Article
Chemistry, Applied
Lu Wang, Hao Lyu, Xinyuan Zhang, Yuelong Xiao, Aofei Li, Zhengxin Ma, Chengchen Guo, Ying Pei
Summary: This study investigated the aggregation behaviors of mesostructured collagen fibrils in suspension by varying pH, ionic strength, temperature, and solvent. Reconstituted collagen films were fabricated with mesostructured fibrils as building blocks. The findings provide comprehensive understanding and guidance for practical applications of mesostructured collagen.
FOOD HYDROCOLLOIDS
(2022)
Article
Endocrinology & Metabolism
Peng Zhou, Chao Yang, Shan Zhang, Zun-Xiang Ke, Dian-Xi Chen, Yi-Qing Li, Qin Li
Summary: The importance of early diagnosis and treatment of diabetes and its cutaneous complications is increasingly recognized. High glucose affects collagen gene expression in human dermal fibroblasts, leading to an imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Inhibiting MMP-2 and MMP-9 can alleviate collagen deposition disorder in the skin of diabetic mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Xiao, Qipu Feng, Lu Huang, Xia Meng, Pengfei Han, Wenjing Zhang, Yujian James Kang
Summary: This study found that copper supplementation can reduce cardiac fibrosis and improve cardiac function. The inhibitory effect of copper may be achieved by reducing the transformation of fibroblasts to myofibroblasts, promoting fibrinolytic switch, and improving cardiac function.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Taihao Quan
Summary: As the most extensive and abundant tissue in the human body, the skin undergoes gradual atrophy during the aging process, causing disruptions to its structure and functionality. Recent molecular discoveries related to skin aging emphasize the importance of preventive approaches, such as the use of topical retinoids, which show promise in enhancing skin texture and thickness.
Article
Engineering, Biomedical
Adam Rauff, Jason C. Manning, James B. Hoying, Steven A. LaBelle, Hannah A. Strobel, Gregory J. Stoddard, Jeffrey A. Weiss
Summary: This study investigated the influence of immediate extracellular cues on the growth trajectories of angiogenic neovessels, and obtained quantitative relationships describing their effects. The results showed that ECM density and nearby cellular bodies were the strongest predictors of neovessel trajectories, while fibril tracks were associated with direction changes in sprout trajectories.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Biomedical
Fernanda F. Fontenele, Nikolaos Bouklas
Summary: In this study, a viscoelastic-plastic constitutive model was developed to analyze the effects of inelasticity and energy dissipation in collagen fibrils, specifically in the context of cyclic loading and overload. The model was validated by comparing the stress-stretch data obtained from experiments with single fibrils subjected to cyclic loading conducted by Liu et al. (2018).
ACTA BIOMATERIALIA
(2023)
Article
Orthopedics
Ke Zhang, Zhuoying Li, Yunyang Lu, Linyi Xiang, Jiadong Sun, Hong Zhang
Summary: In this study, it was demonstrated for the first time that Vangl2 is involved in the process of OA. Silencing Vangl2 can effectively alleviate OA progression in vitro by inhibiting the expression of MMPs and increasing the formation of the cartilage matrix, while also inhibiting the proinflammatory effects of Wnt5a via the MAPK and NF-kappa B pathways. This study provides new insights into the mechanism of cartilage inflammation.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Engineering, Biomedical
Fa Liu, Ke Hu, Luban H. Al-Qudsy, Lan-Qin Wu, Zhe Wang, Hui-Yun Xu, Hui Yang, Peng-Fei Yang
Summary: This study investigated the effects of aging and disuse on the microstructure and mechanical properties of mouse bone, focusing on the mineralized collagen fibrils. The results revealed that the alterations in bone due to aging and disuse initiated from the mineralized collagen fibrils in the bone matrix. The findings provide insights into the adaptation process of bone to aging and the abnormal mechanical environment.
ACTA BIOMATERIALIA
(2022)
Article
Pharmacology & Pharmacy
Robert O. Baratta, Brian J. Del Buono, Eric Schlumpf, Brian P. Ceresa, David J. Calkins
Summary: The cornea, a highly collagenous structure with multiple layers, is at risk for injury due to constant exposure to the external environment. A study found that a collagen mimetic peptide (CMP) can promote epithelial healing following acute corneal wounds by repairing damaged collagen. This suggests that CMPs may represent a novel therapeutic approach for healing corneal tissue in conditions that damage the ocular surface.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tiffany C. Kaspar, Peter Hatton, Kayla H. Yano, Sandra D. Taylor, Steven R. Spurgeon, Blas P. Uberuaga, Daniel K. Schreiber
Summary: Thin film deposition from the vapor phase involves complex adatom adsorption, movement, and incorporation into the growing film. This study provides experimental and simulation evidence for anion intermixing during the deposition process. The research reveals that adatoms on the film surface pull up subsurface oxygen and iron and facilitate their mixing through ring-like rotation mechanisms. These findings contribute to the understanding of thin film deposition and other surface-mediated processes.
Article
Biology
Turki Almubrad, Rita Mencucci, Adrian Smedowski, Ramachandran Samivel, Essam Almutleb, Aljoharah Alkanaan, Adnan Ali Khan, Ali Masmali, Saeed Akhtar
Summary: Electron microscopy revealed that iontophoresis-ultraviolet A (UVA) cross-linking (CXL) with hypotonic riboflavin solution preserved collagen fibril diameter and proteoglycan area size better in the peripheral cornea compared to the central cornea. Riboflavin + UVA application at 3 mW/cm^2 for 30 min and 10 mW/cm(2) for 9 min were effective CXL methods, with the former improving collagen fibril organization and size.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Engineering, Biomedical
Victor R. Martinez-Zelaya, Nathaly L. Archilha, Monica Calasans-Maia, Marcos Farina, Alexandre M. Rossi
Summary: The study investigates the 3D microarchitecture of newly formed trabecular tissue in cortical bone defects and shows that the woven bone trabecular network is organized according to the principle of tensegrity, with highly symmetric geometric motifs. The presence of biomaterials did not disrupt trabecular microarchitecture, suggesting that the formation of intrinsic trabecular motifs is maintained regardless of the presence of a bone graft.
ACTA BIOMATERIALIA
(2021)
Article
Materials Science, Multidisciplinary
Zhijie Wang, M. Ravi Shankar
Summary: FeCoB nanocrystalline layers enable spatially selective removal of diamond through solid-state diffusion reaction. Heat treatment triggers carbon conversion at the diamond-transition metal interface, and removal of reaction products allows recovery of structured diamond surfaces. FeCoB offers high material removal rates due to the key role of B in the process.
DIAMOND AND RELATED MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Prashant Chandrasekaran, Bryan Kwok, Biao Han, Sheila M. Adams, Chao Wang, Daphney R. Chery, Robert L. Mauck, Nathaniel A. Dyment, X. Lucas Lu, David B. Frank, Eiki Koyama, David E. Birk, Lin Han
Summary: This study investigates the role of type V collagen in post-natal growth of temporomandibular joint (TMJ) condylar cartilage, revealing its impact on tissue structure, cell proliferation, and mechanoregulation of progenitor cell activities. Loss of type V collagen leads to abnormal tissue development, reduced cell density, and limited progenitor cell proliferation, highlighting the significance of type V collagen in regulating TMJ condylar cartilage growth.
Article
Chemistry, Multidisciplinary
Olga Yu. Milyaeva, Alexander V. Akentiev, Alexey G. Bykov, Giuseppe Loglio, Reinhard Miller, Irina Portnaya, Anastasiya R. Rafikova, Boris A. Noskov
Summary: The dynamic surface properties of native kappa-casein solutions and their fibril dispersions are significantly different from those of globular proteins. The surface elasticity of kappa-casein solutions has a local maximum, indicating partial displacement of molecules from the proximal region to the distal region with increasing surface pressure. The surface elasticity of fibril dispersions shows a monotonic increase, similar to globular protein fibril dispersions. However, the surface elasticity of fibril dispersions can reach values approximately four times higher than that of native protein solutions at the same concentrations.
Article
Multidisciplinary Sciences
Michael K. Conway, Michael J. Gerger, Erin E. Balay, Rachel O'Connell, Seth Hanson, Neil J. Daily, Tetsuro Wakatsuki
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2015)
Article
Biochemistry & Molecular Biology
Alexey V. Karpushev, Vladislav Levchenko, Tengis S. Pavlov, Vy Lam, Kalyan C. Vinnakota, Alain Vandewalle, Tetsuro Wakatsuki, Alexander Staruschenko
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2008)
Article
Biochemistry & Molecular Biology
Filip Sedlic, Danijel Pravdic, Naoyuki Hirata, Yasushi Mio, Ana Sepac, Amadou K. Camara, Tetsuro Wakatsuki, Zeljko J. Bosnjak, Martin Bienengraeber
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2010)
Meeting Abstract
Biophysics
Alexey Karpushev, Oleh Pochynyuk, Vladislav Levchenko, Tengis Pavlov, Tetsuro Wakatsuki, Alexander Staruschenko
BIOPHYSICAL JOURNAL
(2009)
Meeting Abstract
Biophysics
Kalyan C. Vinnakota, David Mitchell, Robert J. Deschenes, Tetsuro Wakatsuki, Daniel A. Beard
BIOPHYSICAL JOURNAL
(2009)
Article
Cell Biology
Victoriya A. Rufanova, Anna Alexanian, Tetsuro Wakatsuki, Adam Lerner, Andrey Sorokin
JOURNAL OF CELLULAR PHYSIOLOGY
(2009)
Article
Multidisciplinary Sciences
Vy Lam, Tarin Bigley, Scott S. Terhune, Tetsuro Wakatsuki
Article
Cell & Tissue Engineering
Juan Pablo Marquez, Wesley Legant, Vy Lam, Amy Cayemberg, Elliot Elson, Tetsuro Wakatsuki
TISSUE ENGINEERING PART C-METHODS
(2009)
Article
Cardiac & Cardiovascular Systems
Jozef Lazar, Howard J. Jacob, Tetsuro Wakatsuki
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2008)
Proceedings Paper
Engineering, Biomedical
Teresa M. Abney, Tetsuro Wakatsuki, Elliot L. Elson, Guy Genin
PROCEEDINGS OF THE ASME SUMMER BIOENGINEERING CONFERENCE, PTS A AND B
(2012)
Article
Biophysics
Guy M. Genin, Teresa M. Abney, Tetsuro Wakatsuki, Elliot L. Elson
MECHANOBIOLOGY OF CELL-CELL AND CELL-MATRIX INTERACTIONS
(2011)
Article
Biophysics
Clara F. Asnes, J. Pablo Marquez, Elliot L. Elson, Tetsuro Wakatsuki
BIOPHYSICAL JOURNAL
(2006)
Review
Biochemistry & Molecular Biology
T Wakatsuki, J Schlessinger, EL Elson
TRENDS IN BIOCHEMICAL SCIENCES
(2004)
Article
Biochemistry & Molecular Biology
Kalyan C. Vinnakota, David A. Mitchell, Robert J. Deschenes, Tetsuro Wakatsuki, Daniel A. Beard