Article
Cardiac & Cardiovascular Systems
Miruna Nemecz, Diana Simona Stefan, Ioana Karla Comarita, Alina Constantin, Gabriela Tanko, Cristian Guja, Adriana Georgescu
Summary: In this study, miR-218, miR-132, and miR-143 were identified as significantly up-regulated miRNAs in both circulating MVs and plasma from diabetic patients with dyslipidemia. These miRNAs showed significant correlations with important plasma markers representative of this pathology.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Engineering, Biomedical
Zhongkun Zhang, Yirui Huang, Jing Li, Fei Su, Jimmy Chun-Tien Kuo, Yingwen Hu, Xiaobin Zhao, Robert J. Lee
Summary: Lipid nanoparticles have the potential to deliver nucleic acids for the treatment of various diseases. This study explores the use of an optimized formulation of lipid nanoparticles to deliver an anti-cancer drug and evaluates its anti-tumor activity. The results show that these lipid nanoparticles have the ability to inhibit tumor growth and enhance the effectiveness of chemotherapy and immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Oncology
Jia Yang, Zhiling Yan, Yingying Wang, Jinmei Xu, Rui Li, Chuanyin Li, Shuyuan Liu, Li Shi, Yufeng Yao
Summary: Our study suggests that rs2297538 and rs2297537 in miR-126, rs1292037 and rs13137 in miR-21, and rs2745709 in miR-221/222 may play important roles in the development of CIN or CC.
Article
Oncology
Hongfeng Zhao, Minping Bi, Meng Lou, Xiaowei Yang, Liwen Sun
Summary: LncRNA SOX2-OT is highly expressed in HCC cells and tissues, with poor prognosis in patients. Inhibiting SOX2-OT decreased malignant behaviors of HCC cells and promoted MSI2 expression by binding to miR-143-3p. Nude mouse tumorigenesis experiments confirmed the role of SOX2-OT in promoting proliferation and invasion of HCC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
J. Tang, H. Pan, W. Wang, C. Qi, C. Gu, A. Shang, J. Zhu
Summary: The study revealed that miR-143-3p and miR-495-3p target CDK1 to inhibit the occurrence and development of cervical cancer. Overexpression of miR-143-3p or miR-495-3p can down-regulate CDK1 expression in cervical cancer tissues and cells, inhibit cell proliferation, and promote apoptosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Guifeng Zhang, Zhenhua Liu, Jiangming Zhong, Li Lin
Summary: The study revealed that circRNA ACAP2 contributes to the progression and radioresistance of colorectal cancer by promoting cell proliferation, migration, invasion, and inhibiting apoptosis. This effect is partly mediated through targeting the miR-143-3p/FZD4 axis and modulating the Wnt/β-catenin signaling pathway in CRC cells.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Jingang Sun, Cuicui Zhang, Zhigang Zhang
Summary: Atorvastatin attenuates cardiac hypertrophy and inhibits cardiac failure by activating the AMPK pathway to suppress miR-143-3p, which induces cardiomyocytes apoptosis and affects Bcl2 expression.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Hailin Chen, Songsen Ren, Hui Wan, Wengong Wei, Yi Luo, Meiling Cai
Summary: This study demonstrates that overexpression of DUSP1 can suppress the proliferation and invasion ability of CC cells by inhibiting miR-21 and the JAK2/STAT3 signaling pathway, and induce cell apoptosis. This provides a theoretical basis for targeted treatment of clinical CC.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Chun-Yan Zhang, Yan-Chao Hu, Yan Zhang, Wei-Dong Ma, Ya-Fan Song, Xiao-Hui Quan, Xuan Guo, Cong-Xia Wang
Summary: The study revealed that glutamine can promote the phenotypic switch of VSMCs towards a synthetic phenotype by targeting miR-143 and upregulating THY1 expression, providing important insights for targeted therapy of patients with cardiovascular diseases.
Article
Neurosciences
Daixuan Zhou, Zhi Huang, Xiaoxi Zhu, Tao Hong, Yuanli Zhao
Summary: The study showed that circ_0025984 can protect astrocytes from ischemia-induced apoptosis and autophagy by targeting the miR-143-3p/TET1 pathway, thereby inhibiting cerebral injury caused by ischemic stroke. Additionally, TET1 positively regulates ORP150, which may be associated with its neuroprotective role.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Oncology
A. K. M. Nawshad Hossian, Gerardo G. Mackenzie, George Mattheolabakis
Summary: The novel combinatorial miR treatment showed promising results in inhibiting cell cycle progression and inducing apoptosis in lung cancer cells, with minimal toxicity to normal lung fibroblasts. Additionally, it demonstrated effectiveness in inhibiting cell cycle progression and reducing cell growth in pancreatic cancer cells.
Article
Oncology
Ying Du, Gang Geng, Chunquan Zhao, Tian Gao, Bin Wei
Summary: The study found that MEG3 plays a regulatory role in cervical cancer, promoting sensitivity to cisplatin in CC cells through the miR-21/PTEN axis.
Article
Health Care Sciences & Services
Dong Hyeok Kim, Hyunwoo Jin, Kyung Eun Lee
Summary: This study aimed to provide basic data on using urine samples for non-invasive cervical cancer screening. The results showed a high concordance of 93.3% between urine samples and cervical swabs, with a higher HPV infection rate in urine samples among young women. Therefore, urine samples are considered a valuable screening method for preventing cervical cancer.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Sciences
Bin Meng, Pengfei Wang, Chaofei Zhao, Guangwei Yin, Xin Meng, Lin Li, Shengyong Cai, Chengquan Yan
Summary: This study reveals the stimulatory role of miR-21-5p in renal cell carcinoma and its contribution to the progression of the disease through the modulation of its downstream target gene ARHGAP24 expression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Cell Biology
Xi Tang, Xiaomin Wen, Zhouyu Li, Danxia Wen, Ling Lin, Jinquan Liu, Mingyi Li
Summary: This study revealed that circ_0102171 is highly expressed in cervical cancer tissues and cells, and silencing circ_0102171 can inhibit cell proliferation, migration, invasion, and enhance apoptosis. Mechanistically, circ_0102171 acts as a sponge for miR-4465, which in turn regulates the downstream target CREBRF to aggravate cervical cancer progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Julia A. Walker, Kye J. Robinson, Christopher Munro, Thomas Gengenbach, David A. Muller, Paul R. Young, Linda H. L. Lua, Simon R. Corrie
Review
Biochemistry & Molecular Biology
Simon R. Corrie, Magdalena Plebanski
MOLECULAR IMMUNOLOGY
(2018)
Article
Chemistry, Analytical
Jiaul Islam, Blake T. Riley, Christian Fercher, Martina L. Jones, Ashley M. Buckle, Christopher B. Howard, Rosalind P. Cox, Toby D. M. Bell, Stephen Mahler, Simon R. Corrie
ANALYTICAL CHEMISTRY
(2019)
Article
Nanoscience & Nanotechnology
Vidhishri Kesarwani, Hannah G. Kelly, Madhu Shankar, Kye J. Robinson, Stephen J. Kent, Ana Traven, Simon R. Corrie
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Immunology
David A. Muller, Alexandra C. I. Depelsenaire, Ashleigh E. Shannon, Daniel Watterson, Simon R. Corrie, Nick S. Owens, Christiana Agyei-Yeboah, Stacey T. M. Cheung, Jin Zhang, Germain J. P. Fernando, Mark A. F. Kendall, Paul R. Young
Letter
Nanoscience & Nanotechnology
Daniel A. Heller, Prakrit V. Jena, Matteo Pasquali, Kostas Kostarelos, Lucia G. Delogu, Rachel E. Meidl, Slava V. Rotkin, David A. Scheinberg, Robert E. Schwartz, Mauricio Terrones, YuHuang Wang, Alberto Bianco, Ardemis A. Boghossian, Sofie Cambre, Laurent Cognet, Simon R. Corrie, Philip Demokritou, Silvia Giordani, Tobias Hertel, Tetyana Ignatova, Mohammad F. Islam, Nicole M. Iverson, Anand Jagota, Dawid Janas, Junichiro Kono, Sebastian Kruss, Markita P. Landry, Yan Li, Richard Martel, Shigeo Maruyama, Anton V. Naumov, Maurizio Prato, Susan J. Quinn, Daniel Roxbury, Michael S. Strano, James M. Tour, R. Bruce Weisman, Wim Wenseleers, Masako Yudasaka
NATURE NANOTECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Julia Ann-Therese Walker, Xiaowei Wang, Karlheinz Peter, Kristian Kempe, Simon R. Corrie
Article
Chemistry, Multidisciplinary
Diana Alves, Rodrigo Curvello, Edward Henderson, Vidhishri Kesarwani, Julia A. Walker, Samuel C. Leguizamon, Heather McLiesh, Vikram Singh Raghuwanshi, Hajar Samadian, Erica M. Wood, Zoe K. McQuilten, Maryza Graham, Megan Wieringa, Tony M. Korman, Timothy F. Scott, Mark M. Banaszak Holl, Gil Garnier, Simon R. Corrie
Article
Chemistry, Multidisciplinary
Christian Fercher, Martina L. Jones, Stephen M. Mahler, Simon R. Corrie
Summary: Engineering antibodies through directed evolution to modulate dissociation kinetics enables continuous protein sensing in label-free binding assays. This approach enhances dissociation rates while maintaining overall affinity and specificity. The mutant fragment has successfully demonstrated sensing of antigen concentrations in continuous mode.
Article
Biochemical Research Methods
Imanda Jayawardena, Kirsty Wilson, Magdalena Plebanski, Lisbeth Grondahl, Simon Corrie
Summary: The urgent need for rapid, simple in vitro diagnostic methods for disease diagnosis, especially during the COVID-19 pandemic, is emphasized in the article. Research investigated the microstructure and proteomic composition of precipitin rings in immunodiffusion systems using fluorescence microscopy, electron microscopy, and mass spectrometry.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Gabriel T. Huynh, Edward C. Henderson, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: Long-term stability and function are key challenges for optical nanosensors operating in complex biological environments. Research shows that while the organosilica scaffold does not degrade appreciably over time, careful selection of dyes and further systematic investigations into the effects of salt and protein levels are required to realize long-term stable nanosensors.
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Vidhishri Kesarwani, Julia A. Walker, Edward C. Henderson, Gabriel Huynh, Heather McLiesh, Maryza Graham, Megan Wieringa, Mark M. Banaszak Holl, Gil Garnier, Simon R. Corrie
Summary: This article describes a rapid diagnostic platform based on column agglutination test for detecting antibodies against SARS-CoV-2. The method is simple, scalable, and can be easily integrated with established laboratory frameworks.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Edward Henderson, Gabriel Huynh, Kirsty Wilson, Magdalena Plebanski, Simon Corrie
Summary: Ovarian cancer is a highly lethal gynecological cancer and new technologies, particularly nanomaterials, show promise in improving diagnosis and treatment. However, challenges remain in terms of nanomaterial targeting, biodistribution, and clearance from the peritoneal cavity. Developing nanoparticles for ovarian cancer detection and imaging faces hurdles that must be overcome for clinical translation.
Article
Chemistry, Analytical
Michael J. Hertaeg, Vidhishri Kesarwani, Heather McLiesh, Julia Walker, Simon R. Corrie, Gil Garnier
Summary: The paper reports a novel and rapid paper-based antibody test that can quickly detect specific antibodies in patient plasma, with one application being the detection of COVID-19 antibodies. Test results are identified by analyzing the light intensity profile, and can be detected by eye and/or with image processing.