka Miteva, Fabienne Burger, Fabrizio Montecucco, Nicolas Vuilleumier, Francois Mach, Karim J. Brandt
Summary: This study has developed a new diagnostic tool for antiphospholipid antibody syndrome (APS) with high affinity, which could serve as a prevention strategy and an alternative to anticoagulants.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Franziska Seidel, Titus Kuehne, Sebastian Kelle, Patrick Doeblin, Victoria Zieschang, Carsten Tschoepe, Nadya Al-Wakeel-Marquard, Sarah Nordmeyer
Summary: This study investigated cardiac involvement in non-hospitalized children with COVID-19 infection using CMR imaging. It found no evidence of myocardial inflammation, fibrosis, or functional cardiac impairment in these children, with some showing minimal pericardial effusion suggesting mild pericarditis.