Article
Endocrinology & Metabolism
Cheng Li, Jing-Jing Xu, Hong-Tao Hu, Chao-Yi Shi, Chuan-Jin Yu, Jian-Zhong Sheng, Yan-Ting Wu, He-Feng Huang
Summary: Exposure to maternal HFD can lead to obesity and metabolic disorders in male offspring, but has minimal effects on female offspring. Deficiency of Ramp3 in the fetal hypothalamus might contribute to hyperamylinemia in male offspring exposed to maternal HFD.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Bernardo Junqueira de Moraes Arnoso, Fabrizia Mansur Magliaccio, Caroline Alves de Araujo, Ricardo de Andrade Soares, Izabelle Barcellos Santos, Graziele Freitas de Bem, Caroline Fernandes-Santos, Dayane Teixeira Ognibene, Roberto Soares de Moura, Angela Castro Resende, Julio Beltrame Daleprane, Cristiane Aguiar da Costa
Summary: The study found that both Acai seed extract (ASE) and rosuvastatin treatments reduced body weight, improved lipid profile, and showed therapeutic effects on cardiovascular remodeling. However, ASE was more effective in reducing oxidative damage and hyperglycemia, making it a promising natural product for treating cardiovascular alterations associated with obesity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Pengjie Zhang, Yanping Liu, Dan Zhu, Xionghui Chen, Yueming Zhang, Xiuwen Zhou, Qin Huang, Min Li, Youguo Chen, Miao Sun
Summary: The study suggests that high fat diet intake during pregnancy induces insulin resistance in the skeletal muscle of old male offspring rats, possibly through retrograde regulation of Sirt3-Glut4.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Renato S. Gaspar, Amanda J. Unsworth, Alaa Al-Dibouni, Alexander P. Bye, Tanya Sage, Michelle Stewart, Sara Wells, Roger D. Cox, Jonathan M. Gibbins, Dyan Sellayah, Craig E. Hughes
Summary: Maternal and offspring high-fat diet leads to platelet hyperactivation in male mouse offspring, suggesting a novel 'double-hit' effect.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Rola Hammoud, Emanuela Pannia, Ruslan Kubant, Adam Metherel, Rebecca Simonian, Zdenka Pausova, G. Harvey Anderson
Summary: This study found that gestational choline supplementation may improve biomarkers of metabolic syndrome in male Wistar rat offspring fed a high-fat diet, but has no significant effect on offspring fed a normal-fat diet.
Article
Nutrition & Dietetics
Dawid Gawlinski, Kinga Gawlinska, Irena Smaga
Summary: Evidence suggests that exposure to a maternal high-fat diet during pregnancy and lactation can induce changes in offspring's brain structure and function, leading to behavioral alterations such as depressive-like phenotype. This study revealed that the maternal high-fat diet triggered several epigenetic mechanisms in the brains of rat offspring, potentially impacting the next generation.
Article
Peripheral Vascular Disease
Rama Lakshman, Ana-Mishel Spiroski, Lauren B. McIver, Michael P. Murphy, Dino A. Giussani
Summary: Research has shown that pregnancy complicated by chronic fetal hypoxia and oxidative stress can program cardiovascular dysfunction in adult offspring. This study using animal models found that analyzing blood pressure variability and heart rate variability can identify cardiovascular dysfunction in offspring, and that MitoQ may offer protection against programmed endothelial dysfunction.
Review
Food Science & Technology
Marcela Nascimento Sertorio, Debora Estadella, Daniel Araki Ribeiro, Luciana Pellegrini Pisani
Summary: High-fat diet intake can negatively impact the reproductive health of male offspring, leading to issues such as impaired testosterone production, abnormal sperm generation, and prostate problems. Studying the male offspring of overweight and/or obese parents can help improve the quality of human semen.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Beihua Zhong, Shuangtao Ma, Donna H. Wang
Summary: This study investigates the role of TRPV1 in Western diet-induced hypertension. The findings suggest that TRPV1 ablation increases salt sensitivity during Western diet intake due to impaired renal NO production and sodium excretion. Activation of TRPV1 enhances renal NO production and sodium excretion, resulting in the prevention of increased salt sensitivity during Western diet intake.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Philipp Kasper, Jaco Selle, Christina Vohlen, Rebecca Wilke, Celien Kuiper-Makris, Oleksiy Klymenko, Inga Bae-Gartz, Charlotte Schoemig, Alexander Quaas, Bjorn Schumacher, Munevver Demir, Martin Buerger, Sonja Lang, Anna Martin, Hans-Michael Steffen, Tobias Goeser, Jorg Doetsch, Miguel A. Alejandre Alcazar
Summary: Maternal obesity predisposes for hepato-metabolic disorders early in life and induces premature aging processes in the liver, resulting in hepatic growth restriction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Bruna Visniauskas, Virginia Reverte, Caleb M. Abshire, Benard O. Ogola, Carla B. Rosales, Michelle Galeas-Pena, Venkata N. Sure, Siva S. V. P. Sakamuri, Nicholas R. Harris, Isabella Kilanowski-Doroh, Alexandra B. Mcnally, Alec C. Horton, Margaret Zimmerman, Prasad V. G. Katakam, Sarah H. Lindsey, Minolfa C. Prieto
Summary: Plasma soluble prorenin receptor (sPRR) displays sexual dimorphism and is higher in women with type 2 diabetes mellitus (T2DM). This study investigates if plasma sPRR contributes to sex differences in the activation of the systemic renin-angiotensin-aldosterone system (RAAS) and vascular damage in a high-fat diet (HFD)-induced T2DM model.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Amira Sayed Khan, Aziz Hichami, Babar Murtaza, Marie-Laure Louillat-Habermeyer, Christophe Ramseyer, Maryam Azadi, Semen Yesylevskyy, Floriane Mangin, Frederic Lirussi, Julia Leemput, Jean-Francois Merlin, Antonin Schmitt, Muhtadi Suliman, Jerome Bayardon, Saeed Semnanian, Sylvain Juge, Naim Akhtar Khan
Summary: Two high affinity agonists of tongue taste receptors (CD36/ GPR120) have been synthesized, acting as fat taste enhancers and triggering the activation of the tongue-gut satiation loop in male mice. These agents were found to reduce daily fat-rich food intake and body weight gain in diet-induced obese male mice.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qi-chen Yuan, Han Gong, Min Du, Xue-ying Mao
Summary: The study found that maternal MFGM-PL supplementation can promote neurodevelopment and exert long-term effects against HFD-induced cognitive impairment in offspring by alleviating hippocampal insulin resistance. Additionally, MFGM-PL supplementation suppressed body weight gain and hyperinsulinemia in both obese dams and their offspring.
Article
Cardiac & Cardiovascular Systems
Young-Beom Kim, Won Woo Jung, Seung Won Lee, Xiangyan Jin, Hyung Kyung Kang, Eun-Hwa Hong, Sun Seek Min, Yoon-Sik Kim, Hee Chul Han, Christopher S. Colwell, Yang In Kim
Summary: The study found that excessive maternal salt intake can lead to salt sensitivity of blood pressure in male offspring, which is mediated by increased AVP secretion.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ao Sun, Xiaoqin Hu, Huijian Chen, Yulan Ma, Xiyue Yan, Dangsheng Peng, Jie Ping, Youe Yan
Summary: Research has shown that ursolic acid acts as an anti-obesity agent by increasing irisin secretion and promoting the beiging of white adipose tissue (WAT).
Article
Biochemistry & Molecular Biology
E. Antoun, P. Titcombe, K. Dalrymple, N. T. Kitaba, S. J. Barton, Ac Flynn, R. Murray, E. S. Garratt, P. T. Seed, S. L. White, Cyrus Cooper, H. M. Inskip, M. Hanson, L. Poston, K. M. Godfrey, K. A. Lillycrop
Summary: The study identified neonatal methylation changes associated with birthweight and specific maternal factors, suggesting potential insights into developmental pathways affecting birthweight and surrogate markers for adverse prenatal exposures linked to non-communicable diseases.
Article
Public, Environmental & Occupational Health
Wenneke van Weelden, Paul T. Seed, Elie Antoun, Keith M. Godfrey, Negusse T. Kitaba, Karen A. Lillycrop, Kathryn Dalrymple, Agata Sobczynska-Malefora, Rebecca C. Painter, Lucilla Poston, Sara L. White, Angela C. Flynn
Summary: This study found no evidence to link folate and vitamin B12 status with the differential methylation of neonatal DNA previously observed in association with dysglycaemia. However, higher folate levels may be associated with maternal glucose homoeostasis.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2022)
Article
Acoustics
J. Allotey, R. Whittle, K. I. E. Snell, M. Smuk, R. Townsend, P. von Dadelszen, A. E. P. Heazell, L. Magee, G. C. S. Smith, J. Sandall, B. Thilaganathan, J. Zamora, R. D. Riley, A. Khalil, S. Thangaratinam
Summary: This study externally validated published prediction models for stillbirth using individual participant data (IPD) meta-analysis. The results showed that these models had generally poor and uncertain predictive performance, with limited evidence to support their clinical application. The study highlighted methodological shortcomings in the development of these models and called for further research to validate and improve them.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Endocrinology & Metabolism
Samuel Furse, Albert Koulman, Susan E. Ozanne, Lucilla Poston, Sara L. White, Claire L. Meek
Summary: Gestational diabetes in obese women is associated with elevated levels of specific lipids related to de novo lipogenesis, which are also correlated with measures of offspring adiposity. These findings suggest that the effects of GDM on neonatal body composition may not be solely due to hyperglycemia, but may involve other pathways.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Nutrition & Dietetics
Angela C. Flynn, Fatma Suleiman, Hazel Windsor-Aubrey, Ingrid Wolfe, Majella O'Keeffe, Lucilla Poston, Kathryn Dalrymple
Summary: This systematic review evaluated interventions aimed at reducing obesity in children aged 0-5 years old, categorizing them by intervention setting. The study found that home-based interventions, particularly those involving parents/families, were the most effective in preventing childhood obesity.
MATERNAL AND CHILD NUTRITION
(2022)
Article
Urology & Nephrology
Sudha Priya Soundara Pandi, Michael J. Shattock, Bruce M. Hendry, Claire C. Sharpe
Summary: The role of different isoforms of TTCC in mouse mesangial cells was investigated in this study to determine the best therapeutic target for treating mesangioproliferative kidney diseases. Single and double knockout clones of the TTCC isoforms Ca(V)3.1 and Ca(V)3.2 were generated using CRISPR-cas9 gene editing. It was found that the Ca(V)3.1 isoform is required for stimulated phosphorylation of ERK1/2, while the Ca(V)3.2 isoform is not. Neither isoform was necessary for cell proliferation, and the anti-proliferative effects of mibefradil and TH1177 were not isoform-specific.
Article
Endocrinology & Metabolism
Paul D. Taylor, Haotian Gu, Hannah Saunders, Federico Fiori, Kathryn Dalrymple, Priyanka Sethupathi, Liana Yamanouchi, Faith Miller, Bethany Jones, Matias C. Vieira, Claire Singh, Annette Briley, Paul T. Seed, Dharmintra Pasupathy, Paramala J. Santosh, Alan M. Groves, Manish D. Sinha, Philip J. Chowienczyk, Lucilla Poston
Summary: Maternal obesity is associated with changes in offspring's cardiac structure, including increased interventricular septum, posterior wall, and relative wall thickness. However, maternal intervention can mitigate the occurrence of cardiac remodeling in women with obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Biochemistry & Molecular Biology
Ola F. Quotah, Lucilla Poston, Angela C. Flynn, Sara L. White
Summary: This study explores the difficulty of early prediction of gestational diabetes mellitus (GDM) development in obese women in the UK and finds that insulin secretory dysfunction may be an important discriminator for GDM development among pregnant women with obesity.
Article
Endocrinology & Metabolism
Angela C. C. Flynn, Michelle Robertson, Kimberley Kavanagh, Helen R. R. Murphy, Rita Forde, Judith Stephenson, Lucilla Poston, Sara L. L. White
Summary: This study aims to examine the health behaviors and risk factors in women with pre-existing diabetes or previous gestational diabetes who are planning pregnancy. The results show a high proportion of these women have obesity, inadequate folic acid intake, smoking, and drug abuse.
Article
Obstetrics & Gynecology
Daria Andreeva, Carolyn Gill, Anna Brockbank, Joanna Hejmej, Fran J. Conti-Ramsden, Katie T. Doores, Paul Seed, Lucilla Poston
Summary: A repeated cross-sectional surveillance study showed high rates of SARS-CoV-2 infection in pregnant women in an inner-city setting, with higher infection risk and lower vaccine uptake among women of black ethnic backgrounds.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura A. Magee, Erika Molteni, Vicky Bowyer, Jeffrey N. Bone, Harriet Boulding, Asma Khalil, Hiten D. Mistry, Lucilla Poston, Sergio A. Silverio, Ingrid Wolfe, Emma L. Duncan, Peter von Dadelszen
Summary: Among women of reproductive age, older age, White ethnicity, and being in the least-deprived index of multiple deprivation are independently associated with higher vaccine uptake. Ethnicity has the strongest influence, while multiple deprivation has the weakest. These findings are crucial for informing future vaccination policies and public messaging.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Dylan Chase, Thomas R. Eykyn, Michael J. Shattock, Yu Jin Chung
Summary: This study aims to test whether EMPA directly alters cardiac ketone metabolism independent of supply.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Jie Su, Pierre Coleman, Angeliki Ntorla, Rhys Anderson, Michael J. Shattock, Joseph R. Burgoyne
Summary: This study demonstrates that the cytosolic DNA sensor cGAS can activate PKGI directly through the generation of cGAMP, showing a link between inflammation and blood pressure regulation.
Article
Medicine, General & Internal
Julie Nihouarn Sigurdardottir, Sara White, Angela Flynn, Claire Singh, Annette Briley, Mary Rutherford, Lucilla Poston
Summary: This study examines the interrelationships between antenatal depressive symptom trajectories and fetal neurodevelopment in pregnant women with obesity. It identifies different fetal exposures associated with different depression classes and highlights the association between severe depressive symptoms and the risk of preterm birth.