Article
Oncology
Anna Klimaszewska-Wisniewska, Izabela Neska-Dlugosz, Karolina Buchholz, Justyna Durslewicz, Dariusz Grzanka, Anna Kasperska, Paulina Antosik, Jan Zabrzynski, Alina Grzanka, Maciej Gagat
Summary: The study found that KIF11 and KIF14 expression patterns in PAC are associated with patient prognosis, potentially serving as prognostic biomarkers. A five-gene panel was also identified to be associated with prognosis.
Article
Oncology
Ahmad Alkhasawneh, Tasnuva Rashid, Ibraheem Mohammed, Basma Elhaddad, Hassan Al-Balas, Mayur Virarkar, Ziad Awad, Brett Baskovich, Arun Gopinath
Summary: This study evaluated the prognostic significance of duodenal wall invasion in pancreatic adenocarcinoma. It found that duodenal wall invasion is associated with lymph node metastasis but not with disease-free/overall survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jaesung Heo, O. Kyu Noh
Summary: This study found that the initial absolute lymphocyte count (ALC) level has a significant impact on clinical outcomes in patients with pancreatic adenocarcinoma receiving adjuvant RT. The high ALC group had higher survival rates and locoregional recurrence-free survival rates compared to the low ALC group.
Article
Oncology
Xuan Zou, Xuan Lin, He Cheng, Yusheng Chen, Ruijie Wang, Mingjian Ma, Yu Liu, Zhengjie Dai, Yesboli Tasiheng, Yu Yan, Qinqin Hou, Fei Ding, Huan Chen, Xianjun Yu, Xu Wang, Chen Liu
Summary: This study systematically revealed the cellular properties and prognostic values of intratumoral TLSs in pancreatic ductal adenocarcinoma (PDAC) and described the potential impact of neoadjuvant treatment (NAT) on TLS development and function.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Justyna Durslewicz, Anna Klimaszewska-Wisniewska, Ewa Domanowska, Natalia Skoczylas-Makowska, Paulina Antosik, Wioletta Zielinska, Arkadiusz Gzil, Paulina Czajkowska, Klaudia Mikolajczyk, Dariusz Grzanka
Summary: This study explored the role of SATB1, SMAD3, Ezrin, and β-catenin as individual and combined biomarkers for survival prediction in pancreatic adenocarcinoma (PAC). The subcellular localization of SATB1 was found to be related to prognosis, with cytoplasmic SATB1 showing even better prognostic ability than nuclear SATB1. Furthermore, the expression levels of SMAD3, Ezrin, and β-catenin were associated with prognosis. These proteins and mRNA expression levels can serve as potential prognostic biomarkers for PAC.
APPLIED SCIENCES-BASEL
(2022)
Article
Oncology
Duo Zuo, Yongzi Chen, Xinwei Zhang, Zhuozhi Wang, Wenna Jiang, Fan Tang, Runfen Cheng, Yi Sun, Lu Sun, Li Ren, Rui Liu
Summary: This study identified 59 hub genes associated with pancreatic adenocarcinoma, including RSAD2 and SMC4, which are related to immune cell infiltration, and DLGAP5 mRNA as a potential independent risk factor for patient survival. Furthermore, ISG15 protein in peripheral blood was validated as a potential diagnostic biomarker for pancreatic adenocarcinoma.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Genetics & Heredity
Xiaomin Li, Ning Qiu, Qijuan Li
Summary: 13 S100s members were upregulated in PAAD tissues. 15 S100s members were associated with TP53 mutation. Expression levels of S100A3/A5/A6/A10/A11/A14/A16/B/P/Z were significantly correlated with the pathological stage.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Lucy X. X. Ma, Yifan Wang, Osvaldo Espin-Garcia, Michael J. J. Allen, Gun Ho Jang, Amy Zhang, Anna Dodd, Stephanie Ramotar, Shawn Hutchinson, Mustapha Tehfe, Ravi Ramjeesingh, James Biagi, Julie M. M. Wilson, Faiyaz Notta, Sandra E. E. Fischer, George Zogopoulos, Steven Gallinger, Robert C. C. Grant, Rama Khokha, Nathan Chan, Barbara T. T. Gruenwald, Jennifer J. J. Knox, Grainne M. M. O'Kane
Summary: By comparing five systemic inflammatory scores in advanced pancreatic adenocarcinoma, researchers found that some of the scores have good prognostic value and can help select patients for clinical trials.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Hiromitsu Hayashi, Norio Uemura, Liu Zhao, Kazuki Matsumura, Hiroki Sato, Yuta Shiraishi, Hideo Baba
Summary: PDAC is a lethal type of cancer with key genetic mutations. Dysregulation of the Hippo signaling pathway and activation of YAP/TAZ are closely associated with PDAC development and may serve as therapeutic targets.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Justin M. Lebenthal, Junting Zheng, Paul M. Glare, Eileen M. O'Reilly, Andrew C. Yang, Andrew S. Epstein
Summary: The Memorial Sloan Kettering Prognostic Score (MPS), consisting of the neutrophil-lymphocyte ratio (NLR) and albumin levels, is a predictive tool for survival in patients with metastatic pancreatic adenocarcinoma (mPDAC) regardless of performance status, disease characteristics, and cancer therapy. Higher MPS scores, liver metastases, radiation therapy, hospital admissions, thromboembolism, and performance status were associated with worse overall survival in this study.
Article
Oncology
Anna Klimaszewska-Wisniewska, Karolina Buchholz, Izabela Neska-Dlugosz, Justyna Durslewicz, Dariusz Grzanka, Jan Zabrzynski, Paulina Soponska, Alina Grzanka, Maciej Gagat
Summary: The overexpression of SPDL1 protein is identified as a potent independent prognostic factor associated with better survival in PDAC patients, while CCNF, RRM2, and SPDL1 mRNAs are identified as independent prognostic markers for poor survival in PDAC patients due to their high expression levels. These biomarkers may have significant implications for prognosis prediction in PAC patients.
Article
Cell Biology
Feiyu Mao, Heng Duan, Aly Allamyradov, Zechang Xin, Yan Du, Xiaodong Wang, Peng Xu, Zhennan Li, Jianjun Qian, Jie Yao
Summary: The expression of SCAMPs in pancreatic adenocarcinoma (PAAD) shows significant differences compared to normal tissue, with SCAMPI and SCAMPS expression serving as independent prognostic factors for PAAD.
Article
Oncology
Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Anna Willms, Christine Halske, Christian Roder, Sandra Kruger, Christoph Rocken, Thomas Becker, Holger Kalthoff, Anna Trauzold
Summary: HMGA2 expression in the nucleus is associated with tumor dedifferentiation and lymph node metastasis in pancreatic ductal adenocarcinoma (PDAC). The presence of HMGA2 in both the cytoplasm and the nucleus of tumor cells is common, with stronger nuclear staining observed. Additionally, cytoplasmic HMGA2 expression correlates with lymph vessel and venous invasion, suggesting a potential role in nodal spread.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Deirdre Kruger, Nicola Lahoud, Yandiswa Y. Yako, John Dever, Martin Smith
Summary: This study aimed to evaluate the risk factors, symptoms, and potential prognostic biomarkers in PDAC, showing that platelet count, IL-15, and GM-CSF could be potential indicators of metastatic disease in PDAC patients. Some risk factors and symptoms did not differ across different stages of cancer.
Article
Oncology
Sun-Young Jun, Seung-Mo Hong, Kee-Taek Jang
Summary: The expression of Cyclin D1 in small intestinal adenocarcinomas (SIACs) has not been comprehensively studied. This study found that Cyclin D1 is commonly overexpressed in SIACs, and high expression of Cyclin D1 is associated with favorable prognostic indicators.
Review
Biotechnology & Applied Microbiology
Richard J. Weaver, Eric A. Blomme, Amy E. Chadwick, Ian M. Copple, Helga H. J. Gerets, Christopher E. Goldring, Andre Guillouzo, Philip G. Hewitt, Magnus Ingelman-Sundberg, Klaus Gjervig Jensen, Satu Juhila, Ursula Klingmuller, Gilles Labbe, Michael J. Liguori, Cerys A. Lovatt, Paul Morgan, Dean J. Naisbitt, Raymond H. H. Pieters, Jan Snoeys, Bob van de Water, Dominic P. Williams, B. Kevin Park
NATURE REVIEWS DRUG DISCOVERY
(2020)
Article
Pharmacology & Pharmacy
Giulio Giustarini, Suzanna Huppelschoten, Marco Barra, Angela Oppelt, Laura Wagenaar, Richard J. Weaver, Marianne Bol-Schoenmakers, Joost J. Smit, Bob van de Water, Ursula Klingmueller, Raymond H. H. Pieters
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Oncology
Soo-Zin Kim-Wanner, Yassen Assenov, Mridul B. Nair, Dieter Weichenhan, Axel Benner, Natalia Becker, Katharina Landwehr, Ruprecht Kuner, Holger Sultmann, Manel Esteller, Ina Koch, Michael Lindner, Michael Meister, Michael Thomas, Matthias Bieg, Ursula Klingmueller, Matthias Schlesner, Arne Warth, Benedikt Brors, Erhard Seifried, Halvard Boenig, Christoph Plass, Angela Risch, Thomas Muley
JOURNAL OF THORACIC ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Avlant Nilsson, Jurgen R. Haanstra, Martin Engqvist, Albert Gerding, Barbara M. Bakker, Ursula Klingmueller, Bas Teusink, Jens Nielsen
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemistry & Molecular Biology
Frederique Kok, Marcus Rosenblatt, Melissa Teusel, Tamar Nizharadze, Vladimir Goncalves Magalhaes, Christopher Daechert, Tim Maiwald, Artyom Vlasov, Marvin Waesch, Silvana Tyufekchieva, Katrin Hoffmann, Georg Damm, Daniel Seehofer, Tobias Boettler, Marco Binder, Jens Timmer, Marcel Schilling, Ursula Klingmueller
MOLECULAR SYSTEMS BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Niklas Gremke, Pierfrancesco Polo, Aaron Dort, Jean Schneikert, Sabrina Elmshauser, Corinna Brehm, Ursula Klingmuller, Anna Schmitt, Hans Christian Reinhardt, Oleg Timofeev, Michael Wanzel, Thorsten Stiewe
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Sabine Wessels, Thomas Muley, Petros Christopoulos, Michael Meister, Ingrid Heinzmann-Groth, Arne Warth, Esther Herpel, Simone Hummler, Ursula Klingmuller, Jonas Kuon, Claus-Peter Heussel, Ralf Eberhardt, Felix J. F. Herth, Hauke Winter, Helge Bischoff, Albrecht Stenzinger, Martin Reck, Rudolf Maria Huber, Michael Thomas, Marc A. Schneider
TRANSLATIONAL LUNG CANCER RESEARCH
(2020)
Article
Immunology
Soumya R. Mohapatra, Ahmed Sadik, Suraj Sharma, Gernot Poschet, Hagen M. Gegner, Tobias V. Lanz, Philippe Lucarelli, Ursula Klingmueller, Michael Platten, Ines Heiland, Christiane A. Opitz
Summary: The liver plays a critical role in maintaining homeostatic levels of essential amino acids like tryptophan. Hypoxic conditions prompt significant rewiring of tryptophan metabolism in hepatocytes, leading to reduced expression of TDO2 and increased tryptamine production. This hypoxic adaptation may be linked to hallucinogenic responses and immunosuppressive activities, highlighting the importance of hypoxia in regulating tryptophan metabolism and potential implications for mental health.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lorenza A. D'Alessandro, Ursula Klingmueller, Marcel Schilling
Summary: This article investigates the response of liver cells to cytokines and growth factors, with a specific focus on the regulation of growth factor receptors on the cell surface. The study suggests that mechanistic mathematical modeling based on quantitative data can help unravel these molecular-level interactions.
BIOCHEMICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Karolin Dehlke, Linda Krause, Silvana Tyufekchieva, Anastasia Murtha-Lemekhova, Philipp Mayer, Artyom Vlasov, Ursula Klingmueller, Nikola S. Mueller, Katrin Hoffmann
Summary: This study investigates the expression of cytokines and growth factors in post-hepatectomy regeneration and finds that certain expression trajectories are associated with liver failure, morbidity, and mortality. Regression models can predict mortality following major liver resection based on preoperative cytokine and growth factor signatures. Liquid-biopsy based risk profiling can predict postoperative liver failure and mortality on the first day after surgery.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Sajib Chakraborty, Geoffroy Andrieux, Philipp Kastl, Lorenz Adlung, Sandro Altamura, Martin E. Boehm, Luisa E. Schwarzmueller, Yomn Abdullah, Marie-Christine Wagner, Barbara Helm, Hermann-Josef Groene, Wolf D. Lehmann, Melanie Boerries, Hauke Busch, Martina U. Muckenthaler, Marcel Schilling, Ursula Klingmueller
Summary: The lack of erythropoietin receptor leads to a deficiency of hemoglobin in CFU-E cells in embryos, along with massive iron overload in the fetal liver, indicating a communication issue between the liver and placenta. Additionally, the reduction of related proteins also causes a metabolic shift. Balancing interactions between erythropoiesis, iron homeostasis regulation, and metabolic reprogramming is crucial for survival.
Article
Cell Biology
Natella I. I. Enukashvily, Nikita V. V. Ponomartsev, Avanee Ketkar, Roman Suezov, Anna V. V. Chubar, Andrey D. D. Prjibelski, Daria D. D. Shafranskaya, Sabrina Elmshaeuser, Corinna U. U. Keber, Vera N. N. Stefanova, Andrey L. L. Akopov, Ursula Klingmueller, Petra I. I. Pfefferle, Thorsten Stiewe, Matthias Lauth, Anna I. I. Brichkina
Summary: The abnormal tumor microenvironment significantly influences the response of cancer to chemo- and immuno-therapy. This study demonstrates the induction of pericentromeric satellite DNA (satDNA) transcription in cancer-associated fibroblasts (CAFs) of lung adenocarcinoma. The findings suggest that satellite long non-coding (lnc) RNAs in CAFs regulate inflammatory gene expression and can be secreted, potentially playing a role in cell-cell communication in the tumor microenvironment.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Hagen M. Gegner, Thomas Naake, Aurelien Dugourd, Torsten Mueller, Felix Czernilofsky, Georg Kliewer, Evelyn Jaeger, Barbara Helm, Nina Kunze-Rohrbach, Ursula Klingmueller, Carsten Hopf, Carsten Mueller-Tidow, Sascha Dietrich, Julio Saez-Rodriguez, Wolfgang Huber, Rudiger Hell, Gernot Poschet, Jeroen Krijgsveld
Summary: Metabolomic and proteomic analyses of human plasma and serum samples have the potential to advance our understanding of disease biology. However, pre-analytical factors such as temperature and time can impact the integrity of the samples and there is a need for standardized operating procedures to ensure reliable data.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jana Samarin, Piotr Fabrowski, Roman Kurilov, Hana Nuskova, Johanna Hummel-Eisenbeiss, Hannelore Pink, Nan Li, Vivienn Weru, Hamed Alborzinia, Umut Yildiz, Laura Grob, Minerva Taubert, Marie Czech, Michael Morgen, Christina Brandstaedter, Katja Becker, Lianghao Mao, Ashok Kumar Jayavelu, Angela Goncalves, Ulrike Uhrig, Jeanette Seiler, Yanhong Lyu, Sven Diederichs, Ursula Klingmueller, Martina Muckenthaler, Annette Kopp-Schneider, Aurelio Teleman, Aubry K. Miller, Nikolas Gunkel
Summary: A study found a set of antioxidant-capacity biomarkers (ACB) in lung cancer cell lines, which are repressed by STAT3 and STAT5A/B in sensitive cells, making them susceptible to redox-targeting and ferroptosis-inducing drugs. Low ACB expression was associated with a high level of nitric oxide instead of reactive oxygen species (ROS), which is required for high replication rates. ACB expression pattern can help stratify cancer patients for clinical trials of ROS-inducing drugs.
Article
Hematology
Silvia Thoene, Tamoghna Mandal, Naidu M. Vegi, Leticia Quintanilla-Martinez, Reinhild Roesler, Sebastian Wiese, Klaus H. Metzeler, Tobias Herold, Torsten Haferlach, Konstanze Doehner, Hartmut Doehner, Luisa Schwarzmueller, Ursula Klingmueller, Christian Buske, Vijay P. S. Rawat, Michaela Feuring-Buske