Editorial Material
Medicine, General & Internal
Mary E. Norton
Summary: The 2022 Lasker-DeBakey Clinical Medical Research Award is awarded to Yuk Ming Dennis Lo for his discovery of fetal DNA in the maternal circulation, which has revolutionized prenatal screening.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cell Biology
Amani Al-Mekhlafi, Kurt-Wolfram Suhs, Sven Schuchardt, Maike Kuhn, Kirsten Mueller-Vahl, Corinna Trebst, Thomas Skripuletz, Frank Klawonn, Martin Stangel, Frank Pessler
Summary: This research compared concentrations of 188 metabolites in CSF samples from patients with bacterial meningitis, viral meningitis/encephalitis, and noninflamed controls. Results showed that phosphatidylcholine concentrations were significantly higher in bacterial meningitis, associated with local disease and a shift in CNS metabolism.
Article
Multidisciplinary Sciences
Priscilla Van den Ackerveken, Alison Lobbens, Dorian Pamart, Aristotelis Kotronoulas, Guillaume Rommelaere, Mark Eccleston, Marielle Herzog
Summary: This study found that the levels of H3.1-nucleosomes are elevated in the plasma samples of patients with non-Hodgkin lymphoma (NHL) compared to healthy donors. The study also identified eight histone post-translational modifications (PTMs) that were present at higher levels in NHL patients' plasma. These findings suggest that H3.1-nucleosomes and histone PTMs may serve as useful biomarkers for diagnosing and monitoring non-Hodgkin lymphoma.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Ilana Fox-Fisher, Sheina Piyanzin, Bracha Lea Ochana, Agnes Klochendler, Judith Magenheim, Ayelet Peretz, Netanel Loyfer, Joshua Moss, Daniel Cohen, Yaron Drori, Nehemya Friedman, Michal Mandelboim, Marc E. Rothenberg, Julie M. Caldwell, Mark Rochman, Arash Jamshidi, Gordon Cann, David Lavi, Tommy Kaplan, Benjamin Glaser, Ruth Shemer, Yuval Dor
Summary: The immune cell type-specific methylation patterns in circulating cell-free DNA (cfDNA) can be used for studying human immune cell dynamics and provide a novel biomarker for monitoring immune responses to physiological and pathological processes.
Article
Virology
Ann Sofie Olesen, Louise Lohse, Camille Melissa Johnston, Thomas Bruun Rasmussen, Anette Botner, Graham J. Belsham
Summary: This study found that ASFV infection in pigs leads to an increase in the levels of circulating cell-free DNA (cfDNA) and host mitochondrial DNA (mtDNA) in the serum, while infection with CSFV does not cause this change. Therefore, the level of cfDNA in the serum is a sensitive marker of virulent ASFV infection.
Article
Psychiatry
Vanessa F. Goncalves, Ana Paula Mendes-Silva, Emiko Koyama, Erica Vieira, James L. Kennedy, Breno Diniz
Summary: The plasma levels of ccf-mtDNA are higher in LLD cases compared to controls, and are significantly correlated with the severity of depression but not with measures of cognitive decline. This study suggests an association between LLD, elevated mitochondrial damage, and cellular stress.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Nora Siegal, Michal Gutowski, Lakshmi Akileswaran, Norman J. Beauchamp, Lien-Chieh Ding, Christopher B. Chambers, Russell N. Van Gelder
Summary: The study found that enucleation and prosthesis placement can affect the ocular surface microbiome, particularly the virome, with MCPyV potentially being the etiologic cause of Merkel cell carcinoma.
SCIENTIFIC REPORTS
(2021)
Review
Physiology
Jessica L. Bradshaw, Spencer C. Cushen, Nicole R. Phillips, Styliani Goulopoulou
Summary: In this review, we discuss the changes in circulating cell-free mitochondrial DNA during pregnancy and its potential contribution to adverse pregnancy outcomes in pregnancy complications.
Article
Oncology
Amina Gihbid, Raja Benzeid, Abdellah Faouzi, Jalal Nourlil, Nezha Tawfiq, Nadia Benchakroun, Amal Guensi, Karima Bendahhou, Abdellatif Benider, Naima El Benna, Imane Chaoui, Rachida Cadi, Mohammed El Mzibri, Meriem Khyatti
Summary: The present study in Moroccan NPC patients found a significant correlation between pre-treatment plasmatic Epstein-Barr virus DNA load and conventional prognostic factors, suggesting that pre-treatment EBV DNA can be a useful prognostic biomarker for improving NPC treatment outcomes.
INFECTIOUS AGENTS AND CANCER
(2021)
Review
Biochemistry & Molecular Biology
Bernadeta Pietrzak, Iwona Kawacka, Agnieszka Olejnik-Schmidt, Marcin Schmidt
Summary: Human blood contains low biomass of circulating microbial cell-free DNA (cfmDNA) that primarily comes from bacteria. Circulating cfmDNA has been detected in patients with various diseases and in healthy individuals. Differences in microbial composition between healthy individuals and patients suggest potential associations with disease development. Although the function of circulating cfmDNA needs further clarification, it has the potential to serve as a non-invasive biomarker for improved diagnosis and treatment efficacy. The origin and function of circulating cfmDNA require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ata Mahmoodpoor, Mojtaba Mohammadzadeh, Rogayyeh Asghari, Majid Tagizadeh, Afshin Iranpour, Mansour Rezayi, Aynour Jalali Pahnvar, Babak Emamalizadeh, Nasim Sohrabifar, Somayeh Kazeminasab
Summary: This study found a strong association between levels of ccf-mtDNA and mortality, ICU admission, and intubation in COVID-19 patients, and highlighted the role of comorbidities as risk factors for COVID-19 mortality and severity.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Iben Lyskjaer, Neesha Kara, Solange De Noon, Christopher Davies, Ana Maia Rocha, Anna-Christina Strobl, Inga Usher, Craig Gerrand, Sandra J. Strauss, Daniel Schrimpf, Andreas von Deimling, Stephan Beck, Adrienne M. Flanagan
Summary: The study aimed to discover and validate methylation-based biomarkers to detect plasma circulating tumor DNA (ctDNA) in osteosarcoma (OS) patients and explore their utility as prognostic markers. The findings showed the potential of mutation-independent methylation-based ctDNA assays for OS and laid the foundation for further multi-institutional collaborative studies on plasma-derived biomarkers in the management of OS.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Oncology
Ricardo Martins-Ferreira, Barbara Leal, Joao Chaves, Laura Ciudad, Raquel Samoes, Antonio Martins da Silva, Paulo Pinho Costa, Esteban Ballestar
Summary: DNA methylation profiling can be used as a non-invasive and reproducible approach to identify biomarkers for epilepsy.
CLINICAL EPIGENETICS
(2022)
Article
Biochemistry & Molecular Biology
Lampros Chrysavgis, Alkistis Papatheodoridi, Evangelos Cholongitas, Michael Koutsilieris, George Papatheodoridis, Antonios Chatzigeorgiou
Summary: This study evaluated the serum levels of different cf-DNA species in NAFLD patients and found that total cf-DNA and gene-coding DNA levels were associated with the presence of cirrhosis. Lower serum levels of cf-DNA or RNAse P were independently correlated with the presence of cirrhosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Analytical
Pei-Shan Tsai, Pin-Xian Du, Batuhan Birol Keskin, Nan-Yao Lee, Shu-Wen Wan, Ya-Lan Lin, Wen-Yu Su, Pei-Chun Lin, Wei-Hsun Lin, Hsi-Chang Shih, Tzong-Shiann Ho, Guan-Da Syu
Summary: This study aims to analyze the humoral immunity and cross-reactivity in dengue patients using a multiplexed protein microarray. The results show that patients with severe dengue have higher levels of IgG antibodies against multiple Flavivirus antigens. Logistic regression analysis identifies groups of markers that can effectively distinguish dengue patients from healthy controls and hospitalized patients from mild cases.
ANALYTICAL CHEMISTRY
(2023)
Review
Gastroenterology & Hepatology
Randa Elsheikh, Hoang Thuy Tien, Abdelrahman M. Makram, Nguyen Thanh Van, Trang Thi Bich Le, Tamilarasy Vasanthakumaran, Nguyen Tien Huy
Summary: Since April 2022, there has been a rapidly spreading outbreak of acute hepatitis of unknown origin in children under 16 years old in multiple countries. Adenovirus serotype 41 has been identified as the most likely cause of the disease. However, further investigations are being carried out to explain the severity of the clinical presentation, which is not typical for this type of virus.
Review
Virology
Trang Thi Bich Le, Tamilarasy Vasanthakumaran, Hau Nguyen Thi Hien, I-Chun Hung, Mai Ngoc Luu, Zeeshan Ali Khan, Nguyen Thanh An, Van Phu Tran, Wei Jun Lee, Jeza Muhamad Abdul Aziz, Tasnim Ali, Shyam Prakash Dumre, Nguyen Tien Huy
Summary: The emergence of the SARS-CoV-2 Omicron variant has caused global distress. It shows multiple sublineages and is highly transmissible with reduced detection by current tests. The effectiveness of vaccines against Omicron and Delta variants is low, but they still provide protection against severe disease. The severity of illness may be higher in the Omicron sublineage BA.2. Further research is needed to understand the complexity of Omicron and improve its management and prevention.
REVIEWS IN MEDICAL VIROLOGY
(2023)
Article
Public, Environmental & Occupational Health
Marcel Alied, Dang Nguyen, Jeza Muhamad Abdul Aziz, Dang Phuc Vinh, Nguyen Tien Huy
PATHOGENS AND GLOBAL HEALTH
(2023)
Review
Dermatology
Ahmad Altom, Sarah Abd Elaziz Khader, Abdelrahman Gamil Gad, Rami Anadani, Dung Phuong Dang, Farrukh Ansar, Jinalben Chaudhari, Juan Crespo-Quezada, Nguyen Tien Huy
Summary: Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome is a rare, hereditary, autoinflammatory disease. This systematic review summarizes the current evidence and reveals that fever, skin lesions, and systemic inflammatory response are the prominent features of this syndrome, with clinical symptoms and pathological findings playing a crucial role in diagnosis and treatment.
AMERICAN JOURNAL OF DERMATOPATHOLOGY
(2023)
Article
Cell Biology
Nguyen Thi Tam, Abdelrahman M. Makram, Randa Elsheikh, Sarah Abd Elaziz Khader, Anh Nam Mai, Nguyen-Sy Toan, Nguyen Tien Huy, Bui Thi My Hanh
Summary: This study aimed to assess the accuracy of the International Academy of Cytology (IAC) Yokohama system in diagnosing breast cancer in a Vietnamese oncology center. The study evaluated 803 patients' FNAB specimens and calculated the risk of malignancy and other diagnostic indicators for different classification categories. The findings suggest that the IAC Yokohama system is a simple and cost-effective method for predicting breast pathology.
Article
Public, Environmental & Occupational Health
Venkata Vasavi Vadduri, Ayako Toyokawa, Nguyen Ngoc Hoang Linh, Dang Nguyen, Jeza M. Abdul Aziz, Norio Ohmagari, Nguyen Tien Huy
PATHOGENS AND GLOBAL HEALTH
(2023)
Article
Public, Environmental & Occupational Health
Akshay Raut, Nguyen Tien Huy
PATHOGENS AND GLOBAL HEALTH
(2023)
Editorial Material
Immunology
Randa Elsheikh, Abdelrahman M. M. Makram, Nguyen Tien Huy
Article
Public, Environmental & Occupational Health
Thoa Le, Trang T. B. Le, Le Van Truong, Mai Ngoc Luu, Nguyen Tran Minh Duc, Abdelrahman M. Makram, Truong Van Dat, Nguyen Tien Huy
Summary: This study surveyed the public's knowledge, attitude, perception, and practice (KAPP) toward COVID-19 during the rise of the Delta variant outbreak in Ho Chi Minh City. The results showed that medical staff had higher KAPP scores compared to the non-medical group, and there were positive correlations between knowledge and practice, attitude and practice, and perception and practice. The study emphasized the importance of citizens' KAPP in addition to government directives and policies during the pandemic.
FRONTIERS IN PUBLIC HEALTH
(2023)
Letter
Infectious Diseases
Marcel Alied, Patricia Takako Endo, Victor Hugo Aquino, Venkata Vasavi Vadduri, Nguyen Tien Huy
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Randa Elsheikh, Abdelrahman M. Makram, Nguyen Tien Huy
Article
Nursing
Randa Elsheikh, Loc Le Quang, Ngoc Quynh Tram Nguyen, Phu Tran Van, Dang The Hung, Abdelrahman M. Makram, Nguyen Tien Huy
Summary: While the barriers to evidence-based practice adoption among nurses have been well-identified, the specific role of nurse leaders in influencing and supporting evidence-based nursing is not well-demonstrated. This opinion piece explores the potential factors influencing the implementation of evidence-based practice into clinical routine and the contribution of nursing leadership styles in contemporary healthcare settings.
JOURNAL OF PROFESSIONAL NURSING
(2023)
Editorial Material
Public, Environmental & Occupational Health
Ngoc-Ha Tran, Nguyen Khoi Quan, Van Phu Tran, Dang Nguyen, Ngoc Phuong Hong Tao, Nguyen Ngoc Hoang Linh, Nguyen Tien Huy
PATHOGENS AND GLOBAL HEALTH
(2023)
Editorial Material
Public, Environmental & Occupational Health
Randa Elsheikh, Abdelrahman M. Makram, Sajog Kansakar, Khamsamay Xaylovong, Hirotsugu Aiga, Nguyen Tien Huy
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Obstetrics & Gynecology
Hoang Thi Nam Giang, Do Thi Thuy Duy, Nguyen Lam Vuong, Nguyen Thi Tu Ngoc, Thu Thi Pham, Nguyen Tran Minh Duc, Trinh Thi Diem Le, Tran Thi Tuyet Nga, Le Tho Minh Hieu, Nguyen Thi Tuong Vi, Bui Minh Triet, Nguyen Tan Thach, Tran Thi Bach Truc, Nguyen Tien Huy
Summary: Despite the high prevalence of breastfeeding in Vietnam, exclusive breastfeeding in the first six months remains low. Factors such as maternal education level, male infants, duration of skin-to-skin contact, and intention for exclusive breastfeeding during pregnancy are associated with higher rates of exclusive breastfeeding. Protecting mothers against infant formula advertising is crucial for promoting exclusive breastfeeding.
INTERNATIONAL BREASTFEEDING JOURNAL
(2023)
