Article
Oncology
Praful Ravi, Victoria Wang, Raina N. Fichorova, Bradley McGregor, Xiao X. Wei, Shehzad Basaria, Christopher J. Sweeney
Summary: This study aimed to evaluate the association between IGF-1 and its binding proteins with outcomes in men with metastatic prostate cancer treated with ADT. The results showed that a higher IGF-1:IGF-BP1 ratio was associated with better overall survival. Further research will be important to assess the role of the IGF-1 axis as a predictive biomarker.
ENDOCRINE-RELATED CANCER
(2023)
Review
Neurosciences
Weihao Wang, Xiaoye Duan, Zhengxiang Huang, Qi Pan, Chen Chen, Lixin Guo
Summary: Organisms have developed common behavioral and physiological adaptations to the day/night cycle, with the CLOCK system forming an internal circadian rhythm that may influence growth hormone secretion, the GH-insulin-like growth factor 1 axis, and metabolism.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Gastroenterology & Hepatology
Tao Lin, Shanshan Wang, Stefan Munker, Kyounghwa Jung, Ricardo U. Macias-Rodriguez, Astrid Ruiz-Margain, Robert Schierwagen, Hui Liu, Chen Shao, Chunlei Fan, Rilu Feng, Xiaodong Yuan, Sai Wang, Franziska Wandrer, Christoph Meyer, Ralf Wimmer, Roman Liebe, Jens Kroll, Long Zhang, Tobias Schiergens, Peter ten Dijke, Andreas Teufel, Alexander Marx, Peter R. Mertens, Hua Wang, Matthias P. A. Ebert, Heike Bantel, Enrico De Toni, Jonel Trebicka, Steven Dooley, Donghun Shin, Huiguo Ding, Hong-Lei Weng
Summary: The study found that the expression of HNF4 alpha in liver progenitor cells (LPCs) is crucial for determining the clinical outcomes of patients with acute liver failure (ALF). Recovered patients with ALF show normal coagulation function, while those requiring liver transplantation demonstrate abnormal activin/follistatin ratio.
Review
Cell Biology
Anna Ianza, Marianna Sirico, Ottavia Bernocchi, Daniele Generali
Summary: Studies over the past two decades have shown the involvement of IGF-1 in various patho-physiological processes and tumor development, particularly in breast cancer where overexpression and hyperphosphorylation of IGF-1R are common. The IGF-1 axis is closely linked to estrogen regulation, potentially offering a solution to anti-estrogen resistance, and may also impact other therapeutic strategies for cancer treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Fan Yu, Hong-Rui Luo, Xue-Fan Cui, Yi-Jie Wu, Jian-Lin Li, Wen-Rong Feng, Yong-Kai Tang, Sheng-Yan Su, Jun Xiao, Zhi-Shuai Hou, Pao Xu
Summary: Environment-related zinc contamination exhibits heterogeneous toxic effects on brain cells in zebrafish, disrupting neurobehavior and potentially leading to a neurodegeneration-like syndrome.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Churaibhon Wisessaowapak, Apichaya Niyomchan, Daranee Visitnonthachai, Naphada Leelaprachakul, Piyajit Watcharasit, Jutamaad Satayavivad
Summary: Arsenic can lead to insulin and IGF-1 resistance in human neuroblastoma cells, disrupting cellular signaling and potentially affecting growth and neurite formation by inhibiting tyrosine kinase activity.
ENVIRONMENTAL TOXICOLOGY
(2023)
Review
Endocrinology & Metabolism
Makoto Matsushita, Kazutoshi Fujita, Koji Hatano, Marco A. De Velasco, Hirotsugu Uemura, Norio Nonomura
Summary: This study highlights the association between increased levels of circulating IGF-1 and the risk of developing prostate cancer. It also demonstrates that gut microbiota-derived short-chain fatty acids (SCFAs) can promote prostate cancer progression by increasing IGF-1 production. Furthermore, specific bacteria in the gut microbiome are associated with high-grade prostate cancer. These findings suggest that dietary interventions and supplements targeting the gut-IGF-1-prostate axis may be effective for preventing prostate cancer.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Jue Wang, Bin Cao, Yan Gao, Yu-Hua Chen, Juan Feng
Summary: In this study, the researchers investigated the role of lncRNA H19 in insulin-like growth factor-1 regulation in ischemic stroke. They found that plasma exosomal lncRNA H19 was negatively associated with blood levels of insulin-like growth factor-1 in patients with cerebral ischemic stroke. Furthermore, they discovered that lncRNA H19 could be transported from neurons to astrocytes via exosomes and induce downregulation of insulin-like growth factor-1 through the H19/let-7a/insulin-like growth factor-1 receptor axis.
NEURAL REGENERATION RESEARCH
(2023)
Review
Clinical Neurology
Ambika Shandilya, Sidharth Mehan
Summary: The dysregulation of IGF-1 and GLP-1 signaling pathways plays a significant role in motor neuron diseases like ALS, and restoring these abnormal signals could have positive effects on neuroprotection and treatment.
NEUROLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Tomer Adar, Ami Ben Ya'acov, Yehudit Shabat, Meir Mizrahi, Lida Zolotarov, Yoav Lichtenstein, Yaron Ilan
Summary: This study investigates the role of glucocorticoids in the development of non-alcoholic fatty liver disease (NAFLD) and the response of natural killer T cells to steroids. The results show that CD1d is involved in steroid-induced liver damage, while glycosphingolipids have a protective effect. Furthermore, the study suggests a dichotomy between steatosis and steatohepatitis in NAFLD, as CD1d plays a role in steroid-induced steatosis but not in liver necrosis, inflammation, and metabolic changes.
BMC GASTROENTEROLOGY
(2022)
Article
Environmental Sciences
Rui Yan, Jie Ding, Qianlei Yang, Xiaoyun Zhang, Junyu Han, Tingxu Jin, Shudi Shi, Xirui Wang, Yu Zheng, Heran Li, Hengdong Zhang, Yan An
Summary: This study investigated the skeletal toxicity of lead acetate (PbAc) in early life stages of zebrafish. The results showed that PbAc inhibited the differentiation and maturation of osteoblasts and cartilage matrix, promoted the formation of osteoclasts, disrupted the GH/IGF-1 axis, and ultimately induced cartilage defects and bone loss in zebrafish embryos.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Ambika Shandilya, Sidharth Mehan, Sumit Kumar, Pranshul Sethi, Acharan S. Narula, Abdulrahman Alshammari, Metab Alharbi, Abdullah F. Alasmari
Summary: This study aimed to investigate the neuroprotective effects of 4-HI on ALS-like rats exposed to methylmercury. The results showed that 4-HI can alleviate the behavioral, neurochemical, and histopathological abnormalities induced by methylmercury.
Article
Cell & Tissue Engineering
Wen-Cheng Lo, Chi-Sheng Chiou, Feng-Chou Tsai, Chun-Hao Chan, Samantha Mao, Yue-Hua Deng, Chia-Yu Wu, Bou-Yue Peng, Win-Ping Deng
Summary: Nicotine may induce intervertebral disc degeneration, and platelet-derived biomaterials (PDB) can inhibit this process by modulating the IGF-1/AKT/IRS-1 signaling axis.
CELL TRANSPLANTATION
(2021)
Article
Endocrinology & Metabolism
Rita E. Roberts, Jacqueline Cavalcante-Silva, Rhonda D. Kineman, Timothy J. Koh
Summary: Insulin-like growth factor (IGF)-1 plays an important role in tissue repair, stimulating wound cell activity. This study found that the liver is a primary source of IGF-1 in skin wounds, contributing to various aspects of epithelial and dermal healing.
JOURNAL OF ENDOCRINOLOGY
(2022)
Review
Biology
Mohammed El-Mowafy, Abdelaziz Elgaml, Mohamed El-Mesery, Salma Sultan, Tamer A. E. Ahmed, Ahmed I. Gomaa, Mahmoud Aly, Walid Mottawea
Summary: Alterations in gut microbiota composition and function are associated with HCV infection and its treatment regimens, impacting the coordination between the gut and liver along the gut-liver-axis. This dysbiosis contributes to HCV associated liver complications by triggering inflammation and metabolic disturbance, potentially affecting the effectiveness of antiviral medications used in treatment. Manipulating gut microbiota composition may offer a novel therapeutic strategy to manage liver complications following HCV infection.
Review
Clinical Neurology
Claire E. Sexton, Kaarin J. Anstey, Filippo Baldacci, C. J. Barnum, Anna M. Barron, Kaj Blennow, Henry Brodaty, Samantha Burnham, Fanny M. Elahi, Jurgen Gotz, Yun-Hee Jeon, Maya Koronyo-Hamaoui, Susan M. Landau, Nicola T. Lautenschlager, Simon M. Laws, Darren M. Lipnicki, Hanzhang Lu, Colin L. Masters, Wendy Moyle, Akinori Nakamura, Giulio Maria Pasinetti, Naren Rao, Christopher Rowe, Perminder S. Sachdev, Peter R. Schofield, Einar M. Sigurdsson, Kate Smith, Velandai Srikanth, Cassandra Szoeke, Malu G. Tansey, Rachel Whitmer, Donna Wilcock, Tien Y. Wong, Lisa J. Bain, Maria C. Carrillo
Summary: Australian researchers have taken a leading role in advancing the understanding and treatment developments for Alzheimer's disease and other dementias, with significant contributions such as the AIBL study. They have also focused on vascular contributions to cognitive impairment, risk factors for women, and behavioral and psychological symptoms of dementia.
ALZHEIMERS & DEMENTIA
(2022)
Review
Hematology
David Azoulay, Netanel A. Horowitz
Summary: This article reviews the expression of BDNF and its receptors in normal hematopoietic and lymphatic cells and tissue, and discusses their roles in hematological malignancies. The study findings suggest a positive association between BDNF blood levels and prognosis, chemotherapy response, and neurological side effects in patients.
Article
Pediatrics
David Azoulay, Ilan Levov, Ety Shaoul, Amir Asher Kuperman
Summary: This study evaluated laboratory indices in patients with hereditary spherocytosis who underwent flow cytometry eosin-5-melamide (EMA)-bound red blood cells screening test. The results suggest that borderline EMA-test results may indicate a more severe form of hereditary spherocytosis, and using mean corpuscular hemoglobin concentration as a cut-off can help predict and reduce negative EMA tests. Further validation in other flow cytometry laboratories with large EMA test sample pools is needed.
JOURNAL OF PEDIATRICS
(2022)
Review
Neurosciences
Hidehiko K. Inagaki, Susu Chen, Kayvon Daie, Arseny Finkelstein, Lorenzo Fontolan, Sandro Romani, Karel Svoboda
Summary: This article discusses the neural dynamics involved in the planning and execution of voluntary movements in the brain. Recent experimental studies, combined with computational models, reveal that cortical dynamics reflect fixed points of neural activity, which can be reshaped and moved by subcortical control signals to initiate specific movements.
ANNUAL REVIEW OF NEUROSCIENCE
(2022)
Review
Cell Biology
Simone Lista, Andrea Vergallo, Stefan J. Teipel, Pablo Lemercier, Filippo Sean Giorgi, Audrey Gabelle, Francesco Garaci, Nicola B. Mercuri, Claudio Babiloni, Bhakta Prasad Gaire, Yosef Koronyo, Maya Koronyo-Hamaoui, Harald Hampel, Robert Nistico
Summary: Acetylcholinesterase inhibitors (ChEI) are the standard treatment for Alzheimer's disease and other neurodegenerative diseases, but primary outcomes vary across clinics and healthcare systems due to dosing issues, timing of therapy initiation, healthcare providers' ambivalence, lack of disease awareness, delayed medical consultation, and prescription of ChEI in non-AD cognitive disorders.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Yosef Koronyo, Altan Rentsendorj, Nazanin Mirzaei, Giovanna C. Regis, Julia Sheyn, Haoshen Shi, Ernesto Barron, Galen Cook-Wiens, Anthony R. Rodriguez, Rodrigo Medeiros, Joao A. Paulo, Veer B. Gupta, Andrei A. Kramerov, Alexander V. Ljubimov, Jennifer E. Van Eyk, Stuart L. Graham, Vivek K. Gupta, John M. Ringman, David R. Hinton, Carol A. Miller, Keith L. Black, Antonino Cattaneo, Giovanni Meli, Mehdi Mirzaei, Dieu-Trang Fuchs, Maya Koronyo-Hamaoui
Summary: Pathologies of Alzheimer’s disease (AD) can be found in the neurosensory retina, but their exact nature and distribution in relation to disease progression in the brain are still largely unknown. This study conducted extensive histopathological and biochemical investigations of postmortem retina and brain tissues from 86 human donors to better understand the pathological features of AD in the retina. The findings suggest a quantitative relationship between retinopathy, brain pathology, and cognitive impairment, and may lead to the development of reliable retinal biomarkers for noninvasive screening and monitoring of AD.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Haoshen Shi, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Ousman Jallow, Krishna Mandalia, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Andrei A. Kramerov, Alexander V. Ljubimov, Debra Hawes, Carol A. Miller, Keith L. Black, Roxana O. Carare, Maya Koronyo-Hamaoui
Summary: This study found that vascular amyloid beta (Aβ) protein deposits were detected in retinas of mild cognitively impaired (MCI) and Alzheimer's disease (AD) patients, and these deposits were linked to disease status. The study also revealed that the components of retinal vascular tight junctions (TJs) and Aβ expression were correlated with neuropathology. The severe decreases in retinal vascular zonula occludens-1 (ZO-1) and claudin-5 were identified in MCI and AD patients, which correlated with arteriolar Aβ(40) deposition and cerebral pathology and cognitive deficits.
ALZHEIMERS & DEMENTIA
(2023)
Review
Physiology
Ron Danziger, Dieu-Trang Fuchs, Yosef Koronyo, Altan Rentsendorj, Julia Sheyn, Eric Y. Y. Hayden, David B. B. Teplow, Keith L. L. Black, Sebastien Fuchs, Kenneth E. E. Bernstein, Maya Koronyo-Hamaoui
Summary: This review discusses the role of angiotensin-converting enzyme (ACE) in Alzheimer's disease (AD) and its potential as a therapeutic target. ACE has been found to degrade the neurotoxic peptide amyloid beta-protein (Aβ(42)), which is associated with AD. Previous studies have shown that overexpression of ACE in myelomonocytic cells improves immune responses and reduces viral and bacterial infection, tumor growth, and atherosclerotic plaque in mice. In a murine model of AD, introducing ACE-expressing myelomonocytes diminished neuropathology and improved cognitive functions through ACE catalytic activity. The therapeutic effects can be achieved by enhancing ACE expression in bone marrow-derived monocytes alone, without targeting central nervous system resident microglia. These findings suggest the potential for utilizing ACE as a natural mechanism to ameliorate AD pathogenesis.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Immunology
Altan Rentsendorj, Koen Raedschelders, Dieu-Trang Fuchs, Julia Sheyn, Vineet Vaibhav, Rebecca A. Porritt, Haoshen Shi, Jargalsaikhan Dagvadorj, Juliana de Freitas Germano, Yosef Koronyo, Moshe Arditi, Keith L. Black, Bhakta Prasad Gaire, Jennifer E. Van Eyk, Maya Koronyo-Hamaoui
Summary: The expression of OPN in macrophages regulates their inflammatory state and protein synthesis. In OPN-deficient macrophages, protein metabolism disruption and apoptosis occur, whereas GA stimulation restores protein synthesis and cellular homeostasis in macrophages.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Liron L. Israel, Oliver Braubach, Ekaterina S. Shatalova, Oksana Chepurna, Sachin Sharma, Dmytro Klymyshyn, Anna Galstyan, Antonella Chiechi, Alysia Cox, David Herman, Bishop Bliss, Irene Hasen, Amanda Ting, Rebecca Arechavala, Michael T. Kleinman, Rameshwar Patil, Eggehard Holler, Julia Y. Ljubimova, Maya Koronyo-Hamaoui, Tao Sun, Keith L. Black
Summary: In this study using an AD mouse model, the effects of different sized particulate matter from polluted air on Alzheimer's disease development were investigated. The results showed that exposure to airborne PM caused significant dysregulation in the brain transcriptome and accelerated Alzheimer's-related pathology.
NEUROBIOLOGY OF DISEASE
(2023)
Meeting Abstract
Ophthalmology
Haoshen Shi, Yosef Koronyo, Zhuoran Yin, Julia Sheyn, Dieu-trang Fuchs, Miyah Davis, Jered Wilson, Vivek Kumar Gupta, Stuart L. Graham, Keith Black, Mehdi Mirzaei, Oleg Butovsky, Maya Koronyo-Hamaoui
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Altan Rentsendorj, Tania Torbati, Dieu-trang Fuchs, Julia Sheyn, Miyah Davis, Nazanin Mirzaei, Keith Black, Yosef Koronyo, Maya Koronyo-Hamaoui
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Critical Care Medicine
Faizan Anwar, Nicklaus A. Sparrow, Mohammad Harun Rashid, Gena Guidry, Michael M. Gezalian, Eric J. Ley, Maya Koronyo-Hamaoui, Itai Danovitch, E. Wesley Ely, S. Ananth Karumanchi, Shouri Lahiri
Summary: This study demonstrates the pathogenic role of systemic IL-6 in mediating structural and functional acute neuropsychiatric symptoms in VILI. The researchers found that inhibiting IL-6 can reduce neural injury and improve acute neuropsychiatric behaviors in mice with VILI.
Article
Multidisciplinary Sciences
Xiaoxi Du, Yosef Koronyo, Nazanin Mirzaei, Chengshuai Yang, Dieu-Trang Fuchs, Keith L. Black, Maya Koronyo-Hamaoui, Liang Gao
Summary: This study developed a label-free hyperspectral imaging method to detect the spectral signatures of amyloid beta-protein and phosphorylated tau in the retinas of Alzheimer's disease patients. The method accurately predicted the distribution of these pathological markers using deep learning. This finding could pave the way for label-free detection of Alzheimer's disease.
Meeting Abstract
Medicine, General & Internal
T. Torbati, J. Sheyn, D. S. Sherman, M. M. Khansari, K. L. Black, P. D. Lyden, Y. Koronyo, M. Koronyo-Hamaoui, O. M. Dumitrascu
JOURNAL OF INVESTIGATIVE MEDICINE
(2022)