Article
Endocrinology & Metabolism
S. Bonetti, C. Zusi, E. Rinaldi, M. L. Boselli, A. Csermely, G. Malerba, E. Trabetti, E. Bonora, R. C. Bonadonna, M. Trombetta
Summary: This study found that common genetic variability of monogenic diabetes genes is significantly associated with impaired beta-cell function in patients with newly diagnosed type 2 diabetes mellitus (T2DM), suggesting that these genes may be targeted by specific treatments for T2DM.
DIABETES & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Chiara Zusi, Alessandro Csermely, Elisabetta Rinaldi, Kezia Bertoldo, Sara Bonetti, Maria Linda Boselli, Daniela Travia, Enzo Bonora, Riccardo C. Bonadonna, Maddalena Trombetta
Summary: The aim of this study is to evaluate the relationship between genetic variability of ADIPOQ, LEP, and LEPR genes with the glucose-insulin system and markers of subclinical atherosclerosis (ATS) in patients with newly diagnosed type 2 diabetes. The results showed that two SNPs within the ADIPOQ gene were associated with adiponectin levels. Haplotypes of ADIPOQ, LEP, and LEPR genes were associated with circulating levels of adiponectin, leptin, and markers of ATS, providing insight into the role of adipokines in glucose metabolism and atherosclerosis.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Mohamad Nasser, Jacob Stidsen, Kurt Hojlund, Jens Steen Nielsen, Richard Eastell, Morten Frost
Summary: The study found that bone turnover markers are lower in individuals with type 2 diabetes, and their levels are associated with insulin sensitivity. Among the three phenotypes of type 2 diabetes, individuals with the insulinopenic phenotype have higher levels of bone turnover markers. The conclusion is that bone turnover markers are lower in newly diagnosed individuals with type 2 diabetes characterized by low insulin sensitivity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yao Qin, Yiting Huang, Yuxiao Li, Lu Qin, Qianying Wei, Xin Chen, Chuanhui Yang, Mei Zhang
Summary: This study evaluated the contributions of systemic iron status to beta-cell function and insulin sensitivity in patients with newly diagnosed T2DM. The results showed that serum iron and transferrin saturation levels were associated with impaired beta-cell function, while transferrin levels had a protective effect. However, systemic iron status did not affect insulin sensitivity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Linong Ji, Juliana C. N. Chan, Miao Yu, Kun Ho Yoon, Sin Gon Kim, Sung Hee Choi, Chien-Ning Huang, Shih Te Tu, Chih-Yuan Wang, Paivi Maria Paldanius, Wayne H. H. Sheu
Summary: Type 2 diabetes in the East Asian population is characterized by low BMI, beta-cell dysfunction, and high body fat percentage, leading to early onset of the disease and increased risk of stroke and renal disease. Early combination therapy is recommended for better glycemic control in East Asian patients with T2D.
DIABETES OBESITY & METABOLISM
(2021)
Article
Medicine, General & Internal
Eleanor L. Ramos, Colin M. Dayan, Lucienne Chatenoud, Zdenek Sumnik, Kimber M. Simmons, Agnieszka Szypowska, Stephen E. Gitelman, Laura A. Knecht, Elisabeth Niemoeller, Wei Tian, Kevan C. Herold, PROTECT Study Investigators
Summary: Two 12-day courses of teplizumab in children and adolescents with newly diagnosed type 1 diabetes showed benefit with respect to the preservation of beta-cell function, but no significant differences between the groups were observed with respect to the secondary endpoints.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Enzo Bonora, Maddalena Trombetta, Marco Dauriz, Corinna Brangani, Vittorio Cacciatori, Carlo Negri, Isabella Pichiri, Vincenzo Stoico, Elisabetta Rinaldi, Giuliana Da Prato, Maria Linda Boselli, Lorenza Santi, Federica Moschetta, Monica Zardini, Riccardo C. Bonadonna
Summary: In newly diagnosed type 2 diabetes, insulin resistance and beta-cell dysfunction are very common with a wide range of expression but no specific pattern of aggregation.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2022)
Article
Medicine, General & Internal
Anders Gummesson, Elias Bjornson, Linn Fagerberg, Wen Zhong, Abdellah Tebani, Fredrik Edfors, Caroline Schmidt, Annika Lundqvist, Martin Adiels, Fredrik Baeckhed, Jochen M. Schwenk, Per-Anders Jansson, Mathias Uhlen, Goran Bergstrom
Summary: The study found distinct protein patterns in early-stage type 2 diabetes patients, reflecting key metabolic syndrome features. These patterns improved after treatment, indicating that comprehensive protein profiling can be a useful tool in elucidating the biological effects of diabetes treatments.
Article
Clinical Neurology
Minglei Ma, Tao Jiang, Dongxue Zhang, Xiaoai Yao, Zhen Wen, Lei Xiu
Summary: This study investigated the association between bedtime and the risk of early-onset diabetes mellitus (DM) and islet beta cell function. The results showed that later bedtime was associated with a higher risk of early-onset DM and worse late-phase insulin secretion. Therefore, proper bedtime may be important in reducing the risk of early-onset DM.
NATURE AND SCIENCE OF SLEEP
(2023)
Article
Multidisciplinary Sciences
Scott D. Foster, Pierre Feutry, Peter Grewe, Campbell Davies
Summary: The amount of information needed for analytical tasks in population genetics depends on the number of individuals sampled and the genetic markers measured, with different tasks requiring varying numbers of individuals and genetic markers. Real data from sampling locations across the tropical Pacific Ocean were used to assess genetic differences and sample sizes for tasks such as profile testing, stock delineation, and assignment of individuals to stocks in yellowfin tuna populations. Task-specific sample size requirements were determined to help guide the design of molecular ecological surveys for yellowfin tuna.
Article
Endocrinology & Metabolism
Rui Min, Yancheng Xu, Bocheng Peng
Summary: This study evaluated the clinical value of glycosylated hemoglobin (HbA1c) in newly diagnosed ketosis-prone type 2 diabetes (KPD). The results showed that HbA1c was correlated with ketosis, insulin, and islet function. Patients with HbA1c > 10.15% were more likely to develop KPD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Immunology
Geetha Letchumanan, Natasya Abdullah, Muhamad Marlini, Nizam Baharom, Blair Lawley, Mohd Rahman Omar, Fathima Begum Syed Mohideen, Faizul Helmi Addnan, Mohd Manzor Nur Fariha, Zarini Ismail, Siva Gowri Pathmanathan
Summary: Evidence suggests that gut microbiota plays a role in regulating glucose metabolism and the progression of type 2 diabetes mellitus (T2DM). This systematic review summarizes the existing evidence on microbiota composition and diversity in individuals with prediabetes (preDM) and newly diagnosed T2DM (newDM), compared to individuals with normal glucose tolerance (nonDM). The findings reveal lower gut microbial diversity in preDM and newDM compared to nonDM, although the differences in gut microbiota composition between the disease groups and nonDM are inconsistent. Specific alterations in bacterial abundance were observed, with an increased abundance of Firmicutes and decreased abundance of Bacteroidetes in newDM, and changes in abundance of certain genera/species in the disease groups. Lactobacillus was found to positively correlate with fasting plasma glucose, HbA1c, and/or insulin resistance in multiple studies. Further research is needed to understand the role of specific bacterial strains in glucose regulation and T2DM progression, and to establish consistent associations between clinical biomarkers, dietary intake, and gut bacterial composition in prediabetes and early T2DM.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Xiaohan Tang, Xiang Yan, Houde Zhou, Gan Huang, Xiaohong Niu, Hongwei Jiang, Heng Su, Xilin Yang, Xia Li, Zhiguang Zhou
Summary: This study found that high insulin resistance is associated with an increased risk of abnormal lipid metabolism in both type 1 and type 2 diabetes patients, while low beta-cell function is not associated with the risk of abnormal lipid metabolism.
CHINESE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Keddagoda Gamage Piyumi Wasana, Anoja Priyadarshani Attanayake, Thilak Priyantha Weerarathna, Kamani Ayoma Perera Wijewardana Jayatilaka
Summary: The study showed a significant positive correlation between BMI, WC and HOMA, while a significant negative correlation with QUICKI and MCA among patients with newly diagnosed T2DM. The optimal cut-off values for BMI and WC were 24.91 kg/m(2) and 81.5 cm respectively to differentiate patients with IR.
Article
Endocrinology & Metabolism
Russell J. Eason, Nicholas J. Thomas, Anita V. Hill, Bridget A. Knight, Alice Carr, Andrew T. Hattersley, Timothy J. McDonald, Beverley M. Shields, Angus G. Jones
Summary: Recent guidelines recommend routine islet autoantibody testing in newly diagnosed type 1 diabetes patients. This study assessed the impact of this testing and found that negative antibodies may suggest other diabetes subtypes and are associated with successful insulin cessation.
Article
Geriatrics & Gerontology
Andrea M. Brennan, Robert A. Standley, Steven J. Anthony, Kory E. Grench, Nicole L. Helbling, James P. DeLany, Heather H. Cornnell, Fanchao Yi, Maja Stefanovic-Racic, Frederico G. S. Toledo, Paul M. Coen, Elvis A. Carnero, Bret H. Goodpaster
Summary: Exercise with weight loss improves insulin sensitivity, aerobic capacity, and body composition in older obese adults. It also reduces ectopic fat and preserves lean mass and strength. However, weight loss alone may lead to decreased lean mass and strength. Therefore, regular exercise is important for older adults aiming to lose weight in order to achieve cardiometabolic and functional benefits that may not occur with calorie restriction-induced weight loss alone.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Bruce A. Perkins, Ionut Bebu, Xiaoyu Gao, Amy B. Karger, Irl B. Hirsch, Harsha Karanchi, Mark E. Molitch, Bernard Zinman, John M. Lachin, Ian H. de Boer
Summary: In individuals with type 1 diabetes primarily with normal eGFR and normoalbuminuria, rapid loss of eGFR early in the course does not provide additional predictive value for kidney or cardiovascular outcomes beyond the individual's current eGFR level.
Article
Neurosciences
Frederico G. S. Toledo, William F. Martin, Linda Morrow, Carine Beysen, Daiva Bajorunas, Ying Jiang, Bernard L. Silverman, David McDonnell, Mark N. Namchuk, John W. Newcomer, Christine Graham
Summary: The combination drug OLZ/SAM has shown potential advantages in treating schizophrenia and bipolar I disorder, reducing olanzapine-induced weight gain and improving insulin sensitivity. This exploratory study suggests that OLZ/SAM may have a more favorable impact on metabolic effects compared to olanzapine.
NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Pedram Paragomi, Georgios I. Papachristou, Kwonho Jeong, Alice Hinton, Ioannis Pothoulakis, Rupjyoti Talukdar, Rakesh Kochhar, Mahesh K. Goenka, Aiste Gulla, Jose A. Gonzalez, Vikesh K. Singh, Miguel Ferreira Bogado, Tyler Stevens, Sorin T. Barbu, Haq Nawaz, Silvia C. Gutierrez, Narcis Zarnescu, Livia Archibugi, Jeffrey J. Easler, Konstantinos Triantafyllou, Mario Pelaez-Luna, Shyam Thakkar, Carlos Ocampo, Enrique de-Madaria, Gregory A. Cote, Bechien U. Wu, Peter J. Lee, Phil A. Hart, Darwin L. Conwell, Frederico G. S. Toledo, Dhiraj Yadav
Summary: This study examined the impact of pre-existing diabetes mellitus on the severity of acute pancreatitis and found that pre-existing diabetes mellitus itself is not a risk factor for severe acute pancreatitis.
Article
Endocrinology & Metabolism
Vincent M. Monnier, David R. Sell, Xiaoyu Gao, Saul M. Genuth, John M. Lachin, Ionut Bebu
Summary: This study assessed the impact of glycemic control on pAGEs and their association with subsequent microvascular disease. The results showed that certain pAGEs decreased with intensive glycemic control and were correlated with HbA1c. These pAGEs were also associated with the risk of various microvascular complications in patients with diabetes, and the association with diabetic kidney disease remained significant even after adjustment for HbA1c.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Article
Cardiac & Cardiovascular Systems
Evrim B. Turkbey, Jye-Yu C. Backlund, Neville Gai, Marcelo Nacif, Rob J. Van der Geest, John M. Lachin, Anderson Armstrong, Gustavo J. Volpe, Saman Nazarian, Joao A. C. Lima, David A. Bluemke
Summary: This study found that 34.1% of subjects with type 1 diabetes met the criteria for metabolic syndrome. Metabolic syndrome was associated with adverse myocardial structural remodeling and change in myocardial tissue composition.
AMERICAN JOURNAL OF CARDIOLOGY
(2022)
Review
Gastroenterology & Hepatology
Soren S. Olesen, Frederico G. S. Toledo, Phil A. Hart
Summary: The purpose of this review is to discuss pancreatogenic diabetes related to acute and chronic pancreatitis and its overlapping features with type 1 and type 2 diabetes. Recent findings have shown that patients with diabetes related to acute and chronic pancreatitis exhibit overlapping features with other forms of diabetes. Understanding the pathophysiology of pancreatogenic diabetes and its overlapping features with type 1 and type 2 diabetes is expected to improve the diagnosis and treatment of these conditions.
CURRENT OPINION IN GASTROENTEROLOGY
(2022)
Editorial Material
Endocrinology & Metabolism
John M. Lachin, Ionut Bebu, Xiaoyu Gao, David M. Nathan, Bernard Zinman
Editorial Material
Endocrinology & Metabolism
Antonio Ceriello, Francesco Prattichizzo
Article
Geriatrics & Gerontology
Kyle D. Moored, Yujia (Susanna) Qiao, Andrea L. Rosso, Frederico G. S. Toledo, Peggy M. Cawthon, Steven R. Cummings, Bret H. Goodpaster, Stephen B. Kritchevsky, Nancy W. Glynn
Summary: Cardiorespiratory fitness and perceived fatigability are associated with life-space mobility in older adults. Higher fitness levels are associated with greater life-space, but the association plateaus at higher fitness levels. Individuals with higher fatigability are more likely to have lower life-space mobility, especially due to physical fatigability.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Theresa Mau, Li-Yung Lui, Giovanna Distefano, Philip A. Kramer, Sofhia Ramos, Frederico G. S. Toledo, Adam J. Santanasto, Eric G. Shankland, David J. Marcinek, Michael J. Jurczak, Ian Sipula, Fiona M. Bello, Kate A. Duchowny, Anthony J. A. Molina, Lauren M. Sparks, Bret H. Goodpaster, Russell T. Hepple, Stephen B. Kritchevsky, Anne B. Newman, Peggy M. Cawthon, Steven R. Cummings, Paul M. Coen
Summary: This study found that mitochondrial energetics in aging muscle are closely associated with leg power and cardiorespiratory fitness in older adults. Higher muscle mitochondrial energetics are related to better cardiorespiratory fitness and greater leg power.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jay M. Sosenko, David K. Cuthbertson, Emily K. M. Sims, Heba M. M. Ismail, Brandon M. M. Nathan, Laura M. A. Jacobsen, Mark A. Atkinson, Carmella C. Evans-Molina, Kevan C. S. Herold, Jay S. J. Skyler, Maria J. Redondo, TrialNet Study Grp
Summary: Metabolic zones were formed based on AUCGLU and AUCPEP to explore the heterogeneity of type 1 diabetes. The zones were highly correlated with islet autoantibodies, and the predictive ability of glucose for risk depended on the level of C-peptide. Glucose secretion and insulin resistance made different contributions to glucose heterogeneity and diabetes risk.
Article
Endocrinology & Metabolism
John J. Dube, Frederico G. S. Toledo, Paul M. Coen, Bret H. Goodpaster, James P. DeLany
Summary: The purpose of this study was to compare fat oxidation in African American women (AAW) and White women. The results suggest that there is no significant difference in fat oxidation between AAW and White women, but further research is needed to confirm these findings across different exercise intensities, body weights, and ages.
Article
Cell Biology
Yujia (Susanna) Qiao, Adam J. Santanasto, Paul M. Coen, Peggy M. Cawthon, Steven R. Cummings, Daniel E. Forman, Bret H. Goodpaster, Jaroslaw Harezlak, Marquis Hawkins, Stephen B. Kritchevsky, Barbara J. Nicklas, Frederico G. S. Toledo, Pamela E. Toto, Anne B. Newman, Nancy W. Glynn
Summary: Performance fatigability is associated with skeletal muscle energetics, and targeting muscle energetics may help delay the decline in mobility.
Article
Geriatrics & Gerontology
Yujia (Susanna) Qiao, Jaroslaw Harezlak, Peggy M. Cawthon, Steven R. Cummings, Daniel E. Forman, Bret H. Goodpaster, Marquis Hawkins, Kyle D. Moored, Barbara J. Nicklas, Frederico G. S. Toledo, Pamela E. Toto, Adam J. Santanasto, Elsa S. Strotmeyer, Anne B. Newman, Nancy W. Glynn
Summary: The Pittsburgh Performance Fatigability Index (PPFI) is a valid measure for quantifying performance fatigability and shows strong correlations with physical performance. It can be used in future research and clinical trials.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)