Induction of Eosinophil Apoptosis by the Cyclin-Dependent Kinase Inhibitor AT7519 Promotes the Resolution of Eosinophil-Dominant Allergic Inflammation

Effects of the cyclin-dependent kinase inhibitor R-roscovitine on eosinophil survival and clearance

(2011) N. Farahi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Effective Caspase Inhibition Blocks Neutrophil Apoptosis and Reveals Mcl-1 as Both a Regulator and a Target of Neutrophil Caspase Activation

(2011) David J. Wardle et al.   PLoS One

Nadir CD4 T Cell Count as Predictor and High CD4 T Cell Intrinsic Apoptosis as Final Mechanism of Poor CD4 T Cell Recovery in Virologically Suppressed HIV‐Infected Patients: Clinical Implications

(2010) Eugènia Negredo et al.   CLINICAL INFECTIOUS DISEASES

The eosinophil and airway remodelling in asthma

(2010) Per Venge   Clinical Respiratory Journal

The cyclin-dependent kinase inhibitor R-roscovitine down-regulates Mcl-1 to override pro-inflammatory signalling and drive neutrophil apoptosis

(2010) Andrew E. Leitch et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeting granulocyte apoptosis: mechanisms, models, and therapies

(2010) Rodger Duffin et al.   IMMUNOLOGICAL REVIEWS

Cyclin-dependent Kinase 5 Regulates Endothelial Cell Migration and Angiogenesis

(2010) Johanna Liebl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDE4 inhibition drives resolution of neutrophilic inflammation by inducing apoptosis in a PKA-PI3K/Akt-dependent and NF-κB-independent manner

(2010) Lirlândia P. Sousa et al.   JOURNAL OF LEUKOCYTE BIOLOGY

AT7519, a Cyclin-Dependent Kinase Inhibitor, Exerts Its Effects by Transcriptional Inhibition in Leukemia Cell Lines and Patient Samples

(2010) Matthew S. Squires et al.   MOLECULAR CANCER THERAPEUTICS

AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition

(2010) L Santo et al.   ONCOGENE

Delayed Treatment with Systemic (S)-Roscovitine Provides Neuroprotection and Inhibits In Vivo CDK5 Activity Increase in Animal Stroke Models

(2010) Bénédicte Menn et al.   PLoS One

Interleukin-5 inhibits glucocorticoid-mediated apoptosis in human eosinophils

(2010) S. Brode et al.   THORAX

Transepithelial exit of leucocytes: inflicting, reflecting or resolving airway inflammation?

(2010) C. Persson et al.   THORAX

15-Epi-lipoxin A4Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

(2009) Driss El Kebir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Immunobiology of Asthma

(2009) Qutayba Hamid et al.   Annual Review of Physiology

Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents

(2009) AE Leitch et al.   BRITISH JOURNAL OF PHARMACOLOGY

The CDK inhibitor, R-roscovitine, promotes eosinophil apoptosis by down-regulation of Mcl-1

(2009) Rodger Duffin et al.   FEBS LETTERS

Pivotal Advance: Pharmacological manipulation of inflammation resolution during spontaneously resolving tissue neutrophilia in the zebrafish

(2009) Catherine A. Loynes et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Glucocorticoid resistance in inflammatory diseases

(2009) Peter J Barnes et al.   LANCET

Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines

(2009) M. S. Squires et al.   MOLECULAR CANCER THERAPEUTICS

Apoptosis Is Essential for Neutrophil Functional Shutdown and Determines Tissue Damage in Experimental Pneumococcal Meningitis

(2009) Uwe Koedel et al.   PLoS Pathogens

Macrophage phagocytosis of apoptotic neutrophils is critically regulated by the opposing actions of pro-inflammatory and anti-inflammatory agents: key role for TNF-α

(2008) Sylwia Michlewska et al.   FASEB JOURNAL

Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma

(2008) Anne M. Fitzpatrick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Identification ofN-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design†

(2008) Paul G. Wyatt et al.   JOURNAL OF MEDICINAL CHEMISTRY

Relevance of granulocyte apoptosis to resolution of inflammation at the respiratory mucosa

(2008) A E Leitch et al.   Mucosal Immunology

Caspase inhibitor zVAD.fmk reduces infarct size after myocardial ischaemia and reperfusion in rats but not in mice

(2008) Jan Mersmann et al.   RESUSCITATION

Novel pharmacological strategies for driving inflammatory cell apoptosis and enhancing the resolution of inflammation

(2008) John M. Hallett et al.   TRENDS IN PHARMACOLOGICAL SCIENCES