Review
Electrochemistry
Honglin Luo, Bin Liu, Zhiwei Yang, Yizao Wan, Cheng Zhong
Summary: Zinc-based batteries face limitations in cycling performance due to issues like zinc dendrite formation, electrode deformation, corrosion, and hydrogen evolution. Researchers have developed strategies such as surface coating, additives, and structure design to address these problems, but trade-offs must be considered due to intertwined core factors restricting the reversibility of zinc electrodes.
ELECTROCHEMICAL ENERGY REVIEWS
(2022)
Article
Environmental Sciences
Ziyan Han, Jijun Meng, Likai Zhu, Haoran Cheng, Yingdi Wu, Chanjuan Wei
Summary: This study developed a new framework using set pair analysis (SPA) to effectively assess the multifunctionality of land in the Heihe River Basin (HRB) in China. The results showed an overall increase in land multifunctionality in the HRB from 2000 to 2015, with increased production and living functions making significant contributions. The relationship between production function and ecological function shifted from synergy to trade-off, indicating nonlinear characteristics. The coordination among land functions was found to be higher in the south and lower in the north, primarily influenced by ecological functions. Additionally, natural and anthropogenic drivers exhibited nonlinear effects on land functions, with thresholds indicating abrupt changes in influence.
LAND DEGRADATION & DEVELOPMENT
(2022)
Article
Development Studies
Dennis O. Ochieng, Sylvester O. Ogutu
Summary: Participating in supermarket channels can significantly increase total income and dietary diversity for smallholder vegetable farmers in Kenya, without sacrificing income from other sources. However, newcomers may require more initial capital investment to benefit from such partnerships.
Article
Economics
Jingwen Wu, I. Daniel Posen, Heather L. MacLean
Summary: The study finds that technological progress is an effective way to improve fuel economy in vehicles, with a larger impact on joint venture cars compared to foreign and indigenous cars. However, indigenous cars in China may face greater challenges in meeting future fuel consumption standards.
Article
Ecology
Isabella J. Burger, Evin T. Carter, Lexie M. Magner, Martha M. Munoz, Michael W. Sears, Benjamin M. Fitzpatrick, Eric A. Riddell
Summary: Hybridization between species can have various impacts on biodiversity and population sustainability, depending on the fitness of the hybrid relative to the parental species. In this study, the physiological performance of three tiger salamander genotypes was compared at different temperatures, revealing that hybrids have a higher water-gas exchange ratio compared to the native species, potentially explaining the rapid spread of salamander hybrids.
FUNCTIONAL ECOLOGY
(2023)
Article
Engineering, Multidisciplinary
Jordan Nickel, Ada Hurst, P. Robert Duimering
Summary: The traditional approach to studying trade-offs between design goals assumes a fixed formulation and framing of the design problem. This study proposes a novel set-theory framework of design spaces that considers the role of problem reformulation and reframing in resolving design tradeoffs. Empirical evidence from interviews with designers identifies eight distinct trade-off response mechanisms aligned with the framework's predictions.
Article
Biochemistry & Molecular Biology
Severin Josef Schink, Dimitris Christodoulou, Avik Mukherjee, Edward Athaide, Viktoria Brunner, Tobias Fuhrer, Gary Andrew Bradshaw, Uwe Sauer, Markus Basan
Summary: Central carbon metabolism is highly conserved among microbial species, but can catalyze different pathways, with cells struggling to sense flux direction after nutrient shifts. Cells can alleviate this issue by selecting preferred regulation direction, but at the cost of increasing lag times, affecting growth rate or futile cycling. These trade-offs explain why microorganisms specialize in glycolytic or gluconeogenic substrates and elucidate complex growth patterns among microbial species.
MOLECULAR SYSTEMS BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Seirana Hashemi, Roosa Laitinen, Zoran Nikoloski
Summary: Accumulating evidence has shown the importance of trade-offs involving metabolic traits in organism evolution. Different levels of complexity in metabolic models have been used to investigate and explain various metabolic trade-offs. This review discusses the modelling approaches used to study trade-offs in enzyme properties, reaction rates, pathway and network rates and yields, metabolic objectives, and metabolic concentrations. Insights into these trade-offs are provided by constraint-based metabolic modelling, highlighting their relationship to the classical black box Y-model and identifying concerns and future research perspectives.
Article
Biochemistry & Molecular Biology
David M. Ekkers, Sergio Tusso, Stefany Moreno-Gamez, Marina C. Rillo, Oscar P. Kuipers, G. Sander van Doorn
Summary: Mitigating trade-offs between different resource-utilization functions is crucial for the ecological and evolutionary success of organisms. The underlying metabolic constraints have been difficult to understand due to their complex molecular basis. This study investigates how metabolic architecture induces resource-utilization constraints and how these constraints drive evolutionary specialization and diversification. By studying the bacterium Lactococcus cremoris, the researchers found that the evolution of different metabolic specialists can be influenced by the metabolic network structure and historical contingency. These findings contribute to a better understanding of the relationship between molecular constraints and phenotypic trade-offs, and shed light on the mechanisms underlying evolutionary specialization and diversification.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Oceanography
Jie Su, Benrong Peng
Summary: By analyzing the case study of Xiamen ICM programme, it is found that implementing land and sea use policies under the ICM framework can significantly increase annual net benefits, thus improving the efficiency of marine resource use and contributing to sustainable development.
OCEAN & COASTAL MANAGEMENT
(2021)
Article
Parasitology
Winka Le Clec'h, Frederic D. Chevalier, Kathrin Jutzeler, Timothy J. C. Anderson
Summary: This study investigated the trade-off between propagative fitness in the intermediate snail host and reproductive fitness in the definitive vertebrate host of the trematode parasite Schistosoma mansoni. The results showed that high propagative fitness of the parasite in the snail host had a detrimental impact on snail physiology, but resulted in higher reproductive fitness and transmission in the definitive host. Therefore, the trade-off hypothesis was rejected, and it was found that selected parasite lines exhibited low and high shedding phenotype regardless of the snail host genetic background.
PARASITES & VECTORS
(2023)
Article
Environmental Sciences
Baoan Hu, Huifeng Wu, Hairong Han, Xiaoqin Cheng, Fengfeng Kang
Summary: Increased aridity poses challenges for sustainable ecosystem management due to potential trade-offs among ecosystem services. This study found that trade-offs between water yield and carbon storage, as well as habitat quality, exhibit nonlinear relationships with aridity. Climate and human factors primarily influence ecosystem service trade-offs indirectly through their effects on landscape characteristics. The research highlights the importance of landscape characteristics as key regulators of ecosystem service trade-offs and the need for further study on the impact of increasing aridity. This study has a score of 8 out of 10 in terms of importance.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Industrial
Marta Negri, Enrico Cagno, Claudia Colicchia
Summary: This study explores how to develop sustainable and resilient supply chain practices and identifies the synergies and trade-offs between sustainability and resilience in the supply chain.
PRODUCTION PLANNING & CONTROL
(2022)
Article
Zoology
Cristian L. Klunk, Marcio R. Pie
Summary: The study investigated the occurrence of the dominance-discovery trade-off hypothesis in Pheidole ant assemblages in Atlantic Forest remnants. However, the results showed no distinct interspecific variation in the ability to find or dominate food sources, suggesting that this trade-off does not explain their coexistence. Low levels of aggression between Pheidole species may prevent dominance hierarchies, while species order of arrival at food sources may enable resource partitioning through priority effects.
CANADIAN JOURNAL OF ZOOLOGY
(2021)
Review
Plant Sciences
Bhanu Malhotra, Pawan Kumar, Naveen C. Bisht
Summary: Specialized metabolites are a diverse group of naturally occurring compounds in plants that play multiple auxiliary roles, such as regulating the trade-off between growth and defense and offsetting their own production costs. Glucosinolates, as a model, have been found to have multifunctionalities in fine-tuning plant growth and development.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Neyaz A. Khan, Navdeep Kaur, Peter Owens, Olivier P. Thomas, Aoife Boyd
Summary: Sponge bis-indole alkaloids have potent antimicrobial activity against both Gram-positive and Gram-negative bacteria, rapidly disrupting and permeabilizing bacterial cell membranes. They are also capable of reducing pathogen cytotoxicity towards mammalian cells, making them potential candidates for antibiotics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Oussama ElMokh, Saki Matsumoto, Paulina Biniecka, Axel Bellotti, Karin Schaeuble, Francesco Piacente, Hector Gallart-Ayala, Julijana Ivanisevic, Ivan Stamenkovic, Alessio Nencioni, Aimable Nahimana, Michel A. Duchosal
Summary: Researchers found that an enriched tumor environment containing vitamin B3 or nicotinic acid significantly decreases the anti-tumor efficacy of NAMPT inhibitors. In addition, gut bacteria can convert NAM into nicotinic acid, which fuels an alternative NAD synthesis pathway, protecting cancer cells from NAD depletion and promoting their survival.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Hao Li, Alessia Perino, Qingyao Huang, Giacomo V. G. Von Alvensleben, Amir Banaei-Esfahani, Laura A. Velazquez-Villegas, Karim Gariani, Melanie Korbelius, Maroun Bou Sleiman, Jeromine Imbach, Yu Sun, Xiaoxu Li, Alexis Bachmann, Ludger J. E. Goeminne, Hector Gallart-Ayala, Evan G. Williams, Julijana Ivanisevic, Johan Auwerx, Kristina Schoonjans
Summary: This study comprehensively investigates the role of bile acids in metabolic traits using a mouse model, revealing regulators of bile acid homeostasis and the association between CES1C and plasma TUDCA, a bile acid species with disease-preventing actions.
Article
Multidisciplinary Sciences
Yetkin Caka Ince, Johanna Krahmer, Anne-Sophie Fiorucci, Martine Trevisan, Vinicius Costa Galvao, Leonore Wigger, Sylvain Pradervand, Laetitia Fouillen, Pierre Van Delft, Manon Genva, Sebastien Mongrand, Hector Gallart-Ayala, Julijana Ivanisevic, Christian Fankhauser
Summary: Plant growth is influenced by fixed carbon and the availability of light for photosynthesis, and shade conditions enhance growth through a combination of low blue light and a low red to far-red ratio of light. Studies have found that these two light conditions independently trigger different transcriptional reprogramming pathways to promote hypocotyl growth. Low blue light induces starvation responses and promotes autophagy, while a low red to far-red ratio of light induces anabolic processes.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Jessica Medina, Rebecca Borreggine, Tony Teav, Liang Gao, Shanshan Ji, Justin Carrard, Christina Jones, Niek Blomberg, Martin Jech, Alan Atkins, Claudia Martins, Arno Schmidt-Trucksass, Martin Giera, Amaury Cazenave-Gassiot, Hector Gallart-Ayala, Julijana Ivanisevic
Summary: This study presents a targeted LC-MS/MS approach for high-throughput quantification of complex lipid species. The method achieved high precision measurements within and across multiple batches. The method can distinguish between different sample sources and reveal sex-specific differences in the serum lipidome.
ANALYTICAL CHEMISTRY
(2023)
Article
Clinical Neurology
Abigail Strefeler, Maxime Jan, Manfredo Quadroni, Tony Teav, Nadia Rosenberg, Jean-Yves Chatton, Nicolas Guex, Hector Gallart-Ayala, Julijana Ivanisevic
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Multidisciplinary Sciences
Joanna Triscott, Matthias Reist, Lukas King, Francielle C. Moselle, Marika Lehner, John Gallon, Archna Ravi, Gurpreet K. Arora, Simone de Brot, Mark Lundquist, Hector Gallart-Ayala, Julijana Ivanisevic, Salvatore Piscuoglio, Lewis C. Cantley, Brooke M. Emerling, Mark A. Rubin
Summary: Phosphatidylinositol (PI)regulating enzymes, especially PI5P4K alpha isoform, play a crucial role in androgen receptor (AR) signaling and prostate cancer (PCa) cell survival. Metabolic stress adaptation of PCa during androgen deprivation (AD) influences PI abundance and activates intracellular pools of PI-4,5-P2. Dysregulation of the mTORC1 pathway and colocalization of PI5P4K alpha to the lysosome are involved in the PI5P4K alpha-AR relationship. Inhibition of PI5P4K alpha shows potential in disrupting PCa metabolic adaptation and castrate resistance.
Article
Cell Biology
Tanes I. Lima, Pirkka-Pekka Laurila, Martin Wohlwend, Jean David Morel, Ludger J. E. Goeminne, Hao Li, Mario Romani, Xiaoxu Li, Chang-Myung Oh, Dohyun Park, Sandra Rodriguez-Lopez, Julijana Ivanisevic, Hector Gallart-Ayala, Barbara Crisol, Florence Delort, Sabrina Batonnet-Pichon, Leonardo R. Silveira, Lakshmi Sankabattula Pavani Veera Venkata, Anil K. Padala, Suresh Jain, Johan Auwerx
Summary: Disruption of ceramide biosynthesis leads to the decline in mitochondrial and protein homeostasis during muscle aging. Through transcriptome analysis of muscle biopsies, it was found that disturbance in ceramide biosynthesis, mitochondrial function, and protein homeostasis are prevalent features in aged individuals and patients with muscle disorders. Inhibition of ceramide biosynthesis restores proteostasis and mitochondrial function, improving muscle health and lifespan in both nematodes and mice.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Ecology
Sara Heim, Tony Teav, Hector Gallart-Ayala, Julijana Ivanisevic, Nicolas Salamin
Summary: This study analyzed the chemical composition of clownfish and damselfish mucus and found distinct differences in polar and lipid metabolome signatures between the two clades. Clownfish mucus had a greater diversity of ceramides and higher levels of sphingolipids. The metabolic signature of clownfishes also showed higher inter-specific variability, suggesting the impact of symbiosis on metabolic diversity. Furthermore, specialist and generalist clownfish species displayed unique metabolite signatures, indicating a link with their mutualistic nature.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Evolutionary Biology
Fanny Cavigliasso, Loriane Savary, Jorge E. Spangenberg, Hector Gallart-Ayala, Julijana Ivanisevic, Tadeusz J. Kawecki
Summary: Periodic food shortage drives physiological and metabolic adaptations in animals, particularly in juvenile individuals. A study on Drosophila melanogaster populations revealed wide-ranging changes in metabolite abundance as a response to nutrient shortage. Adapted larvae showed lower levels of amino acids but grew faster, indicating increased use of amino acids for energy generation. The study also highlighted the trade-off between acquisition of dietary amino acids and carbohydrates and the unique depletion pattern of branched-chain amino acids.
Article
Chemistry, Medicinal
Tomas Duminis, Marcin Heljak, Wojciech Swieszkowski, Alexander Ereskovsky, Izabela Dziedzic, Marek Nowicki, Martyna Pajewska-Szmyt, Alona Voronkina, Stefan R. Bornstein, Hermann Ehrlich
Summary: Skeletal constructs of marine sponges, especially those isolated from cultivated demosponges, have the potential to be sustainable sources of biocompatible porous biopolymer-based 3D scaffolds for tissue engineering. These chitinous scaffolds have shown promising results in biomimetics and tissue engineering due to their renewability and broad diversity of cells. However, the mechanical features of these constructs have been poorly studied before.
Article
Chemistry, Medicinal
Anita Kubiak, Martyna Pajewska-Szmyt, Martyna Kotula, Bartosz Lesniewski, Alona Voronkina, Parvaneh Rahimi, Sedigheh Falahi, Korbinian Heimler, Anika Rogoll, Carla Vogt, Alexander Ereskovsky, Paul Simon, Enrico Langer, Armin Springer, Maik Foerste, Alexandros Charitos, Yvonne Joseph, Teofil Jesionowski, Hermann Ehrlich
Summary: This study presents a new biomimetic approach for the development of a lepidocrocite-containing 3D spongin scaffold using artificial seawater and iron. The research proposes a mechanism of lepidocrocite formation and suggests the potential application of the biocomposite as an electrochemical dopamine sensor.
Article
Environmental Sciences
Aurelie Portas, Nathan Carriot, Annick Ortalo-Magne, Guillaume Damblans, Maxime Thiebaut, Gerald Culioli, Nolwenn Quillien, Jean-Francois Briand
Summary: This study investigates the impact of water dynamics on biofouling colonization in the Etel Estuary. The results show that shear stress plays a crucial role in shaping the composition and metabolic response of biofouling communities. The findings highlight the importance of hydrodynamics in determining the structure and function of marine biofouling.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Zoology
Andrey Lavrov, Irina Ekimova, Dimitry Schepetov, Alexandra Koinova, Alexander Ereskovsky
Summary: This study presents the first integrative revision of the biodiversity of the genus Leucosolenia in the Boreal and Arctic regions, with a specific focus on the White Sea. The researchers conducted an integrative analysis using morphological data, microbiome observations, ecological data, and molecular phylogenetic analyses. They found different species of Leucosolenia and discovered new informative morphological characters. This study provides a foundation for further revision of this group in other regions.
ZOOLOGICAL JOURNAL OF THE LINNEAN SOCIETY
(2023)
Article
Engineering, Multidisciplinary
Anita Kubiak, Alona Voronkina, Martyna Pajewska-Szmyt, Martyna Kotula, Bartosz Lesniewski, Alexander Ereskovsky, Korbinian Heimler, Anika Rogoll, Carla Vogt, Parvaneh Rahimi, Sedigheh Falahi, Roberta Galli, Enrico Langer, Maik Foerste, Alexandros Charitos, Yvonne Joseph, Hermann Ehrlich, Teofil Jesionowski
Summary: In this study, spongin from Hippospongia communis was used as a template to develop a new 3D composite containing goethite. The obtained composite showed potential industrial applications and exhibited satisfactory performance in the electrochemical sensing of dopamine in human urine samples.