Article
Environmental Sciences
Qin-Yao Zhang, Ling-Ling Xu, Mei-Ting Zhong, Yu-Kui Chen, Ming-Quan Lai, Qi Wang, Xiao-Li Xie
Summary: This study found that gestational exposure to GenX and PFOA can cause histopathological changes in the liver and intestinal mucosa, leading to metabolic disorder and dysfunction of the intestinal mucosal barrier. In addition, GenX also caused DNA damage and cell cycle arrest in the liver, and gut microbiota imbalance may contribute to hepatotoxicity. These findings enrich the understanding of the mechanisms of developmental hepatotoxicity induced by GenX.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Wen-Yuan Lin, Bruce Chi-Kang Tsai, Cecilia Hsuan Day, Ping-Ling Chiu, Ray-Jade Chen, Michael Yu-Chih Chen, V. Vijaya Padma, Hsiang-Ning Luk, Hsiang-Chen Lee, Chih-Yang Huang
Summary: Regular chewing of areca nut may increase the risk of cardiovascular disease mortality, and research shows that the toxic mechanism of areca nut on the heart mainly involves inducing cardiac apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Chemistry, Applied
T. P. Punarvasu, K. V. Harish Prashanth
Summary: Self-assembled microparticles from chitosan (SAMC) prepared by depolymerization induced by potassium persulfate showed anti-tumor and anti-angiogenic properties and could be a safe candidate for anti-tumor dietary supplement production.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Biomedical
Katherine L. Lorentz, Prerak Gupta, Mostafa S. Shehabeldin, Eoghan M. Cunnane, Aneesh K. Ramaswamy, Konstantinos Verdelis, Morgan V. Dileo, Steven R. Little, Justin S. Weinbaum, Charles S. Sfeir, Biman B. Mandal, David A. Vorp
Summary: This study developed a functionalized silk scaffold capable of controlled delivery of a biological payload to improve in vivo performance. By loading microparticles that mimic cell function into the scaffold, improved performance of TEVGs was achieved. The acellular nature of this technology has the potential to reduce risk, increase reproducibility, and be more cost-effective compared to cell-based options.
ACTA BIOMATERIALIA
(2021)
Article
Environmental Sciences
Ruxue Jia, Min Wei, Jinrong Lei, Xianzong Meng, Rui Du, Mengxin Yang, Xinjun Lu, Yizhu Jiang, Ran Cao, Lili Wang, Laiyu Song
Summary: This study demonstrates that PM2.5 can induce myocardial injury in hyperlipidemic mice via the ROS-pyroptosis signaling pathway, providing a potential approach for clinical interventions.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Chemistry, Inorganic & Nuclear
Miguel A. Gonzalvez, Jeffrey R. Harmer, Paul Bernhardt
Summary: This study investigates the formation process of a rare organocopper(II) complex [Cu(Me(6)tren)(CH2CN)](+), and identifies distinct spectroscopic features of the complex through experimental and theoretical calculations. The research reveals the formation mechanism of this unusual complex.
INORGANIC CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Xiao-Ling Zhu, Tao Li, Yu Cao, Qing-Ping Yao, Xing Liu, Ying Li, Yang-Yang Guan, Ji-Jun Deng, Rui Jiang, Jun Jiang
Summary: tRFs and tiRNAs are generated from specific cleavage of tRNAs or their precursors, regulating gene expression in stressful cellular conditions. This study showed that tRF(GlnCTG) is overexpressed in injured arteries and negatively regulates FAS gene expression, promoting vascular smooth muscle cell proliferation. Investigating the roles of tRFs/tiRNAs is crucial for understanding intimal hyperplasia mechanisms and potential treatments.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Environmental Sciences
Zhongjia Huang, Lianxian Guo, Xu Chen, Jiadi Sun, Yongli Ye, Lina Sheng, Yinzhi Zhang, Jianzhong Zhou, Jian Ji, Xiulan Sun
Summary: The consumption of rice contaminated with arsenic on a long-term basis is a significant global public health issue, with particular attention on arsenic-induced urinary injury and kidney damage. In this study, a mice model was established to study the effects of long-term arsenic exposure through rice consumption. The results showed that arsenic exposure led to changes in metabolites related to kidney metabolism and lipid metabolism, as well as disruption of amino acid and energy pathways. This study also suggested a potential association between metabolic disorders caused by arsenic exposure and inherited neurometabolic disorders.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Ying Zhang, Yaqi Jiao, Yue Tao, Zixu Li, Hui Yu, Siyue Han, Yang Yang
Summary: Monobutyl phthalate (MBP) can cause acute effects on zebrafish liver, including endoplasmic reticulum stress, lipid synthesis promotion, lipid droplet accumulation, and inhibition of glucose metabolism, leading to cell death and liver damage.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Cong Zhou, Hao Song, Jie Feng, Zhi Hu, Mei-jie Yang, Pu Shi, Yong-ren Li, Yong-jun Guo, Hai-zhou Li, Tao Zhang
Summary: This study investigated the metabolic responses to hypo-salinity stress and osmoregulation mechanisms in the hard clam Mercenaria mercenaria, a widely cultured euryhaline bivalve species in China. The study identified several changes in response to hypo-salinity stress, including increased vacuoles in gill filaments, up-regulation of Na+/K+-ATPase activity, and up-regulation of antioxidant metabolites. Potential biomarkers of hypo-salinity stress were also identified in the hard clams.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Cong Zhou, Hao Song, Jie Feng, Zhi Hu, Mei-Jie Yang, Pu Shi, Yong-ren Li, Yong-jun Guo, Hai-zhou Li, Tao Zhang
Summary: This study investigated the metabolic responses and osmoregulation mechanisms of the euryhaline bivalve hard clam to hypo-salinity stress using biochemical assays, metabolomics, and gene expression analysis. The results showed that during hypo-salinity stress, the clam developed vacuoles in its gills, decreased Na+ and Cl- concentrations, up-regulated Na+/Cl--ATPase activity, and down-regulated the cAMP-PKA pathway. Antioxidant metabolites were up-regulated, and glycerolipid metabolism was strengthened. Anaerobic metabolism and fatty acid β-oxidation were also observed. Potential biomarkers of hypo-salinity stress were identified. This study provides novel insights into the metabolic regulatory mechanisms of hypo-salinity stress in euryhaline bivalves.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Physiology
Jenna Wilcox-Hagerty, Haifang Xu, Brian A. Hain, Amy C. Arnold, David L. Waning
Summary: The study found that cachexia leads to decreased whole animal energy expenditure in mice and highly dysmorphic mitochondria and mitophagy in skeletal muscle. Understanding these changes will contribute to defining treatments for cancer cachexia.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Jian-yi Dong, Kai-jun Xia, Wei Liang, Lu-lu Liu, Fang Yang, Xue-sheng Fang, Yong-jian Xiong, Liang Wang, Zi-juan Zhou, Chang-yi Li, Wei-dong Zhang, Jing-yu Wang, Da-peng Chen
Summary: This study reveals the pathological role of Hrd1 in colitis and provides a novel insight into alternative treatment of colitis using GRb1 activating the Hrd1 signaling pathway. GRb1 administration normalized Hrd1 expression and alleviated ER stress response, Fas-related apoptosis, and other colitis symptoms.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Medicine, Research & Experimental
Alexandre G. Maganin, Guilherme R. Souza, Miriam D. Fonseca, Alexandre H. Lopes, Rafaela M. Guimaraes, Andre Dagostin, Nerry T. Cecilio, Atlante S. Mendes, William A. Goncalves, Conceicao E. A. Silva, Francisco Isaac Fernandes Gomes, Lucas M. Mauriz Marques, Rangel L. Silva, Leticia M. Arruda, Denis A. Santana, Henrique Lemos, Lei Huang, Marcela Davoli-Ferreira, Danielle Santana-Coelho, Morena B. Sant'Anna, Ricardo Kusuda, Jhimmy Talbot, Gabriela Pacholczyk, Gabriela A. Buqui, Norberto P. Lopes, Jose C. Alves-Filho, Ricardo M. Leao, Jason C. O'Connor, Fernando Q. Cunha, Andrew Mellor, Thiago M. Cunha
Summary: This study found that neuropathic pain can be eliminated by inhibiting the kynurenine metabolic pathway (KYNPATH) initiated by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1). Mechanistically, dendritic cells (DCs) expressing IDO1 accumulate in the dorsal root leptomeninges and lead to an increase in kynurenine levels in the spinal cord. Kynurenine is then metabolized by astrocytes expressing kynurenine-3-monooxygenase (KMO) into the pronociceptive metabolite 3-hydroxykynurenine.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Physiology
Chandra Yallampalli, Ancizar Betancourt, Akansha Mishra, Kathleen A. Pennington, Simone Hernandez Ruano, Moises Tacam, Madhu Chauhan
Summary: This study aimed to assess the specific role of Adrenomedullin2 (AM2) in pregnancy induced vascular and metabolic adaptation. AM2 (-/-) mice were successfully generated using CRISPR/Cas9 system and compared to wild type littermates (AM2 (+/+)). Results indicated that AM2 (-/-) females were fertile, but gestational length was decreased and the number of pups born dead or died after birth was higher in AM2 (-/-) mice. Furthermore, AM2 (-/-) mice exhibited elevated blood pressure, increased vascular sensitivity, higher serum triglycerides levels, glucose intolerance, and higher insulin levels during pregnancy. Discussion: These findings suggest a physiological role for AM2 in pregnancy induced vascular and metabolic adaptations in mice.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neurosciences
Kaja Plucinska, Nimesh Mody, Ruta Dekeryte, Kirsty Shearer, George D. Mcilroy, Mirela Delibegovic, Bettina Platt
Summary: This study assessed the effects of high-fat diet on the metabolic and cognitive phenotypes in diabetic BACE1 knock-in mice and found that high-fat diet worsened metabolism and induced early mortality in these mice. Furthermore, it exacerbated spatial memory deficits in Alzheimer's-like BACE1 mice. However, these effects were partially prevented by Fenretinide treatment.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Nadine Godsman, Michael Kohlhaas, Alexander Nickel, Lesley Cheyne, Marco Mingarelli, Lutz Schweiger, Claire Hepburn, Chantal Munts, Andy Welch, Mirela Delibegovic, Marc Van Bilsen, Christoph Maack, Dana K. Dawson
Summary: This study investigates the specific metabolic adaptations in takotsubo patients and their implications for future therapies. The study reveals dysregulation of glucose and lipid metabolic pathways, impaired Ca2+ handling, inflammation, and upregulation of remodeling pathways in the hearts of takotsubo patients. However, the integrity of both mitochondria and cardiomyocytes is preserved.
CARDIOVASCULAR RESEARCH
(2022)
Review
Nutrition & Dietetics
Sayani Mukherjee, Silje Skrede, Edward Milbank, Ramaroson Andriantsitohaina, Miguel Lopez, Johan Ferno
Summary: Antipsychotic drugs play a crucial role in the treatment of schizophrenia and other psychoses. However, many of these drugs have side effects such as increased appetite, weight gain, and increased risk for diabetes and cardiovascular disease. Understanding the molecular mechanisms behind drug-induced hyperphagia is important for the development of new drugs and advancing our knowledge of appetite regulation.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Ola El Atab, Crystal M. Ghantous, Nabil El-Zein, Rima Farhat, Abdelali Agouni, Hesham M. Korashy, Laiche Djouhri, Layla Kamareddine, Kazem Zibara, Asad Zeidan
Summary: This study investigates the molecular mechanisms involved in hyperglycemia-induced vascular remodeling, with a focus on the role of APN and leptin. It found that hyperglycemia increases APN synthesis but decreases APN receptor expression, and upregulates leptin expression in vascular smooth muscle cells. These changes lead to increased oxidative stress and alterations in actin cytoskeleton dynamics, facilitating vascular remodeling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Arthur Piraux, Marie Cavillon, Aline Ramond-Roquin, Sebastien Faure
Summary: This study assessed the satisfaction among French individuals receiving their COVID-19 vaccination from community pharmacists and found that the service was overwhelmingly appreciated. The majority of those vaccinated by pharmacists had previously received their influenza vaccine at the same pharmacy, indicating a high level of trust in pharmacists and potential for them to perform additional vaccinations.
Letter
Medicine, General & Internal
Nurul Nabilah Akmal Hashim, Sumaiyah Mat, Phyo Kyaw Myint, Sheng Hui Kioh, Mirela Delibegovic, Ai-Vyrn Chin, Shahrul Bahyah Kamaruzzaman, Noran Naqiah Hairi, Selina Khoo, Maw Pin Tan
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Edward Milbank, Nathalia Dragano, Xavi Vidal-Gomez, Veronica Rivas-Limeres, Pablo Garrido-Gil, Mireille Wertheimer, Sylvain Recoquillon, Maria P. Pata, Jose Luis Labandeira-Garcia, Carlos Dieguez, Ruben Nogueiras, M. Carmen Martinez, Ramaroson Andriantsitohaina, Miguel Lopez
Summary: The study found that using a specific type of extracellular vesicles loaded with a defective AMPK alpha 1 gene can alleviate symptoms such as obesity and metabolic disorders in mice.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Medicine, Research & Experimental
Nadine Sommer, Ahlima Roumane, Weiping Han, Mirela Delibegovic, Justin J. Rochford, George D. Mcilroy
Summary: This study suggests that gene therapy has the potential to be an effective treatment for congenital generalized lipodystrophy type 2. Using a mouse model, researchers found that systemic adeno-associated virus delivery of the BSCL2 gene could restore white adipose tissue development and improve metabolic health in adult seipin knockout mice. The findings highlight the therapeutic potential of gene therapy for correcting metabolic complications in patients with congenital lipodystrophy.
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2022)
Article
Cell Biology
Lionel Fizanne, Alexandre Villard, Nadia Benabbou, Sylvain Recoquillon, Raffaella Soleti, Erwan Delage, Mireille Wertheimer, Xavier Vidal-Gomez, Thibauld Oullier, Samuel Chaffron, M. Carmen Martinez, Michel Neunlist, Jerome Boursier, Ramaroson Andriantsitohaina
Summary: The study investigates the role of fEVs and cEVs in liver diseases such as NAFLD and NASH. NASH-fEVs were found to have deleterious effects, increasing intestinal permeability and reducing expression of tight junction proteins through the involvement of nmMLCK and lipopolysaccharide pathways.
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Biochemistry & Molecular Biology
Sarah E. J. Kamli-Salino, Paul A. J. Brown, Timo N. Haschler, Lihuan Liang, Denis Feliers, Heather M. Wilson, Mirela Delibegovic
Summary: This study compared the effects of freshly prepared STZ and anomer-equilibrated STZ on kidney damage in mice and found that anomer-equilibrated STZ caused more severe kidney tubule structural damage, while freshly prepared STZ only caused mild changes. Therefore, anomer-equilibrated STZ provides a reliable mouse model for diabetes and early-stage diabetic nephropathy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Muhammad Ammar Zahid, Shahenda Salaheldin Abdelsalam, Hicham Raiq, Aijaz Parray, Hesham Mohamed Korashy, Asad Zeidan, Mohamed A. Elrayess, Abdelali Agouni
Summary: A timely and adequate response to stress is crucial for maintaining cell function, and disruptions in defense mechanisms against stress can lead to various pathologies. Aging and cardiovascular diseases can reduce the effectiveness of these defense mechanisms. Sestrin2 (SESN2) is a stress-inducible protein that can protect cells by increasing antioxidants, temporarily halting stressful reactions, and promoting autophagy. Maintaining sufficient levels/activity of SESN2 may prevent cardiovascular aging and disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Annesha Sil, Marina Souza Matos, Mirela Delibegovic, Bettina Platt
Summary: Insufficiently characterised controls in biomedical research, including neuroscience and metabolism, have contributed to irreproducibility. Phenotypic differences between commonly used C57BL/6 substrains as control animals are now increasingly recognized. This study investigated metabolic characteristics in multiple C57BL/6 substrains, revealing systematic and tissue-specific differences influenced by vendor and sex, emphasizing the importance of selecting and characterising control subjects to ensure proper experimental outcomes.
Article
Biochemistry & Molecular Biology
Shamma Almuraikhy, Najeha Anwardeen, Asmma Doudin, Maha Sellami, Alexander Domling, Abdelali Agouni, Asmaa A. Althani, Mohamed A. Elrayess
Summary: This study investigated the metabolic pathways involved in the protective effects of moderate physical activity in non-obese and healthy individuals. The results showed increased activation of antioxidative stress pathways in active participants, as well as significant associations between glutathione metabolites and certain clinical traits.
Article
Biochemistry & Molecular Biology
Shamma Almuraikhy, Najeha Anwardeen, Asmma Doudin, Maha Sellami, Alexander Domling, Abdelali Agouni, Asmaa A. Al Thani, Mohamed A. Elrayess
Summary: Healthy non-obese insulin resistant individuals have a higher risk of metabolic syndrome. Physical activity can lower insulin resistance, but the metabolic pathways involved are still unknown. This study analyzed data from 305 non-obese participants and found that active insulin resistant individuals showed differences in fatty acid metabolism, while sedentary insulin resistant individuals showed changes in glucose metabolism. These findings have important implications for the prevention and treatment of metabolic syndrome. Rating: 8 out of 10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Stavroula Kastora, Manisha Patel, Ben Carter, Mirela Delibegovic, Phyo Kyaw Myint
Summary: This study is the first umbrella systematic review and meta-analysis to analyze the outcomes of COVID-19 infection in patients with diabetes, including mortality, ICU admission, ventilation requirement, illness severity, and discharge rate. The results show that patients with diabetes have a higher risk of COVID-19-related mortality, increased ICU admissions, and increased ventilation requirements worldwide.
ENDOCRINOLOGY DIABETES & METABOLISM
(2022)