The Role of Osteopontin (OPN/SPP1) Haplotypes in the Susceptibility to Crohn's Disease

The Osteopontin Gene +1239A/C Single Nucleotide Polymorphism is Associated with Type 1 Diabetes Mellitus in the Italian Population

(2017) A. Chiocchetti et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Increased Osteopontin Expression in Dendritic Cells Amplifies IL-17 Production by CD4+ T Cells in Experimental Autoimmune Encephalomyelitis and in Multiple Sclerosis

(2014) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Genetic Variation in Osteopontin Gene Is Associated with Susceptibility to Sarcoidosis in Slovenian Population

(2013) A. Maver et al.   DISEASE MARKERS

Association of osteopontin regulatory polymorphisms with systemic sclerosis

(2011) Nadia Barizzone et al.   HUMAN IMMUNOLOGY

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Osteopontin, intrinsic tissue regulator of intractable inflammatory diseases

(2011) Toshimitsu Uede   PATHOLOGY INTERNATIONAL

CEACAM6 Gene Variants in Inflammatory Bowel Disease

(2011) Jürgen Glas et al.   PLoS One

Role of osteopontin in synovial Th17 differentiation in rheumatoid arthritis

(2010) Guangjie Chen et al.   ARTHRITIS AND RHEUMATISM

Pregnane X receptor (PXR/NR1I2) gene haplotypes modulate susceptibility to inflammatory bowel disease

(2010) Jürgen Glas et al.   INFLAMMATORY BOWEL DISEASES

Increased osteopontin plasma levels in multiple sclerosis patients correlate with bone-specific markers

(2010) Mario HJ Vogt et al.   Multiple Sclerosis Journal

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Evidence for STAT4 as a Common Autoimmune Gene: rs7574865 Is Associated with Colonic Crohn's Disease and Early Disease Onset

(2010) Jürgen Glas et al.   PLoS One

The NOD2 Single Nucleotide Polymorphisms rs2066843 and rs2076756 Are Novel and Common Crohn's Disease Susceptibility Gene Variants

(2010) Jürgen Glas et al.   PLoS One

Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-  limits IL-17-mediated autoimmune inflammation

(2010) G. Murugaiyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel Genetic Risk Markers for Ulcerative Colitis in the IL2/IL21 Region Are in Epistasis With IL23R and Suggest a Common Genetic Background for Ulcerative Colitis and Celiac Disease

(2009) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Osteopontin: a new emerging role in psoriasis

(2009) Elisabetta Buommino et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Osteopontin gene variation and cardio/cerebrovascular disease phenotypes

(2009) Klaus Schmidt-Petersen et al.   ATHEROSCLEROSIS

Association of alleles at polymorphic sites in the osteopontin encoding gene in young type 1 diabetic patients

(2009) Renato Marciano et al.   CLINICAL IMMUNOLOGY

Age- and gender-specific modulation of serum osteopontin and interferon-α by osteopontin genotype in systemic lupus erythematosus

(2009) S N Kariuki et al.   GENES AND IMMUNITY

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease

(2009) S. Brand   GUT

IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells

(2009) G. Murugaiyan et al.   JOURNAL OF IMMUNOLOGY

Osteopontin attenuation of dextran sulfate sodium-induced colitis in mice

(2009) Andre Paes Batista da Silva et al.   LABORATORY INVESTIGATION

Unknown

(2009) Laura Bazzichi et al.   MOLECULAR MEDICINE

The role of osteopontin in inflammatory processes

(2009) Susan Amanda Lund et al.   Journal of Cell Communication and Signaling

TheATG16L1Gene Variants rs2241879 and rs2241880 (T300A) Are Strongly Associated With Susceptibility to Crohn's Disease in the German Population

(2008) Jürgen Glas et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Increased Osteopontin Levels in the Cerebrospinal Fluid of Patients With Multiple Sclerosis

(2008) Manjit Braitch et al.   ARCHIVES OF NEUROLOGY

Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease

(2008) Lauren A. Zenewicz et al.   IMMUNITY

Engagement of the Type I Interferon Receptor on Dendritic Cells Inhibits T Helper 17 Cell Development: Role of Intracellular Osteopontin

(2008) Mari L. Shinohara et al.   IMMUNITY

Osteopontin as two-sided mediator of intestinal inflammation

(2008) Katja Heilmann et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring

(2008) Ryoichi Mori et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia

(2008) Shean J Aujla et al.   NATURE MEDICINE

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

(2008) Yan Zheng et al.   NATURE MEDICINE

Osteopontin and Systemic Lupus Erythematosus Association: A Probable Gene-Gender Interaction

(2008) Shizhong Han et al.   PLoS One

Circulating levels of osteopontin, osteoprotegerin, total soluble receptor activator of nuclear factor‐kappa B ligand, and high‐sensitivity C‐reactive protein in patients with active rheumatoid arthritis randomized to etanercept alone or in combination with methotrexate

(2008) H. P. Sennels et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

Linking genetic susceptibility to Crohnʼs disease with Th17 cell function: IL-22 serum levels are increased in Crohnʼs disease and correlate with disease activity and IL23R genotype status

(2007) Silke Schmechel et al.   INFLAMMATORY BOWEL DISEASES

Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohnʼs disease and analysis of the IL17F p.His161Arg polymorphism in IBD

(2007) Julia Seiderer et al.   INFLAMMATORY BOWEL DISEASES