Article
Cell Biology
Zhibin Zhou, Jun Ma, Jiajia Lu, Aimin Chen, Lei Zhu
Summary: Circular RNAs play a significant role in osteoarthritis (OA), particularly CircCDH13, which induces chondrocyte apoptosis, promotes extracellular matrix degradation, and inhibits extracellular matrix synthesis in OA cartilage tissues. CircCDH13 acts as a sponge for miR-296-3p and regulates the miR-296-3p-PTEN pathway, contributing to OA pathogenesis. Silencing CircCDH13 reduces chondrocyte apoptosis, inhibits matrix degradation, and promotes matrix synthesis through the miR-296-3p-PTEN pathway, showing promise as a potential target for future OA interventions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Marta Correia de Sousa, Nicolas Calo, Cyril Sobolewski, Monika Gjorgjieva, Sophie Clement, Christine Maeder, Dobrochna Dolicka, Margot Fournier, Laurent Vinet, Xavier Montet, Jean-Francois Dufour, Bostjan Humar, Francesco Negro, Christine Sempoux, Michelangelo Foti
Summary: Despite being considered a potent oncomiR in human cancers, genetic deletion of miR-21 in mouse models surprisingly promotes hepatocellular carcinoma (HCC) development by affecting various signaling pathways and immune responses. These results challenge the current belief in miR-21 as an oncogene and raise caution regarding using miR-21 inhibition as a therapeutic approach for HCC.
Review
Genetics & Heredity
Ledong Wan, Min Deng, Honghe Zhang
Summary: Emerging evidence suggests that dysregulated RNA metabolism is associated with tumor initiation and development. Serine/Arginine-Rich proteins (SR) play crucial roles in spliceosome assembling, genome stability, RNA export, and translation. Dysregulation of SR proteins has been reported to contribute to tumorigenesis, making them potential therapeutic targets for cancer.
Article
Biochemistry & Molecular Biology
Reem Sabry, Makenna Williams, Nicholas Werry, Jonathan LaMarre, Laura A. Favetta
Summary: This study investigates the regulation of miR-21 in bovine granulosa cells and its potential mechanisms. The research shows that miR-21 has anti-apoptotic effects and explains its impact on specific apoptotic targets. Additionally, the study confirms the influence of BPA on miR-21 expression and explores the temporal effects of BPA on miR-21 regulation. Furthermore, the research reveals that BPA induces upregulation of miR-21 expression by modulating upstream regulators. Overall, this study enhances our understanding of the function of miR-21 in granulosa cells and the mechanisms underlying BPA-induced reproductive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Rui Li, Yaoyuan Hu, Shuhong Hou
Summary: Oral-gut pathogens potentially promote pancreatic cancer evasion of host immune surveillance by activating the miR-21/PTEN axis and immune-suppressive cells. Understanding the pattern of the effects of gut pathogens on the miR-21/PTEN axis will provide insights into the specific mechanisms associated with the immune escape of pancreatic cancer caused by oral-gut microbiota.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Hung-Hsi Chen, Hsin- Yu, Rudy Rudy, Sim-Lin Lim, Yi-Fen Chen, Shu-Hsing Wu, Shu-Chun Lin, Muh-Hwa Yang, Woan-Yuh Tarn
Summary: The use of antibody arrays revealed that the RNA helicase DDX3 plays a role in modulating the expression of secreted signaling factors in oral squamous cell carcinoma (OSCC) cells. Furthermore, the interaction between DDX3 and the signal recognition particle (SRP) affects the expression of AREG mRNA, contributing to the progression of tumors.
Article
Biochemistry & Molecular Biology
Chao Tan, Huasheng Du, Yang Wang, Jianjun Zhao, Xiaolong Cheng, Haihe Lan
Summary: This study found that the expression levels of GABPB1-IT1 were downregulated in ccRCC and predicted poor survival. GABPB1-IT1 directly interacted with miR-21 and inhibited ccRCC cell proliferation by upregulating PTEN expression through sequestering miR-21.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Plant Sciences
Hong Wang, Qian Jiang, Li Kang, Ling Yuan, Guan Chen, Xiaoxue Cui, Luyao Wang, Ting Zhang, Lei Wang
Summary: The study found a positive correlation between plasma miR-21 levels and renal fibrosis scores. Rheum palmatum L. and Salvia miltiorhiza Bunge (RS) exert a protective effect against renal fibrosis through the miR-21/PTEN/AKT signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Oncology
Ying Cai, Na Li, Huaibiao Li
Summary: RNA-binding proteins (RBPs) play a role in regulating gene expression and are involved in endometrial cancer development. Y-box-binding protein 2 (YBX2) is a member of the YBX family and maintains cancer stem cell-like phenotypes in endometrial cancer. This study revealed that YBX2 delays cell proliferation by down-regulating heat shock protein family A member 6 (HSPA6) through reduced mRNA stability. YBX2 forms cytoplasmic granules in tumor cells and recruits N6-methyladenosine (m6A) reader proteins via its cold-shock domain, thereby regulating RNA stability.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Environmental Sciences
Bugao Guan, Guangrun Li, Benhai Wan, Xiang Guo, Desong Huang, Jun Ma, Ping Gong, Jinbao Guo, Yanzhi Bu
Summary: It was found that RBM38 is downregulated in colorectal cancer, and it inhibits CRC progression by competitively binding to the PTEN 3' UTR with miR-92a-3p.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Biology
Minmin Song, Guangfeng Zhao, Haixiang Sun, Simin Yao, Zhenhua Zhou, Peipei Jiang, Qianwen Wu, Hui Zhu, Huiyan Wang, Chenyan Dai, Jingmei Wang, Ruotian Li, Yun Cao, Haining Lv, Dan Liu, Jianwu Dai, Yan Zhou, Yali Hu
Summary: Emerging evidence suggests a crucial role of circRNAs in regulating pathological processes, with circPTPN12 identified as a factor in endometrial fibrosis pathology. Dysfunction of the circPTPN12 pathway contributes to the pathogenesis of endometrial fibrosis.
Article
Physiology
Yi Fan, Xingxu Zhao, Jianfei Ma, Lina Yang
Summary: The study demonstrates that lncRNA GAS5 can regulate EMT in human peritoneal mesothelial cells (HPMCs) induced by high glucose by modulating the miR-21/PTEN axis. Additionally, lncRNA GAS5 influences EMT in HPMCs through the Wnt/beta-catenin pathway.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hong Qi, Jiancheng Zhang, You Shang, Shiying Yuan, Chunqing Meng
Summary: Argon preconditioning can inhibit the PDCD4/PTEN pathway through miR-21, reducing oxidative stress and inflammatory factor levels, protecting cardiomyocytes from MI/R injury.
Article
Biotechnology & Applied Microbiology
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang
Summary: METTL3 promotes the maturation of miR-126-5p through m6A modification, which in turn targets PTEN to activate the PI3K/Akt/mTOR pathway in ovarian cancer progression. This study provides potential targets for future ovarian cancer treatment and reveals tumorigenic mechanisms regulated by m6A modification.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Luning Wang, Xiaohong Zhang, Junxiu Sheng, Lei Chen, Lili Zhi, Yangfan Qi, Qianqian Zheng, Linlin Wang, Jinrui Zhang, Jinyao Zhao, Yang Wang, Shu-Xin Liu, Ming-Zhong Sun, Wenjing Zhang
Summary: Cellular senescence is a powerful mechanism for inhibiting the proliferation of cancer cells, and RNA-binding proteins (RBPs) play important roles in regulating senescence. This study discovered that the RBP RBM4 contributes to cellular senescence and its depletion induces senescence in various cell types, including cancer cells. Furthermore, the depletion of RBM4 inhibits cancer cell progression and is mediated by the regulation of SERPINE1 through miR-1244.
CELL DEATH & DISEASE
(2023)
Article
Chemistry, Multidisciplinary
Han Eol Lee, JeHyuk Choi, Seung Hyun Lee, Minju Jeong, Jung Ho Shin, Daniel J. Joe, DoHyun Kim, Chang Wan Kim, Jung Hwan Park, Jae Hee Lee, Daesoo Kim, Chan-Soo Shin, Keon Jae Lee
ADVANCED MATERIALS
(2018)
Editorial Material
Neurosciences
Daesoo Kim, Eunji Cheong, Hee-Sup Shin
Article
Neurosciences
Anna Shin, Jeonghoon Woo, Jung Eun Kim, Daesoo Kim
Article
Chemistry, Physical
Sang Hyun Sung, Young Soo Kim, Daniel J. Joe, Beom Ho Mun, Byoung Kuk You, Do Hee Keum, Sei Kwang Hahn, Magnus Berggren, Daesoo Kim, Keon Jae Lee
Article
Chemistry, Multidisciplinary
Han Eol Lee, Seung Hyun Lee, Minju Jeong, Jung Ho Shin, Yuri Ahn, Daesoo Kim, Sang Ho Oh, Seok Hyun Yun, Keon Jae Lee
Article
Neurosciences
Jineun Kim, Seongju Lee, Yi-Ya Fang, Anna Shin, Seahyung Park, Koichi Hashikawa, Shreelatha Bhat, Daesoo Kim, Jong-Woo Sohn, Dayu Li, Greg S. B. Suh
NATURE NEUROSCIENCE
(2019)
Review
Chemistry, Multidisciplinary
Yong-Cheol Jeong, Han Eol Lee, Anna Shin, Dae-Gun Kim, Keon Jae Lee, Daesoo Kim
ADVANCED MATERIALS
(2020)
Article
Behavioral Sciences
Daekyum Kim, Yong-Cheol Jeong, Chanmin Park, Anna Shin, Kyoung Wan Min, Sungho Jo, Daesoo Kim
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Cell Biology
Hanseul Kweon, Won Beom Jung, Geun Ho Im, Jia Ryoo, Joon-Hyuk Lee, Hogyeong Do, Yeonsoo Choi, You-Hyang Song, Hwajin Jung, Haram Park, Lily R. Qiu, Jacob Ellegood, Hyun-Ji Shim, Esther Yang, Hyun Kim, Jason P. Lerch, Seung-Hee Lee, Won-Suk Chung, Daesoo Kim, Seong-Gi Kim, Eunjoon Kim
Summary: Deletion of the CHD8 gene in mice leads to near-complete elimination of neocortical structures, yet the mice display mostly normal behaviors, including hyperactivity and increased social interaction. These changes are accompanied by thalamic hyperactivity and enhanced somatosensory function, suggesting a critical role of excitatory neuronal CHD8 in neurodevelopment and a compensatory response in CHD8 haploinsufficiency-related macrocephaly.
Article
Multidisciplinary Sciences
Jung Eun Kim, Sujin Chae, Sungsoo Kim, Yeon-Joo Jung, Myoung-Goo Kang, Won Do Heo, Daesoo Kim
Summary: This study demonstrates the significant role of serotonin in dystonia, with photostimulation of 5HT-fDCN inducing dystonia and photoinhibition reducing dystonia. Blocking 5HT-2A receptors can notably reduce dystonia onset, suggesting potential strategies for alleviating symptoms in human patients.
Article
Neurosciences
Sujin Chae, Jiso Hong, Keunsoo Kang, Anna Shin, Dae-Gun Kim, Sinjeong Lee, Moo-young Kim, Inkyung Jung, Daesoo Kim
Summary: Research has shown that stressed mice exhibit asymmetric gene expression between the medial prefrontal cortices, with differences in cortical asymmetry between stressed mice with depressed social activity and resilient mice with normal behavior. Silencing the CTGF gene leads to stress-resistant behavior, while overexpressing CTGF in the right mPFC induces social avoidance.
Article
Neurosciences
Jia Ryoo, Seahyung Park, Daesoo Kim
Summary: Animals have an innate motivation to explore unknown objects and environments. Photostimulation of a subset of medial preoptic area (MPA) neurons can increase exploration without causing place preference. Photoinhibition of these neurons does not lead to emotional changes, suggesting they can enhance innate exploration behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Minju Jeong, Hyeonsu Lee, Youngsoo Kim, Eric Hou-Jen Wang, Se-Bum Paik, Byung Kook Lim, Daesoo Kim
Summary: This study demonstrates that motor cortical neurons generate independent motor signals between different forelimbs during movement transitions, and these signals are transferred from one motor cortical hemisphere to the other via corticocortical projections, suggesting the coordination of sequential bimanual movements through corticocortical pathways.
Article
Biology
Anna Shin, Jia Ryoo, Kwanhoo Shin, Junesu Lee, Seohui Bae, Dae-Gun Kim, Sae-Geun Park, Daesoo Kim
Summary: This study demonstrates that a circuit from CamKII alpha-positive neurons of the medial preoptic area to the ventral periaqueductal gray facilitates exploration and fear extinction in mice. The findings provide insights into the mechanism of exposure therapy and its potential application in treating panic and post-traumatic stress disorder patients.
COMMUNICATIONS BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Seahyung Park, Jia Ryoo, Daesoo Kim
Summary: This article provides a broad overview of recent studies utilizing optic techniques to identify neural circuits and genetic identities underlying innate behaviors, particularly evasion, approach, and predation, and their connection to threat assessment.
MOLECULES AND CELLS
(2022)