Article
Chemistry, Multidisciplinary
Xiao-Ke Yang, Fu-Li Zhang, Wen-Tao Wu, Yun Tang, Jing Yan, Yan-Ling Liu, Christian Amatore, Wei-Hua Huang
Summary: An electrochemical Glu nanobiosensor was introduced to measure Glu fluxes released via exocytosis by large Glu vesicles in living hippocampal neurons. The study revealed a sub-quantal release mode, where only one third to one half of intravesicular Glu molecules are released by individual vesicles during exocytotic events.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Shiri Hodassman, Yuval Meir, Karin Kisos, Itamar Ben-Noam, Yael Tugendhaft, Amir Goldental, Roni Vardi, Ido Kanter
Summary: This study presents an experimental neuronal mechanism for high-precision feedforward sequence identification networks without feedback loops. The mechanism demonstrates reliable identification of handwritten digit sequences and has the potential to be applied to deep convolutional networks. Surprisingly, the network performs well in classifying sequences but poorly in classifying individual objects.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Aida Garrido-Charles, Antoine Huet, Carlo Matera, Anupriya Thirumalai, Jordi Hernando, Amadeu Llebaria, Tobias Moser, Pau Gorostiza
Summary: Artificial control of neuronal activity is crucial for studying neural circuits and restoring neural functions. In this study, researchers developed fast photoswitchable ligands of glutamate receptors (GluRs) to enable direct and reversible control of intact neurons using visible light pulses. These new photoswitchable ligands successfully induced photocurrents in untransfected auditory neurons, offering a drug-based approach for optical stimulation without the need for genetic manipulation. This method shows potential for spatiotemporal control of neural activities in the brain.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Neurosciences
Wei Chen, Lingfei Jiang, Yueqiang Hu, Nong Tang, Ni Liang, Xing-Feng Li, Ye-Wen Chen, Hongling Qin, Lin Wu
Summary: The study investigated the impact of lentivirus-induced ferritin overexpression on hippocampal neuronal injury and death in a rat model of cerebral ischemia-reperfusion. The results showed that ferritin overexpression partially reversed the cognitive and locomotor deficits induced by ischemic injury, reduced tau hyperphosphorylation, and protected against pathogenic changes, apoptosis, and oxidative stress in hippocampal neurons. The study also demonstrated that ferritin reduction is essential for preventing hippocampal neuronal ferroptosis mediated by p53 and SLC7A11 upregulation in response to cerebral ischemia.
Article
Biochemistry & Molecular Biology
Rebekah Tillotson, Justyna Cholewa-Waclaw, Kashyap Chhatbar, John C. Connelly, Sophie A. Kirschner, Shaun Webb, Martha V. Koerner, Jim Selfridge, David A. Kelly, Dina De Sousa, Kyla Brown, Matthew J. Lyst, Skirmantas Kriaucionis, Adrian Bird
Summary: The interaction of MeCP2 with sites of non-CG methylation, particularly mCAC, is crucial for normal brain function and may be related to the pathogenesis of Rett syndrome. Dysregulated genes in Mecp2 null and domain-swap mice are associated with other neurological disorders, suggesting potential targets for the Rett syndrome phenotype.
Article
Clinical Neurology
Jo M. Vanoevelen, Jorgen Bierau, Janine C. Grashorn, Ellen Lambrichs, Erik-Jan Kamsteeg, Levinus A. Bok, Ron A. Wevers, Marjo S. van der Knaap, Marianna Bugiani, Junmei Hu Frisk, Rita Colnaghi, Mark O'Driscoll, Debby M. E. Hellebrekers, Richard Rodenburg, Carlos R. Ferreira, Han G. Brunner, Arthur van den Wijngaard, Ghada M. H. Abdel-Salam, Liya Wang, Constance T. R. M. Stumpel
Summary: The study reveals that impairing the biosynthesis of dTTP, a crucial DNA building block, leads to early-onset neurodegenerative disease characterized by severe microcephaly and growth retardation. Microcephaly, neuronal cell death, and early lethality were replicated in dtymk mutant zebrafish models. Furthermore, increased ribonucleotide incorporation in the genome and impaired responses to DNA damage were observed in these mutant zebrafish, providing novel insights into the pathophysiology of the disease. The loss-of-function of DTYMK was identified as the cause of this severe postnatal neurodegenerative disease, emphasizing the essential role of dTTP synthesis in maintaining genome stability and neuronal survival.
ACTA NEUROPATHOLOGICA
(2022)
Article
Meteorology & Atmospheric Sciences
Peter Uhe, Dann Mitchell, Paul D. Bates, Myles R. Allen, Richard A. Betts, Chris Huntingford, Andrew D. King, Benjamin M. Sanderson, Hideo Shiogama
Summary: Precipitation events are influenced by climate change, but different modeling approaches can lead to varying future projections. There is uncertainty in climate modeling which can greatly impact estimated precipitation changes. Confidence is higher in extreme precipitation changes compared to mean precipitation, highlighting the importance of considering multiple sources of climate projections.
JOURNAL OF CLIMATE
(2021)
Article
Plant Sciences
Antony Justin, Peet Thomas, Gaddam Narasimha Rao, Jeyaram Bharathi Jeyabalan, Chintha Narendar, Sivasankaran Ponnusankar, Jubie Selvaraj, R. Hariprasad
Summary: The study chemically standardized Chandamarutha Chenduram (CC) and found its neuroprotective effect in cerebral ischemia, regulating neurotransmitters, antioxidant enzymes, and inflammatory cytokines to mitigate excitotoxicity.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Barbara Calabrese, Steven Jones, Yoko Yamaguchi-Shiraishi, Michael Lingelbach, Uri Manor, Tatyana M. Svitkina, Henry N. Higgs, Andy Y. Shih, Shelley Halpain
Summary: Ischemia and excess NMDA receptor activation cause actin to reorganize, protecting neurons from death induced by cell edema.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Maya Rozenfeld, Ivana Savic Azoulay, Tsipi Ben Kasus Nissim, Alexandra Stavsky, Moran Melamed, Grace Stutzmann, Michal Hershfinkel, Ora Kofman, Israel Sekler
Summary: We have discovered a link between PDE and mitochondrial calcium signaling, and found that selective PDE2 inhibitor can effectively rescue the efflux of calcium ions from mitochondria in neurons. Our results also demonstrate that the protective effect of PDE2 inhibition against excitotoxicity relies on the presence of NCLX. Additionally, the administration of the PDE2 inhibitor enhances new object recognition in mice.
Article
Neurosciences
Tomoo Inubushi, Masanori Ito, Yutaro Mori, Masami Futatsubashi, Kengo Sato, Shigeru Ito, Masamichi Yokokura, Tomomi Shinke, Yosuke Kameno, Akihiro Kakimoto, Toshihiko Kanno, Hiroyuki Okada, Yasuomi Ouchi, Etsuji Yoshikawa
Summary: The study compared changes in brain activity, cerebral blood flow, and dopamine release during PET scans under restrained and unrestrained conditions, as well as psychological stress responses related to head restraint. The results indicated that head restraint could cause undesired responses in brain physiology and emotional states.
Article
Clinical Neurology
Jun-Xia Yang, Wei-Nan Zhao, Yan-Yu Jiang, Yu Ma, Dan-Dan Chen, Zhi-Hua Lin, Meng-Bing Yin, Kun-Peng Ren
Summary: The study found that Cav-1 plays a role in enhancing presynaptic glutamate release in chronic neuropathic pain in the anterior cingulate cortex. Cav-1 expression was higher in CCI mice and resulted in increased glutamate release. Inhibition of Cav-1 using siRNAs significantly reduced glutamate release.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2023)
Article
Engineering, Mechanical
Kesheng Xu, Jean Paul Maidana, Patricio Orio
Summary: The coexistence of electrical and chemical synaptic communication among excitatory cells has been confirmed, but the theoretical understanding of hybrid synaptic connections in various dynamical states of neural networks is not fully studied. A neural network model including electrical and chemical synaptic connections was used to investigate synchronization and firing patterns among excitatory cells, revealing tendencies towards synchronization and the ability to cause various firing patterns by slightly changing the synaptic weights. This study lays a foundation for understanding the computational significance of mixed synapse in neural functions.
NONLINEAR DYNAMICS
(2021)
Article
Cell Biology
Stefan A. Berghoff, Lena Spieth, Ting Sun, Leon Hosang, Constanze Depp, Andrew O. Sasmita, Martina H. Vasileva, Patricia Scholz, Yu Zhao, Dilja Krueger-Burg, Sven Wichert, Euan R. Brown, Kyriakos Michail, Klaus-Armin Nave, Stefan Bonn, Francesca Odoardi, Moritz Rossner, Till Ischebeck, Julia M. Edgar, Gesine Saher
Summary: Research has shown that in chronic demyelinating diseases, increased neuronal cholesterol synthesis plays a critical role in remyelination, especially when lipid recycling is defective in the affected area. This finding contributes to understanding disease progression and has implications for therapeutic strategies in patients with multiple sclerosis (MS).
Editorial Material
Reproductive Biology
Mohammad Saied Salehi, Sareh Pandamooz, Amin Tamadon, Mohammad Reza Jafarzadeh Shirazi, Afshin Borhani-Haghighi
Summary: Some studies have shown that stroke may increase the risk of pregnancy complications and early menopause. Preclinical investigations have also found that middle cerebral artery occlusion could affect the hypothalamus, potentially leading to long-lasting reproductive disorders.
BIOLOGY OF REPRODUCTION
(2022)
Article
Neurosciences
Yuanchao Xue, Hao Qian, Jing Hu, Bing Zhou, Yu Zhou, Xihao Hu, Aziz Karakhanyan, Zhiping Pang, Xiang-Dong Fu
NATURE NEUROSCIENCE
(2016)
Article
Multidisciplinary Sciences
Zhen-Ning Zhang, Beatriz C. Freitas, Hao Qian, Jacques Lux, Allan Acab, Cleber A. Trujillo, Roberto H. Herai, Viet Anh Nguyen Huu, Jessica H. Wen, Shivanjali Joshi-Barr, Jerome V. Karpiak, Adam J. Engler, Xiang-Dong Fu, Alysson R. Muotri, Adah Almutairi
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Liang Chen, Jia-Yu Chen, Xuan Zhang, Ying Gu, Rui Xiao, Changwei Shao, Peng Tang, Hao Qian, Daji Luo, Hairi Li, Yu Zhou, Dong-Er Zhang, Xiang-Dong Fu
Article
Oncology
Zhilai Yang, Na Chen, Rongjing Ge, Hao Qian, Jin-Hui Wang
Article
Biochemistry & Molecular Biology
Liang Chen, Jia-Yu Chen, Yi-Jou Huang, Ying Gu, Jinsong Qiu, Hao Qian, Changwei Shao, Xuan Zhang, Jing Hu, Hairi Li, Shunmin He, Yu Zhou, Omar Abdel-Wahab, Dong-Er Zhang, Xiang-Dong Fu
Article
Biochemistry & Molecular Biology
Haiyun Tang, Hongyu Long, Chang Zeng, Yi Li, Fangfang Bi, Jinhui Wang, Hao Qian, Bo Xiao
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2012)
Article
Neurosciences
Bo Wen, Hao Qian, Jing Feng, Rong-Jing Ge, Xin Xu, Zhi-Qiang Cui, Ru-Yuan Zhu, Long-Sheng Pan, Zhi-Pei Lin, Jin-Hui Wang
CNS NEUROSCIENCE & THERAPEUTICS
(2015)
Article
Multidisciplinary Sciences
Na Chen, Jiandong Yu, Hao Qian, Rongjing Ge, Jin-Hui Wang
Article
Neurosciences
Rongjing Ge, Hao Qian, Jin-Hui Wang
Article
Neurosciences
Jiandong Yu, Hao Qian, Jin-Hui Wang
Article
Neurosciences
Rongjing Ge, Hao Qian, Na Chen, Jin-Hui Wang
Article
Multidisciplinary Sciences
Hao Qian, Xinjiang Kang, Jing Hu, Dongyang Zhang, Zhengyu Liang, Fan Meng, Xuan Zhang, Yuanchao Xue, Roy Maimon, Steven F. Dowdy, Neal K. Devaraj, Zhuan Zhou, William C. Mobley, Don W. Cleveland, Xiang-Dong Fu
Review
Genetics & Heredity
Hao Qian, Xiang-Dong Fu
Summary: Neurodegenerative diseases, characterized by progressive neural loss, pose significant challenges in aging societies. Current treatment strategies have limited impact on disease progression, but new approaches suggest that replenishing neurons and harnessing the brain's plasticity may reverse the disease phenotype.
ANNUAL REVIEW OF GENETICS, VOL 55
(2021)