Review
Neurosciences
Byoung Ju Lee, Che Ho Yang, Seung Yeon Lee, Suk-Ho Lee, Yujin Kim, Won-Kyung Ho
Summary: The coupling distance between VGCCs and synaptic vesicles determines the VGCC dependence of spontaneous release at synapses, with tightly coupled synapses showing significant VGCC contribution while loosely coupled synapses have minimal VGCC involvement.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Neurosciences
Alexandre Bouron
Summary: The endoplasmic reticulum (ER) is the primary storage compartment for calcium (Ca2+) in eukaryotic cells. Ca2+ is mobilized from the ER through store-operated Ca2+ channels (SOCCs), leading to a store-operated Ca2+ entry (SOCE) that has been extensively studied in non-excitable cells. The presence of this Ca2+ entry route in neurons has been a subject of debate, but experimental evidence suggests that SOCE can be generated by the recruitment of Ca2+ from neuronal ER Ca2+ stores. This review summarizes the main supporting studies and explores the molecular composition, expression, pharmacological properties, and physiological relevance of neuronal SOCCs.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Pragnya Chakraborty, Gaiti Hasan
Summary: Key components of endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) are expressed in all metazoan cells. This review presents evidence on how these two mechanisms impact neuronal physiology and their interaction with ion channels in neurons. The careful regulation of neural SOCE is essential due to the detrimental effects of Ca2+ imbalance on neurons. The study also discusses different mechanisms of SOCE regulation in Drosophila and mammalian neurons, and their significance in human neurodegenerative diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Review
Pharmacology & Pharmacy
Xiao-Yu Liu, Ling-Ling Qian, Ru-Xing Wang
Summary: This review summarizes the role of hydrogen sulfide (H2S) in the regulation of vascular tone, specifically through its interaction with different vascular potassium channels. Studies have shown that H2S plays a key role in the pathophysiology of vascular diseases and physiological vascular homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Physiology
Declan Manning, Caroline Dart, Richard L. Evans
Summary: The skin is a complex organ with various functions such as protection, temperature regulation, sensation, immune surveillance, and biochemical functions. Dysfunction in store-operated channels is linked to skin pathologies, and these channels play vital roles in the normal physiology and function of the skin.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Declan Manning, Richard Barrett-Jolley, Richard L. Evans, Caroline Dart
Summary: Skin is the largest organ in the human body, mainly composed of keratinocytes which maintain a healthy skin barrier through regulated differentiation driven by Ca2+-transcriptional coupling. Disruption of this process leads to various skin conditions. Our study suggests that TRPC2 and Orai1 channels do not insert into the plasma membrane during store-operated Ca2+ entry.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Nicholas C. Vierra, Samantha C. O'Dwyer, Collin Matsumoto, L. Fernando Santana, James S. Trimmer
Summary: In mammalian brain neurons, membrane depolarization triggers Ca2+ influx through voltage-gated Ca2+ channels, leading to diverse cellular responses, including gene expression. The L-type Ca2+ channels in neuronal soma and dendrites play a key role in this process. The organization of signaling complexes by Kv2.1 at endoplasmic reticulum-plasma membrane junctions enhances the clustering and activity of Cav1.2 channels, impacting somatic Ca2+ signals and excitation-transcription coupling.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Quanquan Cao, Shaowu Yin
Summary: This study focused on the morphological changes of gill tissues in eels when faced with environmental calcium challenges, showing differences in filament and lamella lengths, lamellar frequency, and lamella width in different calcium environments. Ultrastructural changes in gills were examined using transmission electron microscopy, indicating expansion in calcium-deficient water and shrinkage in high-calcium water compared to the control group. Branchial surface areas are regulated in different calcium waters through calcium transporters such as CACNB2.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Virology
P. Sanjai Kumar, Anukrishna Radhakrishnan, Tathagata Mukherjee, Somlata Khamaru, Soma Chattopadhyay, Subhasis Chattopadhyay
Summary: This review highlights the importance of Ca2+ in diverse viruses and the role of Ca2+-conducting TRP channels in viral pathophysiology. TRP channels play a crucial role in various viral life-cycle events and may act as a target for antiviral therapeutics.
Article
Biochemistry & Molecular Biology
Konstantin Gusev, Alexey Shalygin, Dmitrii Kolesnikov, Leonid Shuyskiy, Sofia Makeenok, Lyubov Glushankova, Konstantin Sivak, Kirill Yakovlev, Yana Orshanskaya, Guanghui Wang, Andrey Bakhtyukov, Kira Derkach, Alexander Shpakov, Elena Kaznacheyeva
Summary: Research shows that TRPC6 channels play a crucial role in podocyte function and their dysregulation is associated with kidney diseases. Through single channel patch clamp technique, it is found that TRPC6 channels in human podocytes and rat glomerular podocytes are sensitive to calcium store depletion. In a rat model of DM2, a reduction in store-operated calcium entry was observed in glomerular podocytes, along with a reorganization of calcium influx mediated by TRPC6 channels and ORAI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Yiliam Cruz-Garcia, Katalin Barkovits, Michael Kohlhaas, Simone Pickel, Michelle Gulentz, Cornelia Heindl, Kathy Pfeiffer, Petra Eder-Negrin, Christoph Maack, Katrin Marcus, Michaela Kuhn, Erick Miranda-Laferte
Summary: Ca2+ influx through LTCCs in cardiomyocytes plays a crucial role in regulating Ca2+-dependent processes. In this study, proximity labeling and quantitative proteomics were used to identify proteins associated with Ca-v beta(2) in cardiomyocytes. These proteins are involved in diverse cellular functions. Additionally, interaction between Ca-v beta(2) and RyR2 was found to be necessary for the Ca2+-induced Ca2+ release mechanism in cardiomyocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Carmen Costas-Ferreira, Ana Carolina de Jesus Silva, Lorane Izabel da Silva Hage-Melim, Lilian R. Ferreira Faro
Summary: This study investigated the role of voltage-sensitive calcium channels (VSCCs) in the striatal dopamine release induced by the pesticide glyphosate (GLY). The results showed that GLY-induced dopamine release depends on the influx of extracellular calcium through T- and N-type VSCCs. These findings have important implications for assessing pesticide risks in non-target organisms.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Allergy
Jun-Hao Huang, Hui-Wen Gao, Dong-Dong Gao, Wei-Yue Yang, Meng-Ke Zhao, Bing Shen, Min Hu
Summary: Aerobic exercise can improve airway smooth muscle contractile function in asthmatic rats by inhibiting IL-4 secretion and down-regulating the expression of STIM1, Orai1, and Orai2, thus decreasing excessive SOCE-mediated ASM contraction.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Lilliana Beck, Estefano Pinilla, Daniel Dias Rufino Arcanjo, Raquel Hernanz, Judit Prat-Duran, Asbjorn Graver Petersen, Ralf Kohler, Majid Sheykhzade, Simon Comerma-Steffensen, Ulf Simonsen
Summary: Pirfenidone induces relaxation in pulmonary and coronary arteries, and improves endothelium-dependent vasodilatation in the aorta of diabetic animals, possibly through involvement of K(V)7 channels.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Zheng Fang Yang, Pankaj Panwar, Ciaran R. McFarlane, Wietske E. Tuinte, Marta Campiglio, Filip Van Petegem
Summary: Junctophilins (JPH) are proteins that connect the plasma membrane and the endoplasmic or sarcoplasmic reticulum, facilitating communication between proteins in different membranes. This study presents crystal structures of two JPH isoforms, revealing their importance in muscle excitation-contraction coupling. Various mutations in JPH2 and the L-type calcium channel affect their interaction and have been linked to cardiomyopathy and cardiac arrhythmia, respectively.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Correction
Endocrinology & Metabolism
C. Tsuji, T. Tsuji, A. Allchorne, G. Leng, M. Ludwig
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Review
Biology
Gareth Leng, Duncan J. MacGregor
MATHEMATICAL BIOSCIENCES
(2018)
Review
Endocrinology & Metabolism
Gareth Leng, John A. Russell
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Gareth Leng
ENDOCRINE CONNECTIONS
(2018)
Review
Multidisciplinary Sciences
Gareth Leng, Rhodri Ivor Leng, Stewart Maclean
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Article
Neurosciences
Jorge Maicas Royo, Gareth Leng, Duncan J. MacGregor
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Biochemical Research Methods
Duncan J. MacGregor, Gareth Leng
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Shumsuzzaman Khan, Xinjiang Lu, Qingyao Huang, Jiawei Tang, Jian Weng, Zhi Yang, Minchao Lv, Xiaokang Xu, Fangyuan Xia, Mengchen Zhang, Yi Li, Shuangshuang Liu, Gareth Leng, Nicholas Spitzer, Jizeng Du, Xuequn Chen
Article
Endocrinology & Metabolism
Catherine Hume, Andrew Allchorne, Valery Grinevich, Gareth Leng, Mike Ludwig
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Luis Paiva, Gareth Leng
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Neurosciences
Yan Tang, Diego Benusiglio, Arthur Lefevre, Louis Hilfiger, Ferdinand Althammer, Anna Bludau, Daisuke Hagiwara, Angel Baudon, Pascal Darbon, Jonas Schimmer, Matthew K. Kirchner, Ranjan K. Roy, Shiyi Wang, Marina Eliava, Shlomo Wagner, Martina Oberhuber, Karl K. Conzelmann, Martin Schwarz, Javier E. Stern, Gareth Leng, Inga D. Neumann, Alexandre Charlet, Valery Grinevich
NATURE NEUROSCIENCE
(2020)
Article
Physiology
Takahiro Tsuji, Chiharu Tsuji, Maja Lozic, Mike Ludwig, Gareth Leng
PHYSIOLOGICAL REPORTS
(2019)
Review
Physiology
Catherine Hume, Gareth Leng
CURRENT OPINION IN PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Jorge Maicas-Royo, Gareth Leng, Duncan J. MacGregor
Meeting Abstract
Clinical Neurology
G. Leng
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)