Article
Pharmacology & Pharmacy
Hassan Maleki, Mohammad Reza Hosseini Najafabadi, Thomas J. Webster, Mahmoud Reza Hadjighassem, Esmaeil Sadroddiny, Hossein Ghanbari, Masood Khosravani, Mahdi Adabi
Summary: The study aimed to co-load paclitaxel and etoposide in mPEG-PLGA NPs for enhanced therapeutic efficacy in treating intracranial glioblastoma, showing improved cytotoxic effects and anti-glioma activity without inducing blood-related issues.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Zhongchao Zhao, Andrea Simms, Nicole F. Steinmetz
Summary: This study utilizes tobacco mosaic virus (TMV) protein nanotubes as drug carriers to deliver platinum therapies to ovarian tumors, increasing efficacy and maintaining safety. It demonstrates superior efficacy compared to free drugs in mouse models and may induce immune response against tumors.
Article
Pharmacology & Pharmacy
Yanhai Xi, Weiheng Wang, Liang Ma, Ning Xu, Changgui Shi, Guohua Xu, Hailong He, Wenming Pan
Summary: A novel nano-carrier with bone targeting, AS-AL-mPEG-PLGA, was successfully prepared to enhance the oral bioavailability, bone targeting, and anti-osteoporotic effect of AS.
Article
Polymer Science
Pierluigi Stipa, Stefania Marano, Roberta Galeazzi, Cristina Minnelli, Giovanna Mobbili, Emiliano Laudadio
Summary: Biodegradable polymeric nanoparticles are promising non-toxic vehicles for drug delivery, but lack of regulatory guidance in assessment and characterization delays their clinical success. Understanding drug-polymer interactions is crucial for optimizing drug delivery systems.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Shiyi Xu, Xinyu Zhang, Xingyu Zhu, Hui Su, Xueying Yan
Summary: Co-loading nanoparticle encapsulation is an effective strategy for anti-tumor treatment. The combination of arsenic trioxide and tetrandrine synergistically inhibits tumor growth and metastasis. This study developed co-loading nanoparticle formulations and demonstrated their improved drug distribution and anti-tumor activity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mohammad Reza Malekpour, Saereh Hosseindoost, Fatemeh Madani, Morteza Kamali, Masood Khosravani, Mahdi Adabi
Summary: This study explores the use of Poly(lactic co-glycolic acid) nanoparticles loaded with Paclitaxel (PTX) and Doxorubicin (DOX) to improve the treatment of glioblastoma tumors. The results show that these nanoparticles enhance cytotoxicity and decrease tumor size. MRI results also demonstrate a longer median survival rate for the combination therapy. Additionally, the combination therapy has a positive effect on rat movement, as indicated by behavioral tests.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Hassan Maleki, Majid Naghibzadeh, Amir Amani, Mahdi Adabi, Masood Khosravani
Summary: The purpose of this study was to develop etoposide (ETP) and paclitaxel (PTX) co-loaded methoxy poly(ethylene glycol)-poly(lactic-co-glycolic acid) (mPEG-PLGA) nanoparticles (NPs) with optimized size to achieve co-delivery of ETP and PTX. The nanoparticles prepared were spherical with mean size of about 150 nm, zeta potential of -22.2 mV, and high loading efficiency for both drugs. Fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analyses confirmed that the drugs were successfully dispersed in the NP matrix as an amorphous phase without any change in chemical structures, and the NPs exhibited sustained release profiles for both drugs. The optimized ETP and PTX co-loaded mPEG-PLGA NPs could be suggested as a promising method for enhanced chemotherapy.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2021)
Article
Pharmacology & Pharmacy
Peng He, Shenglin Xu, Zehao Guo, Peng Yuan, Yulei Liu, Yu Chen, Tiantian Zhang, Yukang Que, Yong Hu
Summary: The study developed a PLGA-based DOX-loaded implant and evaluated its efficacy in intratumoral chemotherapy for osteosarcoma. The results showed that the implant inhibited tumor growth in a dose-dependent manner and had a higher drug concentration in tumors compared to normal tissues, which improved the efficacy and reduced systemic side effects.
Article
Pharmacology & Pharmacy
Xia Liu, Mengying Zhang, Yuxin Tian, Ruijia Liu, Yunfei Wang, Feifei Guo, Yanling Gong, Meixing Yan
Summary: This study developed a new strategy for the colon-targeted delivery of luteolin, a flavonoid compound, by encapsulating it into nanoparticles. The coated nanoparticles showed uniform particle size distribution, high encapsulation efficiency, and good stability. In vitro and in vivo studies demonstrated the safety and effectiveness of the colon-targeted delivery system.
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Mohammad Mahdi Eshaghi, Erfan Rahmani, Narges Ajalli, Shohreh Bakhshi, Helia Mirkhaef, Maryam Vahdat Lasemi, Abbas Rahdar, Razieh Behzadmehr, Ana M. Diez-Pascual
Summary: This review summarizes different drug delivery systems for cisplatin and compares their performance and potential. Stimuli-responsive systems are highlighted for enhanced drug delivery. Additionally, systems with co-delivery capabilities are discussed in detail.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Engineering, Environmental
Mozhgan Shajari, Mostafa Zamani, Nahid Ahmadi, Kobra Rostamizadeh, Reza Shapouri
Summary: This research investigated the antibacterial effect of curcumin entrapped in polymeric nanoparticles on resistant bacteria, showing a stronger impact on wild strains. Additionally, it was found that mPEG-PCL/curcumin can reduce the total microbial count in wastewater at specific concentrations and temperatures.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Jahar Dey, Sang-Jo Lee, Jiwhan Kim, Sung-Hwan Lim, Jae-Min Ha, Min-Jae Lee, Sung-Min Choi
Summary: This study introduces a method for forming nanoparticle supercrystals driven by covalent bonding interactions, which provide stronger structural stability compared to traditional intermolecular forces. The versatility and cost-effectiveness of the covalent bonding approach make it highly practical for various applications.
Article
Biochemistry & Molecular Biology
Linjuan Huang, Jing Zhang, Youling Deng, Hao Wang, Piao Zhao, Guozhi Zhao, Wei Zeng, Yonghui Wang, Connie Chen, William Wagstaff, Rex C. Haydon, Russell R. Reid, Tong-Chuan He, Le Shen, Hue H. Luu, Ling Zhao
Summary: Ovarian cancer is a highly lethal malignancy, often diagnosed at advanced stages due to the lack of early diagnosis methods. The standard treatment includes surgery and chemotherapy, but many patients develop chemoresistant tumors. Therefore, there is a need to develop new therapeutic agents to overcome chemoresistance. Niclosamide, an anti-parasite agent, has shown potent anti-cancer activities in ovarian cancer and other types of human cancers. This study investigates the potential of repurposing niclosamide as a therapeutic agent.
Article
Chemistry, Analytical
Amir Khajavinia, Mehran Yarahmadi, Anas El-Aneed, Azita Haddadi
Summary: In this study, an efficient LC-MS/MS method was developed to quantify docetaxel in PLGA nanoparticles. By optimizing the nanoparticle formulation and using MS/MS fingerprints, a reliable quantification method was developed. This is of importance for future research on docetaxel-loaded polymeric nanodelivery systems.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pharmacology & Pharmacy
N. Brandhonneur, Y. Boucaud, A. Verger, N. Dumait, Y. Molard, S. Cordier, G. Dollo
Summary: Poly (lactic-co-glycolic) acid nanoparticles loaded with inorganic molybdenum octahedral clusters were used for photodynamic therapy of ovarian cancer. Among the studied cluster compounds, CMIF-loaded nanoparticles showed higher internalization efficiency in A2780 ovarian cancer cell line and significant decrease in cellular viability following photo-activation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)