Article
Biochemistry & Molecular Biology
Charlotte Claeyssen, Nathan Bulangalire, Bruno Bastide, Onnik Agbulut, Caroline Cieniewski-Bernard
Summary: Maintenance of striated muscle tissue relies on a dynamic network of protein-protein interactions. Desmin intermediate filaments play a crucial role in heart and skeletal muscle by maintaining cell structure and contributing to various cellular processes. The assembly of desmin intermediate filaments requires aB-crystallin, which is involved in multiple cellular functions.
Article
Multidisciplinary Sciences
Guilherme G. Moreira, Francois-Xavier Cantrelle, Andrea Quezada, Filipa S. Carvalho, Joana S. Cristovao, Urmi Sengupta, Nicha Puangmalai, Ana P. Carapeto, Mario S. Rodrigues, Isabel Cardoso, Guenter Fritz, Federico Herrera, Rakez Kayed, Isabelle Landrieu, Claudio M. Gomes
Summary: The study demonstrates that S100B protein acts as an extracellular chaperone for Tau, inhibiting its aggregation and providing evidence for neuro-protective functions.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Jing Zhang, Shuaiwei Qi, Hao Yu, Ze Lin, Bao Li, Ming Wang, Zeyuan Dong
Summary: In this study, a simple supramolecular strategy was adopted to effectively control the tautomerism of ureidopyrimidinone (UPy) moiety and achieve the complete arrangement of enol configuration. The UPy derivatives containing self-complementary quadruple hydrogen bonding interactions could spontaneously self-assemble into well-controlled, self-organized supramolecular nanostructures in both chloroform and water. This study demonstrates the utility and feasibility of multiple hydrogen bonds for directing the self-assembly of small-molecule building blocks in aqueous media, providing a strategy for constructing well-defined and stable supramolecular architectures with chemical functionalities and physical properties as advanced materials for biological applications.
CHINESE CHEMICAL LETTERS
(2022)
Article
Food Science & Technology
Xuejiao Qie, Yaru Wu, Yao Chen, Chan Liu, Maomao Zeng, Fang Qin, Zhaojun Wang, Jie Chen, Zhiyong He
Summary: The study investigates the competitive interaction among tea catechins, milk proteins, and digestive enzymes on protein digestibility, catechin bioaccessibility, and antioxidant activity. The results show that the binding affinity between catechins and digestive enzymes plays a crucial role in the inhibitory effect of catechins on digestive enzymes. Additionally, the competition among proteins, catechins, and digestive enzymes can enhance the bioaccessibility of catechins and the antioxidant activity.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Shizuka Hozuki, Hideki Yoshioka, Satoshi Asano, Mikiko Nakamura, Saori Koh, Yukihiro Shibata, Yuta Tamemoto, Hiromi Sato, Akihiro Hisaka
Summary: This study aimed to establish a new MSPK analysis framework for the comprehensive prediction of drug interactions (DI), overcoming the limitations of traditional models in using in vitro information and distinguishing multiple cytochrome P450 (CYP) isoenzymes and hepatic and intestinal first-pass effects appropriately.
CLINICAL PHARMACOKINETICS
(2023)
Article
Immunology
R. P. Gorter, E. Nutma, M. -C. Jahrei, J. C. de Jonge, R. A. Quinlan, P. van der Valk, J. M. van Noort, W. Baron, S. Amor
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2018)
Article
Biochemical Research Methods
Laura K. Young, Miguel Jarrin, Christopher D. Saunter, Roy A. Quinlan, John M. Girkin
BIOMEDICAL OPTICS EXPRESS
(2018)
Editorial Material
Biochemistry & Molecular Biology
Roy A. Quinlan, Philip J. Hogg
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Review
Biotechnology & Applied Microbiology
Alice Uwineza, Alexia A. Kalligeraki, Nobuyuki Hamada, Miguel Jarrin, Roy A. Quinlan
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2019)
Article
Multidisciplinary Sciences
Stephen G. R. Barnard, Roisin McCarron, Jayne Moquet, Roy Quinlan, Elizabeth Ainsbury
SCIENTIFIC REPORTS
(2019)
Article
Genetics & Heredity
Vanita Berry, Alex Ionides, Nikolas Pontikos, Ismail Moghul, Anthony T. Moore, Roy A. Quinlan, Michel Michaelides
Article
Multidisciplinary Sciences
Alexia A. Kalligeraki, Archie Isted, Miguel Jarrin, Alice Uwineza, Robert Pal, Christopher D. Saunter, John M. Girkin, Boguslaw Obara, Roy A. Quinlan
SCIENTIFIC REPORTS
(2020)
Article
Ophthalmology
Weiju Wu, Noemi Lois, Alan R. Prescott, Adrian P. Brown, Veerle Van Gerwen, Marie-Jose Tassignon, Shane A. Richards, Christopher D. Saunter, Miguel Jarrin, Roy A. Quinlan
Summary: The success of human lens regeneration and cataract treatment with Bag-in-the-Lens surgery relies on lens capsule closure. Research shows that the first three days after surgery are critical, with cell proliferation, reorganization and marker expression playing important roles in the long-term outcomes. The spatial and cellular cues are essential for lens cells to produce a functional tissue in addition to maintaining capsule integrity and the epithelial-fibre cell interface.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Roy A. Quinlan, John I. Clark
Summary: In this review, the authors highlight the potential protective effects of post-translational modifications (PTMs) on lens proteins during normal development and propose a forward-looking hypothesis that aims to prevent age-related cataract (ARC) by protecting the biochemical and biophysical properties of lens proteins.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Cell Biology
Miguel Jarrin, Alexia A. Kalligeraki, Alice Uwineza, Chris S. Cawood, Adrian P. Brown, Edward N. Ward, Khoa Le, Stefanie Freitag-Pohl, Ehmke Pohl, Bence Kiss, Antal Tapodi, Roy A. Quinlan
Summary: Research has shown that the C-terminal sequences of BFSP1 protein have independent membrane binding properties, binding to cell membranes through an adjacent amphipathic helix. This conclusion is of great significance for understanding the function of BFSP1 protein.
Article
Ophthalmology
Vanita Berry, Alexander Ionides, Michalis Georgiou, Roy A. Quinlan, Michel Michaelides
Summary: A five generation family was subjected to whole exome sequencing (WES) to identify genetic associations with congenital cataract (CC), retinitis pigmentosa (RP), and Crohn's disease (CD). Pathogenic variants in the WFS1, RP1, and NOD2 genes were reported, which cosegregated with the phenotypic combinations of autosomal dominant CC, RP, and CD within the family members. This study expands the spectrum of potential cataract-associated genes to include RP1 and NOD2.
BMJ OPEN OPHTHALMOLOGY
(2023)
Article
Biology
S. Barnard, A. Uwineza, A. Kalligeraki, R. McCarron, F. Kruse, E. A. Ainsbury, R. A. Quinlan
Summary: The study found that high doses of ionizing radiation transiently increased lens epithelial cell proliferation, which was undetectable 14 days post-irradiation. Additionally, there was a significant dose-dependent effect on proliferation, while the effect of dose rate was not significant, with significant interactions between dose rate and lens epithelial cell region.
RADIATION RESEARCH
(2022)
Article
Cell Biology
Sarika Sharma, Gloria M. Conover, Jayne L. Elliott, Ming Der Perng, Harald Herrmann, Roy A. Quinlan
CELL STRESS & CHAPERONES
(2017)
Article
Cell Biology
Serena Carra, Simon Alberti, Patrick A. Arrigo, Justin L. Benesch, Ivor J. Benjamin, Wilbert Boelens, Britta Bartelt-Kirbach, Bianca J. J. M. Brundel, Johannes Buchner, Bernd Bukau, John A. Carver, Heath Ecroyd, Cecilia Emanuelsson, Stephanie Finet, Nikola Golenhofen, Pierre Goloubinoff, Nikolai Gusev, Martin Haslbeck, Lawrence E. Hightower, Harm H. Kampinga, Rachel E. Klevit, Krzysztof Liberek, Hassane S. Mchaourab, Kathryn A. McMenimen, Angelo Poletti, Roy Quinlan, Sergei V. Strelkov, Melinda E. Toth, Elizabeth Vierling, Robert M. Tanguay
CELL STRESS & CHAPERONES
(2017)
Article
Cell Biology
John A. Carver, Aidan B. Grosas, Heath Ecroyd, Roy A. Quinlan
CELL STRESS & CHAPERONES
(2017)