Article
Cell Biology
Larissa Rugila S. Stopa, Camila F. de Souza, Andressa B. Martins, Gabriela Mendicelli Lopes, Nathalia O. Costa, Daniela C. Ceccatto Gerardin, Giovana Gomes de Carvalho, Dimas Augusto Morozin Zaia, Cassia Thais B. Zaia, Ernane Torres Uchoa, Cristiane Mota Leite
Summary: This study found that neonatal overfeeding in female rats can lead to reproductive dysfunctions and disruptions in the noradrenaline-kisspeptin-GnRH pathway in adulthood.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Cell Biology
Rocio Schumacher, Maria Florencia Rossetti, Gisela Paola Lazzarino, Guillermina Canesini, Ana Paula Garcia, Cora Stoker, Maria Florencia Andreoli, Jorge Guillermo Ramos
Summary: Using a small litter model, researchers found that neonatal overfeeding leads to increased body weight and metabolic syndrome features in weaning rats. Early obesity development may involve changes in the GHSR/NPY system and POMC methylation status. Although body weight and metabolic parameters were restored at PND90, POMC methylation state remained altered.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Rocio Schumacher, Maria Florencia Rossetti, Guillermina Canesini, Luisa Gaydou, Ana Paula Garcia, Gisela Paola Lazzarino, Pamela Rocio Fernandez, Cora Stoker, Maria Josefina Carrio, Maria Florencia Andreoli, Jorge Guillermo Ramos
Summary: This study found that neonatal overfeeding disrupts the mesolimbic dopaminergic circuitry and causes changes in feeding behavior. Additionally, alterations observed during the neonatal period persist into adulthood and impact sensory-specific satiety.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Francesc Ribas-Aulinas, Silvia Ribo, Marcela Parra-Vargas, Antonio Fernandez-Perez, Judith Cebria, Maria Guardiola-Perello, Marta Ramon-Krauel, Carles Lerin, Ruben Diaz, Susana G. Kalko, Mario Vallejo, Antoni Diez-Noguera, Trinitat Cambras, Josep C. Jimenez-Chillaron
Summary: Childhood obesity is a strong risk factor for adult obesity, type 2 diabetes, and cardiovascular disease. A mouse model of early adiposity was developed through litter size reduction, with mice reared in small litters experiencing obesity, insulin resistance, and hepatic steatosis during adulthood. The study found that the liver played a major role in the development of the disease, with the circadian rhythm being a key factor in the long-term programming of metabolic health.
MOLECULAR METABOLISM
(2021)
Article
Pediatrics
Fang Huang, Pingping Zhu, Jingwen Wang, Jie Chen, Wenting Lin
Summary: This study showed that postnatal overfeeding leads to overexpression of hepatic miR-221 and impairs the PI3K/AKT signaling pathway, potentially causing insulin resistance. Avoiding overfeeding in early postnatal life may help prevent obesity and T2DM.
PEDIATRIC RESEARCH
(2021)
Article
Medicine, Research & Experimental
Flavia Natividade da Silva, Priscila Laiz Zimath, Thais Alves do Amaral, Jose Rodrigo Nascimento Martins, Alex Rafacho
Summary: This study investigated whether the coadministration of olanzapine exacerbates the diabetogenic effects of dexa-methasone in antiemetic cocktails used for chemotherapy. The results showed that the coadministration of olanzapine did not worsen the effects of dexamethasone on glucose metabolism and had only minor effects on lipid homeostasis in rats. Based on these findings, it is recommended to include olanzapine in the antiemetic cocktail due to its low incidence of metabolic adverse effects in male and female rats.
Article
Biochemistry & Molecular Biology
Eduardo Sanches, Yohan van de Looij, Dini Ho, Laura Modernell, Analina da Silva, Stephane Sizonenko
Summary: Combining early oral administration of lactoferrin with whole body hypothermia can enhance neuroprotection in neonatal hypoxic-ischemic encephalopathy, preventing lactate accumulation, reducing inflammation, and mitigating brain damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Wenyan Li, Yun Shu, Jing Zhang, Mengmeng Wu, Guang-hua Zhu, Wen-yan Huang, Li Shen, Yulin Kang
Summary: Long-term prednisone treatment caused dysbiosis in fungal microbiota and altered the ecological interaction between gut mycobiome and bacteriome in rats.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Cell Biology
Emily T. Stoneham, Daniel G. McHail, Sabina Samipour-Biel, Nicole Liehr, Christina M. Lee, Jean C. Evans, Katelyn Boggs, Theodore C. Dumas
Summary: The study compared the effects of two common maternal deprivation schedules on cognitive ability in young rats, finding that daily separation impaired spatial learning, while randomly spaced separation did not affect maze performance. Additionally, some biological effects were observed, such as differences in body weight and thymus weight normalized by body weight.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Goher Kerem, Xiangfang Yu, Aynur Ismayi, Bin Teng, Anjaneyulu Udduttula, Chang Liu, Zhongjia Yu, Dilbar Tohty, Jian V. Zhang, Pei-Gen Ren
Summary: Obesity is a global concern due to the increased risk of diseases, and it has been found that a high salt diet can alter the gut microbiota. This study investigated the changes in Small Intestinal Microbiota (SIM) in obesity-T2DM mice and found that high salt intake reduced body weight to some extent and led to the development of T2DM. High-throughput sequencing analysis revealed an increase in the F/B ratio and a decrease in beneficial bacteria in the high salt-high fat diet group. Additionally, Halorubrum luteum was observed in the small intestine for the first time.
SCIENTIFIC REPORTS
(2023)
Article
Physiology
Sara Landi, Federica Giannetti, Patrizia Benzoni, Giulia Campostrini, Giuliana Rossi, Chiara Piantoni, Giorgia Bertoli, Chiara Bonfanti, Luca Carnevali, Annalisa Bucchi, Mirko Baruscotti, Giorgia Careccia, Graziella Messina, Andrea Barbuti
Summary: Nfix is a transcription factor that plays important roles in the development and function of the heart. Lack of Nfix leads to a decrease in fast twitching fibers and an increase in heart rate. It was found that Nfix regulates heart rate by increasing the activity of L-type calcium channels.
Article
Nutrition & Dietetics
Ge Song, Qianyun Gan, Wentao Qi, Yong Wang, Meihong Xu, Yong Li
Summary: The dysbiosis of intestinal microbiota and their metabolites is associated with metabolic syndrome. This study evaluated the effects of low intake of sucrose and fructose on experimental colitis in rats by examining the microbiome and metabolome. The results showed that sucrose and fructose reduced body weight, colon length, and increased inflammation in the colon. They also inhibited the expression of a tight junction protein and increased the level of lipopolysaccharide in the plasma. Moreover, sucrose and fructose altered the composition of gut microbiota and disrupted amino metabolism in the colon. These findings suggest that fructose aggravates colitis by affecting the interaction between gut microbiota and their metabolites.
Article
Endocrinology & Metabolism
Gustav Collden, Emilie Caron, Sebastien G. Bouret
Summary: Early postnatal overnutrition causes metabolic alterations, but these alterations can be permanently attenuated through the administration of a leptin antagonist during a restricted developmental window.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Oncology
Yu-Wen Su, Alice M. C. Lee, Xukang Xu, Belinda Hua, Heather Tapp, Xue-Sen Wen, Cory J. Xian
Summary: Vitamin D deficiency is common in childhood cancer patients and survivors after chemotherapy, and more research is needed to explore the reasons behind it and the effectiveness of vitamin D supplementation in preventing chemotherapy-induced bone loss. This study used a rat model to show that methotrexate chemotherapy causes vitamin D deficiency, bone loss, and altered intestinal vitamin D metabolism, and that vitamin D supplementation can attenuate the bone loss.
Article
Neurosciences
Jocelyn J. Lippman-Bell, Marcus Handy, Cassidy G. Nieder, Mollie Getzfread, Frances E. Jensen
Summary: Early-life seizures may disrupt normal dendritic spine maturation and pruning in the hippocampal CA1 region, leading to an excess of less efficient synapses, potentially through activity-dependent modification of actin-regulating proteins like cofilin. These changes could be a deficit in structural plasticity and contribute to later-life cognitive consequences associated with early-life seizures, sharing similarities with developmental spine pruning failures in other neurodevelopmental disorders.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Clinical Neurology
Niklas Boman, Jonas Buren, Henrik Antti, Michael B. Svensson
Article
Nutrition & Dietetics
Jessica Nilsson, Madelene Ericsson, Masoumeh Motamedi Joibari, Fredrick Anderson, Leif Carlsson, Stefan K. Nilsson, Anna Sjodin, Jonas Buren
NUTRITION & METABOLISM
(2016)
Article
Endocrinology & Metabolism
Caroline Blomquist, Malin Alvehus, Jonas Buren, Mats Ryberg, Christel Larsson, Bernt Lindahl, Caroline Mellberg, Ingegerd Soderstrom, Elin Chorell, Tommy Olsson
Article
Endocrinology & Metabolism
Juliet Evans, Julia H. Goedecke, Ingegerd Soderstrom, Jonas Buren, Malin Alvehus, Caroline Blomquist, Fredrik Jonsson, Philip M. Hayes, Kevin Adams, Joel A. Dave, Naomi S. Levitt, Estelle V. Lambert, Tommy Olsson
CLINICAL ENDOCRINOLOGY
(2011)
Article
Endocrinology & Metabolism
Malin Alvehus, Kotryna Simonyte, Therese Andersson, Ingegerd Soderstrom, Jonas Buren, Eva Rask, Cecilia Mattsson, Tommy Olsson
CLINICAL ENDOCRINOLOGY
(2012)
Article
Physiology
Malin Alvehus, Niklas Boman, Karin Soderlund, Michael B. Svensson, Jonas Buren
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2014)
Article
Obstetrics & Gynecology
Asa Lindholm, Caroline Blomquist, Marie Bixo, Ingrid Dahlbom, Tony Hansson, Inger Sundstrom Poromaa, Jonas Buren
HUMAN REPRODUCTION
(2011)
Article
Endocrinology & Metabolism
Lijun Zhu, Miao Hou, Bin Sun, Jonas Buren, Li Zhang, Jun Yi, Olle Hernell, Xiaonan Li
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2010)
Article
Endocrinology & Metabolism
Miao Hou, Chenlin Ji, Jing Wang, Yanhua Liu, Bin Sun, Mei Guo, Jonas Buren, Xiaonan Li
JOURNAL OF ENDOCRINOLOGY
(2012)
Article
Biochemistry & Molecular Biology
Chenlin Ji, Yanyan Dai, Weiwei Jiang, Juan Liu, Miao Hou, Junle Wang, Jonas Buren, Xiaonan Li
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2014)
Article
Endocrinology & Metabolism
Malin Alvehus, Jonas Buren, Michael Sjostrom, Julia Goedecke, Tommy Olsson
Article
Nutrition & Dietetics
Anna Sjodin, Fredrik Hellstrom, EwaCarin Sehlstedt, Michael Svensson, Jonas Buren
Article
Nutrition & Dietetics
Jonas Buren, Madelene Ericsson, Nagila Raquel Teixeira Damasceno, Anna Sjodin
Summary: The study found that a ketogenic low-carbohydrate high-fat diet led to adverse lipid profiles in healthy, young, normal-weight women, including increased LDL cholesterol and other related markers.
Editorial Material
Nutrition & Dietetics
Jonas Buren, Madelene Ericsson, Nagila Raquel Teixeira Damasceno, Anna Sjodin