Article
Neurosciences
Joana F. da Rocha, Luisa Bastos, Sara C. Domingues, Ana R. Bento, Uwe Konietzko, Odete A. B. da Cruz e Silva, Sandra I. Vieira
Summary: The study revealed that the APP protein interacts with HB-EGF and EGF EGFR ligands, affecting ERK activation and neurite outgrowth. The interaction between APP and HB-EGF was confirmed, with implications for ERK pathway activation and neuronal differentiation. The synergistic effect of EGF and APP on neuritogenesis was shown to involve the EGFR pathway and has potential implications for Alzheimer's disease and adult neuroregeneration.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yousef Salama, Nidal Jaradat, Koichi Hattori, Beate Heissig
Summary: ALOC-EO has an anti-tumor effect on melanoma growth and tumor cell migration by blocking EGFR and ERK1/2 signaling pathways, enhancing its efficacy as a monotherapy or in combination with myelosuppressive drugs in melanoma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Claudia Tito, Ilaria Genovese, Flavia Giamogante, Anna Benedetti, Selenia Miglietta, Lucia Barazzuol, Loredana Cristiano, Alessia Iaiza, Sabatino Carolini, Luciana De Angelis, Silvia Masciarelli, Stefania Annarita Nottola, Giuseppe Familiari, Vincenzo Petrozza, Mattia Lauriola, Luca Tamagnone, Andrea Ilari, Tito Cali, Hector H. Valdivia, Carmen R. Valdivia, Gianni Colotti, Francesco Fazi
Summary: This study elucidates a functional mechanism that links calcium homeostasis to EGFR signaling in cancer. Sorcin directly binds EGFR protein in a calcium-dependent fashion, regulating calcium homeostasis and controlling EGFR proteostasis and signaling. This promotes cancer cell proliferation, migration, invasion, epithelial-to-mesenchymal transition, malignant progression, and resistance to chemotherapeutic drugs. Sorcin can also enhance the effectiveness of EGFR-targeting therapies.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Oncology
Li-Xia Peng, Ming-Dian Wang, Ping Xie, Jun-Ping Yang, Rui Sun, Li-Sheng Zheng, Yan Mei, Dong-Fang Meng, Xing-Si Peng, Yan-Hong Lang, Yuan-Yuan Qiang, Chang-Zhi Li, Liang Xu, Zhi-Jie Liu, Ling-Ling Guo, De-Huan Xie, Di-Tian Shu, Si-Ting Lin, Fei-Fei Luo, Bi-Jun Huang, Chao-Nan Qian
Summary: Nasopharyngeal carcinoma (NPC) originates in the nasopharyngeal epithelium and is known for its high metastatic rate. The study found elevated expression of LACTB in tumor tissues of NPC, which correlated with poorer patient survival. The role of LACTB in promoting NPC metastasis is dependent on the activation of ERBB3/EGFR-ERK signaling pathway.
Article
Oncology
Jian Sun, Lin Chen, Ming Dong
Summary: The study revealed that miR-338-5p controls epithelial-mesenchymal transition and metastasis of pancreatic cancer cells by targeting the EGFR/ERK pathway, and its expression in clinical analysis is negatively associated with lymph node metastasis and AJCC staging.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Zhongjian Yu, Xiongjie Zhu, Ying Li, Min Liang, Meijun Liu, Zhile Liu, Lingyu Qin, Xiaoran Wu, Kunpeng Du, Lu Liu, Yong Wang, Yanfang Zheng
Summary: The study shows that in lung adenocarcinoma, circ-HMGA2 promotes cell metastasis through the miR-1236-3p/EMT axis, indicating that it could be a therapeutic target in LUAD.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Minle Li, Xue Zhao, Hongmei Yong, Bingqing Shang, Weihua Lou, You Wang, Jin Bai
Summary: The study revealed that FBXO22 is significantly upregulated in epithelial ovarian cancer tissues and is closely correlated with tumor growth and metastasis. Furthermore, FBXO22 was found to promote cancer cell proliferation and migration through the MAPK/ERK pathway while inhibiting autophagic flux.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Hui-Huang Lai, Liang-Yi Hung, Chia-Jui Yen, Hsu-Chin Hung, Ruo-Yu Chen, Yu-Chao Ku, Hang-Tat Lo, Hung-Wen Tsai, Yun-Ping Lee, Tz-Hsuan Yang, Yen-Yu Chen, Yi-Shuian Huang, Wenya Huang
Summary: The overexpression of DNA repair gene NEIL3 in hepatocellular carcinoma (HCC) is associated with tumor development and metastasis. NEIL3 activates specific pathways to promote epithelial-mesenchymal transition, leading to tumor resistance and metastasis. This study suggests that NEIL3 may serve as a potential biomarker for predicting HCC recurrence and clinical intervention.
JOURNAL OF PATHOLOGY
(2022)
Article
Cell Biology
Ji-Hye Park, Jae-Kyung Myung, Sun-Joo Lee, Hyewon Kim, Soyeon Kim, Seung-Bum Lee, Hyosun Jang, Won-Il Jang, Sunhoo Park, Hyunwon Yang, Sehwan Shim, Min-Jung Kim
Summary: Papillary thyroid cancer (PTC) is the most common type of thyroid cancer worldwide, and it can metastasize to regional lymph nodes as well as distant sites. Radioactive iodine (RAI) therapy is effective for treating TC, but resistance can occur in patients with distant metastasis (DM). This study investigated the potential of DM-related biomarkers as therapeutic targets for PTC therapy.
Article
Oncology
Shelan Rasool, Qais Al Ismaeel, Srdar H. Arif
Summary: This study investigated the expression pattern of matricellular proteins SPARC and CYR61 in colorectal cancer and found their association with cancer progression. High expression of CYR61 was associated with migration, invasion, proliferation, and apoptosis of colorectal cancer cells. This discovery provides new insights for the treatment of colorectal cancer.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jiunn-Min Shieh, Ting-Wei Chang, Jing-He Wang, Song-Ping Liang, Pei-Lu Kao, Liang-Yi Chen, Chia-Jui Yen, Yun-Ju Chen, Wen-Chang Chang, Ben-Kuen Chen
Summary: This study reveals the correlation between RNA-binding proteins (RBPs), specifically nucleolin (NCL) and heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2B1), and the mesenchymal phenotype of head and neck squamous cell carcinoma (HNSCC). The RBPs regulate fibronectin, an epithelial-mesenchymal transition (EMT) marker, through the ERK and NF-κB pathway, enhancing tumor cell metastasis. The RBPs/fibronectin axis plays a crucial role in EGF-induced tumor-endothelial cell interactions and HNSCC metastasis.
Article
Oncology
Lumin Wang, Yi Gao, Dongdong Tong, Xiaofei Wang, Chen Guo, Bo Guo, Yang Yang, Lingyu Zhao, Jing Zhang, Juan Yang, Yannan Qin, Liying Liu, Chen Huang
Summary: The study revealed the function of the MeCP2/HOXD3/HB-EGF regulatory axis in HCC, providing insights for the development of targeted therapeutics and potential biomarkers. The expression of HOXD3 gene is regulated by the cooperative action of MeCP2 and CREB1, leading to promotion of HCC metastasis, invasion, and angiogenesis.
MOLECULAR ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hao Lin, Junyong Weng, Haitao Mei, Mingkai Zhuang, Xinzhu Xiao, Fan Du, Liying Lin, Juhua Wu, Zhixin Chen, Yuehong Huang, Fenglin Chen, Xiaozhong Wang
Summary: The study showed that 5-lipoxygenase is upregulated in gastric cancer tissues and is associated with poor overall survival in patients with gastric cancer. 5-lipoxygenase promotes cell proliferation, migration, and invasion in gastric cancer, as well as inducing epithelial-mesenchymal transition. This process involves activation of the extracellular signal-regulated kinase signaling pathway.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Sebastian P. Gnosa, Laia Puig Blasco, Krzysztof B. Piotrowski, Marie L. Freiberg, Simonas Savickas, Daniel H. Madsen, Ulrich Auf Dem Keller, Pauliina Kronqvist, Marie Kveiborg
Summary: Macrophages in the tumor microenvironment play a significant role in tumor progression, and ADAM17 is identified as a key mediator in controlling macrophage education. Through a paracrine EGFR ligand-chemokine feedback loop, ADAM17 facilitates cancer cells in hijacking macrophages to promote tumor progression.